|
Name |
Accession |
Description |
Interval |
E-value |
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
9-457 |
3.33e-149 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 434.07 E-value: 3.33e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 9 VALPRALRDTRRMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHF--------TLSNRLQEWVVSSMMLGAAIGALFNG 80
Cdd:TIGR00879 13 LVTPAGLGSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFIGALFAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 81 WLSFRLGRKYSLMVGAILFVAGSLGS---AFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMV 157
Cdd:TIGR00879 93 WLSDRFGRKKSLLIIALLFVIGAILMglaAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 158 TLGIVLAFLSDTA---FSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAREELNE 234
Cdd:TIGR00879 173 TFGILVAYGFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 235 -----IRESLKLKQG---GFQLFKNNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTtEEQMIATLVVGLT 306
Cdd:TIGR00879 253 lelidIKRSIEKRSVqpsWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVST-DHAFLVSIIVGAV 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 307 FMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNGtASSGLSWVSVGMTMLCIAGYAMSAAPVVWILCSE 386
Cdd:TIGR00879 332 NFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTG-SSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSE 410
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1231036662 387 IQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPETKNVTLEHI 457
Cdd:TIGR00879 411 IFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
25-459 |
4.59e-137 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 402.04 E-value: 4.59e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 25 VSVSAAVAGLLFGLDIGVIAGALPFI--TDHFTLSNR---------LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLM 93
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIdfFKNFGLSKSvsslaalsvLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 94 VGAILFVAGSLGSAFAT---SVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTA 170
Cdd:pfam00083 81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 171 FSYSGN---WRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEkAREELNEIRESLKLKQGG-- 245
Cdd:pfam00083 161 LNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPD-VDRELDEIKDSLEAGQEAek 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 246 --FQLFKNNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeeqMIATLVVGLTFMFATFIAVFTVDKAGR 323
Cdd:pfam00083 240 asWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 324 KPALKIGFSVMAIGTLILGYClmqFDNGTA-SSGLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTT 402
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIV---ALLGVSkSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1231036662 403 TNWVSNMIIGATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPETKNVTLEHIER 459
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDE 450
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
29-448 |
8.95e-123 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 362.28 E-value: 8.95e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFITD--HFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKdlGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 107 AFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYS--GNWRAMLGVL 184
Cdd:cd17315 82 ALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFALA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 185 ALPAVLLIILVIFLPNSprwlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnrnvrRAVFLGML 264
Cdd:cd17315 162 AVPALLQLLLMFFLPES-------------------------------------------------------RALLVGVG 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 265 LQAMQQFTGMNIIMYYAPRIFKMAGftTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYC 344
Cdd:cd17315 187 LQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 345 LMqfdNGTASSGLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA 424
Cdd:cd17315 265 FL---LPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGL 341
|
410 420
....*....|....*....|....
gi 1231036662 425 AGTFWLYTALNLAFVGVTFWLVPE 448
Cdd:cd17315 342 AGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
24-448 |
7.35e-110 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 329.91 E-value: 7.35e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 24 FVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGS 103
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 104 LGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN------- 176
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGadwlgae 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 177 -WRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnrnv 255
Cdd:cd17359 161 gWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG---------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 256 RRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMA 335
Cdd:cd17359 195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGF-SENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMA 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 336 IGTLILGYClMQFDNGTASSGlsWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATF 415
Cdd:cd17359 274 ISLLLIGTA-FYFAPGSQASG--IVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTF 350
|
410 420 430
....*....|....*....|....*....|....
