Conserved Protein Domain Family
BTB_POZ_ZBTB24_ZNF450
?
cd18212: BTB_POZ_ZBTB24_ZNF450 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24)
ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
Links
?
Statistics
?
PSSM-Id: 349521
Aligned: 7 rows
Threshold Bit Score: 204.259
Created: 13-Sep-2017
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 

O43167        14 VHSDAHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEE.[2].IGQSIYMLEGMVADTFGIL 90  human
XP_006006708  16 IHSNTLKDTVLANFEKQWRKDFLCDITLVVGNTQFRAHKALLAASSEYFCVMFADE.[2].IGQSIYMLDGMVAETFSAL 92  coelacanth
Q52KB5        16 LHSATHKDTILHKFDTLRRSELLCDITLIVEDVHFKAHKALLAASSEYFSALFTAE.[2].VSQSLYKLDGMTANTFSSV 92  zebrafish
XP_016853421  15 IHSKVHRDTILANFEEQRRKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFGDE.[2].IGQSIYMLEGMVADAFGAL 91  green anole
XP_004914613  76 ISSKAHTDRVLTCLEEQRKKDFLCDITLIVENVQFRAHKAVLAATSEYFSMMFAEE.[2].VGQSVYVMEGMVAEIFEAL 152 western clawed frog
XP_007891067  16 IQSKTHKDTILTNFEEQRKRDFLCDITLIVENVHFKAHKALLAASSEYFSLMFADE.[2].LGQTIYMLDGMAADTFHIV 92  elephant shark
OCT67519      18 IRSKAHTDRVLTCLEEQRKKDFLCDITLIVENVQFRAHKAVLAASSEYFSMMFAEE.[2].VGQSVYVMEGMVAEVFGAL 94  African clawed frog


O43167        91 LEFIYTG.[5].EKSTEQILATAQFLKV.[1].DLVKAYTDFQNN 131 human
XP_006006708  93 LEFIYTG.[5].ENDLEQIIATAQILKV.[1].DLVKAYVDFQNN 133 coelacanth
Q52KB5        93 LEFMYSA.[5].ESSSEQLMEMARFLVI.[1].DLIKAHEDLQAV 133 zebrafish
XP_016853421  92 LEFVYTG.[5].EKSTEQILATAHLLKV.[1].DLVRAYSDQQKN 132 green anole
XP_004914613 153 LQFVYTG.[5].EKALQQILATAQILKV.[1].DLVKAYGNYQED 193 western clawed frog
XP_007891067  93 LEFIYTG.[5].EKSIEHIVSTAQVLKV.[1].DLVKAYSDYQHN 133 elephant shark
OCT67519      95 LQFVYTG.[5].EKTLQQIVATAQLLKV.[1].DLVKAYANYHDN 135 African clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap