Noncutaneous melanoma, integrates the expertise of a multidisciplinary group of clinicians and investigators to help shed light on recent advances in the understanding of noncutaneous melanomas. The authors skillfully present a comprehensive review of uveal melanoma, the most common type of ocular melanoma, as well as nasopharyngeal, genitourinary, and anorectal melanoma, and finally melanoma of unknown primary. This book will be highly valuable to clinicians caring for patients with noncutaneous melanoma who desire a review of the current literature regarding these entities. As the diagnostic and therapeutic approaches to these patients are continually evolving, it is imperative for clinicians to stay well versed on new advances gleaned from the primary literature. This book addresses each topic in sophisticated detail, and it will be a valuable resource for clinicians and investigators to assist in patient care and guide further research.

Contents

• Foreword
• Preface
• Contributors
• 1. Uveal Melanoma
  Salvatore Grisanti and Ayseguel Tura.
  • INTRODUCTION
  • CYTOGENETIC AND MOLECULAR ALTERATIONS IN UVEAL MELANOMA
  • CLINICAL FEATURES AND CLASSIFICATION
  • DIAGNOSTICS
  • THERAPY
  • METASTATIC DISEASE AND PROGNOSIS
  • FUTURE PERSPECTIVE
  • CONCLUSION
  • REFERENCES
• 2. Genetics of Uveal Melanoma
  Rachel E. Doherty, Mohammed Alfawaz, Jessica Francis, Beckie Lijka-Jones, and Karen Sisley.
  • INTRODUCTION
  • COMMON CHROMOSOME CHANGES IN POSTERIOR UM
  • MUTATIONS ASSOCIATED WITH POSTERIOR UM
  • GENETIC BIOMARKERS OF POSTERIOR UM
  • GENETIC ANALYSIS OF METASTATIC LESIONS OF POSTERIOR UM
  • THE SEQUENCE OF GENETIC PROGRESSION IN POSTERIOR UM
  • IRIS MELANOMAS
  • CONCLUSION
  • REFERENCES
• 3. Liquid Biopsy for Uveal Melanoma
  Ayseguel Tura, Julia Lueke, and Salvatore Grisanti.
  • INTRODUCTION
  • TUMOR CELL DISSEMINATION AND SYSTEMIC CIRCULATION IN UVEAL MELANOMA
  • TECHNIQUES TO DETECT CTC AND CMC
  • PRESENT POTENTIAL OF CMC DETECTION
  • FUTURE POTENTIAL
  • CONCLUSION
  • REFERENCES
• 4. Nasopharyngeal Melanoma
  Giovanni Paolino, Dario Didona, Giulia Macrì, Stefano Calvieri, and Santo Raffaele Mercuri.
  • INTRODUCTION
  • EPIDEMIOLOGY
  • PATHOGENESIS
  • GENETICS
  • CLINICAL FEATURES
  • PATHOLOGY
  • STAGING OF NPM
  • THERAPY
  • CONCLUSIONS
  • REFERENCES
• 5. Genitourinary Melanoma
  Pooja H. Rambhia, Jeffrey F. Scott, Ritva Vyas, and Meg R. Gerstenblith.
  • INTRODUCTION
  • EPIDEMIOLOGY OF GU MELANOMA
  • GENETIC AND MOLECULAR ALTERATIONS IN GU MELANOMA
  • DIAGNOSTIC WORK-UP OF GU MELANOMA
  • CLASSIFICATION AND STAGING OF GU MELANOMA
  • TREATMENT
  • FUTURE PERSPECTIVES
  • CONCLUSION
  • REFERENCES
• 6. Anorectal Melanoma
  Giovanni Paolino, Dario Didona, Giulia Macrì, Stefano Calvieri, and Santo Raffaele Mercuri.
  • INTRODUCTION
  • EPIDEMIOLOGY
  • PATHOGENESIS AND GENETICS OF AM
  • GENETICS
  • CLINICAL FEATURES AND INSTRUMENTAL DIAGNOSIS
  • PATHOLOGY
  • STAGING
  • TREATMENT
  • CONCLUSION
  • REFERENCES
• 7. Melanoma of Unknown Primary
  Jeffrey F. Scott and Meg R. Gerstenblith.
  • INTRODUCTION
  • HYPOTHESES REGARDING THE ORIGIN OF MUP
  • GENETICS
  • INCIDENCE AND DEMOGRAPHICS
  • METASTATIC SITES
  • STAGING AND PROGNOSTIC FACTORS
  • SURVIVAL
  • DIAGNOSIS
  • MANAGEMENT
  • CONCLUSION
  • REFERENCES

Noncutaneous Melanoma

ISBN: 978-0-9944381-5-7

DOI: http://dx.doi.org/10.15586/codon.noncutaneousmelanoma.2018

Edited by

Jeffrey F. Scott, MD and Meg R. Gerstenblith, MD

Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA

Published by

Codon Publications

Brisbane, QLD 4122, Australia

Copyright© 2018 Codon Publications

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First Published in March 2018

Printed in Australia

A free online version is available at http://codonpublications.com