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Conserved domains on  [gi|219281887|ref|NP_001136433|]
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lysophosphatidic acid receptor 5 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
23-308 3.77e-155

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15154:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 285  Bit Score: 437.66  E-value: 3.77e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15154    1 TLHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15154   81 MNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVYRCFESFSDN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKgRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd15154  161 DWK-GLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15154  240 NLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
 
Name Accession Description Interval E-value
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
23-308 3.77e-155

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 437.66  E-value: 3.77e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15154    1 TLHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15154   81 MNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVYRCFESFSDN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKgRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd15154  161 DWK-GLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15154  240 NLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-297 2.74e-45

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 155.92  E-value: 2.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887   40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNMYGSCIFLMLINV 117
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLlTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  118 DRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpSRCRYRDLEVRLCFESFSDELWKGRLlpLVLLAEA 197
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFG--WTLTVPEGNVTVCFIDFPEDLSKPVS--YTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  198 LGFLLPLAAVVYSSGRVFWTLAR-----PDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVaasvpaR 272
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKsaskqKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCEL------S 231
                         250       260
                  ....*....|....*....|....*
gi 219281887  273 DRVRGVLMVMVLLAGANCVLDPLVY 297
Cdd:pfam00001 232 RLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
14-309 9.36e-35

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 130.28  E-value: 9.36e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  14 PCPDYRPTHRLHL---VVYSLVLAAGLPLNALALwVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFP 90
Cdd:PHA03087  29 DCDLNIGYDTNSTiliVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  91 DLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDL 170
Cdd:PHA03087 108 EFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTK----KDH 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 171 EVRLCFESFSDE--LWKgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdATQSQRRRKTVRLLLANLVIFLLCFV 248
Cdd:PHA03087 184 ETLICCMFYNNKtmNWK---LFINFEINIIGMLIPLTILLYCYSKILITLKG--INKSKKNKKAIKLVLIIVILFVIFWL 258
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 249 PYNSTLAVYgLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGF----RNTLR 309
Cdd:PHA03087 259 PFNVSVFVY-SLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFnkhkKKSLK 322
 
Name Accession Description Interval E-value
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
23-308 3.77e-155

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 437.66  E-value: 3.77e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15154    1 TLHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15154   81 MNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVYRCFESFSDN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKgRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd15154  161 DWK-GLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15154  240 NLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
24-308 2.11e-91

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 275.68  E-value: 2.11e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQ 102
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGgWWPFGDFLCRLTGLLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcrYRDLEVRLCFESFSDe 182
Cdd:cd14982   82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTI---AKENNSTTCFEFLSE- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 lWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPD--ATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd14982  158 -WLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSkqSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RSKlVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14982  237 RLS-FIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
24-308 1.16e-59

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 194.30  E-value: 1.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15156    2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd15156   82 NMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQ--STNNQLNNNSETCFENFSSKT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQR--RRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLR 261
Cdd:cd15156  160 WKTYLSKIVIFIEIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKlnKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVR 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 262 SK-LVAASVPArdRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15156  240 TQtFKNCSVVA--AVRTMYPITLCIAVSNCCFDPIVYYFTSETIQNSI 285
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
24-308 1.07e-55

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 183.97  E-value: 1.07e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15155    2 LYGAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRyrdlEVRLCFESFSDEL 183
Cdd:cd15155   82 NIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSN----TSTTCFEGFSKSI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPdATQSQ---RRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15155  158 WKTYLSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRKP-ATLSQigtNKEKVLKMILVHVAIFVVCFVPYNSILFLYALV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RSKLVAASVPARdRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15155  237 RSQAIANCGVER-FARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
27-305 5.23e-50

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 169.10  E-value: 5.23e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMNM 105
Cdd:cd15160    5 VVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHnWTFGPLSCKVVGFFFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYrdlEVRLCFESFSDELWK 185
Cdd:cd15160   85 YASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEP---NHTLCYEKYPMEGWQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRllpLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLV 265
Cdd:cd15160  162 AS---YNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 219281887 266 AASVPARdRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15160  239 GLCGFEK-RVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
24-307 1.70e-48

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 165.20  E-value: 1.70e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLsYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15165    2 LQLVVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKM-HSSKKQWPLGRTLCSFLESLYFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRdlevrlCFESFSDEL 183
Cdd:cd15165   81 NMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPTNNTR------CFHGFSNKT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTL-ARPDATQSQRRRKT-VRLLLANLVIFLLCFVPYNSTLAVYGLLR 261
Cdd:cd15165  155 WS---KKVIVVVEEFGFLIPMAVMVFCSVQIIRTLlDMRRPEQPKVKQNKsVKIVLSNLVVFLVCFTPYHLGIFLQFLVK 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 262 SKLVAASVpARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15165  232 NDIINDCS-TKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRES 276
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
27-308 6.01e-47

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 161.23  E-value: 6.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPF-WAVYAADGWVFGSFLCKLVSALYTINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPA---ARVHRP---SRCRYRdlevrlcFESFS 180
Cdd:cd14984   84 SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEfifSQVSEEngsSICSYD-------YPEDT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWKGRLLPLVLLaeaLGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd14984  157 ATTWKTLLRLLQNI---LGFLLPLLVMLFCYSRIIRTLLR---ARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQ 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14984  231 LLGIISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-297 2.74e-45

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 155.92  E-value: 2.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887   40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNMYGSCIFLMLINV 117
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLlTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  118 DRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpSRCRYRDLEVRLCFESFSDELWKGRLlpLVLLAEA 197
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFG--WTLTVPEGNVTVCFIDFPEDLSKPVS--YTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  198 LGFLLPLAAVVYSSGRVFWTLAR-----PDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVaasvpaR 272
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKsaskqKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCEL------S 231
                         250       260
                  ....*....|....*....|....*
gi 219281887  273 DRVRGVLMVMVLLAGANCVLDPLVY 297
Cdd:pfam00001 232 RLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
27-308 2.19e-43

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 151.88  E-value: 2.19e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15921    5 TAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNsHWPFGDIACRIILYVLYVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARvhrpSRCRYRDLEVRLCFESFSDElwK 185
Cdd:cd15921   85 YSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLF----AKSKQHDEGSTRCLELAHDA--V 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQR---RRKTVRLLLANLVIFLLCFVPYNSTLAVYgLLRS 262
Cdd:cd15921  159 DKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTrpsRRKACALIIISLGIFLVCFLPYHIVRTIH-LITE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15921  238 RQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
27-305 4.46e-43

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 150.93  E-value: 4.46e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGdHWIFGDFMCKLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRdlevRLCFESFSDELWK 185
Cdd:cd15168   85 YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNR----TTCYDTTSPEELN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 gRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDA--TQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15168  161 -DYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGegVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 264 LVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15168  240 SGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
26-304 7.40e-42

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 147.41  E-value: 7.40e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLsYYALHHWPfPDLLCQTTGAIFQMNM 105
Cdd:cd15164    4 LIIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVL-YFLKHSWP-DDELCLVLQSIYFINR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPsrcryrdlEVRLCFESFSDelwk 185
Cdd:cd15164   82 YMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIISVSLRLAWEEQ--------EENFCFGKTST---- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 gRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRR---RKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd15164  150 -RPSKRTLIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTNPHEEkliQKAIYIVSANLIVFIVCFLPLHIGLLVRFVMES 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 263 klVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGF 304
Cdd:cd15164  229 --NKASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
27-308 3.20e-41

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 146.34  E-value: 3.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15159    5 LFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALgFDWPFGDWLCRLTALLFYINT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP---AARVHRPSrcryrdlEVRLCFESFSDE 182
Cdd:cd15159   85 YAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPllfMPMTKEMG-------GRITCMEYPNFE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGrlLPLVLL-AEALGFLLPLAAVVYSSGRVFWTLAR-----PDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAV 256
Cdd:cd15159  158 KIKR--LPLILLgACVIGFGVPVGIILFCYSQITLKLCRtakenPLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIQ 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 257 YgLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15159  236 F-MIRKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
27-308 1.33e-40

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 144.34  E-value: 1.33e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15178    5 VIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPF-WAVSVVKGWIFGTFMCKLVSLLQEANFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVaRLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVrLCFESFSDELWKG 186
Cdd:cd15178   84 SGILLLACISVDRYLAIVHATRALTQKRHLV-KFVCAGVWLLSLLLSLPAL-LNRDAFKPPNSGRT-VCYENLGNESADK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 RLLPLVLLAEALGFLLPLAAVVYSSGrvfWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVA 266
Cdd:cd15178  161 WRVVLRILRHTLGFLLPLVVMLFCYG---FTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLIT 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 267 ASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15178  238 ETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
27-306 7.33e-39

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 139.89  E-value: 7.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYY-ALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15162    5 AVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHiHGNNWIFGEALCRLVTVAFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRpsRCRYRDLEVRLCFESFSDELWK 185
Cdd:cd15162   85 YCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQ--TIFLPALDITTCHDVLPEQLLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRK-TVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKl 264
Cdd:cd15162  163 GDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKrAIKLAATVLAIFIICFAPSNLLLLAHYSLISS- 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 265 vaasvPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15162  242 -----SGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
28-308 5.05e-38

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 137.95  E-value: 5.05e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKgQWLFGDFLCRISSYALYVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP--AARVHRPSRCRYRdlevrlCFESFSDELW 184
Cdd:cd15158   86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPflMSGSHDTETNKTK------CFEPPQSNQQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDAT---QSQRRRKTVRLLLANLVIFLLCFVPYN--STLAVYGL 259
Cdd:cd15158  160 LTKLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKarkQQSSRKKAIRMIIIVLLAFLVSFMPYHiqRTIHLHFL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LRSKlvaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15158  240 SRKD---STCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
29-308 2.45e-37

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 135.61  E-value: 2.45e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  29 YSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYY-ALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15161    7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHlSGNHWPFGEVPCRLAGFLFYLNMYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARvhrpSRCRYRDLEVRLCFESFSDELWKGR 187
Cdd:cd15161   87 SLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLV----SPQTVEVNNTTVCLQLYREKASRGA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 LLPLvllaeALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSkLVAA 267
Cdd:cd15161  163 LVSL-----AVAFTIPFVTTVTCYLLIIRSLRTGKREEKPLKDKAIKMIILVLTIFLICFVPYHISRYIYILSHN-GAGA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 268 SVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15161  237 SCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
27-308 9.61e-36

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 131.41  E-value: 9.61e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFL-RALRVHSvvSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15372    5 SLYTLVFLVGLPANGLALWVLAtQVKRLPS--TIFLINLAVADLLLILVLPFKISYHFLgNNWPFGEGLCRVVTAFFYGN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRcRYRDLEVRLCFESFSDELW 184
Cdd:cd15372   83 MYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLT-LQRQSY-PLERLNITLCHDVLPLDEQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdatQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYgllrskL 264
Cdd:cd15372  161 DTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLLR----SGQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLH------Y 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15372  231 SDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDKV 274
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
26-299 1.45e-35

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 130.87  E-value: 1.45e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLlVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRpsrcRYRDLEVRLCFESFSDELW 184
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWG----VYDYGGYCCCCLCWPDLTL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLaeaLGFLLPLAAVVYSSGRVFWTL------------ARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNS 252
Cdd:cd00637  158 SKAYTIFLFV---LLFLLPLLVIIVCYVRIFRKLrrhrrrirssssNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 219281887 253 TLAVYgllrsklvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYF 299
Cdd:cd00637  235 LLLLD--------VFGPDPSPLPRILYFLALLLAYLNSAINPIIYAF 273
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
14-309 9.36e-35

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 130.28  E-value: 9.36e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  14 PCPDYRPTHRLHL---VVYSLVLAAGLPLNALALwVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFP 90
Cdd:PHA03087  29 DCDLNIGYDTNSTiliVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  91 DLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDL 170
Cdd:PHA03087 108 EFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTK----KDH 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 171 EVRLCFESFSDE--LWKgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdATQSQRRRKTVRLLLANLVIFLLCFV 248
Cdd:PHA03087 184 ETLICCMFYNNKtmNWK---LFINFEINIIGMLIPLTILLYCYSKILITLKG--INKSKKNKKAIKLVLIIVILFVIFWL 258
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 249 PYNSTLAVYgLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGF----RNTLR 309
Cdd:PHA03087 259 PFNVSVFVY-SLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFnkhkKKSLK 322
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
27-305 1.48e-34

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 128.65  E-value: 1.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANqYDWPFGAFLCKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCrYRDLEVRLCFESFSDELWK 185
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTF-LLRSLQA-IENLNKTACIMLYPHEAWH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 grlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQ---SQRRRKTVRLLLANLVIFLLCFVPYNsTLAVYGLLRS 262
Cdd:cd14985  163 ---FGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTgknGRKRRKSLKIIFALVVAFLVCWLPFH-FFKFLDFLAQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd14985  239 LGAIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
26-310 7.07e-34

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 126.61  E-value: 7.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSV-VSVYMCNLAASDLLFTLSLPVRLSYYA-LHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15170    4 LAVYIITFLIGLPANLLAFYTFIRKVRRKPTpIDILLLNLTVSDLIFLLFLPFKMAEAAsGMIWPLPYFLCPLSSFIFFS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWAL-----ILVFAVpaarVHRPSRCRYRDLEVRLCFES 178
Cdd:cd15170   84 TIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLafshcSIVYIV----EYHIDSENTSVTNNSRCYDN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWKgRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVyG 258
Cdd:cd15170  160 FTPEQLK-ILLPVRLELFLVLFCIPFLITCFCYINFIRILSSLPHISRQRKQRAIGLAVATLLNFIVCFAPYNISHVV-G 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 259 LLRSKlvaaSVPARDRVrgvlmvmVLLAGANCVLDPLVYYFSAEGFRNTLRG 310
Cdd:cd15170  238 FIQRK----SPEWRMYA-------LLLSTLNACLDPIIFYFSSSAVRRAFKE 278
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
27-305 1.44e-33

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 126.04  E-value: 1.44e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15968    5 ICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdRWLFGDFMCRLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRdlevRLCFESFSDELWK 185
Cdd:cd15968   85 YGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNR----TVCYDLAPPALFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 gRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPD----ATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLR 261
Cdd:cd15968  161 -HYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLgpaePPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVR 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 262 SKLvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15968  240 VTP-GVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFG 282
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
27-308 1.78e-33

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 125.57  E-value: 1.78e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRlSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15180    5 VLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFW-AVQAVHGWIFGTGLCKLAGAVFKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPA---ARVHRPSRcryrdLEVRLCFESFSDEL 183
Cdd:cd15180   84 CGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDfifLEATKDPR-----QNKTECVHNFPQSD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLpLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15180  159 TYWWLA-LRLLYHIVGFLLPLAVMVYCYTSILLRLLR--SSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLS 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 264 LVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15180  236 VLDRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
27-305 1.96e-33

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 125.48  E-value: 1.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP---AARVHRPsrcryrDLEVRLCFESFSDEL 183
Cdd:cd14970   85 TSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPviiFARTLQE------EGGTISCNLQWPDPP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLpLVLLAEALGFLLPLAAVVYSSGRVFWTLAR------PDATQSQRRRKTV-RLLLANLVIFLLCFVPYNstlaV 256
Cdd:cd14970  159 DYWGRV-FTIYTFVLGFAVPLLVITVCYSLIIRRLRSsrnlstSGAREKRRARRKVtRLVLVVVAVFVVCWLPFH----V 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 257 YGLLRsklVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd14970  234 FQIVR---LLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFR 279
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 3.13e-33

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 124.92  E-value: 3.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15374    5 VSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHnHWPFGVVACKIVRFLFYANL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcryRDLEVrLCFESFSDELWK 185
Cdd:cd15374   85 YCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSR---KDNIT-LCHDTTRPEEFD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 gRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARP-----DATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15374  161 -HYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPrvgssRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RskLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15374  240 R--LLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
27-308 8.27e-33

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 123.67  E-value: 8.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15157    5 TVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGsHWVFGDIACRIMSYSLYVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILvfaVPAARVHRPSRCRYRDLEVrlCFESFSDELWK 185
Cdd:cd15157   85 YCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVM---AASSPLLSKGTSKYNSQTK--CLDLHPSKIDK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTLARPDATQSQRR---RKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd15157  160 LLILNYIVL--VVGFILPFCTLSICYILIIKALLKPRVPQSKLRvshKKALLTIIITLILFLLCFLPYHILRTVHLMQWS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KlvaasVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15157  238 E-----GQCNLRLHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
27-307 8.28e-33

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 124.05  E-value: 8.28e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15922    5 VFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLgSHWPFGQFLCQLKVFLLSTHM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRyrdlEVRLCFESFSDELWK 185
Cdd:cd15922   85 YGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVID----GKTKCLSIHQSELSL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAeALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRR---KTVRLLLANLVIFLLCFVPYNSTLAVyGLLRS 262
Cdd:cd15922  161 LYFVWNFVLL-ILGFLLPFGVSLTCYALLGASIAKMNSNNARGRAmkaKSLQMIGISLVIFIICFVPLHVTRTV-GVVVK 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15922  239 LFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKS 283
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
24-308 8.88e-33

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 123.68  E-value: 8.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15152    2 IYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYaAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP-----AARVHRPSRCrYRDLEVRlcfes 178
Cdd:cd15152   82 NMYASIYFLVCISVRRC-LYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPfpllrQSQDTNPTCC-FADLPLR----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 fsdELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPD--ATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAV 256
Cdd:cd15152  155 ---NVGLTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTpvLQDLGEKKKALKMILTCAVVFLICFAPYHISFPL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 257 YGLLRSKLVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15152  232 DFLVKSNKI-KSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
27-302 3.83e-32

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 121.79  E-value: 3.83e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15367    5 VVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevRLCFESFSDELWK 185
Cdd:cd15367   85 YISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKDKENH---SVCFEHYPIKAWE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAealGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLV 265
Cdd:cd15367  162 HNINYYRFYA---GFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDCN 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 219281887 266 AAsvparDRVRGVLMVMVLLAGANCVLDPLVYYFSAE 302
Cdd:cd15367  239 FA-----EGIFNYYHFSLLLTSFNCVADPVLYCFASE 270
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
26-308 4.03e-32

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 121.64  E-value: 4.03e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMN 104
Cdd:cd14974    4 LVLYALIFLLGLPGNGLVIWVAGFKMK-RTVNTVWFLNLALADFLFCLFLPFLIVYIAMgHHWPFGSVLCKLNSFVISLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArvhrpsrcRYRDLEVRL-----CFESF 179
Cdd:cd14974   83 MFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYF--------VFRDTVTHHngrscNLTCV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELW-KGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSqrrRKTVRLLLANLVIFLLCFVPYNstlaVYG 258
Cdd:cd14974  155 EDYDLrRSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKS---SKPLRVLLAVVVAFFLCWLPYH----VFA 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 219281887 259 LLRskLVAASVPaRDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14974  228 LLE--LVAAAGL-PEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 9.10e-32

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 121.01  E-value: 9.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15373    5 VSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADeNDWPFSEALCKIVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRdlevRLCFESFSDELWk 185
Cdd:cd15373   85 YCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGN----ITCHDTSSPELF- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDA---TQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd15373  160 DQFVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAgtsTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 klVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15373  240 --MDLSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
28-308 1.03e-31

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 121.03  E-value: 1.03e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSY-YALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15369    6 VYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYhFSGNDWLFGEAMCRVVTAAFYCNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAarVHRPSRCRYRDLEVRLCFESFSDELWKG 186
Cdd:cd15369   86 CSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPL--LLSEQTIQIPDLGITTCHDVLNEQLLMG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 RLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRR-KTVRLLLANLVIFLLCFVPYNSTlavygLLRSKLV 265
Cdd:cd15369  164 YYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSKKtRALFMAVAVFCVFVICFGPTNVL-----LLAHYVR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 266 AASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15369  239 FAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
24-305 2.07e-31

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 119.87  E-value: 2.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAlHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15923    2 LQYAIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYR-RESAGLQKLCNFVLSLYYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpsrcryRDLEVRLCFESFSDEL 183
Cdd:cd15923   81 NMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLD-------SSNEKTMCFQRTKQTE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLlaeaLGFLLPLAAVVYSSGRVFWTLA--RPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLR 261
Cdd:cd15923  154 SLKVFLLLEI----FGFLLPLIIMTFCSARVIHTLQkrLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVG 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 262 SklvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15923  230 K---SYSCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
36-308 5.56e-31

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 119.00  E-value: 5.56e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  36 GLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNMYGSCIFLML 114
Cdd:cd15201   14 GLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGkHWKFGDIPCRIVLFMLAMNRAGSIFFLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 115 INVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILvfavpAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLL 194
Cdd:cd15201   94 VAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTI-----AMTVYLLTKKHLFPRGNATQCESFNICTGTDSSSNWHEA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 195 AEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASvPARDR 274
Cdd:cd15201  169 MFLLEFFLPLAIILYCSVRIIWQLRGRQLDRHAKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKHTSNEDC-QYYRS 247
                        250       260       270
                 ....*....|....*....|....*....|....
gi 219281887 275 VRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15201  248 VDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
27-307 6.92e-31

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 118.64  E-value: 6.92e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMNM 105
Cdd:cd15148    5 VFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNqWTLGPLLCKVVGNLFYMNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILV----FAVPAARVHRPSRC-RYRDLevrlcfesfS 180
Cdd:cd15148   85 YISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVgfvpMIVLTEKNEESTKCfQYKDR---------K 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWKGRLLPLVLLAealgFLLPLAAVVYSSGRVFWTL-----ARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLA 255
Cdd:cd15148  156 NAKGKAIFNFLIVAM----FWLVFLLLILSYGKIAKKLlrisrDKPDFPNAAKYNRTARKSFFVLFIFTVCFVPYHAFRI 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 256 VYglLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15148  232 FY--ITSQLQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRKV 281
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
27-308 2.49e-30