gi 1231036662 416 LTLLDAIGAAGTFWLYTALN-LAFVGVTFWlVPE 448
Cdd:cd17359 351 PILLAAFGLAFTFLIFAVICvLAFLFVWKF-VPE 383
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
24-456 |
2.06e-93 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 289.86 E-value: 2.06e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 24 FVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQE----WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILF 99
Cdd:cd17358 2 LATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVaqfsWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 100 VAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFsysgNWRA 179
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 180 MLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAREELNEIRESLK-----LKQGGFQLFKnNRN 254
Cdd:cd17358 158 LALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAelekeAKESSFSDLF-QRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 255 VRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVM 334
Cdd:cd17358 237 YLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPN--TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 335 AIGTLILG-YCLMQFDNGTASSgLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGA 413
Cdd:cd17358 315 GIGLLALGlYFYLQEHGALLSS-VSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTK 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1231036662 414 TFLTLLDAIGAAGTFWLYTALN-LAFVGVTFwLVPETKNVTLEH 456
Cdd:cd17358 394 TFPFLTLAWGASGTFWIFAGICgLALVFVLL-FVPETKGKSLEE 436
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
28-448 |
2.09e-93 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 287.24 E-value: 2.09e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 28 SAAVAGLLFGLDIGVIAGALPFITDHF---TLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSL 104
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 105 GSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSY-SGNWRAMLGV 183
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYlPGGWRWMLGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 184 LALPAVLLIILVIFLPNSPRWlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnRNVRRAVFLGM 263
Cdd:cd17360 161 AAVPAVLQFIGLLFLPESPRW------------------------------------------------PSTRRALIVGC 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 264 LLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGy 343
Cdd:cd17360 193 GLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLA- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 344 clmqfdngtassglSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIG 423
Cdd:cd17360 272 --------------VWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIG 337
|
410 420
....*....|....*....|....*.
gi 1231036662 424 AAGTFWLYTALN-LAFVGVTFWlVPE 448
Cdd:cd17360 338 PYGTFLLFAGLAvLGLIFIYFC-VPE 362
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
29-457 |
1.51e-85 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 267.68 E-value: 1.51e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFI-------TDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVA 101
Cdd:cd17362 2 PALGGLLFGYDIGATSGALLSItspalsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 102 GSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF-SYSGNWRAM 180
Cdd:cd17362 82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFaDVVGGWRYM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 181 LGVLALPAVLLIILVIFLPNSPRWlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknNRNVRRAVF 260
Cdd:cd17362 162 YGLAAPPALLLGIGMWFLPPSPRW-----------------------------------------------QGNYRKPLI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 261 LGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLI 340
Cdd:cd17362 195 IGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 341 LGYCLMQFDNGTAssGLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLD 420
Cdd:cd17362 275 LAAYNLFVQMGPA--GLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQE 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 1231036662 421 AIGAAGTFWLYTALNLAFVGVTFWLVPETKNVTLEHI 457
Cdd:cd17362 353 LIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
23-459 |
4.84e-80 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 256.54 E-value: 4.84e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 23 MFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQE--------WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMV 94
Cdd:PRK10077 11 FSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSEsaansllgFCVASALIGCIIGGALGGYCSNRFGRRDSLKI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 95 GAILFVAGSLGSAF------------ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIV 162
Cdd:PRK10077 91 AAVLFFISALGSAWpefgftsigpdnTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 163 LAFL--------SDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTsEKAREELNE 234
Cdd:PRK10077 171 VVYFvnyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN-TLATQALQE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 235 IRESLKLKQ-GGFQLFKNNRNVrraVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGfTTTEEQMIATLVVGLTFMFATFI 313
Cdd:PRK10077 250 IKHSLDHGRkTGGKLLMFGVGV---IVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINLTFTVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 314 AVFTVDKAGRKPALKIGFSVMAIGTLILGYCLmqfdnGTASSGLswVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCR 393
Cdd:PRK10077 326 AIMTVDKFGRKPLQIIGALGMAIGMFSLGTAF-----YTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIR 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1231036662 394 DFGITCSTTTNWVSNMIIGATF------LTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPETKNVTLEHIER 459
Cdd:PRK10077 399 GKALAIAVAAQWIANYFVSWTFpmmdknSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEA 470
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-455 |
2.25e-73 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 237.08 E-value: 2.25e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 24 FVSVSAAVAG-LLFGLDIGVIAGALPFITD----HFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAIL 98
Cdd:cd17433 1 FLATFAAVLGpLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 99 FVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYsgNWR 178
Cdd:cd17433 81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDW--RWL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 179 AMLGvlALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGFQLFK-NNRNVRR 257
Cdd:cd17433 159 AVLG--SIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLALlKQPGIYK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 258 AVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEeqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIG 337
Cdd:cd17433 237 PLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS---VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 338 TLILGyclmqfdngtassglsWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLT 417
Cdd:cd17433 314 TAAFG----------------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSS 377
|
410 420 430
....*....|....*....|....*....|....*...
