Conserved Protein Domain Family
7tmA_P2Y11

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cd15376: 7tmA_P2Y11 
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors
P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).
Statistics
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PSSM-Id: 320498
Aligned: 9 rows
Threshold Bit Score: 412.552
Created: 25-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:partly based on the structure of human P2Y1 receptor with bound nucleotide antagonist MRS2500
  • Comment:also based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                    #  ##              
Q96G91         29 DFLWPILVVEFLVAVASNGLALYRFSIRKQ.[2].WHPAVVFSVQLAVSDLLCALTLPPLAAYLY.[1].PKHWRYGE 99   human
NP_001089146   16 TFLAPMYGVAFVVSVLGNSLAIWLLGPGSS.[2].RHAGIIFSLNLAVSDLFYSLSLPLLVAYYT.[1].NKNWVFGL 86   African clawed frog
XP_007909111   18 AVLPPLLGVECVLALAGNSLAVWLFVCRVA.[2].WHSGTVLAFSLALSDLLYAASLPLLIAYYA.[1].GKSWRFGQ 88   elephant shark
XP_006005946   17 DFLPPVFGIEFLLALLGNSLAMWLLYTREK.[1].WHTGIIYAFNLAVNDLLYVLSLPLLMVYYL.[1].NKDWIFGN 86   coelacanth
XP_008174243  698 EHMWPAVTVEFFLAFAGNAFAIYRFVARER.[1].WHTGIVYSFNLAVSDLLYALSLPFLAAYYY.[1].PKHWRYGL 767  western painted turtle
XP_006631649  415 GFLPPVFGIEFCLAFPGNVLALWLLLTRER.[2].WHTGVVFSFNLAVSDLLYVLTLPLLVIYYL.[1].EKEWIFGE 485  spotted gar
ETE64813      549 EKLWIIIILQFFFAVLGNGFTIYHFVAWER.[1].WHPGIIFSFNLALSDLFYTISLLPLAVYYF.[1].PKDWRYGC 618  king cobra
NP_001191383   15 DLLPPMYGIEMTVALLGNIFALWLLGTRER.[2].WHTGVVFSCNLAISDVLYILTLPLLIIYYG.[1].KKNWTFGD 85   zebrafish
ERE75648       56 GYLWAILMAEFLVAVGGNGLALFRFITQEQ.[2].WNPAVVFSAQLAVSNLCYSFTLPPLAAYFY.[1].PKNWSFGE 126  Chinese hamster

Feature 1               ###### ##  #                                                # #####   
Q96G91        100 .[1].ACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLR.[1].KHAWAVSAAGWVLAALLAMPTLSF 167  human
NP_001089146   87 .[1].MCKVERFVFNCNLYGSIFFITCISANRYLGIVFPFYTRGRVE.[1].KHAKWVSLGVWVLVAAISAPVFLF 154  African clawed frog
XP_007909111   89 .[1].LCRAERFLFTCNLYGSILFITFISLNRYLGIVRPMLARAHVR.[1].GRAKLASLAGWLLTAAITGPTLSY 156  elephant shark
XP_006005946   87 .[1].VCKLERFLFTCNFYGSIFFVTCISFNRYIGIVHPFFSHGKVH.[1].KHAKMVSLAVWVLIFTSSTPVLFF 154  coelacanth
XP_008174243  768 .[1].LCKLERFLFSCNLYGSIFFLTCISLNRYLGIVHPLLVHGRLE.[1].RHAKLLSGAGWLLVAGLSTPTLHF 835  western painted turtle
XP_006631649  486 .[1].TCKIERFLFTCNLYSSIFFITCISVNRYVGIVHPMFTHSHVR.[1].KHAKLVSVGVWALVTVLSCPVLKY 553  spotted gar
ETE64813      619 .[1].FCKLDRFAFFVNLYGSTFFIACISLNRYVAIVHPFFAHERVE.[1].FHAKVVSGVIWLLAIAISAPVLHF 686  king cobra
NP_001191383   86 .[1].VCKIERFLFTSNLYVSIFFIMCISVNRYIAIVYPFFTRSYVR.[1].VHAKIASVLVWFIVIITSSPVFSF 153  zebrafish
ERE75648      127 .[1].ACRLERFVFTCNLLGGIIFITCISLSRYMVVVHPFFTRRHLR.[1].KHAWVISAASWAMAILLAAPMLGF 194  Chinese hamster