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 117.55  E-value: 2.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVF--LRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQM 103
Cdd:cd15147    5 IVYSIIFVLGLIANCYVLWVFarLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEgNWILPKFLCNVAGCLFFI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd15147   85 NTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVKIDSGNFTRCFEGYEKDN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTLARPDAtQSQR----RRKTVRLLLANLVIFLLCFVPYNS-----TL 254
Cdd:cd15147  165 SKPVLIIHFII--IGLFFLVFLLILVCNLVIARTLLSQPV-QGQRnagvKRRALWMVCTVLAVFVICFVPHHVvqgpwTL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219281887 255 AVYGLLRSKlvaaSVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15147  242 AVLQQWRYW----DCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
27-308 4.61e-30

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 116.44  E-value: 4.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYyalHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY---QNTAGPLSFCKIVGAFFYLNMY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHR-PSRCRYRdlevrlCFESFSdelwK 185
Cdd:cd15920   82 ASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRnEGPCDNK------CFHFRS----K 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLAR--PDATQSQRRRKTVRLLLAN---LVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15920  152 GLTAGGINLTAVVIFYILSLLFLYFYAKISHKLYKvsLGNAQQQIKKASKRAIIKTfivLAIFIVCFVPYHIVRVPYVLA 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RSKlVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15920  232 QID-VISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRRAV 278
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
23-305 4.81e-30

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 116.42  E-value: 4.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLsYYALHH--WPFPDLLCQTTGAI 100
Cdd:cd15365    1 YLFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWI-DYLWNGdnWTLSGFVCIFSAFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 101 FQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFavpAARVHRPSRCRYRDLEVRLCFESFS 180
Cdd:cd15365   80 LYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICF---NAVILTWEDSFHESSSHTLCYDKFP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWKGRllpLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLavygLL 260
Cdd:cd15365  157 LEDWQAR---LNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVVL----LI 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 RSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15365  230 RSIVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFVTESGR 274
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
27-308 8.05e-30

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 115.66  E-value: 8.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVhPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPsrCRYRDLEVRLCFESFSDELWK 185
Cdd:cd15370   85 YCSILFMTCLSVQRYWVIV-NPMSHSRKKANIAIGISLAIWLLILLVTIPLYLVKQT--VFIPALDITTCHDVLPEQLLV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLP--LAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAV-YGLLRS 262
Cdd:cd15370  162 GDMFNYFLSLAIGVFLFPafLTAVAYVLMIRALKSSINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVhYFLLKN 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KlvaasvpARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15370  242 Q-------GQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 1.52e-29

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 114.77  E-value: 1.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYaLHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15182    5 VFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYH-SSGWIFGEILCKAVTSIFYIGFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpsRCRYRDLEVRLCfeSFSDELWK- 185
Cdd:cd15182   84 SSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILS---TVMKSDEDGSLC--EYSSIKWKl 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLaealgFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLavygLLRSkLV 265
Cdd:cd15182  159 GYYYQQNLF-----FLIPLGIIVYCYVRILQTLMR---TRTMRKHRTVKLIFVIVLVFFLSWAPYNIVI----FLRS-LK 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 266 AASVPARDRVRGVLMVMVL---LAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15182  226 DLTIPICECSKQLDYAFYIcrnIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
28-306 4.24e-29

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 113.74  E-value: 4.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYaLHH--WPFPDLLCQTTGAIFQMNM 105
Cdd:cd15366    6 LYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYF-LHRdnWIHGPESCKLFGFIFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevRLCFESFSDELWK 185
Cdd:cd15366   85 YISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNH---TFCFEKYPMEDWV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRllpLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLavygLLRSKLV 265
Cdd:cd15366  162 AW---MNLYRVFVGFLFPWVLMLFSYRGILRAVRGNVSTEQQEKAKIKRLALSLIAIVLLCFAPYHVLL----LSRSVVY 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 266 ---AASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15366  235 lgkPCDCGFEERVFTAYHVSLALTSLNCVADPILYCLVNEGARS 278
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-305 6.82e-29

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 113.33  E-value: 6.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  36 GLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPvrlsYYALH-----HWPFPDLLCQTTGAIFQMNMYGSCI 110
Cdd:cd15189   14 GLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLP----FWAMNilnqfNWPFGELLCRVVNGVIKVNLYTSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 111 FLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRpSRCRYRDLEVRLCFESFSDELWKgrlLP 190
Cdd:cd15189   90 LLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTF-LLR-KIKAIPDLNITACVLLYPHEAWH---FA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 191 LVLLAEALGFLLPLAAVVYSSGRVFWTLARPDAT---QSQRRRKTVRLLLANLVIFLLCFVPYNsTLAVYGLLRSKLVAA 267
Cdd:cd15189  165 HIVLLNIVGFLLPLLVITFCNYNILQALRTREEStrcEDRNDSKATALVLAVTLLFLVCWGPYH-FFTFLDFLFDVGVLD 243
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 219281887 268 SVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15189  244 ECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
24-308 9.25e-29

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 112.96  E-value: 9.25e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15153    2 LYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLrrprvARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFS-DE 182
Cdd:cd15153   82 NMYASICFLTCISIQRCFFLLHPFKARDW-----KRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGmKK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQ--SQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15153  157 LNFGAAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQqsTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RSKLVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15153  237 SESII-TNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
26-308 1.22e-28

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 112.57  E-value: 1.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMN 104
Cdd:cd15364    4 VVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHkWPWGSLACKITGYIFFCN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALIL-----VFAVPAARVHRPSRCrYRDLEVRLCFESF 179
Cdd:cd15364   84 IYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGlvhspVFIMREGQTEGSHTC-FETLQMDTQVAGF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 sdelWKGRLLplvllaeaLGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGL 259
Cdd:cd15364  163 ----YYARFC--------IGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAI 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15364  231 AFSLYPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
26-306 1.34e-28

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 112.54  E-value: 1.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAlHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15172    4 PVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEA-HQWIFGNFSCKLLRGIYAINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVA--RLLCLGVWALILVFAVPAARVhrpSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd15172   83 YSGMLLLACISVDRYIAIVQATKSFRLRSRTLAysKLICAAVWLLAILISLPTFIF---SEVYDFGLEEQYVCEPKYPKN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAE--ALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLR 261
Cdd:cd15172  160 STAIMWKLLVLSLqvSLGFFIPLLVMIFCYSFIIKTLLQ---AQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 262 SKlvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15172  237 GE--QQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRN 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
27-308 1.40e-28

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 112.60  E-value: 1.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVF--LRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQM 103
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALdFVWPFGTAMCKVVRYVTKL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd14976   85 NMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIF---STDTWSSVNHTLCLLRFPKNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLV----LLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGL 259
Cdd:cd14976  162 SVTRWYNWLgmyqLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSAL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14976  242 IKFDDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
27-308 2.68e-28

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 111.76  E-value: 2.68e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYyALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15181    5 LAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVE-SIAGWVFGTFLCKLVGAIHKLNFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP------AARVHRPSR--CRYRDlevrlcfES 178
Cdd:cd15181   84 CSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPnlvfleVETSTNANRtsCSFHQ-------YG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWkgrLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYG 258
Cdd:cd15181  157 IHESNW---WLTSRFLYHVVGFFLPLLIMGYCYATIVVTLCQ--SSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDT 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 219281887 259 LLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15181  232 LDDLKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
27-308 5.43e-28

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 111.00  E-value: 5.43e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd14987    5 FFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHnQWPMGEFTCKITHLIFSINL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVrlCFESFSDELWK 185
Cdd:cd14987   85 FGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETY--CRSFYPEESFK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSsgrvFWTLARP-DATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKL 264
Cdd:cd14987  163 EWLIGMELVSIVLGFVIPFPIIAVF----YFLLARAiSASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14987  239 IPFSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
28-308 5.45e-28

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 111.16  E-value: 5.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYY-ALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15377    6 VYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYfNKTDWIFGDAMCKLQRFIFHVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarVHRPSRCRYRDLEVRLCFESFSDELWKG 186
Cdd:cd15377   86 GSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISP---ILFYSGTGVRKNKTITCYDTTSDEYLRS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 RLLpLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQR-----RRKTVRLLLANLVIFLLCFVPYNSTLAVYglLR 261
Cdd:cd15377  163 YFI-YSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEEnnaplRRKSIYLVIIVLTVFAVSYLPFHVMKTLN--LR 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 219281887 262 SKL---VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15377  240 ARLdfqTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
27-305 5.50e-28

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 110.98  E-value: 5.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSrCRYRDLEVRLC---FESFSDE 182
Cdd:cd15192   85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAI-IHRDV-FFIENTNITVCafhYPSQNST 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LwkgrLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRR--KTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15192  163 L----LVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRndEIFKMIMAVVLFFFFCWIPHQIFTFLDVLI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 RSKlVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15192  239 QLK-VIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFR 282
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
27-308 5.87e-28

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 110.69  E-value: 5.87e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15186    5 IFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPF-WTHYLINEWGLHNAMCKLTTAFFFIGFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarvhrpsRCRYRDLEVRLCFESFSDELWKg 186
Cdd:cd15186   84 GGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVP--------QFMFTKMKENECLGDYPEVLQE- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 rLLPLVLLAEA--LGFLLPLAAVVYSSGRVFWTLArpdATQSQRRRKTVRLLLANLVIFLLCFVPYN-----STLAVYGL 259
Cdd:cd15186  155 -IWPVLRNVELnfLGFLLPLLIMSYCYFRIIQTLF---SCKNHKKARAIKLILLVVIVFFLFWTPYNvmiflETLKLYDF 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LrsklvaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15186  231 F------PSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
27-308 6.87e-28

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 110.27  E-value: 6.87e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15187    5 VLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPF-QAYYLLDQWVFGNAMCKIVSGAYYIGFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryrDLEVRL-CFESF--SDEL 183
Cdd:cd15187   84 SSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVA-----SEDGRLqCIPFYpgQGNS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGlLRSK 263
Cdd:cd15187  159 WK---VFTNFEVNILGLLIPFSILIFCYHNILRNLRR---CHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDS-LHSL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 264 LVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15187  232 HIIDGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
31-305 7.24e-28

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 110.63  E-value: 7.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNMYGSC 109
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 110 IFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcRYRDLEVRLCFESFSDELWKgrlL 189
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVM--YFPEYNITACVLDYPSEGWH---V 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 190 PLVLLAEALGFLLPLAAVVYSSGRVFWTLaRPDATQS----QRRRKTVRLLLANLVIFLLCFVPYN-----STLAVYGLL 260
Cdd:cd15381  164 ALNILLNVVGFLIPLSIITFCSTQIIQVL-RNNKMQKfkeiQTERKATVLVLAVLLMFFICWLPFHiftflDTLHKLGLI 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 RSKLVaasvpaRDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15381  243 SGCRW------EDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
27-305 9.97e-28

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 110.16  E-value: 9.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINgESWIFGEFMCKFIRFIFHFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILV------FAVPAARVHRPSRCryrdlevrLCFESf 179
Cdd:cd15375   85 YGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAevspmtFLITTKEKNNRTIC--------LDFTS- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWKGRLLPLVLlaEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNstlaVYGL 259
Cdd:cd15375  156 SDNLNTIWWYNWIL--TVLGFLLPLVIVTLCYTRIIYTLAKGPHTGSASKQKARRLIILILLVFYVCFLPFH----ILRV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 260 LR--SKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15375  230 VRieTRLPPVSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQ 277
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
27-308 2.03e-27

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 109.47  E-value: 2.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15368    5 VVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQrNHWIFGKPLCNVVTVLFYANM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCryRDLEVRLCFESF------ 179
Cdd:cd15368   85 YSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYV--KELNITTCFDVLkwtmlp 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWKGRLLPLVLLAealgFLLPLAAVVYSSGRVFWTLAR-PDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYG 258
Cdd:cd15368  163 NIAAWAAFLFTLFILL----FLIPFIITVYCYVLIILKLVQtSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHM 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 219281887 259 LLRSKLVAASVPARDrvrgvlmVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15368  239 VSRLFYGKSLYHAYK-------LTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
27-305 3.81e-27

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 108.69  E-value: 3.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALgGQWLFGEGLCKLSSFIIAVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArvhrpsrcRYRDLEVR-LCFESFSDELW 184
Cdd:cd15193   85 CSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSL--------VYRNLINEsVCVEDSSSRFF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAealgFLLPLAAVVYSSGRVFWTLARP---DATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLR 261
Cdd:cd15193  157 QGISLATLFLT----FVLPLIVILFCYCSILVRLRRHfhgAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLE 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 262 SKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15193  233 LGGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
28-299 1.58e-26

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 106.80  E-value: 1.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYaLH--HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15371    6 VYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDLLFCITLPFKIVYH-LNgnNWVFGETMCRIITITFYGNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRpsRCRYRDLEVRLCFESFSDELWK 185
Cdd:cd15371   84 YCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQ--TYYLKELNITTCHDVLPECEQN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEAL-GFLLPLAAVVYSSGRVFWTLARPDatqsQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGllrskl 264
Cdd:cd15371  162 SNFQFYYFISMAVfGFLIPLVITIFCYISIIRTLNAYE----HKWFWYVKITALVLIIFTICFAPSNVILIIHH------ 231
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYF 299
Cdd:cd15371  232 FNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLYFL 266
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-305 2.25e-26

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 106.39  E-value: 2.25e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15093    6 IYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpSRCRYRDLEVRLCFESFSDE--LWk 185
Cdd:cd15093   86 SIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVF---AGTRENQDGSSACNMQWPEPaaAW- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 grLLPLVLLAEALGFLLPLAAV----VYSSGRVFWTLARPDATQSQR-RRKTVRLLLANLVIFLLCFVPYnstlavYGLL 260
Cdd:cd15093  162 --SAGFIIYTFVLGFLLPLLIIclcyLLIVIKVKSAGLRAGWQQRKRsERKVTRMVVMVVVVFVICWLPF------YVLQ 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 RSKLVAASVPARDRVrGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15093  234 LVNVFVQLPETPALV-GVYHFVVILSYANSCANPILYGFLSDNFK 277
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
27-308 2.32e-26

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 106.37  E-value: 2.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYgYNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRvARLLCLGVWALILVFAVPAArvhrpsrcRYRD------LEVRLCFESF 179
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLRSQRRRSWQ-ARLVCLLVWVLACLSSLPTF--------YFRDtyyieeLGVNACIMAF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWKGRLLPLVLLAEALGFLLPLA--AVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNsTLAVY 257
Cdd:cd15191  156 PNEKYAQWSAGLALMKNTLGFLIPLIviATCYFGIGRHLLKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFH-VLTFL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 219281887 258 GLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15191  235 DALARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
28-308 2.70e-26

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 105.99  E-value: 2.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15184    6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPF-WAHYAANEWVFGNAMCKLLTGLYHIGFFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHlrrprvARLLCLGV------WALILVFAVPAARVHRPSR--CRYRdlevrlCFESF 179
Cdd:cd15184   85 GIFFIILLTIDRYLAIVHAVFALK------ARTVTFGVvtsvvtWVVAVFASLPGIIFTKSQKegSHYT------CSPHF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLavygL 259
Cdd:cd15184  153 PPSQYQFWKNFQTLKMNILGLVLPLLVMIICYSGILKTLLR--CRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVL----L 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 260 LRS---KLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15184  227 LNTfqeFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
27-308 3.28e-26

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 106.00  E-value: 3.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd16001    5 VTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRdRWPFGDFLCKLVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevrLCFESFSDELWk 185
Cdd:cd16001   85 YGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRT----VCYDLTSPDNF- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDA---TQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRS 262
Cdd:cd16001  160 GNYFPYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEaagVGKAARAKSIRTILLVCGLFALCFVPFHITRTIYLFVRV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd16001  240 YLV-QDCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
28-305 4.81e-26

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 105.73  E-value: 4.81e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15379    6 VYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKdYWPFGDFTCRLVRFQFYTNLH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRL-RHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevrLCFEsFSDELWK 185
Cdd:cd15379   86 GSILFLTCISVQRYLGICHPLASwHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRT----VCYD-LSPPARS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPD------ATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGL 259
Cdd:cd15379  161 TAYFPYGITLTRTGFLLPFAARLACYCSMATILCRVViavavvAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 260 LRSklvAASVPA--RDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15379  241 VRS---WDGGPCttRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFR 285
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
26-308 8.41e-26

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 104.79  E-value: 8.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMN 104
Cdd:cd15114    4 LVLYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVPIAQDgHWPFGAAACKLLPSLILLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVrLCFESFSDElw 184
Cdd:cd15114   83 MYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSF-IYRRIHQEHFPEKT-VCVVDYGGS-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVfwtLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNstlaVYGLlrskL 264
Cdd:cd15114  159 TGVEWAVAIIRFLLGFLGPLVVIASCHGVL---LVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYH----VVGL----I 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 219281887 265 VAASVPARDRVRGVLMVMVL---LAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15114  228 IAASAPNSRLLANALKADPLtvsLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 9.68e-26

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 104.93  E-value: 9.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVsVYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15149    5 VFYSLVFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPFKiLSDVELGPWQLNVIVCRYSAVIFYLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP-------AARVHRPSRCRYRDLEVRLCFES 178
Cdd:cd15149   84 YVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPniiltnqSFHEANYTKCARLKSELGIQWHK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWKGRLLPLVLLaeALGFLLPLAAVVYSSGRVFwtlarpDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYG 258
Cdd:cd15149  164 ASNYICVSIFWVVFLL--LIIFYVAISRKIYKSNQKF------RRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPYT 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 219281887 259 LLRSKlVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15149  236 LSQTG-ADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
26-308 1.49e-25

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 103.72  E-value: 1.49e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYalhhWPFPDLLCQTTGAIFQ--M 103
Cdd:cd15163    4 MVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMY----YSAGNCLTCSFVHIFSyfV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVW--ALILVFAVPAARVHRPSRCryrdlevrlcfesfsd 181
Cdd:cd15163   80 NMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWlfAIVVTFSILTTAIKFASCC---------------- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 elwkgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQS--QRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGL 259
Cdd:cd15163  144 -------LSKLFALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQsrERRMRAVQLLITVLIIFMICFTPFHVRQVAVAF 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LRSklvaasvPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15163  217 NPD-------IPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQSTM 258
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
27-308 3.38e-25

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 103.30  E-value: 3.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd14991    5 PLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrPSRCRYRDLEVRLCFESFSDELWK 185
Cdd:cd14991   85 SASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLS--TLLTVNSNKSSCHSFSSYTKPSLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEalgFLLPLAAVVYSSGRVFWTLARPDATQSQRR-RKTVRLLLANLVIFLLCFVPynSTLAVYGLLRSKL 264
Cdd:cd14991  163 IRWHNALFLLE---FFLPLGLIVFCSVRIACNLRIRQSLGKQARvQRAIRLVFLVVIVFVLCFLP--SIIAGLLALVFKN 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 265 VAASvPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14991  238 LGSC-RCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-306 3.52e-25

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 102.93  E-value: 3.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQ 102
Cdd:cd15115    2 LSLVVLSLTFLLGVPGNGLVIWVAGLKMK-RTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNgHWPYGRFLCKLLPSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpsRCRYRDLEVRLCFESFSDE 182
Cdd:cd15115   81 LNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIY----RTTVTDGNHTRCGYDFLVA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGRLLplvllaeaLGFLLPLAAVVYSSGRVFWTLARPDATQSQrrRKTVRLLLANLVIFLLCFVPYNstlaVYGLLRS 262
Cdd:cd15115  157 ITITRAV--------FGFLLPLLIIAACYSFIAFRMQRGRFAKSQ--SKTFRVIIAVVVAFFVCWAPYH----IIGILSL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 263 klvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15115  223 ---YGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
24-305 5.00e-25

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 102.92  E-value: 5.00e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQ 102
Cdd:cd15116    2 LSMVIYSVVFVLGVLGNGLVIFITGFKMK-KTVNTVWFLNLAVADFLFTFFLPFSIAYTAMdFHWPFGRFMCKLNSFLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRdlEVRLCFESFS-- 180
Cdd:cd15116   81 LNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNN--NKIICFNNFSls 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 --------DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSqrrRKTVRLLLANLVIFLLCFVPYNs 252
Cdd:cd15116  159 gdnsspevNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKS---SKPFKIIAAVIVTFFLCWAPYH- 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 219281887 253 tlaVYGLLRsklVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15116  235 ---ILNLLE---MEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFK 281
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
28-308 6.33e-25

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 102.26  E-value: 6.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDLEVRLCFESFSDELWKGR 187
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQ----WEFTHHTCSAHFPRKSLIRW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 LLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVyGLLRSKLVAA 267
Cdd:cd15183  162 KRFQALKLNLLGLILPLLVMIICYTGIINILLR---RPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFV-SAFQDVLFTP 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 268 SVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15183  238 SCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
26-306 7.01e-25

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 102.68  E-value: 7.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd14993    4 IVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLfCMPLTLLENVYRPWVFGEVLCKAVPYLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA---RVHRPSRCRYRDLEVRLCFESFSD 181
Cdd:cd14993   84 VSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLvvyELEEIISSEPGTITIYICTEDWPS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELWKgRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTLARPDA---------TQSQR----RRKTVRLLLANLVIFLLCFV 248
Cdd:cd14993  164 PELR-KAYNVALF--VVLYVLPLLIISVAYSLIGRRLWRRKPpgdrgsansTSSRRilrsKKKVARMLIVVVVLFALSWL 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 249 PYN--STLAVYGLLRSKLVAASvpardrVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd14993  241 PYYvlSILLDFGPLSSEESDEN------FLLILPFAQLLGYSNSAINPIIYCFMSKKFRR 294
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
24-308 8.31e-25