gi 1231036662 418 LLDAIGAAGTFWLYTALNLAFVGVTFWLVPETKNVTLE 455
Cdd:cd17433 378 LMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
29-459 |
1.30e-70 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 229.44 E-value: 1.30e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGAL---------PFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILF 99
Cdd:cd17356 6 VSLGGFLFGYDTGSISGILnmksfqkyfADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 100 VAGSLGSAFATSVEV-LLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN-- 176
Cdd:cd17356 86 IIGAIIQVAAIGKWYqLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGsa 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 177 -WRAMLGVLALPAVLLIILVIFLPNSPRWLaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnrnv 255
Cdd:cd17356 166 qWRIPLGLQIVWGLLLLIGMFFLPESPRWL-------------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 256 rRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMA 335
Cdd:cd17356 196 -YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGS-SPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMS 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 336 IGTLILGYCLMQFDNGTASSGLSWVSVG-----MTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMI 410
Cdd:cd17356 274 ICLFIYAAVGVRYLIPNPQSGTSNKSAGngmivFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWNFL 353
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1231036662 411 IGATFLTLLDAIGaAGTFWLYTALNLAFVGVTFWLVPETKNVTLEHIER 459
Cdd:cd17356 354 ISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDE 401
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-451 |
1.85e-66 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 220.21 E-value: 1.85e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 64 VVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSL---GSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEM 140
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLlmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 141 ASENVRGKMISMYQLMVTLGIVLA--FLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLA-QKGRHIEAEEV 217
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGqvFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 218 LRMLRDTSEKAREELNEIR-ESLKLKQGGF----QLFKNNRNvRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtT 292
Cdd:cd17357 214 LKFLRGIEDDVDQELEEIKkESEQMGDQKQvslmQLLRDPSL-RLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGF-S 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 293 TEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNgtaSSGLSWVSVGMTMLCIAGY 372
Cdd:cd17357 292 PQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQ---NSWMSYGCIVAIFLFIFFF 368
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1231036662 373 AMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAgTFWLYTALNLAFVGVTFWLVPETKN 451
Cdd:cd17357 369 AIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGF-VFIIFAIPCALFLLYLYRYLPETKG 446
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
29-457 |
3.41e-64 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 212.26 E-value: 3.41e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:cd17437 2 ASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFS---YSGNWRAMLGVLA 185
Cdd:cd17437 82 APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSglpLHVGWRLMLGVGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 186 LPAVLLIILVIFLPNSPRWlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknNRNVRRAVFLGMLL 265
Cdd:cd17437 162 VPSLFLAIGVLAMPESPRW-----------------------------------------------TPAVRRMLIAALGI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 266 QAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCL 345
Cdd:cd17437 195 HFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 346 MQFDNGTASSGLSWV-SVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA 424
Cdd:cd17437 275 TFIDRNGGGLTWALVlAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITT 354
|
410 420 430
....*....|....*....|....*....|...