Feature 1                 # ###      #  ### ### ##                                               #
Q96G91        168 .[20].CIKCLGTA.[6].YRAYSLVLAGLGCGLPLLLTLAAYGALGRAVL.[4].MTVAEKLRVAALVASGVALYASSY 261  human
NP_001089146  155 .[ 8].KTECLGTA.[7].YFPYSLFLAGFGCALPFLITFLSYIGIAKAVW.[4].LEPREKRKVVTLVCVVVLLYAISF 237  African clawed frog
XP_007909111  157 .[ 8].KLQCLGTA.[7].YLHYSLFLAVWSCALPFLVTLSCYLSVVRAVW.[4].VERAERHRVLALVLVVLSLYGVSF 239  elephant shark
XP_006005946  155 .[11].KTECLGSS.[7].YFPYSLSMAVLGCGLPFLITLASYVAIFWTVF.[4].ISMLEKKKIAYMITIVVILYAVSF 240  coelacanth
XP_008174243  836 .[ 8].CTECLGSA.[7].YLPYSLFLAAFGCGLPFLLTLFSYAAILRTVC.[4].ITWLEKRKVGRLVSVGVALYAVSY 918  western painted tu...
XP_006631649  554 .[ 9].NTECVSFD.[5].YFVYSVFLATVGCLVPFLATFASYFAILWVVW.[4].ITPLEKRKVAAMIALVVVLYAVSF 635  spotted gar
ETE64813      687 .[ 8].ATVCLGSA.[7].YLSYSWFLLAVGCGLPFLLTLFSCVAIVCAVR.[4].TTREEKCKVKILVSIVVLLYALFY 769  king cobra
NP_001191383  154 .[13].RTLCVSCK.[7].HLKYTLFLMVVGCMIPFLVTFASYLGVIWTVL.[4].ITTLEKRKVALMVALVCILYATSF 241  zebrafish
ERE75648      195 .[20].CVKCLGMM.[7].FRNYSLVLACLGGILPLLLTLMAYSALGSVVL.[4].MTTAQKLHVVVLVTSGVALYACSY 289  Chinese hamster

Feature 1           ## ##  #       ## ###  #  ##                         
Q96G91        262 VPYHIMRVLNV.[26].PYVGYQVMRGLMPLAFCVHPLLYMAAV.[2].LGCCCR 333  human
NP_001089146  238 VPYHILRNLNL.[14].IHSAFQVAKALVSLNPCIHPLLYTAVI.[5].KLGCYQ 300  African clawed frog
XP_007909111  240 LPYTVLRNVNL.[13].IYKAYQVSKGLVTLNACLHPLLYAALP.[4].ALCCPG 300  elephant shark
XP_006005946  241 LPYSILRNINL.[14].IHKAYQVTKGLVTLNMCIHPLLYASVA.[3].RSICRR 301  coelacanth
XP_008174243  919 LPYHTLRNLNL.[19].VHSAYQLSKILVTLNICAHPLLYGALA.[3].RGWCRA 984  western painted turtle
XP_006631649  636 IPYHVLRNVNF.[12].LYQSIQVTKGLVTLNMCIHPLLYMTVF.[3].RTICCG 694  spotted gar
ETE64813      770 LPFHVFRNVNL.[11].IYFTYQITKILVNFHVCIHPFIYAALA.[3].PKCCCK 827  king cobra
NP_001191383  242 VPYHFLQTYHV.[11].LYNSYQVSKGLATLNMCLHPLLYMAVF.[3].RTVCCG 299  zebrafish
ERE75648      290 VPYHITQVLYV.[26].AFFGYQTTRILVPLATCMHPLLYMAVA.[4].CHSCHG 363  Chinese hamster

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