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 102.13  E-value: 8.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVH-SVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd14983    2 LSLMVYVLTILLGLPSNLLALYAFVNRARLRlTPNVIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEV---RLCFESF 179
Cdd:cd14983   82 STLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFHVTLVFILETSGGTLDINTPVgnsSTCYENF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWkGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQsQRRRKTVRLLLANLVIFLLCFVPYNSTlAVYGL 259
Cdd:cd14983  162 TPEQL-ALLAPVRLELSLVLFFLPLAITAFCYVRCIRILVRSRLHE-RRKRRAVRVAVSTLLTFVVCFGPYNIS-HVVGF 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LRSKlvaaSVPARDrvrgvlmVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14983  239 VRHE----SVWWRK-------LALLTSTCNAFLDPLIFYFLSSSMERGF 276
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
27-308 1.61e-24

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 101.35  E-value: 1.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15087    5 VIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRV--ARLLCLGVWALILVFAVPA---ARVHRPsrcryrDLEVRLCFESF-- 179
Cdd:cd15087   85 SSIYFLTVMSVDRYLVVLATVRSRRMPYRTYraAKIVSLCVWLLVTIIVLPFtvfAGVYSN------ELGRKSCVLSFps 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELW--KGRLLPLVllaeaLGFLLPLAAVVYSSGRVFWTLARPDATQSQR-----RRKTVRLLLANLVIFLLCFVPYNs 252
Cdd:cd15087  159 PESLWfkASRIYTLV-----LGFAIPVSTICILYTMMLYKLRNMRLNSNAKaldkaKKKVTLMVLVVLAVCLFCWTPFH- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 253 tLAVYGLLRSKLvaasvPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15087  233 -LSTVVALTTDL-----PQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
27-308 1.75e-24

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 101.37  E-value: 1.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRaLRVHSVVSVYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15924    5 VLYTVIFFAGILLNGLAMWIFFH-IPSKSSFIIYLKNTVVADLLMILTFPFKiLSDAGLGPWQLRTFVCRVTSVLFYFTM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcryRDLEVRLCFESFSD--EL 183
Cdd:cd15924   84 YTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQP---REKNVKKCSFLKSElgLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15924  161 WHEIVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSRRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQTR 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 264 LVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15924  241 DV-FDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
27-305 2.92e-24

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 100.23  E-value: 2.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15173    5 CMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPF-WAYSAAHEWIFGTVMCKITNGLYTINLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRH--LRRPRVARLLCLGVWALILVFAVPAARVHrpsrcRYRDLEVRLCFESFSDELW 184
Cdd:cd15173   84 SSMLILTCITVDRFIVIVQATKAHNchAKKMRWGKVVCTLVWVISLLLSLPQFIYS-----EVRNLSSKICSMVYPPDAI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLlaeALGFLLPLAAVVYSSGRVFWTLARPDATQsqrRRKTVRLLLANLVIFLLCFVPYNstlaVYGLLRSkl 264
Cdd:cd15173  159 EVVVNIIQM---TVGFFLPLLAMIICYSVIIKTLLHAKGFQ---KHKSLKIIFVVVAVFILTQLPYN----IMKLIRT-- 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15173  227 LHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFR 267
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
28-308 3.08e-24

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 100.62  E-value: 3.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15177    6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPF-AAAETLQGWIFGNAMCKLIQGLYAINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRL--RHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDLEVRLCFESFSDELWK 185
Cdd:cd15177   85 GFLFLTCISVDRYVVIVRATSAhrLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVE----NRSELSSCRMIFPEVVSR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLArpdATQSQRRRKTVRLLLANLVIFLLCFVPYNstLAVYGLLRSKLV 265
Cdd:cd15177  161 TVKGATALTQVVLGFAIPLIVMAVCYAAIGRTLL---AARGWERHRALRVIAALVVAFVLFQLPYS--VVLLLDTADLLA 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 266 AASVPARDRVRGVLMVMVL--LAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15177  236 TLELSCSQSKRKDIALLVTsgLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
26-306 3.20e-24

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 100.76  E-value: 3.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLvSLPFTLIYTLTKNWPFGSILCKLVPSLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAA--RVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15203   84 IFVSTLTLTAIAIDRYQLIVYPTRPRMSKRH--ALLIIALIWILSLLLSLPLAifQELSDVPIEILPYCGYFCTESWPSS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKgRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTL--------ARPDATQSQ------RRRKTVRLLLANLVIFLLCFV 248
Cdd:cd15203  162 SSR-LIYTISVL--VLQFVIPLLIISFCYFRISLKLrkrvkkkrGKRTLSSRRrrselrRKRRTNRLLIAMVVVFAVCWL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 249 PYNstlaVYGLLRSKLVAASVPARDRVRgVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15203  239 PLN----LFNLLRDFEPLPQIDGRHFYL-IFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
23-305 6.35e-24

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 99.85  E-value: 6.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIF 101
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 102 QMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVrlCFESFSD 181
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTV--CSEAWPS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 elwKGRLLPLVLLAEALGFLLPLAAVVYSSGRV---FWTLARPDATQSQRRR---KTVRLLLANLVIFLLCFVPYNSTLA 255
Cdd:cd14971  159 ---RAHRRAFALCTFLFGYLLPLLLICVCYAAMlrhLWRVAVRPVLSEGSRRakrKVTRLVLVVVVLFAACWGPIHAILL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 219281887 256 VYGLLRSKLVAASVPARdrvrgvlMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd14971  236 LVALGPFPLTYATYALR-------IWAHCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
36-305 7.94e-24

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 99.49  E-value: 7.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  36 GLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLP-----VRLSYyalhHWPFPDLLCQTTGAIFQMNMYGSCI 110
Cdd:cd15380   14 GLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPfwaenIRNQF----NWPFGNFLCRVISGVIKANLFISIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 111 FLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpSRCRYRDLEVRLCFESFSDELWkgrLLP 190
Cdd:cd15380   90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFR--SVKHVPDLNISACILLFPHEAW---HFA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 191 LVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQR-----RRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLV 265
Cdd:cd15380  165 RRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRcgglkDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVI 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 219281887 266 AASVpARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15380  245 QGCF-WEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
28-304 9.65e-24

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 99.38  E-value: 9.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15967    6 VYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKgRKWIFGQVFCKITRFCFNLNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRdlevrlCFESFSDELWKG 186
Cdd:cd15967   86 GSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNSNGTK------CFDTTFNDYLES 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 rLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYglLRSKLVA 266
Cdd:cd15967  160 -YLTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDKGLKQRCLKLVIILIVLFSVCYIPYHVFRNLN--LLSRILQ 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 267 ASVPARDRVRGVLMVMVL---LAGANCVLDPLVYYFSAEGF 304
Cdd:cd15967  237 KQGSCTQWFRGIYIAHQVsrgLVCLNSALNPLVYLMGSEDI 277
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
28-308 1.37e-23

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 98.77  E-value: 1.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpSRCRYRDLEVRLCFESFSDELWKGR 187
Cdd:cd15973   86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIF---ADTATRKGQAVACNLIWPHPAWSAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 LLPLVLLaeaLGFLLPLAAV--VYSSGRVFWTLARPDATQSQRRR---KTVRLLLANLVIFLLCFVPYNSTlavygllrs 262
Cdd:cd15973  163 FVIYTFL---LGFLLPVLAIglCYILIIGKMRAVALKAGWQQRRKsekKITRMVLMVVTVFVICWMPFYVV--------- 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPARDRVrgVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15973  231 QLLNLFLPRLDAT--VNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
27-308 2.24e-23

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 98.29  E-value: 2.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15174    5 PLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPF-WATAASSGWVFGTFLCKVVNSMYKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRV--ARLLCLGVWALILVFAVPAARVHRPSrcryRDLEVRLCFESFSDELW 184
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRLlySKLVCFFVWLLSTILSLPEILFSQSK----EEESVTTCTMVYPSNES 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKL 264
Cdd:cd15174  160 NRFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQ---AKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15174  237 TITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
27-308 2.38e-23

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 97.93  E-value: 2.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALR-VHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15188    5 VFYTLVFLLGLAGNLLLFVVLLLYVPkKKKMTEVYLLNLAVSDLLFLVTLPF-WAMYVAWHWVFGSFLCKFVSTLYTINF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPA---ARVHRPSRcryrdlEVRLCFESFSDE 182
Cdd:cd15188   84 YSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDmvfVQTHHTNN------GVWVCHADYGGH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 --LWKgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15188  158 htIWK---LVFQFQQNLLGFLFPLLAMVFFYSRIACVLTR---LRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQ 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 RSKlVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15188  232 DLH-VIGNCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-305 2.41e-23

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 98.68  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  17 DYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRA-LRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLC 94
Cdd:cd15190    5 EWKPSYALIPVIYMLVFVLGLSGNGLVLWTVFRSkRKRRRSADTFIANLALADLTFVVTLPLWAVYTALgYHWPFGSFLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  95 QTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPA------ARVHRPSRCRYr 168
Cdd:cd15190   85 KLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPAlilrttSDLEGTNKVIC- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 169 DLEVRLCFESFSDELWKGrllPLVLLAEALGFLLPLAA--VVYSS-----GRVFWTLARPDatqSQRRRKTVRLLLANLV 241
Cdd:cd15190  164 DMDYSGVVSNESEWAWIA---GLGLSSTVLGFLLPFLImlTCYFFigrtvARHFSKLRRKE---DKKKRRLLKIIITLVV 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 219281887 242 IFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15190  238 TFALCWLPFHLVKTLYALMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
28-308 2.89e-23

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 97.67  E-value: 2.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15970    6 IYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWAL-------ILVFAVPAARVHRPSRCRYRDLEvrlcfesfS 180
Cdd:cd15970   86 SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFsilvilpIIIFSNTAPNSDGSVACNMQMPE--------P 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWkgrLLPLVLLAEALGFLLPLAAV------VYSSGRVfwtLARPDATQSQRR--RKTVRLLLANLVIFLLCFVPYNS 252
Cdd:cd15970  158 SQRW---LAVFVVYTFLMGFLLPVIAIclcyilIIVKMRV---VALKAGWQQRKRseRKITLMVMMVVTVFVICWMPFYV 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 253 TLAVygllrsklvaaSVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15970  232 VQLV-----------SVFVGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
26-305 5.97e-23

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 96.81  E-value: 5.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAifqMNM 105
Cdd:cd15166    4 LVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGA---LTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLML---INVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcryRDLEVRLCFEsFSDE 182
Cdd:cd15166   81 FYPSIALWLlafISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPD---KASNFTTCLK-MLDI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTL--ARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVyGLL 260
Cdd:cd15166  157 IHLKEVNVLNFTRLIFFFLIPLFIMIGCYLVIIHNLvhGRTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAF-LML 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 RSKLVAASVPArdrvrgvlMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15166  236 QNGDNSYNPWA--------AFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
24-308 1.49e-22

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 95.97  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQ 102
Cdd:cd15119    2 VSIVIYIVAFVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLHITYVALdFHWPFGVWLCKINSFVAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAarvhrpsrCRYRD-----LEVRLCFE 177
Cdd:cd15119   81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPA--------LYFRDtmelsINVTICFN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 178 SF---SDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNstl 254
Cdd:cd15119  153 NFhkhDGDLIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKR---RTLLISSKFFWTISAVIVAFFVCWTPYH--- 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 255 aVYGLLrsKLVA-ASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15119  227 -IFSIL--ELSIhHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
27-308 2.81e-21

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 92.27  E-value: 2.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGaiFQMNM 105
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYSNLSGRWSFGDPGCVIYG--FAVTF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YG--SCIFLMLINVDRYAAIVHPLRLRHLRRPRVArLLCLGVWALILVFAVP-----AARVHRPSRCRyrdlevrlCFES 178
Cdd:cd14969   83 LGlvSISTLAALAFERYLVIVRPLKAFRLSKRRAL-ILIAFIWLYGLFWALPplfgwSSYVPEGGGTS--------CSVD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWKGRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTLARPDATQSQRR------------RKTVRLLLANLVIFLLC 246
Cdd:cd14969  154 WYSKDPNSLSYIVSLF--VFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKnsaitkrtkkaeKKVAKMVLVMIVAFLIA 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 219281887 247 FVPYnstlAVYGLLRSKLVAASVPArdrvrGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14969  232 WTPY----AVVSLYVSFGGESTIPP-----LLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
24-303 4.63e-21

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 91.78  E-value: 4.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd14975    2 LGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArvhrPSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd14975   82 SMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVI----AFRHVEETVENGMCKYRHYSDG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKgrlLPLVLLAEALGFLLPLAAVVYSSGRVfwtLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNstlaVYGLLR-S 262
Cdd:cd14975  158 QL---VFHLLLETVVGFAVPFTAVVLCYSCL---LRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYH----VGNLLEvV 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 263 KLVAASVPARDRVRGVLMVMVLLAGA----NCVLDPLVYYFSAEG 303
Cdd:cd14975  228 SELIGGSKMAGTLGKVAEAGRPIAGAlaflSSSINPLLYAFAARG 272
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
27-308 6.09e-21

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 91.37  E-value: 6.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15175    5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPF-WAASAAKKWVFGEEMCKAVYCLYKMSFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRV--ARLLCLGVWALILVFAVPAARvhRPSRCRYRDLEVRLCFESFSDELW 184
Cdd:cd15175   84 SGMLLLMCISIDRYFAIVQAASAHRHRSRAVfiSKVSSLGVWVLAFILSIPELL--YSGVNNNDGNGTCSIFTNNKQTLS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGrllpLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKL 264
Cdd:cd15175  162 VK----IQISQMVLGFLVPLVVMSFCYSVIIKTLLQ---ARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15175  235 NTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
40-297 9.03e-21

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 90.91  E-value: 9.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRV--HSVVsVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNMYGSCIFLMLIN 116
Cdd:cd15376   18 NGLALWLFVTRERRpwHTGV-VFSFNLAVSDLLYALSLPLLAAYYYPpKNWRFGEAACKLERFLFTCNLYGSIFFITCIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 117 VDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAarvhrpsrCRYRDLEVR-----LCFESFSDELWKGrLLPL 191
Cdd:cd15376   97 LNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPV--------LSFSHLEVErhnktECLGTAVDSRLPT-YLPY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 192 VLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYN--STLAVYGLLRSKLVAASV 269
Cdd:cd15376  168 SLFLAVVGCGLPFLLTLASYLAIVWAVLRSPGITTLEKRKVAALVAVVVALYAVSFVPYHilRNLNLYRRLQWLKAAASL 247
                        250       260
                 ....*....|....*....|....*...
gi 219281887 270 pardRVRGVLMVMVLLAGANCVLDPLVY 297
Cdd:cd15376  248 ----RIYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
27-306 9.07e-21

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 90.96  E-value: 9.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPF-WAADAVNGWVLGTAMCKITSALYTMNFS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIvhPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVH--RPSRCRYRdlevrlCFESFSDELW 184
Cdd:cd15176   84 CGMQFLACISVDRYVAI--TKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFStvRENSDRYR------CLPVFPPSLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKL 264
Cdd:cd15176  156 TSAKATIQILEVLLGFVLPFLVMVFCYSRVARALSR---TPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 265 VAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15176  233 LITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFKS 274
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
28-308 1.05e-20

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 90.66  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15185    6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDLEVRLCFESFSDELWKGR 187
Cdd:cd15185   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQ----ELFEEFLCSPLYPEDTEDSW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 LLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLaVYGLLRSKLVAA 267
Cdd:cd15185  162 KRFHALRMNIFGLALPLLIMVICYTGIIKTLLR---CPSKKKYKAIRLIFVIMVVFFIFWTPYNLVL-LLSAFQSIFFET 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 268 SVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15185  238 DCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
27-308 1.07e-20

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 90.60  E-value: 1.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPF-WAVDAAANWYFGNFLCKAVHVIYTVNLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLcFESFSDELWkg 186
Cdd:cd15179   84 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRI-YPEDTFELW-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 rLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQsqrRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVA 266
Cdd:cd15179  161 -VVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQ---KRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 267 ASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15179  237 QSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
26-308 3.03e-20

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 89.26  E-value: 3.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVfCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA--RVHRPSRCRyRDLEVRLCFESFSDE 182
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLfgQGLVRYESE-NGVTVYHCQKAWPST 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWkGRLLPLVLLaeALGFLLPLAAVVYSSGRvfwtlarpdatqsQRRRKTVRLLLANLVIFLLCFVPynstLAVYGLLRS 262
Cdd:cd15001  162 LY-SRLYVVYLA--IVIFFIPLIVMTFAYAR-------------DTRKQVIKMLISVVVLFAVCWGP----LLIDNLLVS 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPARdRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15001  222 FDVISTLHTQ-ALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
27-308 3.87e-20

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 89.26  E-value: 3.87e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVcCVPFTAALYATPSWVFGDFMCKFVNYMMQVTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcRYRDLEVRLCFESFSDELW- 184
Cdd:cd15095   85 QATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEE-GYWYGPQTYCREVWPSKAFq 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAealgFLLPLAAVVYSSGRVF---WTLARPDATQSQ--------RRRKTVRLLLANLVIFLLCFVPYNst 253
Cdd:cd15095  164 KAYMIYTVLLT----YVIPLAIIAVCYGLILrrlWRRSVDGNNQSEqlseralrQKRKVTRMVIVVVVLFAICWLPNH-- 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 254 laVYGLLRskLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15095  238 --VLNLWQ--RFDPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
27-308 4.71e-20

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 88.66  E-value: 4.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15088    5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDgQWYFGEVMCKIITALDANNQ 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarVHRPSRCRYRDLEVRLCFESFSDELwk 185
Cdd:cd15088   85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILP---VWVYSSLIYFPDGTTFCYVSLPSPD-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 gRLLPLVLLAEALGFLLPLAAVVYSSGRVF---WTLARPDATQ--SQRRRKTVRLLLANLVIFLLCFVPYNSTLAVygll 260
Cdd:cd15088  160 -DLYWFTIYHFILGFAVPLVVITVCYILILhrlARGVAPGNQShgSSRTKRVTKMVILIVVVFIVCWLPFHVVQLV---- 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 261 rskLVAASVPARDRVRGVLMVMVlLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15088  235 ---NLAMNRPTLAFEVAYFLSIC-LGYANSCLNPFVYILVSENFRKRL 278
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
27-306 6.20e-20

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 88.57  E-value: 6.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLsLPVRLSYYA---LHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAV-FCVPFSFIAlliLQYWPFGEFMCPVVNYLQAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAA---RVHRPSRCRyrdLEVRLCFESFS 180
Cdd:cd15392   84 SVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQ--ALLLIAVIWIFALATALPIAitsRLFEDSNAS---CGQYICTESWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DeLWKGRLLPLVLLaeALGFLLPLA--AVVYSS-GRVFWTLARPDATQSQR-------RRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15392  159 S-DTNRYIYSLVLM--ILQYFVPLAvlVFTYTRiGIVVWAKRTPGEAENNRdqrmaesKRKLVKMMITVVAIFALCWLPL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 251 NStlavygLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15392  236 NI------LNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
27-307 7.30e-20

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 88.32  E-value: 7.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAarvhrpsrCRYRDLEVRL--CFESFSD--E 182
Cdd:cd15974   85 TSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPV--------IIFSDVQPDLntCNISWPEpvS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGrllPLVLLAEALGFLLPLAAV----------VYSSGrvfwtlARPDATQSQR-RRKTVRLLLANLVIFLLCFVPYn 251
Cdd:cd15974  157 VWST---AFIIYTAVLGFFGPLLVIclcyllivikVKSSG------LRVGSTKRRKsERKVTRMVVIIVVVFVFCWLPF- 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 252 STLAVYGLlrsklvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15974  227 YMLNIVNL------IVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQS 276
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 2.08e-19

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 87.18  E-value: 2.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRaLRVHSVVSVYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15150    5 LLYTVLFIVGLTMNGLAMRVFFQ-IPSKSNFIIFLKNTVISDLLMILTFPFKiLSDAKLGSWPLRGFVCQVTSVIFYFTM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcryRDLEVRLCFESFSD--EL 183
Cdd:cd15150   84 YISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQP---TPKNVKKCSLLKSEfgLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15150  161 WHEIVNYICQVIFWVNFLIVIVCYTLITKELYKSYKRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTR 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 264 LVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15150  241 DV-FDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 2.78e-19

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 86.76  E-value: 2.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRaLRVHSVVSVYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15151    5 VLYTVLFLVGLILNSVAAWIFFH-IPSTSTFIVYLKNTLVADLIMTLMLPFKiLSDSGLGPWQLRAFVCRFSAVVFYITM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpSRCRYRDLEVRLC--FESFSDEL 183
Cdd:cd15151   84 YISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMIL---SNKPATPISVKKCasLKSPLGLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15151  161 WHEVVNYICQFIFWGVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLSQTG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 264 LVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15151  241 KI-TDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
28-308 3.44e-19

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 86.44  E-value: 3.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15971    6 IYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDELWKGr 187
Cdd:cd15971   86 SIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIM-IYAGVQTKHGRSSCTIIWPGESSAWYTG- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 llpLVLLAEALGFLLPLAAV----------VYSSG-RVfwtlarPDATQSQRRRKTVRLLLANLVIFLLCFVPYnstlav 256
Cdd:cd15971  164 ---FIIYTFILGFFVPLTIIclcylfiiikVKSSGiRV------GSSKRKKSEKKVTRMVSIVVAVFVFCWLPF------ 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 257 YGLLRSKLVAASVPARDrVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15971  229 YIFNVSSVSVSISPTPG-LKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
27-262 3.49e-19

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 86.62  E-value: 3.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15389    5 VAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITlLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLgvWALILVFAVPAARVHRPSRCRYRDLEVR-LCFESF---SD 181
Cdd:cd15389   85 YVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAII--WIMASCLSLPHAIYQKLVEFEYSNERTRsRCLPSFpepSD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELWKgrllPLVLLAEALGFLLPLAAVVYSSGRVFWTL----ARPDATQSQR------RRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15389  163 LFWK----YLDLATFILQYVLPLLIIGVAYTRVAKKLwlrnAIGDVTTEQYvaqrrkKKKTIKMLMLVVLLFAICWLPLN 238
                        250
                 ....*....|.
gi 219281887 252 stlaVYGLLRS 262
Cdd:cd15389  239 ----CYHVLLS 245
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
28-305 3.87e-19

