BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  29 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 107
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24647984 108 LQVRG 112
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  29 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 107
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24647984 108 LQVRG 112
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984     31 DVTLACEGETVKAHQTILSACSPYFETIFLQNQ--HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESL 108
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 24647984    109 QVRGLTD 115
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  29 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 107
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24647984 108 LQVRG 112
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984     31 DVTLACEGETVKAHQTILSACSPYFETIFLQNQ--HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESL 108
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 24647984    109 QVRGLTD 115
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKG 89
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100
                ....*....|....*....|..
gi 24647984  90 EVNVGQSSLPMFLKTAESLQVR 111
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984   8 RWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPiIYLKDVRYSEMRSLLD 84
Cdd:cd18266   4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigMREAHQKE-VELVGASYIGLKAVID 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647984  85 FMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 115
Cdd:cd18266  83 FLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  10 NNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMY 87
Cdd:cd18242   2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmsEKGKSEVELQGLTASTMEILLDFVY 81

                        90       100
                ....*....|....*....|....*
gi 24647984  88 KGEVNVGQSSLPMFLKTAESLQVRG 112
Cdd:cd18242  82 TETVHVTVENVQELLPAACLLQLKG 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKG 89
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmtESKSSEVELKDAEPDIIELLVEFAYTA 83

                        90       100
                ....*....|....*....|.
gi 24647984  90 EVNVGQSSLPMFLKTAESLQV 110
Cdd:cd18237  84 RISVNSNNVQSLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  19 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYKGEVNVGQ 95
Cdd:cd18235  11 VMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFtgdLSESRANRVT-LQDVDGKALLLLIDYVYTAEIQVTE 89

                        90       100
                ....*....|....*....|
gi 24647984  96 SSLPMFLKTAESLQvrgLTD 115
Cdd:cd18235  90 ENVQVLLPAANLLQ---LTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYK 88
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgeLAESRQTEVT-IRDIDERAMELLIDFAYT 84

                        90       100
                ....*....|....*....|....*..
gi 24647984  89 GEVNVGQSSLPMFLKTAESLQVRGLTD 115
Cdd:cd18249  85 SQITVEEGNVQTLLPAACLLQLAEIQE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  11 NHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHpHPIIYLKDVRYSEMRSLLDFMY 87
Cdd:cd18256   2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFaggMSESS-KDVVQIHGVEPDIFHILLDFIY 80

                        90       100
                ....*....|....*....|..
gi 24647984  88 KGEVNVGQSSLPMFLKTAESLQ 109
Cdd:cd18256  81 TGVVEVTVSNVQELLVAADMLQ 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984   6 CLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLK-DVRYSEMRSLL 83
Cdd:cd18331   1 CIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTdQLKCNLSVINLDpEINPEGFNILL 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 24647984  84 DFMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 115
Cdd:cd18331  81 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  20 LTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF----LQNQHPHpiIYLKDVRYSEMRSLLDFMYKGEVNVGQ 95
Cdd:cd18246  30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFtnemSESRQTH--VTLHDIDPQALEQLVQYAYTAEIVVGE 107

                        90       100
                ....*....|....*....|
gi 24647984  96 SSLPMFLKTAESLQVRGLTD 115
Cdd:cd18246 108 GNVQTLLPAASLLQLNGVRD 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  29 LCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIY--LKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAE 106
Cdd:cd18306  18 FCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTvkLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAK 97

                ....*
gi 24647984 107 SLQVR 111
Cdd:cd18306  98 KLKMD 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQ-----NQHphpIIYLKDVRYSEMRSLLDFM 86
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmresSQD---EIELKGVSAKGLKHILDFA 77

                        90       100
                ....*....|....*....|....
gi 24647984  87 YKGEVNVGQSSLPMFLKTAESLQV 110
Cdd:cd18255  78 YTSELTLDLDCIQDVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  16 LTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQH-----PHPIIyLKDVRYSEMRSLLDFMYKGE 90
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPkddgsTYKIE-LEGISVEVMEEILDYIYTGQ 79

                        90       100
                ....*....|....*....|....*
gi 24647984  91 VNVGQSSLPMFLKTAESLQVRGLTD 115
Cdd:cd18245  80 IKLSEDNIQDIVQAADLLLMTDLKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYK 88
Cdd:cd18250   4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFageLRESRADRVV-LHGVSAEILGLLLDFSYT 82

                        90       100
                ....*....|....*....|.
gi 24647984  89 GEVNVGQSSLPMFLKTAESLQ 109
Cdd:cd18250  83 GRVTVTQDNVEALLRAADLFQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYF-ETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGE 90
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFlQALVGQTENDLVVSLPEEVTARGFGPLLQFAYTAK 93

                        90       100
                ....*....|....*....|....*.
gi 24647984  91 VNVGQSSLPMFLKTAESLQVRGLTDN 116
Cdd:cd18278  94 LLLSRENIQEVIRCAEFLRMHNLEDS 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQnQHPHPIIYLKDVRYSEMRS---LLDFMYK 88
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSG-RVGEGVSVLTLPSGLEARGfqlLLDFMYT 80