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 86.55  E-value: 3.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15091    6 VYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRyRDLEVRLCFESFSDELWKGR 187
Cdd:cd15091   86 SIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAI-VLGGTKVR-EDVDSTECSLQFPDDDYSWW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 LLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARP---DATQSQRR--RKTVRLLLANLVIFLLCFVPYNSTLAVYGLlrs 262
Cdd:cd15091  164 DTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVrllSGSREKDRnlRRITRLVLVVVAVFVVCWTPIHIFILVEAL--- 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 263 klvaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15091  241 ----GSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFK 279
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
27-308 4.00e-19

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 86.37  E-value: 4.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMNM 105
Cdd:cd14988    5 ILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYtWLWGSFLCKFTHYFYFANM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHrpsrCRYRDLEVRLCFESFSDELWK 185
Cdd:cd14988   85 YSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEV-VH----MQLLDGVEPMCLFLAPFETYD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSqrrRKTVRLLLANLVIFLLCFVPYNSTLAVYGL------ 259
Cdd:cd14988  160 EWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPES---RRHCLLIYAYILVFVVCWLPYHVTLLLLTLhgshis 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 260 LRSKLVAASVPARDRVRGVLMVmvllagaNCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14988  237 LHCNLVHFLYFFYDVIDCFSLL-------HCVANPILYNFLSKSFRGKL 278
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
26-305 4.15e-19

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 86.32  E-value: 4.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRA--LRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15098    4 PVVFGLIFCLGVLGNSLVITVLARVkpGKRRSTTNVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHYFFT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15098   84 VSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVA-VHQDLVHHWTASNQTFCWENWPEK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGRLLPLVLLaeaLGFLLPLAAVVYSSGRV---FWTLARPDATQSQR-RRKTVRLLLANLVIFLLCFVPYNST--LAV 256
Cdd:cd15098  163 QQKPVYVVCTFV---FGYLLPLLLITFCYAKVlnhLHKKLKNMSKKSERsKKKTAQTVLVVVVVFGISWLPHHIIhlWVE 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 257 YGllrsklvaaSVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15098  240 FG---------DFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
27-307 6.44e-19

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 85.60  E-value: 6.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15094    5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDLEVRLCFESFSDELWKG 186
Cdd:cd15094   85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTV----PDSGRYSCTIVWPDSSAVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 RLLPLVLLAEALGFLLPLAAVVyssgrVFWTL-------ARPDATQSQRR---RKTVRLLLANLVIFLLCFVPYnstlAV 256
Cdd:cd15094  161 GQKAFTLYTFLLGFAIPLLLIS-----VFYTLvilrlrtVGPKNKSKEKRrshRKVTRLVLTVISVYIICWLPY----WA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 219281887 257 YGLLRSKLVAASVPARDRVRgVLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15094  232 FQVHLIFLPPGTDMPKWEIL-MFLLLTVLSYANSMVNPLLYAFLSENFRKS 281
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
27-305 9.89e-19

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 85.24  E-value: 9.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15972    5 LVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcryrdlEVRLCFESFSD--ELW 184
Cdd:cd15972   85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPG------GMGTCHIAWPEpaQVW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGrllPLVLLAEALGFLLPLAAV----------VYSSGRvfwtlaRPDATQSQRR---RKTVRLLLANLVIFLLCFVPYn 251
Cdd:cd15972  159 RA---GFIIYTATLGFFCPLLVIclcyllivvkVRSSGR------RVRATSTKRRgseRKVTRMVVIVVAAFVLCWLPF- 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219281887 252 stlavYGLLRSKLVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15972  229 -----YALNIVNLV-CPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFK 276
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
27-305 1.24e-18

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 85.04  E-value: 1.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVfCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCfeSFSDELWK 185
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYC--TFLTEVGT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GrLLPLVLLAEALGFLLPLAAVVYSSGRV---FWTLARPD---ATQSQRRRKTV-RLLLANLVIFLLCFVPYN--STLAV 256
Cdd:cd15096  163 A-AQTFFTSFFLFSYLIPLTLICVLYMLMlrrLRRQKSPGgrrSAESQRGKRRVtRLVVVVVVVFAICWLPIHiiLLLKY 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219281887 257 YGLLRSklvaasvpardrvrGVLMVMVL-----LAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15096  242 YGVLPE--------------TVLYVVIQilsncLAYGNSCVNPILYAFLSQNFR 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
29-305 1.56e-18

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 84.81  E-value: 1.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  29 YSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSY-YALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15167    7 YYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVdLGIAPWKLKIFHCQVTACLIYINMYL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpsrcRYRDLEVRL---CFEsFSDELW 184
Cdd:cd15167   87 SIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAI------PIKTIEEKPgvgCAD-FKTEFG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALgFLLPLAAVVYSSGRVFWTLARPDATQSQRR-RKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15167  160 RHWHVLTNFICMAI-FLNFSAIILISNFLVIRKLYRNKDSEEYRNaRQALVNILLVTAGYVICFVPYHIVRIPYTLSQSE 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 264 LVaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15167  239 VI-TDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
27-305 4.62e-18

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 83.30  E-value: 4.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMNM 105
Cdd:cd15199    5 SLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNrWSLGGGTCKALLFMLSLSR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP---AARVHRPSRC-RYRDLEVrlcfESFSD 181
Cdd:cd15199   85 GVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPtllASQPKNFTECnSFSPKDD----EDFSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 eLWKGRLLplvllaeALGFLLPLAAVVYSSGRVFWTLAR--PDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGL 259
Cdd:cd15199  161 -TWQEAVF-------FLQFLLPFGLIVFCTVRIIRRLKKrlRDVGKQPKLQRAMALVTSVVVVFGFCFLPCFLARVLMLI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 260 LRSKLVAASVPARDRVRGVLMVMVLLagaNCVLDPLVYYFSAEGFR 305
Cdd:cd15199  233 FQNKESCNALNIAVHTYDVTMCLTYL---NSVLDPIVYCFSSPTFR 275
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
27-305 6.31e-18

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 84.68  E-value: 6.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRAlRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:PHA02638 103 IFYIIIFILGLFGNAAIIMILFCK-KIKTITDIYIFNLAISDLIFVIDFPF-IIYNEFDQWIFGDFMCKVISASYYIGFF 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKG 186
Cdd:PHA02638 181 SNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASNIIFSAQDSNETISNYQCTLIED 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 R------LLPLVLLAE--ALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTL---A 255
Cdd:PHA02638 261 NeknnisFLGRILQFEinILGMFIPIIIFAFCYIKIILKLKQ---LKKSKKTKSIIIVSIIIICSLICWIPLNIVIlfaT 337
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 219281887 256 VYGLLR-SKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:PHA02638 338 MYSFKGfNSIISEHICGFIKLGYAMMLAEAISLTHCCINPLIYTLIGENFR 388
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
27-305 1.33e-17

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 81.80  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRA-LRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcRYRDLEVrlCFESFSDelW 184
Cdd:cd15097   85 MYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLI--DYANSTV--CMPGWEE--A 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLaeALGFLLPLAAVVYSSGRV---FWTLARPDATQSQRR---RKTVRLLLANLVIFLLCFVPYNSTLAVYG 258
Cdd:cd15097  159 RRKAMDTCTF--AFGYLIPVLVVSLSYTRTikyLWTAVDPLEAMSESKrakRKVTKMIIIVTALFCLCWLPHHVVILCYL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 219281887 259 LLRSKLVAASVPARdrvrgvlMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15097  237 YGDFPFNQATYAFR-------LLSHCMAYANSCLNPIVYALVSKHFR 276
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
28-308 1.40e-17

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 81.77  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15118    6 LHGIVSTLGIVENLLILWVVGFRLR-RTVISIWILNLALSDLLATLSLPFFTYYLASgHTWELGTTFCRIHSSIFFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLevRLCFESFS------ 180
Cdd:cd15118   85 VSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYF-VFRDVIERKDGR--KLCYYNFAlfspsp 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 ---DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLArpdatQSQRRR--KTVRLLLANLVIFLLCFVPYNstla 255
Cdd:cd15118  162 dnnHPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIR-----HRCRRRpgRFVRLVVSVVVSFALCWAPYH---- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 219281887 256 VYGLLRsklvaASVPARDRVRGV----LMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15118  233 IFSIIE-----VMAHNQHSLRPLviqgLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
23-304 1.50e-17

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 81.79  E-value: 1.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15121    1 QLGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVW--ALILVFAVPAARVHRPSRCRyrdleVRLCFESFS 180
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWivAFLLSLPMPFYRTVLKKNIN-----MKLCIPYHP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DElwkGRLLPLVLLAEALGFLLPLAAVVYSSGRVfwtLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYN--STLAVYG 258
Cdd:cd15121  156 SV---GHEAFQYLFETITGFLLPFTAIVTCYSTI---GRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHvvNLIQVAG 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 219281887 259 LLRSKLVAASV-PARDRVRGVLMVMVLLAGAncvLDPLVYYFSAEGF 304
Cdd:cd15121  230 ALQNQAGNASVlKAAKLARPNVTALAFLSSS---VNPVLYAFAGGSL 273
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
27-305 1.83e-17

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 81.78  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15202    5 VAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLfNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVHRPSRCRYR-DLEVRLCFESF---SD 181
Cdd:cd15202   85 HVSAYTLTAIAVDRYQAIMHPLKPRISKTK--AKFIIAVIWTLALAFALPHAICSKLETFKYSeDIVRSLCLEDWperAD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELWKGRLLPLVllaeALGFLLPLAAVVYSSGRV---FWTLARPDATQSQR-------RRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15202  163 LFWKYYDLALF----ILQYFLPLLVISFAYARVgikLWASNMPGDATTERyfalrrkKKKVIKMLMVVVVLFALCWLPFN 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219281887 252 stlaVYGLLRSKLVAASVparDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15202  239 ----IYVLLLSSKPDYLI---KTINAVYFAFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
28-305 2.14e-17

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 81.54  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15089    6 LYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarVHRPSRCRYRDLEVRLCFESFSDELWKGR 187
Cdd:cd15089   86 SIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVP---IMVMAVTKTPRDGAVVCMLQFPSPSWYWD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 188 LLPLVLLAeALGFLLPLAAVVYSSGRVFWTLAR----PDATQSQRR-RKTVRLLLANLVIFLLCFVPYNSTLAVYGLL-- 260
Cdd:cd15089  163 TVTKICVF-IFAFVVPILVITVCYGLMILRLRSvrllSGSKEKDRNlRRITRMVLVVVAAFIICWTPIHIFVIVWTLVdi 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 219281887 261 --RSKLVAASvpardrvrgvLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15089  242 drRNPLVVAA----------LHLCIALGYANSSLNPVLYAFLDENFK 278
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
27-308 5.42e-17

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 80.22  E-value: 5.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRaLRVHSVVSVYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15969    5 VLYLIIFIGSILLNGLAVWIFFH-IRNKTSFIFYLKNIVIADLLMTLTFPFKiIQDSGLGPWNFNFFLCRYTSVLFYASM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARV--HRPSRCRYRD---LEVRLCFESFS 180
Cdd:cd15969   84 YTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILtnGQPTEDNIHDcskLKSPLGVKWHT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFwtlarpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15969  164 AVSYINICIFVAVLVILIVCYISISRYIYKSSKQF-------ISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFS 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 261 RSKLVAAsvparDRVRGVLM----VMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15969  237 QLDKILD-----CTIKTILYyckeATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
30-261 6.59e-17

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 80.14  E-value: 6.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  30 SLVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGS 108
Cdd:cd15393   11 SLVAVVG---NFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLfSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 109 CIFLMLINVDRYAAIVhpLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRC--RYRDLEVRLCFESF-SDELWK 185
Cdd:cd15393   88 VFTLTVIAVDRYRAVI--HPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELtdKTNNGVKPFCLPVGpSDDWWK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLAealgFLLPLAAVVYSSGRV---FWTLARPDATQSQR-------RRKTVRLLLANLVIFLLCFVPYNstla 255
Cdd:cd15393  166 IYNLYLVCVQ----YFVPLVIICYAYTRIavkIWGTKAPGNAQDVRddeilknKKKVIKMLIIVVALFALCWLPLQ---- 237

                 ....*.
gi 219281887 256 VYGLLR 261
Cdd:cd15393  238 TYNLLN 243
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
26-305 7.10e-17

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 79.91  E-value: 7.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDeLWK 185
Cdd:cd15092   84 FTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVM-VMGSAQVEDEEIECLVEIPTPQD-YWD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLaeaLGFLLPLA--AVVYS-------SGRVFWTLARPDatqsQRRRKTVRLLLANLVIFLLCFVPYNSTLAV 256
Cdd:cd15092  162 PVFGICVFL---FSFIIPVLiiSVCYSlmirrlrGVRLLSGSKEKD----RNLRRITRLVLVVVAVFVGCWTPIQIFVLA 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 257 YGLlrsklvaASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15092  235 QGL-------GVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
27-308 8.97e-17

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 79.55  E-value: 8.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVF--LRALRvHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQM 103
Cdd:cd15926    5 IVYSVVCALGLVGNLLVLYLMksKQGWK-KSSINLFVTSLAVTDFQFVLTLPFWAVENALDfTWLFGKAMCKIVSYVTAM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevrLCFESFSD-- 181
Cdd:cd15926   84 NMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEE----LCLVKFPDnr 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ---ELWKGRLLPLVLLaeaLGFLLPLA--AVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPyNSTLAV 256
Cdd:cd15926  160 gnaQFWLGLYHAQKVL---LGFLIPLGiiSLCYLLLVRFITDKNITGSSTKRRSKVTKSVTIVVLSFFLCWLP-NQALTT 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 219281887 257 YG-LLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15926  236 WGiLIKLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
27-305 1.47e-16

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 79.01  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd14992    5 VALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALfCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRD--LEVRLCFESFSDEL 183
Cdd:cd14992   85 YASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKnqEKIFCCQIPPVDNK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKG---RLLPLVLLaealgFLLPLAAVVYSSGRV---FWTLARPDATQSQR-------RRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd14992  165 TYEkvyFLLIFVVI-----FVLPLIVMTLAYARIsreLWFRKVPGFSIKEVerkrlkcKRRVIKMLVCVVVLFVICWLPF 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 251 NstlaVYGLLRSKLVAASVPARDR-VRGVLMvmvLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd14992  240 H----LFFLLRDFFPLIMKEKHTLqVYYFLH---WIAMSNSMYNPIIYVTLNNNFR 288
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
24-308 1.67e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 78.37  E-value: 1.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPsrcrYRDLEVRLCFESFSDE 182
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRD----ETQPSVVDCECEFTPN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWkgrllpLVLLAEALGFLLPLAAVVYSSGRVFWTLarpdatqsQRRRKTVRLLLANLVIFLLCFVPYNstlaVYGLLRS 262
Cdd:cd14967  157 KI------YVLVSSVISFFIPLLIMIVLYARIFRVA--------RRELKAAKTLAIIVGAFLLCWLPFF----IIYLVSA 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVPardrvRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14967  219 FCPPDCVP-----PILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
24-308 3.33e-16

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 77.85  E-value: 3.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALrVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQ 102
Cdd:cd15117    2 LSLVIYSSAFVLGTLGNGLVIWVTGFRM-TRTVTTVCFLNLAVADFAFCLFLPFSVVYTALgFHWPFGWFLCKLYSTLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFS-- 180
Cdd:cd15117   81 FNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHL-VFRDTRKENGCTHCYLNFDPWNet 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 -------DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRrrkTVRLLLANLVIFLLCFVPYNst 253
Cdd:cd15117  160 aedpvlwLETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSR---PFRVLTAVVAAFFLCWFPFH-- 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 254 lavyglLRSKLVAASVPARDRVRGVLMVMVL-----LAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15117  235 ------LVSLLELVVILNQKEDLNPLLILLLplsssLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
27-306 4.64e-16

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 77.66  E-value: 4.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15207    5 VSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVfCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVhpLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRP-SRCRYRDLEVRLCFESFSDELW 184
Cdd:cd15207   85 AASVFTLVAIAVDRYRAVV--HPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVkEYQFFRGQTVHICVEFWPSDEY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KgRLLPLVLLaeALGFLLPLAAVVYSSGRV---FWTLARP---------DATQSQRRRKTVRLLLANLVIFLLCFVPYNS 252
Cdd:cd15207  163 R-KAYTTSLF--VLCYVAPLLIIAVLYVRIgyrLWFKPVPgggsasreaQAAVSKKKVRVIKMLIVVVVLFALSWLPLHT 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219281887 253 T--LAVYGLLrsklvaaSVPARDrvrgVLMVMV-----LLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15207  240 VtmLDDFGNL-------SPNQRE----VLYVYIypiahWLAYFNSCVNPIVYGYFNRNFRK 289
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-250 8.59e-16

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 76.71  E-value: 8.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMH 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRvARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEV-RLCFESFSDELWK 185
Cdd:cd14999   84 ASIFTLTVMSTERYLAVVKPLDTVKRSKSY-RKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSkRICLPTWSEESYK 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219281887 186 GRLLPLVLLAealgFLLPLAAVVYSSGRV---FWTLARPDATQSQRR---RKTVRLLLANLVIFLLCFVPY 250
Cdd:cd14999  163 VYLTLLFSTS----IVIPGLVIGYLYIRLarkYWLSQAAASNSSRKRlpkQKVLKMIFTIVLVFWACFLPF 229
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
27-306 1.41e-15

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 76.18  E-value: 1.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15390    5 IVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYnDWPFGLFYCKFSNFVAITTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVhpLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVR-LCFESFSDELW 184
Cdd:cd15390   85 AASVFTLMAISIDRYIAIV--HPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERtVCFIAWPDGPN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLA--AVVYSS-GRVFWTLARP-DATQSQRR-----RKTVRLLLANLVIFLLCFVPYNstla 255
Cdd:cd15390  163 SLQDFVYNIVLFVVTYFLPLIimAVAYTRvGVELWGSKTIgENTPRQLEsvrakRKVVKMMIVVVVIFAICWLPYH---- 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 219281887 256 VYGLLRSklVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15390  239 LYFILTY--LYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRY 287
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
27-299 1.48e-15

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 76.05  E-value: 1.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYA-LHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15194    5 ILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVvLGPWRSGSFLCKGSSYIISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAarVHRPSRCRYRDLEvrLCFEsfsDELWK 185
Cdd:cd15194   85 YCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPT--LLSRELKKYEEKE--YCNE---DAGTP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLpLVLLAEALGFLLPLAAVVYSSGRVFWTLA---RPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLA---VYGL 259
Cdd:cd15194  158 SKVI-FSLVSLIVAFFLPLLSILTCYCTIIWKLChhyQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKAlaiASGL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 219281887 260 LRSKLVAASVPARDRVRgvlmVMVLLAGANCVLDPLVYYF 299
Cdd:cd15194  237 QVEVTCLPYTLAQLGME----VSAPLAFANSCANPFIYYF 272
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
31-304 1.51e-15

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 76.00  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAA--GLPLNALALWVFL--RALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15122    7 LLLAAllGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRP--SRCRYRDLEVRLCFESfsdelw 184
Cdd:cd15122   87 ASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAF-VYRHvwKDEGMNDRICEPCHAS------ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVfwtLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYN--STLAVYGLLRS 262
Cdd:cd15122  160 RGHAIFHYTFETLVAFVLPFGVILFSYSVI---LVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHvvNLLQVVANLAP 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 263 KLVAASVpaRDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGF 304
Cdd:cd15122  237 GEVLEKL--GGAAKAARAGATALAFFSSSVNPLLYVFAAGDL 276
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
26-311 2.11e-15

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 76.10  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLrALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:PHA02834  32 IVFYILLFIFGLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLVFSFPF-IIHNDLNEWIFGEFMCKLVLGVYFVGF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVhPLRLRHLRRPRVARLLCLGVWALILVFAVPAA------RVHRPSRCRYRDLEVRLCFESF 179
Cdd:PHA02834 110 FSNMFFVTLISIDRYILVV-NATKIKNKSISLSVLLSVAAWVCSVILSMPAMvlyyvdNTDNLKQCIFNDYHENFSWSAF 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 sdelwkgrllpLVLLAEALGFLLPLAAVVYSSGRVFWTLarpDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGL 259
Cdd:PHA02834 189 -----------FNFEINIFGIVIPLIILIYCYSKILYTL---KNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSL 254
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 260 LRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGL 311
Cdd:PHA02834 255 QSVGLIDIGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNM 306
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
26-305 3.34e-15

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 75.03  E-value: 3.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15090    4 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFeSFSDELWK 185
Cdd:cd15090   84 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTF-SHPSWYWE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLaeaLGFLLPLAAVVYSSGRVFWTLAR----PDATQSQRR-RKTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15090  162 NLLKICVFI---FAFIMPVLIITVCYGLMILRLKSvrmlSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 rsklvaaSVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15090  239 -------TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 276
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
29-251 6.29e-15

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 74.39  E-value: 6.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  29 YSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSyYALHH--WPFPDLLCQTTGAIFQMNM 105
Cdd:cd15394    7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLA-YAFEPrgWVFGRFMCYFVFLMQPVTV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLClgVWALILVFAVPAArVHrPSRCRYRDLEVRLCfESFSDELWK 185
Cdd:cd15394   86 YVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAA--IWLLSCGLALPAA-AH-TYYVEFKGLDFSIC-EEFWFGQEK 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 186 GRLLPLVLLAeALGFLLPLAAVVYSSGRVFWTLAR----PDATQSQ------RRRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15394  161 QRLAYACSTL-LITYVLPLLAISLSYLRISVKLRNrvvpGSMTQSQaewdraRRRKTFRLLVVVVVAFAICWLPLH 235
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
29-308 7.39e-15

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 73.98  E-value: 7.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  29 YSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGS 108
Cdd:cd15378    7 YSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 109 CIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcryRDLEVRLCFESFSDELWKGRL 188
Cdd:cd15378   87 ILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPN----LKDNVTKCKDYASSGDATNSL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 189 LPLVLLAeALGFLLPLAAVVYSSGRVFWTLARPDATQSQRR--RKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVA 266
Cdd:cd15378  163 IYSLFLT-VTGFLIPLCVMCFFYYKIALFLKNRNRQLANATsfEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLDSIG 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 267 ASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15378  242 VSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
26-306 8.27e-15

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 73.97  E-value: 8.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15195    4 VLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFfNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVhPLRLRHLRRPRVARLLCLGvWALILVFAVPAARVHRPSRCRYRDLEVRLCFeSFSDELW 184
Cdd:cd15195   84 MYLSSFMLVVIALDRVFAIL-SPLSANQARKRVKIMLTVA-WVLSALCSIPQSFIFSVLRKMPEQPGFHQCV-DFGSAPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARP-----DATQSQRRR-----------KTVRLLLANLVIFLLCFV 248
Cdd:cd15195  161 KKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMakrarDTPISNRRRsrtnslerarmRTLRMTALIVLTFIVCWG 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 249 PYnstlAVYGLLRSKLVAASVPARDRVRGVLMVMVLLagaNCVLDPLVYYFSAEGFRN 306
Cdd:cd15195  241 PY----YVLGLWYWFDKESIKNLPPALSHIMFLLGYL---NPCLHPIIYGVFMKEIRN 291
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
28-308 1.65e-14

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 72.98  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVF-LRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15925    6 AYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTATVLNV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCryrdLEVRLCFESFSDELWK 185
Cdd:cd15925   86 YASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEV----CGVELCLLKFPSNYWL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRL-LPLVLLAealgFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVI--FLLCFVPyNSTLAVYG-LLR 261
Cdd:cd15925  162 GAYhLQRVVVA----FVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVRLVVasFFLCWFP-NHVVTFWGvLVK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 219281887 262 SKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15925  237 FRAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
40-308 1.97e-14

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 72.55  E-value: 1.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRL-----SYYALhhwpfpDLLCQTTGAIFQMNMYGSCIFLML 114
Cdd:cd14989   18 NILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVfnlneKYYDI------AVLCTFMSLFLQINMYSSIFFLTW 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 115 INVDRYAAIVHPLRLRHLRRPRVARLLCLGVW-ALILVFAVPAARVHrpsrCRYRDlEVRLCFESFSDELWkgrllplvl 193
Cdd:cd14989   92 MSFDRYIALAKVMKSSPLRTMQHARLSCGLIWmASISATLLPFTAVQ----AQHTG-EVHFCFADVREIQW--------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 194 LAEALGFLLPLAAVVYSSGRVFWTLARPDATQS--QRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPA 271
Cdd:cd14989  158 LEVTLGFIIPFSIIGLCYSLIVRVLVRAQKHRRlrPRRQKALRMILVVVLVFFICWLPENVFISIQLLQGTQEPSESYDE 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 219281887 272 RDRVRGVLM--VMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14989  238 SFRHNHPLTghIVNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
40-308 2.27e-14

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 72.55  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVD 118
Cdd:cd15391   18 NYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALfCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGID 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 119 RYAAIVHPLRLRHLRrprvARLLC--LGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLae 196
Cdd:cd15391   98 RFFAVIFPLRSRHTK----SRTKCiiASIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPDTSRSAYTVFVM-- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 197 ALGFLLPLAAVVYSS---GRVFWTLARP-------DATQSQRRRKTVRLLLANLVIFLLCFVPynstLAVYGLL-RSKLV 265
Cdd:cd15391  172 LLTYIIPLLILTSTYgyvGFRLWNRTAPgnadkgrDDMQIKSKRKVIKMLVFVVLMFGICWLP----LHLFNLVqDFSTV 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 266 AASVPaRDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15391  248 FRNMP-QHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
27-308 6.09e-14

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 71.76  E-value: 6.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAI----F 101
Cdd:cd14996    5 IIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKgFYWKYQSTQCRIANFFgtlvI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 102 QMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPR----------------VARLLCLGVWALILVFAVPAARVHrpSRC 165
Cdd:cd14996   85 HVSMCVSILILSWIAISRYATLMKHDSATQKQSCYekifyghflkrfrqpkFARYLCIYIWGVVLCIIIPVVVYY--SVR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 166 RYRDLEVRLCFeSFSDELWKGRLLPLVLLAEALGFLLPLAAVV--YSSGRVFWTLARPDATQSQRR--RKTVRLLLANLV 241
Cdd:cd14996  163 EADEDGESLCY-NRQVELGAKGSQIAGLIATTFFFLFFLVVLLsyYSFVNHLRRIQKNTCISEKDLiyRSVKRNILIIQA 241
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219281887 242 IFLLCFVPYNSTLAVYGLLRSK----LVAASVPARDrvrgvlmVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14996  242 LLVVCFLPYHIFKPVFYVLHQRedcqQLNYLIETKN-------ILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
27-305 1.19e-12

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 67.44  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALR--VHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARkgKPSLIDSLILNLSAADLLLlLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLcLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd15002   84 CMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVV-ASIWVPACLLPLPQW-LFRTVKQSEGVYLCILCIPPLAHEF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 wkgrLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLAR----PDATQSQRRRKTVRLLLANLVI-FLLCFVP-YNSTLAVY 257
Cdd:cd15002  162 ----MSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRrgtkTQNLRNQIRSRKLTHMLLSVVLaFTILWLPeWVAWLWLI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 258 GLlrsklvAASVPArdRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15002  238 HI------KSSGSS--PPQLFNVLAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
27-306 1.51e-12

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 67.29  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGaIFQMNM 105
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLtCVPFTSTIYTLDSWPFGEFLCKLSE-FLKDTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIF-LMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA---RVHRPSRCRYRDLEVRLCF-ESFS 180
Cdd:cd15927   84 IGVSVFtLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAifsHVVTFTLTDNQTIQICYPYpQELG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWKGR---------LLPLVLLAEalgFLLPLAAVVYSSGRVFWTLARPDA-TQSQRRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15927  164 PNYPKIMvllrflvyyLIPLLIIGV---FYVLMARHLIRSTRNIGSGQNQAAqRQIEARKKVAKTVLAFVVLFAVCWLPR 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 251 NstlaVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15927  241 H----VFMLWFHFAPNGLVDYNAFWHVLKIVGFCLSFINSCVNPVALYLLSGSFRR 292
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
24-308 1.75e-12

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 67.27  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRaLRVHSVVSVYMCNLAASDLLF------TLSLPVRLSYYALHHWPFPDLLCQTT 97
Cdd:cd14978    2 LYGYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVllsalpLFLLPYIADYSSSFLSYFYAYFLPYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  98 GAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarvhrpsrcRYRDLEVRLCFE 177
Cdd:cd14978   81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLP----------RFFEYEVVECEN 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 178 SFSDELWKGRLLPL-----------VLLAEALGFLLPLAAVVYSSGRVFWTL-------------ARPDATQSQRRRKTV 233
Cdd:cd14978  151 CNNNSYYYVIPTLLrqnetyllkyyFWLYAIFVVLLPFILLLILNILLIRALrkskkrrrllrrrRRLLSRSQRRERRTT 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 234 RLLLANLVIFLLCFVPYnstlAVYGLLRSKLVAASVPARDRVRGVLMVMVLLagANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14978  231 IMLIAVVIVFLICNLPA----GILNILEAIFGESFLSPIYQLLGDISNLLVV--LNSAVNFIIYCLFSSKFRRTF 299
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
36-308 2.83e-12

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 66.34  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  36 GLPLNALALWVfLRALRVHSVVSVYMCNLAASDLLFTLSLPvrlsYYALH-----HWPFPDLLCQTTGAIFQMNMYGSCI 110
Cdd:cd15120   14 GLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLIFTLILP----FMAVHvlmdnHWAFGTVLCKVLNSTLSVGMFTSVF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 111 FLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP--AARVHRPSR-----CrYRDLEVRLCFESFSDEL 183
Cdd:cd15120   89 LLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPylAFRETRLDEkgktiC-QNNYALSTNWESAEVQA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRL-LPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSqrrRKTVRLLLANLVIFLLCFVPYNstlAVYGLLRS 262
Cdd:cd15120  168 SRQWIhVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARS---SKPFKVMFTAVVSFFVCWLPYH---LHSGLVLT 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219281887 263 KLVAASVpardrVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15120  242 RGRPPSL-----TDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
36-306 4.21e-12

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 65.95  E-value: 4.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  36 GLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMNMYGSCIFLML 114
Cdd:cd15200   14 GLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTASIVFLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 115 INVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP---AARVHRPSRCRYRDLEVrlcfESFSDELWKGRLLpl 191
Cdd:cd15200   94 IALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHlllLDHVQSNSTCLSYDHGT----DPSASDRWHRILF-- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 192 vllaeALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPyNSTLAVYGLLRSKLVAAsvpa 271
Cdd:cd15200  168 -----FLEFFLPLGIILFCIFSIILTLKQRKLAKQAGPQRAVKVLAVIVLVYTVCFLP-SILFALASLVAFKVSQC---- 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 272 rdrvRGVLMVMVLLAGA------NCVLDPLVYYFSAEGFRN 306
Cdd:cd15200  238 ----RSLDLCTQLFHGSlaftylNSALDPVLYCFSSPSFLN 274
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
26-251 6.44e-12

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 65.61  E-value: 6.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15399    4 ILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVarlLCLGV-WALILVFAVPAARVHRPSRCRYR-DLEVRLCFESFSDE 182
Cdd:cd15399   84 VHVSTVTLTVIALDRHRCIVYHLESKISKKISF---LIIGLtWAASALLASPLAIFREYSVIEISpDFKIQACSEKWPNG 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219281887 183 -LWKGRLLPLVLLAeaLGFLLPLAAVVYSSGRVfWTLARPDATQS-------QRRRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15399  161 tLNDGTIYSVSMLL--IQYVLPLAIISYAYIRI-WTKLKNHVSPGggndhyhQRRRKTTKMLVCVVVVFAVSWLPFH 234
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
27-250 1.13e-11

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 64.82  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRL-SYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLyRLWRYRPWRFGDLLCRLMYFFSETCT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARV----HRPSRCRYRDLEVRlcfesfsD 181
Cdd:cd15928   85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLvgveHIQGQQTPRGFECT-------V 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219281887 182 ELWKGRLLPLVLLAEALGFLLPLA--AVVYS-SGRVFWTLARPDAT-----QSQRRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15928  158 VNVSSGLLSVMLWVSTSFFFVPMVclSLLYGlIGRALWDRRQRSRTagasrRDNNHRQTVRMLAVIVLAFVLCWLPF 234
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
28-307 1.59e-11

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 64.30  E-value: 1.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLL-FTLSLPVRL-SYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd14979    6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLiLLVGLPVELyNFWWQYPWAFGDGGCKLYYFLFEACT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA----RVHRPSRCRYRDLEVRLCFESFSD 181
Cdd:cd14979   86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILflmgIQYLNGPLPGPVPDSAVCTLVVDR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELwkgrLLPLVLLAEALGFLLPLA--AVVYS-------------SGRVFWTLARPDATQSQRRRKTVRLLLANLVI-FLL 245
Cdd:cd14979  166 ST----FKYVFQVSTFIFFVLPMFviSILYFrigvklrsmrnikKGTRAQGTRNVELSLSQQARRQVVKMLGAVVIaFFV 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 219281887 246 CFVPYNstlaVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd14979  242 CWLPFH----AQRLMFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVA 299
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-261 2.34e-11

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 63.83  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHH--WPFPDLLCQTTGAIFQM 103
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAvFCLPFEMDYYVVRQrsWTHGDVLCAVVNYLRTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRprVARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevrlcfESFSDEL 183
Cdd:cd15204   85 SLYVSTNALLVIAIDRYLVIVHPLKPRMKRR--TACVVIALVWVVSLLLAIPSAVYSKTTPYANQG-------KIFCGQI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLP-------LVLLAEalgFLLPLAAVVYSSGRVFWTL----------ARPDATQsQRRRKTVRLLLANLVIFLLC 246
Cdd:cd15204  156 WPVDQQAyykayylFLFVLE---FVLPVLIMTLCYLRIVRKVwfrrvpgqqtEQIRRRL-RRRRRKVRLLVVILTAFVLC 231
                        250
                 ....*....|....*
gi 219281887 247 FVPYNstlaVYGLLR 261
Cdd:cd15204  232 WAPYY----GYAIVR 242
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
39-307 4.75e-11

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 62.45  E-value: 4.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  39 LNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINV 117
Cdd:cd15050   17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 118 DRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWkgrllpLVLLAEA 197
Cdd:cd15050   97 DRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGERVVLEDKCETDFHDVTW------FKVLTAI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 198 LGFLLPLAAVVYSSGRVFWTLarpdatqsQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSklvaasvparDRVRG 277
Cdd:cd15050  171 LNFYIPSLLMLWFYAKIFKAV--------NRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKN----------CCNEN 232
                        250       260       270
                 ....*....|....*....|....*....|
gi 219281887 278 VLMVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15050  233 LHMFTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
40-308 6.09e-11

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 62.74  E-value: 6.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVD 118
Cdd:cd15083   18 NGLVIYAFCRFKSLRTPANYLIINLAISDFLMCiLNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 119 RYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarvhrP----SRCRYRDLEVRLCFESFSDElWKGRLLPLVLL 194
Cdd:cd15083   98 RYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP------PlfgwSRYVLEGLLTSCSFDYLSRD-DANRSYVICLL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 195 aeALGFLLPLAAVVYSSGRVFWTLARPD---------------ATQSQRRRKTVRLLLANLVI---FLLCFVPYnstlAV 256
Cdd:cd15083  171 --IFGFVLPLLIIIYCYSFIFRAVRRHEkamkemakrfskselSSPKARRQAEVKTAKIALLLvllFCLAWTPY----AV 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 257 YGLLRSKLVAASVPARdrvrgVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15083  245 VALIGQFGYLEVLTPL-----ATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-305 1.06e-10

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 61.89  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIfQMNMY 106
Cdd:cd15125    6 LYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVI-QLTSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIF-LMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRD-LEVRLCFE-SFSDEL 183
Cdd:cd15125   85 GVSVFtLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDnTTFTACIPyPQTDEM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WKGRLLPLVLLAEalgFLLPLAAVVYSSGRVFWTLARP------DATQSQRRRKTVRLLLANLVI-----FLLCFVPyNS 252
Cdd:cd15125  165 HPKIHSVLIFLVY---FLIPLAIISIYYYHIAKTLIKSahnipgEYSEHSKRQMETRKRLAKIVLvfvglFAFCWFP-NH 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 219281887 253 TLAVYGLLRSKLVAASVparDRVRGVLMVMVLLAGANCVlDPLVYYFSAEGFR 305
Cdd:cd15125  241 VLYMYRSFNYNEIDSSL---GHMIVTLVARVLSFCNSCV-NPFALYLLSESFR 289
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
27-258 2.00e-10

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 61.19  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSYY-ALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15134    5 IIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIwQQYPWVFGEVFCKLRAFLSEMS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA---RVHR---PSRCRYRDLEVRLCfeS 178
Cdd:cd15134   85 SYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAiqtRIVYleyPPTSGEALEESAFC--A 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWKgrLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARP------------DATQSQRRRKTVRLLLANLVIFLLC 246
Cdd:cd15134  163 MLNEIPP--ITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRStllrrgqrsvsgGRRSSQSRRTVLRMLVAVVVAFFIC 240
                        250
                 ....*....|....
gi 219281887 247 FVPYNST--LAVYG 258
Cdd:cd15134  241 WAPFHAQrlLTVYA 254
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
27-251 2.01e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 60.91  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15397    5 VSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLvCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVrlCFESFSD---- 181
Cdd:cd15397   85 TVSILSLVLIALERHQLIINPTGWKPSVSQ--AYLAVVVIWMLACFISLPFLAFHILTDEPYKNLSH--FFAPLADkavc 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 -ELWKGRLLPLVLLAEALGF--LLPLAAVVYSSGRVFWTLAR-----PDATQSQRRR---KTVRLLLANLVI-FLLCFVP 249
Cdd:cd15397  161 tESWPSEHHKLAYTTWLLLFqyCLPLLFILVCYLRIYLRLRRrkdmlERRGEYNRRAghsKRINVMLVSLVAaFALCWLP 240

                 ..
gi 219281887 250 YN 251
Cdd:cd15397  241 LN 242
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
26-308 3.06e-10

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 60.47  E-value: 3.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd14986    4 VAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFfTVLTQIIWEATGEWVAGDVLCRIVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVHRPsrcryRDLE--VRLCFESFSDE 182
Cdd:cd14986   84 LFASTYILVSMSLDRYQAIVKPMSSLKPRKR--ARLMIVVAWVLSFLFSIPQLVIFVE-----RELGdgVHQCWSSFYTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 lwKGRLLPLVLLAEALgFLLPLAAVVYSSGRVFWTLARPDATQSQR-------------------------RRKTVRLLL 237
Cdd:cd14986  157 --WQRKVYITWLATYV-FVIPLIILSYCYGRILRTIWIRSRQKTDRpiaptamscrsvscvssrvslisraKIKTIKMTL 233
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219281887 238 ANLVIFLLCFVPYN--STLAVYGLLRSKLVAASVpardrvrgvlmVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd14986  234 VIILAFILCWTPYFivQLLDVYAGMQQLENDAYV-----------VSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
24-250 3.08e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 60.15  E-value: 3.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQnLSIYLIPSWPFGEVLCRMYQFVHS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaaRVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15012   81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTP--YFVFSQTVEILVTQDGQEEEICVLD 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 183 LWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSqrRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15012  159 REMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEA--RRKVVRLLVAVVVSFALCNLPY 224
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
31-305 7.53e-10

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 58.82  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSC 109
Cdd:cd15210    9 VFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFcAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 110 IFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArvhrPSRCRYRDLEVRLCFESFSDELwKGRLL 189
Cdd:cd15210   89 LTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLW----LGIWGRFGLDPKVCSCSILRDK-KGRSP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 190 PLVLLaeALGFLLPLAAVVyssgrVFWTLArpdatqsqRRRKTVRLLLANLVIFLLCFVPYnstlavygllrskLVAASV 269
Cdd:cd15210  164 KTFLF--VFGFVLPCLVII-----ICYARR--------EDRRLTRMMLVIFLCFLVCYLPI-------------TLVNVF 215
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 219281887 270 PARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15210  216 DDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYR 251
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-305 8.81e-10

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 59.09  E-value: 8.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQMNM 105
Cdd:cd16004    5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNdWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPaarvhrpsRCRYRDLEVR----LCFESFSD 181
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPFKPRLSAGS--TKVVIAGIWLVALALAFP--------QCFYSTVTMDqgrtKCIVAWPG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELWKGRLLPLVLLAEALGFLLPLAA--VVYSS-GRVFWTLARPDAT-------QSQRRRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd16004  155 DSGGKHQLTYHLAVIVLIYLLPLAVmfVTYSIiGITLWRSAVPGHQahgayhrQLQAKKKFVKTMVVVVVTFAICWLPYH 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219281887 252 stlaVYGLLRSklVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd16004  235 ----LYFILGS--FNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-305 9.46e-10

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 58.94  E-value: 9.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15208    4 IALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIiCLPATLLVDVTETWFFGQVLCKIIPYLQTVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRL---CFESFSD 181
Cdd:cd15208   84 VSVSVLTLSCIALDRWYAICHPLMFKSTAKR--ARVSILIIWIVSLLIMIPQAIVMECSRVVPLANKTILltvCDERWSD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELW-KGRLLPLVLLAealgFLLPLAAVVYSSGRVF------------------WTLARPDA-----TQSQRRRKTVRLLL 237
Cdd:cd15208  162 SIYqKVYHICFFLVT----YLLPLCLMILAYFQIFrklwcrqipgtssvvqrkWNKPRKSAvaaeeKQLRSRRKTAKMLI 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 238 ANLVIFLLCFVPynstLAVYGLLRSKLVAASVpARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15208  238 VVVIMFAICYLP----VHLLNILRYVFGLFTV-DRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFR 300
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
26-305 9.46e-10

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 59.02  E-value: 9.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15205    4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFfCIPFTLLQNISSNWLGGAFMCKMVPFVQSTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRpsrcryrdLEVRLCF-----ESF 179
Cdd:cd15205   84 VVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQ--------LEVKYDFlyekrHVC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWKGR-------LLPLVLLaealgFLLPLAAVVYSSGRVFWTL----------------ARPDATQSQRRRKTVRLL 236
Cdd:cd15205  156 CLERWYSPtqqkiytTFILVIL-----FLLPLTTMLFLYSRIGYELwikkrvgdasvlqtihGIEMSKISRKKKRAVKMM 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219281887 237 LANLVIFLLCFVPYNST--LAVYGLLRSKLvaasvpARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15205  231 VTVVLLFAVCWAPFHVVhmMIEYSNLENKY------DGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
23-251 1.19e-09

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 58.65  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLV-VYSLVLAAGLpLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIF 101
Cdd:cd14994    1 TYSLIfLYSVVLIGGV-IGVILMSFLLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 102 QMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEvrlCFEsFSD 181
Cdd:cd14994   80 HIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKEYGSSSSYNSDQ---CFK-FHK 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219281887 182 ELWKG--RLLPLVLLAEALGFLLPLAAV-VYSSGRVFWTLARPDATQSQRRRKTVRLLLanLVIFLLCFVPYN 251
Cdd:cd14994  156 ELEVHyvKVLNYIIICIVLIVTLALLGFqVFILGHVYRKLRASLLSHQEFWAQMKSLFF--IVVIIVCFVPYN 226
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
31-251 1.76e-09

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 58.36  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLP---VRLSYYalHHWPFPDLLCQTTGAIFQMNMYG 107
Cdd:cd15131    9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPldlYRLWQY--RPWNFGDLLCKLFQFVSESCTYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 108 SCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPA-ARVHRPSRCRYRDLEVRLCfeSFSDELWKG 186
Cdd:cd15131   87 TILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIfVLVGVEHENGTNPIDTNEC--KATEYAVRS 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219281887 187 RLLPLVLLAEALGFLLPL--AAVVYS-SGRVFWTLARPDATQS-----QRRRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15131  165 GLLTIMVWVSSVFFFLPVfcLTVLYSlIGRKLWRRRRENIGPNashrdKNNRQTVKMLAVVVFAFVLCWLPFH 237
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
36-308 1.82e-09

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 58.10  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  36 GLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL--HHWPFPDLLCQT---TGAIFQMNmygSCI 110
Cdd:cd15337   14 GVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSfnKKWIWGKVACELygfAGGIFGFM---SIT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 111 FLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPaarvhrP--SRCRYRdLEVRLCFESFsDEL---WK 185
Cdd:cd15337   91 TLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP------PffGWGRYV-PEGFQTSCTF-DYLsrdLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 GRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTLAR-------------PDATQSQRRRKTVRLLLANLVI-----FLLCF 247
Cdd:cd15337  163 NRLFILGLF--IFGFLCPLLIIIFCYVNIIRAVRNhekemtqtaksgmGKDTEKNDARKKAEIRIAKVAIilislFLLSW 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 219281887 248 VPYnSTLAVYGLLRSklvaasvpaRDRVRGVLMVM-VLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15337  241 TPY-AVVALLGQFGP---------AYWITPYVSELpVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
27-305 2.51e-09

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 57.62  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIfQMNM 105
Cdd:cd15123    5 VTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFI-QLTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIF-LMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrPSRCRYRDLEVRLCFESFSDELW 184
Cdd:cd15123   84 VGVSVFtLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVF--SDLYSFRDPEKNTTFEACAPYPV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLLPLV--LLAEALGFLLPLAAV-VYSS--GRVFW--TLARPDATQS------QRRRKTVRLLLANLVIFLLCFVPyN 251
Cdd:cd15123  162 SEKILQEIhsLLCFLVFYIIPLSIIsVYYFliARTLYksTFNMPAEEHSharkqiESRKRVAKTVLVLVALFAFCWLP-N 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219281887 252 STLAVYgllRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15123  241 HILYLY---RSFTYHTSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFR 291
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-305 4.13e-09

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 56.86  E-value: 4.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd16003    5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHsEWYFGEAYCRFHNFFPITSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLClgVWALILVFAVPaarvhrpsRCRYRDLEV----RLCFESF-- 179
Cdd:cd16003   85 FASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGS--IWILAFLLAFP--------QCLYSKTKVmpgrTLCFVAWpg 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 -SDELWKGRLLPLVLLaealgFLLPL--AAVVYS-SGRVFWTLARPDAT------QSQRRRKTVRLLLANLVIFLLCFVP 249
Cdd:cd16003  155 gPDQHFTYHIIVIVLV-----YCLPLlvMGITYTiVGITLWGGEIPGDTsdkyheQLRAKRKVVKMMIIVVLTFAICWLP 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 250 YNSTLAVYGLLRsklvaaSVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd16003  230 YHIYFIVTGLYQ------QLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
29-308 1.01e-08

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 55.61  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  29 YSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVrLSYYALHHWPFPDLLCQTTGAIFQMNMYGS 108
Cdd:cd15171    7 CSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPF-WAHAAWHGGSLGNPTCKVLVALSSVGLHSE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 109 CIFLMLINVDRY-AAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEV--RLCFESFSDELWK 185
Cdd:cd15171   86 ALFNVLLTVQASrVFFHGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAfsRPHFLPAEETFWK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 grlLPLVLLAEALGFLLPLAAVVYSSGRVfwtlaRPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVyGLLRSKLV 265
Cdd:cd15171  166 ---YFLTLKMNIVVLVFPLLVFIICCVQL-----RKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFL-SAFKEHFS 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 266 AASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15171  237 LRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
27-250 1.06e-08

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 55.77  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15048    5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRcRYRDLEVRLCFESFSDElwk 185
Cdd:cd15048   85 TASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWT-GYSIVPTGDCEVEFFDH--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 186 grlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLAR------------------PDATQSQRRRKTVRL------LLANLV 241
Cdd:cd15048  161 ---FYFTFITSVLEFFIPFISVSFFNLLIYLNIRKrsrrrplrsvpilpasqnPSRARSQREQVKLRRdrkaakSLAILV 237
                        250
                 ....*....|
gi 219281887 242 -IFLLCFVPY 250
Cdd:cd15048  238 lVFLICWAPY 247
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
26-305 1.82e-08

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 55.28  E-value: 1.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15980    4 IASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIfCMPTTLLDNIIAGWPFGSTVCKMSGMVQGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVarLLCLGVWALILVFAVPAARVHRPSRCRY---------RDLEVRLC 175
Cdd:cd15980   84 VSASVFTLVAIAVDRFRCIVYPFKQKLTISTAV--VIIVIIWVLAIAIMCPSAVMLHVQEEKNyrvvlgsqnKTSPVYWC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 176 FESFSDELWKgRLLPLVLLAEAlgFLLPLAAVVYSSGRVFWTLAR------------PDATQSQRRRKTVRLLLANLVIF 243
Cdd:cd15980  162 REDWPNQEMR-KIYTTVLFANI--YLAPLSLIVIMYARIGITLFKtamphtgkhnqeQRHVVSRKKQKVIKMLLIVALLF 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 219281887 244 LLCFVPynstlaVYGLLRSKLVAASVPARDRVRGVLMVMVL--LAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15980  239 ILSWLP------LWTLMMLSDYANLSPNQLQIINIYIYPFAhwLAFFNSSVNPIIYGFFNENFR 296
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
28-251 3.20e-08

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 54.43  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRAlRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTIIRS-RKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARgGEWVFGSPLCTIITSLDTCNQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWkg 186
Cdd:cd15339   85 ACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNLTSPDDVLW-- 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 187 rllpLVLLAEALGFLLPLAAV----------VYSSGRVFWTLARPDAT-QSQRRRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15339  163 ----YTLYQTITTFFFPLPLIlicyililcyTWEMYRKNKKAGRYNTSiPRQRVMRLTKMVLVLVGVFLVSAAPYH 234
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
24-124 7.68e-08

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 53.30  E-value: 7.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15396    2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQS 81
                         90       100
                 ....*....|....*....|..
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIV 124
Cdd:cd15396   82 VSVSVSIFSLVLIAIERYQLIV 103
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
28-308 7.94e-08

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 53.05  E-value: 7.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd17790    9 ILSLVTVTG---NLLVLISFKVNSELKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALDYVASN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDElwkg 186
Cdd:cd17790   86 ASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAI-LFWQYLVGERTVLAGQCYIQFLSQ---- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 rllPLVLLAEAL-GFLLPLAAVVYssgrVFWTLARpdatQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVygllrSKLV 265
Cdd:cd17790  161 ---PIITFGTAIaAFYLPVTIMII----LYWRIYR----ETIKEKKAARTLSAILLAFILTWTPYNIMVLV-----STFC 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 266 AASVPARDRVRGVLMVMVllagaNCVLDPLVYYFSAEGFRNTL 308
Cdd:cd17790  225 KDCVPKTLWELGYWLCYV-----NSTVNPMCYALCNKSFRDTF 262
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
26-250 8.51e-08

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 52.82  E-value: 8.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPF-PDLLCQTTGAIFQMN 104
Cdd:cd14964    2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHrpsrcryrDLEVRLCFESFSDELW 184
Cdd:cd14964   82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGK--------GAIPRYNTLTGSCYLI 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219281887 185 KGRLLpLVLLAEALGFLLPLAAVVYSSGRVFWTLAR----PDATQSQRRRKTVRL---LLANLVIFLLCFVPY 250
Cdd:cd14964  154 CTTIY-LTWGFLLVSFLLPLVAFLVIFSRIVLRLRRrvraIRSAASLNTDKNLKAtksLLILVITFLLCWLPF 225
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
24-297 1.16e-07

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 52.82  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15384    2 LKIVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFfCIPSEAIWAYTVAWLAGNTMCKLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15384   82 FGLYLSTYITVLISLDRCVAILYPMKRNQAPER--VRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVTYGFYTA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 LWKGRL---LPLVLLaealgFLLPLAAVVYSSGRVFWTLARPD-----------ATQSQRRR-------KTVRLLLANLV 241
Cdd:cd15384  160 EWQEQLynmLSLVFM-----FPIPLVIMVTCYVLIFITLSKSSrdfqgleiytrNRGPNRQRlfhkakvKSLRMSAVIVT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 242 IFLLCFVPYNSTLAVYGLLRSKlvaasvPARDRVRGVLMvmvLLAGANCVLDPLVY 297
Cdd:cd15384  235 AFILCWTPYYVIMIWFLFFNPY------PLNDILFDVIF---FFGMSNSCVNPLIY 281
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
27-297 1.20e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 52.58  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFL--RALRVHSvvSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSttKSLRTPS--NMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVArLLCLGVWALILVFAVPAARVhrpSRCRYRdLEVRL--C-FESFSD 181
Cdd:cd15079   83 GIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKAL-LLILFIWLYALPWALLPLLF---GWGRYV-PEGFLtsCsFDYLTR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ElWKGRLlpLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKT-----------------VRL---LLANLV 241
Cdd:cd15079  158 D-WNTRS--FVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEKALREQAKKMnvvslrsnadankqsaeIRIakvALTNVF 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 242 IFLLCFVPYN--STLAVYGlLRSKLvaasVPardrvrGVLMVMVLLAGANCVLDPLVY 297
Cdd:cd15079  235 LWFIAWTPYAvvALIGAFG-NQSLL----TP------LVSMIPALFAKTAACYNPIVY 281
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
23-250 1.58e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 51.85  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-------TLSLPVRLSYYAlhhwpfPDLLCQ 95
Cdd:cd15196    1 KVEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLValfnvlpQLIWDITYRFYG------GDLLCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  96 TTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVaRLLCLGVWALILVFAVPAA---RVHRPSRCRYRdlev 172
Cdd:cd15196   75 LVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRV-HLMVAIAWVLSLLLSIPQLfifSYQEVGSGVYD---- 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 173 rlCFESFSDElWKGRLlpLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdatqsqRRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15196  150 --CWATFEPP-WGLRA--YITWFTVAVFVVPLIILAFCYGRICYVVWR-------AKIKTVKLTLVVVACYIVCWTPF 215
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-306 3.76e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 51.06  E-value: 3.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  58 SVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPR 136
Cdd:cd15977   36 NVLIASLALGDLLYILiAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVASWSRIRGIGIPV 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 137 VARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLC---------FESFSDELWKGRL------LPLVllaeALGFL 201
Cdd:cd15977  116 WKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYRGQTLLVCmlpmeqtssFMRFYQDVKDWWLfgfyfcLPLA----CTGVF 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 202 LPLAAVVYSSGRVFWTLARPDatQSQRRRKTVRLLLANLVIFLLCFVPynstLAVYGLLRSKLVAASVPARDRVRGVLMV 281
Cdd:cd15977  192 YTLMSCEMLSIKNGMRIALND--HMKQRREVAKTVFCLVVIFALCWLP----LHLSRILKKTIYDVKDPQRCELLSFLLV 265
                        250       260
                 ....*....|....*....|....*....
gi 219281887 282 M----VLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15977  266 MdytgINMASLNSCINPVALYFVSRKFKN 294
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
31-370 5.55e-07

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 50.97  E-value: 5.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAAGLPLNALALWVFLRALRVH--SVVSVYMCNLAASDLLFTLSLPvrlsYYALHHWpfpDLLCQTTGA--IFQMNMY 106
Cdd:PHA03235  41 LIISVGGPLNLIVLVTQLLANRVHgfSTPTLYMTNLYLANLLTVFVLP----FIMLSNQ---GLLSGSVAGckFASLLYY 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIF----LMLINVDRYAAIVHPLRLRHLRRPRVARLLCLgVWALILVFAVPAAR-----VHRPSRCRYRDLEVrlCFE 177
Cdd:PHA03235 114 ASCTVgfatVALIAADRYRVIHQRTRARSSAYRSTYKILGL-TWFASLICSGPAPVyttvvAHDDVDPEAPGYET--CVI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 178 SFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAV- 256
Cdd:PHA03235 191 YFRADQVKTVLSTFKVLLTLVWGIAPVVMMTWFYTFFYRTLKR---ASYKKRSRTLTFVCILLLSFLCLQTPFVAIMIFd 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 257 -YGLLRSKLVAASVPARDRVRgvlMVMVLLAGANCVLDPLVYYFSAEGF----RNTLRGLGTPHRA----RTSATNGTRA 327
Cdd:PHA03235 268 sYATLIWPSDCEHINLRDAVS---TLSRLVPNLHCLLNPILYAFLGNDFlkrfRQCFRGELFSRRAflrsRQKCGATAIS 344
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 328 ALAQSERSAVTTDATRPDAA-----SQGLLRPSDSHSLSSFTQCPQDS 370
Cdd:PHA03235 345 TVCALPSKTSTLSTSSGTRQqkikrSQSLNLPNATPKNKPKTRCAQND 392
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
26-249 5.65e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 50.59  E-value: 5.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15981    4 ILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVhpLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRY--------RDLEVRLCF 176
Cdd:cd15981   84 VSASVFTLVAIAVERFRCIV--HPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHhfmvddynNSYPLYSCW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 177 ESFSDELWKgRLLPLVLLAEAlgFLLPLAAVVYSSGRVFWTL------ARPDATQ-------SQRRRKTVRLLLANLVIF 243
Cdd:cd15981  162 EAWPDTEMR-KIYTTVLFSHI--YLAPLTLIVIMYARIAFKLfkssapIRGSQGEeeegrrvSKRKIKVINMLIIVALFF 238

                 ....*.
gi 219281887 244 LLCFVP 249
Cdd:cd15981  239 TLSWLP 244
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
30-308 5.79e-07

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 50.40  E-value: 5.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  30 SLVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGS 108
Cdd:cd15049   11 SLVTVGG---NILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 109 CIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDElwkgrl 188
Cdd:cd15049   88 VMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAI-LGWQYFVGERTVPDGQCYIQFLDD------ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 189 lPLVLLAEALG-FLLPLAAVVYSSGRVFWTLArpdatqsqRRRKTVRLLLANLVIFLLCFVPYNsTLAVYgllrSKLVAA 267
Cdd:cd15049  161 -PAITFGTAIAaFYLPVLVMTILYWRIYRETA--------RERKAARTLSAILLAFIITWTPYN-ILVLV----STFCAK 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 268 SVPARdrvrgVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15049  227 CIPDT-----LWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
23-253 6.04e-07

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 50.39  E-value: 6.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVS-VYMCNLAASDLLFTLSLPVR-LSYYALHHWPFPDLLCQTTGAI 100
Cdd:cd15169    1 QLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSlVYALNLGCSDLLLTVSLPLKaVEALASGAWPLPASLCPVFAVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 101 FQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILV-------FAVPAARVHRPSRCRYRDLEVR 173
Cdd:cd15169   81 HFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLChlglvfgLEAPGGWLDHSNTSLGINTPVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 174 ---LCFESFSDELWKGRLLPLVLLAealgFLLPLAAVVYSSGRVFWTLARPDATQsQRRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15169  161 gspVCLEAWDPASAGPARFSLSLLL----FFLPLAITAFCYVGCLRALARSGLTH-RRKLRAAWVAGGALLTLLLCVGPY 235

                 ...
gi 219281887 251 NST 253
Cdd:cd15169  236 NAS 238
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
53-308 9.69e-07

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 49.58  E-value: 9.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  53 VHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRH 131
Cdd:cd15297   31 LQTVNNYFLFSLACADLIIGVfSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 132 LRRPRVARLLCLGVWALILVFAVPAARVHRpSRCRYRDLEVRLCFESFSDElwkgrllPLVLLAEAL-GFLLPLAAVVYs 210
Cdd:cd15297  111 KRTTKMAGMMIAAAWVLSFILWAPAILFWQ-FIVGGRTVPEGECYIQFFSN-------AAVTFGTAIaAFYLPVIIMTV- 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 211 sgrVFWTLARpdatQSQRRRKTVRLLLANLVIFLLCFVPYNSTlavygLLRSKLVAASVPardrvRGVLMVMVLLAGANC 290
Cdd:cd15297  182 ---LYWQISR----ASSREKKVTRTILAILLAFIITWTPYNVM-----VLINTFCASCIP-----NTVWTIGYWLCYINS 244
                        250
                 ....*....|....*...
gi 219281887 291 VLDPLVYYFSAEGFRNTL 308
Cdd:cd15297  245 TINPACYALCNATFKKTF 262
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
40-299 1.38e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 49.21  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLL------FTLSLPVRLSYYALhhwPFPDLLCQTtgaIFQMNMYGSCIFLM 113
Cdd:cd14972   16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLagiafvFTFLSVLLVSLTPS---PATWLLRKG---SLVLSLLASAYSLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 114 LINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWAL-ILVFAVPAARVHrpsrCRYRDLEVrlCfesfsdeLWKGRLLP-- 190
Cdd:cd14972   90 AIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWsVLLALLPVLGWN----CVLCDQES--C-------SPLGPGLPks 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 191 -LVLLAEAlgFLLPLAAVVYSSGRVFWTLAR-----------PDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYG 258
Cdd:cd14972  157 yLVLILVF--FFIALVIIVFLYVRIFWCLWRhanaiaarqeaAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 219281887 259 LlrsklvaasVPARDRVRGVLMVMVLLAGANCVLDPLVYYF 299
Cdd:cd14972  235 L---------CPSVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
25-251 1.64e-06

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 48.96  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  25 HLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd14977    3 IMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLlCVPLNAYNLLTKDWLFGDVMCKLVPFIQVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEV-RLCF---ESF 179
Cdd:cd14977   83 SLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSlTVCImkpSTP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 SDELWKGRLLPLVLlaeALGFLLPLA-AVVYSSgrVFWTLARPDATQSQR--------RRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd14977  163 FAETYPKARSWWLF---GCYFCLPLAfTAVCYL--LMARTLIRAAKEYTRgtkkhmkqRRQLAKTVLCLVLVFAFCWLPE 237

                 .
gi 219281887 251 N 251
Cdd:cd14977  238 H 238
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
53-305 2.14e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 48.74  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  53 VHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRH 131
Cdd:cd15325   31 LQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 132 LRRPRVARLLCLGVWALILVFAV-PAARVHRPSrcryrDLEVRLCfeSFSDElwkgrllPLVLLAEALG-FLLPLAAVVY 209
Cdd:cd15325  111 IMTERRGLLALLCVWVLSLVISIgPLFGWKEPA-----PEDETIC--QITEE-------PGYALFSALGsFYLPLAIILV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 210 SSGRVFWTlarpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAvygllrsklVAASVPARDRVRGVLMVMVLLAGAN 289
Cdd:cd15325  177 MYCRVYVV-----ALKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP---------IGSIFPAYKPSDTVFKITFWLGYFN 242
                        250
                 ....*....|....*.
gi 219281887 290 CVLDPLVYYFSAEGFR 305
Cdd:cd15325  243 SCINPIIYPCSSQEFK 258
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
40-308 3.40e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 48.18  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQT---TGAIFQMNmygSCIFLMLI 115
Cdd:cd15336   18 NALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKRWIFGEKGCELyafCGALFGIT---SMITLLAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 116 NVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP-----AARV-----------HRPSRCRYRDLEVRLCFESF 179
Cdd:cd15336   95 SLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPplfgwSAYVpeglltsctwdYMTFTPSVRAYTMLLFCFVF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 180 sdelwkgrLLPLVLLAEALGFLLplaAVVYSSGRVFWTLARPD----ATQSQRRR---KTVRLLLANLVIFLLCFVPYNS 252
Cdd:cd15336  175 --------FIPLGIIIYCYLFIF---LAIRSTGREVQKLGSQDrkekAKQYQRMKnewKMAKIAFVVILLFVLSWSPYAC 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 219281887 253 TLAVYGLLRSKLV---AASVPArdrvrgvlmvmvLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15336  244 VALIAWAGYAHLLtpyMKSVPA------------VIAKASAIYNPIIYAITHPKYREAI 290
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
26-305 3.48e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 47.74  E-value: 3.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYAL-HHWPFPDLLCQTTGAIFQM 103
Cdd:cd15067    6 LSLFCLVTVAG---NLLVILAVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTgGYWLFGRDWCDVWHSFDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLcfesFSDEl 183
Cdd:cd15067   83 ASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCL----FTDD- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 wkgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTlarpdATQSQRRRKTVRLLLAnlvIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15067  158 -----SGYLIFSSCVSFYIPLVVMLFTYYRIYRA-----AAKEQKAAKTLGIVMG---VFILCWLPFFVTNILIGFCPSN 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 219281887 264 LVaasvparDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15067  225 CV-------SNPDILFPLVTWLGYINSGMNPIIYACSSRDFR 259
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
27-305 3.52e-06

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 48.15  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS--LP-VRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd14995    5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAagLPnEIESLLGPDSWIYGYAGCLLITYLQYL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDEL 183
Cdd:cd14995   85 GINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKVSRHY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 184 WkgrlLPLVLLAEALGFLLP--LAAVVYssgrvfWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNsTLAVYGLLr 261
Cdd:cd14995  165 Y----LPIYLADFVLFYVIPllLAIVLY------GLIGR---ILFSSRKQVTKMLAVVVVLFALLWMPYR-TLVVYNSF- 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 219281887 262 sklvaASVPARDrvRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd14995  230 -----ASPPYLD--LWFLLFCRTCIYLNSAINPILYNLMSQKFR 266
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
24-306 3.56e-06