                        90       100
                ....*....|....*....|....*..
gi 24647984  89 GEVNVGQSSLPMFLKTAESLQVRGLTD 115
Cdd:cd18332  81 SRLPLTPRTVPAVLAAATYLQMEHVVE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  11 NHPTNLTGVLTSLLQREALCDVTLACEGETVKA--------HQTILSACSPYFETIFL--QNQHPHPIIYLKDVRYSEMR 80
Cdd:cd18273   8 AHARALLAQLKSFYDARLLTDVTIEVNGPGSGPgsgrlfpcNRNVLAAASPYFKSMFTggLYESKQETVTIHDVDSESMA 87

                        90       100       110
                ....*....|....*....|....*....|
gi 24647984  81 SLLDFMYKGEVNVGQSSLPMFLKTAESLQV 110
Cdd:cd18273  88 LIIDYCYTGRVTLSEANVQRLYAAANMLQL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  14 TNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETI---FLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGE 90
Cdd:cd18330   3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALlihYIQDSGRHSTASLDIVTSEAFSIILDFLYSGK 82

                        90       100
                ....*....|....*....|
gi 24647984  91 VNVGQSSLPMFLKTAESLQV 110
Cdd:cd18330  83 LDLCSENVIEVMSAASYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHpIIYLKDVRYSEMRSLLDFMYKGEV 91
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQ-RVELNDISPLGLATVITYAYTGKL 79

                        90       100
                ....*....|....*....|..
gi 24647984  92 NVGQSSLPMFLKTAESLQVRGL 113
Cdd:cd18260  80 TLSLYTIGSTISAASYLQIHAL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  12 HPTNLTGVLTSLLQ-------REALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRysEMRSLLD 84
Cdd:cd18208   1 HSINLHNFSNSVLEtlneqrnRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQ--SVQKLID 78

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647984  85 FMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 115
Cdd:cd18208  79 FMYSGVLRVSQSEALQILTAASILQIKTVID 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  11 NHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPH---PIIYLKDVRYSEMRSLLDFMY 87
Cdd:cd18230   3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSdqaTVTHLDIVTAQGFKAIIDFMY 82

                        90       100
                ....*....|....*....|...
gi 24647984  88 KGEVNVGQSSLPMFLKTAESLQV 110
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24647984  20 LTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYKGE 90
Cdd:cd18280   5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLfgpMREENEGEIV-IEDVEPPVFKALLHFIYKDE 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  30 CDVTLACEGETVKAHQTILSACSPYFETIFlQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEV--NVGQSSLPMFlkTAES 107
Cdd:cd18290  28 CDVSVVVKGHAFKAHRAVLAASSSYFRDLF-NSSRSAVVELPAAVQPQSFQQILSFCYTGRLsmNVGDQFLLMY--TAGF 104

                ....*...
gi 24647984 108 LQVRGLTD 115
Cdd:cd18290 105 LQIQEIME 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984   7 LRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKD-VRYSEMRSLLDF 85
Cdd:cd18224   4 LHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDfITPANFEKVLSF 83

                        90       100
                ....*....|....*....|....*...
gi 24647984  86 MYKGEVNVGQSSLPMFLKTAESLQVRGL 113
Cdd:cd18224  84 IYTSELFTDLINVGVIYEVAEKLGMEDL 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  29 LCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAE 106
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDvrEATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                ...
gi 24647984 107 SLQ 109
Cdd:cd18234  81 LLQ 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  17 TGVLT---SLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF--LQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEV 91
Cdd:cd18264  13 EAVLSqyqSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFkdYTQESKARVIHLPVVSAAGLQRVLDFIYTSWL 92

                        90
                ....*....|....*....
gi 24647984  92 NVGQSSLPMFLKTAESLQV 110
Cdd:cd18264  93 SLSLDTLEDTLEAASYLQV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  30 CDVTLACEGETVKAHQTILSACSPYFETIFLQNqhpHPIIYLKDVRYSE-MRSLLDFMYKGEVNVGQSSLPMFLKTAESL 108
Cdd:cd18229  19 CDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLG---HSEIEVPPVVPAQtVRQLVEFMYSGSLVVAQSEALQILTAASIL 95

                ....*..
gi 24647984 109 QVRGLTD 115
Cdd:cd18229  96 QIKTVID 102

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647984  23 LLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL-------QNQHPHPIIYLKDvryseMRSLLDFMYKGEVNVGQ 95
Cdd:cd18263   7 LWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTsgmkestQSVVQLPTIPAKD-----LRLLISFAYSGILHLSW 81

                        90
                ....*....|....*...
gi 24647984  96 SSLPMFLKTAESLQVRGL 113
Cdd:cd18263  82 ENLFEATCTALQLQISGA 99