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 48.19  E-value: 3.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHH-WPFPDLLCQTTGAIFQ 102
Cdd:cd15000    1 IKSSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQnYVLGSVGCKLEGFLEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRlrhlrrprvARLLCLGVWALI-------LVFAVPAArVHRPSRCR-YRDLEVRL 174
Cdd:cd15000   81 SLLLASVLALCAVSYDRLTAIVLPSE---------ARLTKRGAKIVIvitwivgLLLALPLA-IYRSYRERqWKNFLETY 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 175 CFE--SFSDELWKGRLLPLVLLaealgfllPLAAVVYSSGRVFWTLARPDATQSQR--------RRKTVRLLLANLVIFL 244
Cdd:cd15000  151 CAEntQVLPIYWHVIITVLVWL--------PLGIMLICYSAIFWKLDKYERRVLRRehpsvvryKKKAAKTLFIVLITFV 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 245 LCFVPYNSTLAVYGLLRSKLVAASVpardrVRGVLMVM----VLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15000  223 VCRIPFTALIFYRYKLVPNDNTQNS-----VSGSFHILwfasKYLMFLNAAVNPLIYGFTNENFRK 283
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-251 4.12e-06

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 47.87  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRL-SYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15132    5 IVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLyRLWKSRPWIFGEFLCRLYHYISEGCT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP---AARVHRPSRCrYRDLEVRLCFESFSde 182
Cdd:cd15132   85 YATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPflfLVGVEQDNNI-HPDDFSRECKHTPY-- 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219281887 183 LWKGRLLPLVLLAEALGFLLPLA--AVVYSS-GRVFWT----LARPDATQSQR-RRKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd15132  162 AVSSGLLGIMIWVTTTYFFLPMLclSFLYGFiGRKLWKskndLRGPNAAARERsHRQTVRILAVVVLAFIICWLPFH 238
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
26-305 4.73e-06

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 47.39  E-value: 4.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15206    4 IPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVfCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARV--HRP--SRCRYRdleVRLCFESFS 180
Cdd:cd15206   84 VSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFsnLIPmsRPGGHK---CREVWPNEI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DELWKGRLLPLVLlaealgFLLPLAAVVYSSGRVFWTLArpdatqsQRRRKTVRLLLANLVIFLLCFVPynstlaVYGLL 260
Cdd:cd15206  161 AEQAWYVFLDLML------LVIPGLVMSVAYGLISWTLL-------EAKKRVIRMLFVIVVEFFICWTP------LYVIN 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 219281887 261 RSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15206  222 TWKAFDPPSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFR 266
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
24-307 4.84e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 47.32  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15064    2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAvLVMPLSAVYELTGRWILGQVLCDIWISLDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP------AARVHRPSRCRYRDLEVRLCF 176
Cdd:cd15064   82 TCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPplfgwrTPDSEDPSECLISQDIGYTIF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 177 ESFSdelwkgrllplvllaealGFLLPLAAVVYSSGRVFWTlarpdatqSQRRRKTVRLLLANLVIFLLCFVPYNSTLAV 256
Cdd:cd15064  162 STFG------------------AFYIPLLLMLILYWKIYRA--------AARERKAAKTLGIILGAFIVCWLPFFLVALI 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 219281887 257 YGLLRSKLVAASVPArdrvrgvlmVMVLLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15064  216 VPLCSHCWIPLALKS---------FFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
60-305 5.68e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 47.19  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  60 YMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVA 138
Cdd:cd15326   38 FIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 139 RLLCLGVWALILVFAV-PAARVHRPSrcRYRDLEVRLCFESFsdelwkgrllpLVLLAEALGFLLPLAAVVYSSGRVFWT 217
Cdd:cd15326  118 ILALLGVWVLSTVISIgPLLGWKEPA--PPDDKVCEITEEPF-----------YALFSSLGSFYIPLIVILVMYCRVYIV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 218 larpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVyGLLRSKLVAASVpardrvrgVLMVMVLLAGANCVLDPLVY 297
Cdd:cd15326  185 -----ALKFSREKKAAKTLGIVVGMFILCWLPFFIALPL-GSLFSHLKPPET--------LFKIIFWLGYFNSCLNPIIY 250

                 ....*...
gi 219281887 298 YFSAEGFR 305
Cdd:cd15326  251 PCSSKEFK 258
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
30-297 5.71e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 47.63  E-value: 5.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  30 SLVLAAGLPLNALALWVFLRALRVH--SVVSVYMCNLAASDLLFTLSL-PVRLSYYALH-HWPFPDLLCQTTGAIFQMNM 105
Cdd:cd14981    8 ALMFVFGVLGNLLALIVLARSSKSHkwSVFYRLVAGLAITDLLGILLTsPVVLAVYASNfEWDGGQPLCDYFGFMMSFFG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFA-VPAARVHRPSR---CRYrdlevrlCFESFSD 181
Cdd:cd14981   88 LSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAsLPLLGLGSYVLqypGTW-------CFLDFYS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ELWKGRLLPlvLLAEALGFLLPLAA------VVYSSGRVFWTLARPDATQSQRRRK------TVRLLLANLVIFLLCFVP 249
Cdd:cd14981  161 KNTGDAAYA--YLYSILGLLILLVTllcnllVIITLLRMRRRKKRHRRSRRSARRQkrneiqMVVLLLAITVVFSVCWLP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 219281887 250 ynstlavygLLRSKLVAASVPARDRVRGVLmVMVLLAGANCVLDPLVY 297
Cdd:cd14981  239 ---------LMIRVLINATGDSEKNGKTDL-LAVRMASWNQILDPWVY 276
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
27-257 5.94e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 47.50  E-value: 5.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15395    5 LAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTImCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRrprvaRLLCLGV---WALILVFAVPAARVHRPSRCRYRDLEVRL-------- 174
Cdd:cd15395   85 TVSIFSLVLIAIERHQLIINPRGWRPNN-----RHAYVGIaviWVLAVLTSLPFLIFQVLTDEPFKNVNVSLdaykgkyv 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 175 CFESFSDELWKGRLLPLVLLAEALGfllPLAAVVYSSGRVFWTLARPDATQSQRRRKTVR---------LLLANLVIFLL 245
Cdd:cd15395  160 CLDQFPSDTIRLSYTTCLLVLQYFG---PLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRssetkriniMLISIVVAFAV 236
                        250
                 ....*....|..
gi 219281887 246 CFVPYNSTLAVY 257
Cdd:cd15395  237 CWLPLNIFNAVF 248
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
61-306 8.65e-06

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 47.16  E-value: 8.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  61 MCNLAASDLLF-TLSLPVRLSYYALHHWPFPD-----LLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRR 134
Cdd:cd15975   39 IASLALGDLIYiVIDIPINVYKLLAQKWPFDDssfgvFLCKLVPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 135 PRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVyssgrV 214
Cdd:cd15975  119 PLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYNGEQYRTCMLNATTKFMNFYVDAKDWWLFGFYFCVPLACTA-----I 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 215 FWTLARPD-------------ATQSQRRRKTVRLLLANLVIFLLCFVPynstLAVYGLLRSKLVAASVPARDRVRGVLMV 281
Cdd:cd15975  194 FYTLMTCEmlnrrkgslrialSEHLKQRREVAKTVFCLVVIFALCWFP----LHLSRILKKTVYNENDPRRCELLSFLLV 269
                        250       260
                 ....*....|....*....|....*....
gi 219281887 282 M----VLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15975  270 MdyisINLATMNSCINPIALYFVSKKFKN 298
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
27-305 1.08e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 46.71  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNAL---ALWVFLRALRVHSVVSVYMCNLAASDLL-FTLSLPVRLsyYALHHWPFP----DLLCQTTG 98
Cdd:cd15135    5 LLYSLILVAGILGNSAtikVTQVLQKKGYLQKSVTDHMVSLACSDLLvLLLGMPVEL--YSAIWDPFAtpsgNIACKIYN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  99 AIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLgVW------ALILVFA------VPAARVHRPSRCR 166
Cdd:cd15135   83 FLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICF-VWltsalvALPLLFAmgtedpLEAFPSYRGTRHH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 167 YRDLEVRLCFES--------FSDELWKGRLLPLVLLAeALGFLL------------PLAAVVYSSGRVfWTLARPDATQS 226
Cdd:cd15135  162 CQDQKSNLTICTslsskwtvFQASIFSAFVLYLLVLA-SVAFMCrrmmralmgskkGAVAVKGPGGSV-QLLRKHESAEG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 227 QRRRKTVRLLLANLVIFL-LCFVPYNStlavygllrSKLVAASVPARDRVRGVLMV-MVLLAGANC------VLDPLVYY 298
Cdd:cd15135  240 KTARKQTILFLGLIVGTLaVCWMPNQI---------RRIMAAAKPKDDWTRSYFRAyIILLPIADTffylssVLNPLLYN 310

                 ....*..
gi 219281887 299 FSAEGFR 305
Cdd:cd15135  311 LSSQQFR 317
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
52-250 1.35e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 46.20  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  52 RVHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLR 130
Cdd:cd15061   29 RLRTITNCYIVSLATADLLVGvLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 131 HLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRyrdlEVRLCFESFSDElwkgrllpLVLLAEALGFLLPLAAVVYS 210
Cdd:cd15061  109 TKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRR----GLGSCYYTYDKG--------YRIYSSMGSFFLPLLLMLFV 176
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 219281887 211 SGRVFWTLArpdatqsqRRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15061  177 YLRIFRVIA--------KERKTAKTLAIVVGCFIVCWLPF 208
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-155 1.51e-05

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 46.38  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRV---HSVVSVYMCNLAASDLL-FTLSLPVRL-SYYALHH-WPFPDLLCQTTGAI 100
Cdd:cd15355    5 AIYLALFVVGTVGNSITLYTLARKKSLqhlQSTVHYHLASLALSDLLiLLLAMPVELyNFIWVHHpWAFGDAACRGYYFL 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 101 FQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP 155
Cdd:cd15355   85 RDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIP 139
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
24-308 1.91e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 45.73  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLA-AGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSL-PVRLSYYALHHWPFPDLLCQT---TG 98
Cdd:cd15074    1 IIIGIYLTVIGiLSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCVFygfCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  99 AIFQMnmyGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLClGVWALILVFAVP--------AARVHRPSRCryrdl 170
Cdd:cd15074   81 FLFGC---CSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIV-AIWLYALFWAVAplvgwgsyGPEPFGTSCS----- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 171 evrLCFESFSDELwKGRLLPLVLLaeALGFLLPLAAVVYSSGRVFWTL-------ARPDATQSQRR---RKTVRLLLANL 240
Cdd:cd15074  152 ---IDWTGASASV-GGMSYIISIF--IFCYLLPVLIIVFSYVKIIRKVkssrkrvAGFDSRSKRQHkieRKVTKVAVLIC 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 241 VIFLLCFVPYnstlAVYGLLRSKLVAASVPARdrvrgVLMVMVLLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15074  226 AGFLIAWTPY----AVVSMWSAFGSPDSVPIL-----ASILPALFAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-308 3.16e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 45.05  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAAGLplNALALW-VFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGS 108
Cdd:cd15383   11 FVLSACS--NLAVLWsATRNRRRKLSHVRILILHLAAADLLVTFVvMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 109 CIFLMLINVDRYAAIVHPLRLRHLRRPRvaRLLCLGVWALILVFAVPAA----RVHRPSRCRYRDLEVRLCFESFsdelW 184
Cdd:cd15383   89 AFVTVVISLDRHAAILNPLAIGSARRRN--RIMLCAAWGLSALLALPQLflfhTVTATPPVNFTQCATHGSFPAH----W 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 185 KGRLlpLVLLAEALGFLLPLAAVVYSSGRVFWTLARP-----------------DATQSQRRRKTVRLLLANLVIFLLCF 247
Cdd:cd15383  163 QETL--YNMFTFFCLFLLPLLIMIFCYTRILLEISRRmkekkdsaknevalrssSDNIPKARMRTLKMTIVIVSSFIVCW 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219281887 248 VPYnSTLAVYGLLRSKLVAASVParDRVRGVLMVMVLLagaNCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15383  241 TPY-YLLGLWYWFSPEMLEQTVP--ESLSHILFLFGLL---NACLDPLIYGLFTISFRRGL 295
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
53-305 4.21e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 44.79  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  53 VHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRH 131
Cdd:cd15062   31 LRTPTHYFIVNLAVADLLLSfTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 132 LRRPRVARLLCLGVWALILVFAV-PAARVHRPSrcryrDLEVRLCfeSFSDElwkgrllPLVLLAEALG-FLLPLAAVVY 209
Cdd:cd15062  111 IVTARRATVALLIVWVLSLVISIgPLLGWKEPA-----PADEQAC--GVNEE-------PGYVLFSSLGsFYLPLAIILV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 210 SSGRVFWTlarpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLrsklvaasvPARDRVRGVLMVMVLLAGAN 289
Cdd:cd15062  177 MYCRVYVV-----AFKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLF---------STLKPPEPVFKVVFWLGYFN 242
                        250
                 ....*....|....*.
gi 219281887 290 CVLDPLVYYFSAEGFR 305
Cdd:cd15062  243 SCLNPIIYPCSSREFK 258
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
53-305 5.01e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 44.52  E-value: 5.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  53 VHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRH 131
Cdd:cd15327   31 LQTVTNYFIVNLAIADLLLSTTvLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 132 LRRPRVARLLCLGVWALILVFAV-PAARVHRP-----SRCRYRDLEVRLCFESFsdelwkgrllplvllaeaLGFLLPLA 205
Cdd:cd15327  111 IMTERKAGVILVLLWVSSMVISIgPLLGWKEPpppdeSICSITEEPGYALFSSL------------------FSFYLPLM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 206 AVVYSSGRVFWTlarpdATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLrsklvaasvPARDRVRGVLMVMVLL 285
Cdd:cd15327  173 VILVMYFRVYVV-----ALKFSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFF---------PALKPSEMVFKVIFWL 238
                        250       260
                 ....*....|....*....|
gi 219281887 286 AGANCVLDPLVYYFSAEGFR 305
Cdd:cd15327  239 GYFNSCVNPIIYPCSSKEFK 258
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-263 5.65e-05

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 44.37  E-value: 5.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLL-FTLSLPVRLsYYALHHWPFpdLL----CQTTGAIF 101
Cdd:cd15358    5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLvLLLGMPLEL-YEMWSNYPF--LLgaggCYFKTLLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 102 QMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVH----RPSRCRYRDLEVRLCfe 177
Cdd:cd15358   82 ETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHgifqLTVPCRGPVPDSATC-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 178 SFSDELWKGRLlpLVLLAEALGFLLPLA--AVVY-------------------SSGRVFWTLARPDATQSQRRRKTVRLL 236
Cdd:cd15358  160 MLVKPRWMYNL--IIQITTLLFFFLPMGtiSVLYlliglqlkrekmllvleakGSKAGDSYQHRRIQQEKRRRRQVTKML 237
                        250       260
                 ....*....|....*....|....*..
gi 219281887 237 LANLVIFLLCFVPYNSTLAVYGLLRSK 263
Cdd:cd15358  238 FVLVVVFGICWAPFHTDRLMWSFISQW 264
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
49-308 6.00e-05

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 44.16  E-value: 6.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  49 RALRVHSvvSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPL 127
Cdd:cd15323   29 RALRAPQ--NLFLVSLASADILVaTLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 128 RLRHLRRPRVARLLCLGVWALILVFAVPaarvhrPSRCRYRDLE-VRLCFESFSDELWkgrllplVLLAEALG-FLLPLA 205
Cdd:cd15323  107 EYNLKRTPRRVKAIIVTVWLISAVISFP------PLISMYRDPEgDVYPQCKLNDETW-------YILSSCIGsFFAPCL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 206 AVVYSSGRVFWTlarpdatqSQRRRKTVRLLLANLV-IFLLCFVPYNSTLAVYGLLRSklvAASVPardrvRGVLMVMVL 284
Cdd:cd15323  174 IMILVYIRIYRV--------AKAREKRFTFVLAVVMgVFVVCWFPFFFSYSLYGICRE---ACEVP-----EPLFKFFFW 237
                        250       260
                 ....*....|....*....|....
gi 219281887 285 LAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15323  238 IGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
24-252 6.26e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 44.09  E-value: 6.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVH---SVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWP--FPDLLCQTT 97
Cdd:cd15356    2 LFTAVYALIWALGAAGNALTIHLVLKKRSLRglqGTVHYHLVSLALSDLLILLiSVPIELYNFVWFHYPwvFGDLVCRGY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  98 GAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARV-----HRPSRCRYRDLEV 172
Cdd:cd15356   82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFImgqkyELETADGEPEPSS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 173 RLCFESFSdelwKGRLLPLVLLAEALGFLLPLAAVvysSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNS 252
Cdd:cd15356  162 RVCTVLVS----RATLKVFIQVNAFVSFVLPLALI---AFLNGVTVSH---LRIQSLQHSVQVLRAIVIAYVICWLPYHA 231
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-160 6.53e-05

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 44.08  E-value: 6.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLL-FTLSLPVRLsYYALHHWPF--PDLLCQTTGAIFQM 103
Cdd:cd15357    5 LVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLvLLFGMPLEV-YEMWSNYPFlfGPVGCYFKTALFET 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVH 160
Cdd:cd15357   84 VCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIH 140
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
52-305 7.90e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 43.76  E-value: 7.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  52 RVHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLR 130
Cdd:cd15335   30 KLHQPANYLICSLAVTDFLVAvLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 131 HLRRPRVARLLCLGVWALILVFAVPAA--RVHR----PSRCRYR-DLEVRLCFESFSdelwkgrllplvllaealGFLLP 203
Cdd:cd15335  110 RKRTAKRAGLMILTVWTISIFISIPPLfwRNHHdaniPSQCIIQhDHVIYTIYSTFG------------------AFYIP 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 204 LAAVVYSSGRVFwtlarpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLlrsKLVAASVPARDrvrgvlmVMV 283
Cdd:cd15335  172 LTLILILYYRIY--------HAASRERKAARILGLILGAFILSWLPFFIKELIVGL---SVMTVSPEVAD-------FLT 233
                        250       260
                 ....*....|....*....|..
gi 219281887 284 LLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15335  234 WLGYVNSLVNPLLYTSFNEDFK 255
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
28-307 9.32e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 43.66  E-value: 9.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMY 106
Cdd:cd15301    9 VLSLVTVGG---NVMVMISFKIDKQLQTISNYFLFSLAVADFAIgVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 107 GSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAArVHRPSRCRYRDLEVRLCFESFSDElwkg 186
Cdd:cd15301   86 ASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWI-YSWPYIEGKRTVPAGTCYIQFLET---- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 187 rlLPLVLLAEAL-GFLLPLAAVVYSSGRVFWTLARpdaTQSQRRRKTVRLLLANLVIFLLCFVPYNSTLavygllrskLV 265
Cdd:cd15301  161 --NPYVTFGTALaAFYVPVTIMCILYWRIWRETKK---RQKKQESKAAKTLSAILLAFIVTWTPYNVLV---------LI 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 266 AASVPARDRVRGVLMVMV-LLAGANCVLDPLVYYFSAEGFRNT 307
Cdd:cd15301  227 KAFFPCSDTIPTELWDFSyYLCYINSTINPLCYALCNAAFRRT 269
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
26-300 9.33e-05

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 43.84  E-value: 9.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNALALWVFLRALRVHSV-VSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQM 103
Cdd:cd15382    4 IIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTfIMMPLEIGWAATVAWLAGDFLCRLMLFFRAF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRvaRLLCLGVWALILVFAVPAARV-HRPSRCRYRDLEVRLCFESFSDE 182
Cdd:cd15382   84 GLYLSSFVLVCISLDRYFAILKPLRLSDARRRG--RIMLAVAWVISFLCSIPQSFIfHVESHPCVTWFSQCVTFNFFPSH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 183 lwkGRLLPLVLLAEALGFLLPLAAVVYSSGRVFW--------------------TLARPDATQSQR-RRKTVRLLLANLV 241
Cdd:cd15382  162 ---DHELAYNIFNMITMYALPLIIIVFCYSLILCeisrkskekkedvseksssvRLRRSSVGLLERaRSRTLKMTIVIVL 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 242 IFLLCFVPYNSTLAVYGLLRSKlvAASVPArdRVRGVLMVMvllAGANCVLDPLVY-YFS 300
Cdd:cd15382  239 VFIICWTPYFIMSLWYWFDRES--ASKVDP--RIQKGLFLF---AVSNSCMNPIVYgYFS 291
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-306 9.46e-05

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 43.66  E-value: 9.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPD-----LLCQTTGAI 100
Cdd:cd15128    5 VVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIViDLPINVYKLLAMDWPFGDqpfgqFLCKLVPFI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 101 FQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLC----- 175
Cdd:cd15128   85 QKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYKGVTLRTCllrpe 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 176 ------FESFSDELWKGRLLPLVLLAEALGF-LLPLAAVVYSSGrvfwTLARPDATQSQRRRKTVRLLLANLVIFLLCFV 248
Cdd:cd15128  165 tsfmkfYIDVKDWWLFGFYFCLPLVCTAIFYtLMTCEMLRKRNG----MLRIALNEHLKQRREVAKTVFCLVVIFALCWL 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 219281887 249 PynstLAVYGLLRSKLVAASVPARDRVRGVLMVM----VLLAGANCVLDPLVYYFSAEGFRN 306
Cdd:cd15128  241 P----LHLSRILKLTVYDQNDPNRCELLSFLLVLdyfgINLATLNSCINPIALYFVSRKFKN 298
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-305 9.81e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 43.78  E-value: 9.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSV---YMCNLAASDLLFTL-SLPVRL-SYYALHH-WPFPDLLCQTT 97
Cdd:cd15130    2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLILLlAMPVELyNFIWVHHpWAFGDAGCRGY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  98 GAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVhrpsrcryRDLEVRLcfe 177
Cdd:cd15130   82 YFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFT--------MGLQNES--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 178 sfSDELWKGRLLPLVLLAEA-----------LGFLLPLAAVVYSSGRVFWTLARPdatqsqrRRKTVRLLLANLVIFLLC 246
Cdd:cd15130  151 --DDGTHPGGLVCTPIVDTAtlkvviqvntfMSFLFPMLVTSILNTVIANKLVQA-------LRRGVLVLRAVVIAFVVC 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 219281887 247 FVPYNSTLAVYGLLRSKlvAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15130  222 WLPYHVRRLMFCYISDE--QWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-168 1.22e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 43.29  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLsYYALHHWPFP--DLLCQTTGAIFQM 103
Cdd:cd15133    5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLlGMPLEL-YELWQNYPFLlgSGGCYFKTFLFET 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 104 NMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYR 168
Cdd:cd15133   84 VCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSG 148
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
23-299 1.34e-04

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 43.26  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSlpVRLSYYALHH----WPFPDLLCQTTG 98
Cdd:cd15198    1 RTRLIFLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGG--TALSQIIWELlgdrWMAGDVACRLLK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  99 AIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLrrprvARLLCLGVWALILVFAVPAA---RVHRPSRCRYRDLEVRLC 175
Cdd:cd15198   79 LLQASARGASANLVVLLALDRHQAIRAPLGQPLR-----AWKLAALGWLLALLLALPQAyvfRVDFPDDPASAWPGHTLC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 176 FESFSDeLWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVF----------------WTLARPDATQSQ-------RRRKT 232
Cdd:cd15198  154 RGIFAP-LPRWHLQVYATYEAVVGFVAPVVILGVCYGRLLlkwweranqapgakkpWKKPSKSHLRATapsalprAKVKT 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219281887 233 VRLLLANLVIFLLCFVPYNStlavygllrSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYF 299
Cdd:cd15198  233 LKMTLVIALLFVGCSLPYFI---------AELAAAFGSGDWEPEKVAAALGVMAVANSATNPFVFLF 290
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
55-305 1.68e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 42.74  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  55 SVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLR 133
Cdd:cd15213   33 SAINLLLANLAFSDIMLSLvCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPH 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 134 RprvARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSdelwkGRLLPLVLLAEALgFLLPLAAVVYSsgr 213
Cdd:cd15213  113 R---AKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGYTESP-----ADRIYVVLLLVAV-FFIPFLIMLYS--- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 214 VFWTLarpDATQSQRRR--KTVRLLLanlVIFLLCFVPY--NSTLAVYGLLRSKLVAASVpardrvrgvlmVMVLLAGAN 289
Cdd:cd15213  181 YFCIL---NTVRSFKTRafTTILILF---IGFSVCWLPYtvYSLLSVFSRYSSSFYVIST-----------CLLWLSYLK 243
                        250
                 ....*....|....*.
gi 219281887 290 CVLDPLVYYFSAEGFR 305
Cdd:cd15213  244 SAFNPVIYCWRIKKFR 259
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
23-300 2.59e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 42.45  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  23 RLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL--SLPvRLSYYALHHWPFPDLLCQTTGAI 100
Cdd:cd15388    1 QVEIAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfqVLP-QLVWDITDRFRGPDVLCRLVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 101 FQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGvWALILVFAVPaaRVHRPSRCRYRDlEVRLCFESFS 180
Cdd:cd15388   80 QVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLP--QVFIFSKVEVAP-GVYECWACFI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 dELWKGRllPLVLLAEALGFLLPLAAVVYSSGRVFWTL------------------------ARPDATQSQRRRKTVRLL 236
Cdd:cd15388  156 -EPWGLK--AYVTWITLVVFVLPTLIITVCQVLIFKEIhiniylksqiivavvkkkqllssrASSVAEVSKAMIKTVKMT 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 237 LANLVIFLLCFVPYNSTlavygllrsKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVY-YFS 300
Cdd:cd15388  233 LVIVLVYVLCWAPFFLV---------QLWSVWDPKAPTEGATFTILMLLASLNSCTNPWIYmAFS 288
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
27-250 2.91e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 42.28  E-value: 2.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRL-SYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd14997    5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPVALvETWAREPWLLGEFMCKLVPFVELTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLE-VRLCfESFSDEL 183
Cdd:cd14997   85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTpVAVC-RTPADTF 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 184 WKgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQR-----------RRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd14997  164 WK---VAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRadaanrhtlrsRRQVVYMLITVVVLFFVCLLPF 238
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
40-155 3.02e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 42.10  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVD 118
Cdd:cd15063   18 NLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLD 97
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 219281887 119 RYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP 155
Cdd:cd15063   98 RYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFP 134
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
40-311 3.27e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 41.86  E-value: 3.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVD 118
Cdd:cd15299   21 NILVIVSFKVNKQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFD 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 119 RYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRyRDLEVRLCFESFSDElwkgrllPLVLLAEAL 198
Cdd:cd15299  101 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGK-RTVPPDECFIQFLSE-------PIITFGTAI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 199 -GFLLPLAAVVYssgrVFWTLARpdatQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVygllrSKLVAASVPardrvRG 277
Cdd:cd15299  173 aAFYLPVTIMTI----LYWRIYK----ETIKEKKAAQTLSAILLAFIITWTPYNIMVLV-----NTFCDSCIP-----KT 234
                        250       260       270
                 ....*....|....*....|....*....|....
gi 219281887 278 VLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGL 311
Cdd:cd15299  235 YWNLGYWLCYINSTVNPVCYALCNKTFRTTFKML 268
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
24-215 3.65e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 42.06  E-value: 3.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LP-VRLSYYALHHWPFPDLLCQTTGAIF 101
Cdd:cd15005    2 LKLTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPfVMASVRHGSGWIYGALSCKVIAFLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 102 QMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAarVHRPSRCRYRDLEVRLCFESFSD 181
Cdd:cd15005   82 VLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPP--VFDVGTYTFIREEDQCTFEHRSY 159
                        170       180       190
                 ....*....|....*....|....*....|....
gi 219281887 182 ElwkgrllplvlLAEALGFLLPLAAVVYSSGRVF 215
Cdd:cd15005  160 K-----------ANDTLGFMLVLAVVIAATHLVY 182
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
28-157 3.82e-04

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 41.81  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-LPVRLSYYALHHWPFPDLLCQTTGAIfQMNMY 106
Cdd:cd15124    6 VYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFI-QLTSV 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 107 GSCIF-LMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA 157
Cdd:cd15124   85 GVSVFtLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEA 136
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
26-306 4.28e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 41.65  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAA--GLPLNALALWVFlRALRvHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLlCQTTGAIFQ 102
Cdd:cd15057    5 CILYLLVLLTllGNALVIAAVLRF-RHLR-SKVTNYFIVSLAVSDLLVAiLVMPWAAVNEVAGYWPFGSF-CDVWVSFDI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWAL-ILVFAVP----AARVHRPSRCRYRDLEVRLCFE 177
Cdd:cd15057   82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLsALISFIPvqlgWHRADDTSEALALYADPCQCDS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 178 SFSdelwkgRLLPLVllAEALGFLLPLAAVVYSSGRVFwTLARPDATQ---------------------SQRRRKTVRLL 236
Cdd:cd15057  162 SLN------RTYAIS--SSLISFYIPVAIMIVTYTRIY-RIARRQIRRiaaleraaqestnpdsslrssLRRETKALKTL 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219281887 237 LANLVIFLLCFVPY---NSTLAVYGLlrSKLVAASVPARdrvrgVLMVMVLLAGANCVLDPLVYYFSAEgFRN 306
Cdd:cd15057  233 SIIMGVFVCCWLPFfilNCVLPFCDL--RTAQFPCVPDT-----TFIVFVWLGWANSSLNPIIYAFNAD-FRK 297
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
31-266 4.47e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 41.82  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  31 LVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSC 109
Cdd:cd15959   12 LVIVGG---NLLVIVAIAKTPRLQTMTNVFVTSLACADLVMgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 110 IFLMLINVDRYAAIVHPLRLRHLRRPRVARLlclgvwALILVFAVPAARVHRPSRCRY----RDLEVRLCFES-----FS 180
Cdd:cd15959   89 ETLCAIAVDRYLAITNPLRYEALVTKRRART------AVCLVWAISAAISFLPIMNQWwrdgADEEAQRCYDNprccdFV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 181 DElwkgrlLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdatqsqrrrkTVRLLLANLVIFLLCFVPYNSTLAVYGLL 260
Cdd:cd15959  163 TN------MPYAIVSSTVSFYVPLLVMIFVYVRVFVVATR-----------QVRLIRKDKVRFPPEESPPAESRPACGRR 225

                 ....*.
gi 219281887 261 RSKLVA 266
Cdd:cd15959  226 PSRLLA 231
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
28-305 6.75e-04

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 40.95  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  28 VYSLVLAAGLPLNALALWVFLRALRVH---SVVSVYMCNLAASDLLFTLSLPvrlsyYALHH------WPFPDLLCQTTG 98
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMP-----FLIHQllgngvWHFGETMCTLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  99 AIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFES 178
Cdd:cd15338   81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLLPN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWKGRLLPLVllaeaLGFLLPLAAVVYSSGRVFWTLARPDATQSQ-----RRRKTVRLLLANLVIFLLCFVPYnST 253
Cdd:cd15338  161 PETDTYWFTLYQFF-----LAFALPLVVICVVYFKILQNMASTVAPLPQrslrvRTKKVTRMAVAICLAFFICWAPF-YI 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 219281887 254 LAVYGLLRSKLVAASVPARDrvrgvlmVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15338  235 LQLAHLSIDRPSLAFLYAYN-------VAISMGYANSCINPFLYIMLSETFK 279
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-306 9.54e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 40.49  E-value: 9.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVD 118
Cdd:cd15197   18 NSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLiNVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSID 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 119 RYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVhrPSRCRYRDLEVRlCFESFSDEL-WKgrllPLVLLAEA 197
Cdd:cd15197   98 RYDAICHPMNFSQSGRQ--ARVLICVAWILSALFSIPMLII--FEKTGLSNGEVQ-CWILWPEPWyWK----VYMTIVAF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 198 LGFLLPL----------AAVVYSSGRVFWTLAR------PDATQSQR------RRKTVRLLLANLVIFLLCFVPYN--ST 253
Cdd:cd15197  169 LVFFIPAtiisicyiiiVRTIWKKSKIQVTINKaglhdgSSRRSSSRgiipraKIKTIKMTFVIVTVFIICWSPYFvfDL 248
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 219281887 254 LAVYGLL-RSK-LVAASVpardrvrgvlmVMVLLAGANCVLDPLVYY-FSAEGFRN 306
Cdd:cd15197  249 LDVFGLLpRSKtKIAAAT-----------FIQSLAPLNSAINPLIYClFSTHLCRP 293
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
27-146 1.10e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 40.62  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSL-PVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVvPFGAAHILLKTWTFGNFWCEFWTSIDVLCV 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVW 146
Cdd:cd15957   85 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVW 125
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
24-123 2.59e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 39.08  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15978    2 VRILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLKDFIFGSAVCKTATYFMG 81
                         90       100
                 ....*....|....*....|.
gi 219281887 103 MNMYGSCIFLMLINVDRYAAI 123
Cdd:cd15978   82 ISVSVSTFNLVAISLERYSAI 102
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
26-250 2.64e-03

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 39.04  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  26 LVVYSLVLAAGLPLNAlalWVFLRALRVHSvvSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMN 104
Cdd:cd15295    9 LLALVIVLGNALVIIA---FVVDKNLRHRS--NYFFLNLAISDFFVgAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 105 MYGSCIFLMLINVDRYAAiVHPLRLRHLRRPRVARLLCLGVWALILVFAV--PAARVHRPSRCRYRDLEVRLCFESFsde 182
Cdd:cd15295   84 CTASVYNIVLISYDRYQS-VSNAVSYRNQQTATLRIVTQMVAVWVLAFLVhgPAILVSDSWKTEDGECEPEFFSNWY--- 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219281887 183 lwkgrllpLVLLAEALGFLLPLAAVVYSSGRVFWTLARpdatqSQRRRKTVRLLLANLVIFLLCFVPY 250
Cdd:cd15295  160 --------ILAITSVLEFLVPVILVAYFNTQIYWSLWK-----RLRDRKLAKSLAIILGTFAICWAPY 214
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
40-305 2.69e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 39.25  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVD 118
Cdd:cd15059   18 NVLVIVAVLTSRKLRAPQNWFLVSLAVADILVgLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 119 RYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVP---AARVHRPS-----RCRYRDlevrlcfesfsdelwkgrLLP 190
Cdd:cd15059   98 RYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPplfGWKDEQPWhgaepQCELSD------------------DPG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 191 LVLLAEALGFLLPLAAVVYSSGRVFwtlarpDATQSQRRRKTvrlLLANLVI--FLLCFVPYNSTLAVYGLLRSKLVAas 268
Cdd:cd15059  160 YVLFSSIGSFYIPLLIMIIVYARIY------RAAKRKERRFT---LVLGVVMgaFVLCWLPFFFTYPLVVVCKTCGVP-- 228
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 219281887 269 vpardrvRGVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15059  229 -------ELLFKFFFWLGYCNSALNPVIYTIFNKDFR 258
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
52-305 3.15e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 38.85  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  52 RVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLR 130
Cdd:cd15051   30 RLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 131 HLRRPRVARLLCLGVWALILVFAV---------PAARV---HRPSRCRYRDLEvrlcfesfsdelwkgrllPLVLLAEAL 198
Cdd:cd15051  110 SRVTPRRVAIALAAIWVVSLAVSFlpihlgwntPDGRVqngDTPNQCRFELNP------------------PYVLLVAIG 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 199 GFLLPLAAVVYSSGRVF----------------WTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYnSTLAVYGLLRS 262
Cdd:cd15051  172 TFYLPLLIMCGVYLRIFriareqakrinaltpaSTANSSKSAATAREHKATVTLAAVLGAFIICWFPY-FTYFTYRGLCG 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 219281887 263 KLVAASvpardrvrgVLMVMVLLAGANCVLDPLVYYFSAEGFR 305
Cdd:cd15051  251 DNINET---------ALSVVLWLGYANSALNPILYAFLNRDFR 284
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
40-155 3.81e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 38.60  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  40 NALALWVFLRALRVHSVVSVYMCNLAASDLLFT-LSLPVR-LSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINV 117
Cdd:cd15212   18 NCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTAlLCLPFAfLTLFSRPGWLFGDRLCLANGFFNACFGIVSTLTMTLISF 97
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 219281887 118 DRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVP 155
Cdd:cd15212   98 DRYYAIVRQPQGKIGRRR--ALQLLAAAWLTALGFSLP 133
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
52-305 3.84e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 38.73  E-value: 3.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  52 RVHSVVSVYMCNLAASDLLF-TLSLPVRL-SYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRL 129
Cdd:cd15305   30 KLQNATNFFLMSLAVADMLVgILVMPVSLiAILYDYAWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 130 RHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYrdLEVRLCfeSFSDELWkgrllplVLLAEALGFLLPLAAVVY 209
Cdd:cd15305  110 SRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKV--FVNGTC--VLNDENF-------VLIGSFVAFFIPLIIMVI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 210 SSGRVFWTLARPDATQSQRRRKTVrlLLANLVIFLLCFVPYNSTLAVYGLLRSKLvaasvpARDRVRGVLMVMVLLAGAN 289
Cdd:cd15305  179 TYCLTIQVLQRQQAINNERRASKV--LGIVFFLFLIMWCPFFITNILSVLCKEAC------DQKLMEELLNVFVWVGYVS 250
                        250
                 ....*....|....*.
gi 219281887 290 CVLDPLVYYFSAEGFR 305
Cdd:cd15305  251 SGINPLVYTLFNKTYR 266
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
27-308 4.16e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 38.61  E-value: 4.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLS-------LPVRLSYYALHHWPFPDLLCQTTGA 99
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktlenilIILADMGYLNRRGPFETKLDDIMDS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 100 IFQMNMYGSCIFLMLINVDRYAAIV-------HPLRLRHLRRPRVARLLCLGVWALILVFavpaarvhrpsrcrYRDLEV 172
Cdd:cd15350   85 LFCLSLLGSIFSILAIAADRYITIFhalryhnIMTMRRTLVILAIIWTFCGGSGILMILF--------------FHFVAT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 173 RLCFESfsdelwkgrLLPLVLLaealgFLLPLAAVVYSSGRVFWT-LARPDATQSQRRRKTVR---LLLANLVIFLLCFV 248
Cdd:cd15350  151 VICFTV---------LFFLMLV-----LILCLYVHMFLLARSHARkIASLPNHHAQHQRSNMRgaiTLTILLGVFVCCWA 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 249 PYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVmvllagANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15350  217 PFVLHLLLMMFCPMNPYCACYRSLFQVNGTLIM------SHAVIDPAIYAFRSPELRNTF 270
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
24-306 4.27e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 38.48  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGlplNALALWVFLRALRVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYAL-HHWPFPDLLCQTTGAIF 101
Cdd:cd15053    5 LFLLLLPLLTVFG---NVLVIMSVFRERSLQTATNYFIVSLAVADLLVaILVMPFAVYVEVNgGKWYLGPILCDIYIAMD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 102 QMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSrcRYRDLEVrlCfeSFSD 181
Cdd:cd15053   82 VMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNV--PYRDPEE--C--RFYN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 182 ElwkgrllPLVLLAEALGFLLPLAAVVYSSGRVFWTLarpdatqsQRRRKTVRLLLANLVIFLLCFVPY---NSTLAVYG 258
Cdd:cd15053  156 P-------DFIIYSSISSFYIPCIVMLLLYYRIFRAL--------RREKKATKTLAIVLGVFLFCWLPFftlNILNAICP 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 219281887 259 LLRSKlvAASVPARdrvrgVLMVMVLLAGANCVLDPLVY-YFSAEgFRN 306
Cdd:cd15053  221 KLQNQ--SCHVGPA-----LFSLTTWLGYVNSFLNPIIYtIFNIE-FRK 261
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
53-308 7.43e-03

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 37.65  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  53 VHSVVSVYMCNLAASDLLFT-LSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRH 131
Cdd:cd15330   31 LQNVANYLIGSLAVTDLMVSvLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 132 LRRPRVARLLCLGVWALILVFAVPAARVHR-------PSRCRYRDLEVRLCFESFSdelwkgrllplvllaealGFLLPL 204
Cdd:cd15330  111 KRTPRRAAVLISLTWLIGFSISIPPMLGWRtpedrsdPDACTISKDPGYTIYSTFG------------------AFYIPL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 205 AAVVYSSGRVFWTLArpdatqsqRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVpardrvrgVLMVMVL 284
Cdd:cd15330  173 ILMLVLYGRIFKAAA--------RERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMPEL--------LGAIINW 236
                        250       260
                 ....*....|....*....|....
gi 219281887 285 LAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15330  237 LGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
24-308 9.23e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 37.49  E-value: 9.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  24 LHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTL-SLPVRLSYYALHHWPFPDLLCQTTGAIFQ 102
Cdd:cd15979    2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVfCMPFTLIPNLMGTFIFGEVICKAVAYLMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 103 MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAA----RVHRPSRCRYRDLEVRLCFES 178
Cdd:cd15979   82 VSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPvysvTVPVPVGDRPRGHQCRHAWPS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 179 FSDELWKGRLLPLVLlaealgFLLPLAAVVYSSGRVFWTLARPDATqsqrRRKTVRLLLANLVIFLLCFVPYNSTlavyg 258
Cdd:cd15979  162 AQVRQAWYVLLLLIL------FFIPGVVMIVAYGLISRELYRGLLA----KKRVIRMLVVIVAMFFLCWLPIFSA----- 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 219281887 259 llRSKLVAASVPARDRVRGVLMVMV-LLAGANCVLDPLVYYFSAEGFRNTL 308
Cdd:cd15979  227 --NTWRAFDPLSAHRALSGAPISFIhLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-251 9.57e-03

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 37.54  E-value: 9.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  27 VVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLA-ASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNM 105
Cdd:cd16002    5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAfAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 106 YGSCIFLMLINVDRYAAIVHPLRLRHLRRPrvARLLCLGVWALILVFAVPAARVHRPSRCRYRDlevrLCFESFSDELWK 185
Cdd:cd16002   85 FASIYSMTAIALDRYMAIIHPLQPRLSATA--TKVVICVIWVLAFLLAFPQGYYSDTEEMPGRV----VCYVEWPEHEER 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219281887 186 GRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTL-ARPDATQSQRR--------RKTVRLLLANLVIFLLCFVPYN 251
Cdd:cd16002  159 KYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLwASEIPGDSSDRyheqvsakRKVVKMMIVVVCTFAICWLPYH 233
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
52-308 9.78e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 37.31  E-value: 9.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887  52 RVHSVVSVYMCNLAASDLLF-TLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLR 130
Cdd:cd15298   30 QLQTVNNYFLFSLACADLIIgAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 131 HLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRyRDLEVRLCFESFSDElwkgrllPLVLLAEAL-GFLLPLaaVVY 209
Cdd:cd15298  110 ARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGK-RTVPDNQCFIQFLSN-------PAVTFGTAIaAFYLPV--VIM 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219281887 210 SSGRVFWTLArpdatqSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVygllrSKLVAASVPARdrvrgVLMVMVLLAGAN 289
Cdd:cd15298  180 TVLYIHISLA------SARERKVTRTIFAILLAFILTWTPYNVMVLV-----NTFCQSCIPDT-----VWSIGYWLCYVN 243
                        250
                 ....*....|....*....
gi 219281887 290 CVLDPLVYYFSAEGFRNTL 308
Cdd:cd15298  244 STINPACYALCNATFKKTF 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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