gi 1231036662 425 AGTFWLYTALNLAFVGVTFWLVPETKNVTLEHI 457
Cdd:cd17437 355 GGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
26-457 |
7.96e-63 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 208.50 E-value: 7.96e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 26 SVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLG 105
Cdd:cd17435 3 SVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 106 SAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF-SYSGNWRAMLGVL 184
Cdd:cd17435 83 LVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFaNVSNGWKYMFGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 185 ALPAVLLIILVIFLPNSPRWLAQKGrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnrNVRRAVFLGML 264
Cdd:cd17435 163 IPLAALQAIAMYFLPPSPRFLVMKD--------------------------------------------NMRARLLIGLT 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 265 LQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGyc 344
Cdd:cd17435 199 LVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMG-- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 345 lmqfdngtassglSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA 424
Cdd:cd17435 277 -------------LWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGL 343
|
410 420 430
....*....|....*....|....*....|...
gi 1231036662 425 AGTFWLYTALNLAFVGVTFWLVPETKNVTLEHI 457
Cdd:cd17435 344 PWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
28-451 |
6.77e-60 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 202.57 E-value: 6.77e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 28 SAAVAGLLFGLDIGVIAGALPFITDHF--TLSNRLQE----------WVVSSMM--LGAAIGALFNGWLSFRLGRKYSLM 93
Cdd:cd17431 5 VAVLGSLQFGYNTGVINAPQKVIEEFYnkTLGDRYGEpispetlttlWSLSVAIfsVGGMIGSFSVGLFVNRFGRRNSML 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 94 VGAILFVAGSLGSAF---ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--FLSD 168
Cdd:cd17431 85 YNNLLAFAGAALMGLsklAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISqiFGLE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 169 TAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWL-AQKGRHIEAEEVLRMLR---DTSEKAREELNEIRESLKLKQG 244
Cdd:cd17431 165 FILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRgttDVSEDIQEMKEESRQMMREKKV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 245 GF-QLFKnNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGfttTEEQMIATLVVGLTFMFATFIAVFTVDKAGR 323
Cdd:cd17431 245 TIlELFR-SSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAG---VQQPVYATIGAGVVNTIFTVVSLFLVERAGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 324 KPALKIGFSVMAIGTLILGYCLMQFDNgtaSSGLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTT 403
Cdd:cd17431 321 RTLHLIGLGGMAICAILMTIALLLLEG---YPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFS 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1231036662 404 NWVSNMIIGATFLTLLDAIGAAgTFWLYTALNLAFVGVTFWLVPETKN 451
Cdd:cd17431 398 NWTSNFIVGMCFQYIANLCGPY-VFIIFTVFLLTFFIFTYFKVPETKG 444
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
29-448 |
4.90e-58 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 196.32 E-value: 4.90e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGAL---PFITDHF----------------TLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRK 89
Cdd:cd17361 2 AALGGLIFGYDIGISGGVTsmdPFLEKFFpsvyekkkgasennycKYDDQLLQLFTSSLYLAGLVASLLASYVTRKWGRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 90 YSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDT 169
Cdd:cd17361 82 PSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLINY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 170 AFSYSG--NWRAMLGVLALPAVLLIILVIFLPNSPrwlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfq 247
Cdd:cd17361 162 GTSKIKpnGWRLSLGLAAVPALILLLGSLFLPETP--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 248 lfknnrnVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPAL 327
Cdd:cd17361 197 -------NSPQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGF-GSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 328 KIGFSVMAIGTLILGYCLMQF--DNGTASSGLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNW 405
Cdd:cd17361 269 LEGGVQMLASQVAIGILLAVKfgDGGELPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNF 348
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1231036662 406 VSNMIIGATFLTLLDAIgAAGTFWLYTALNLAFVGVTFWLVPE 448
Cdd:cd17361 349 LFTFVIAQAFLSMLCAM-KFGIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
28-457 |
4.70e-53 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 182.69 E-value: 4.70e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 28 SAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSA 107
Cdd:cd17436 5 VSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 108 FATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFS-YSGNWRAMLGVLAL 186
Cdd:cd17436 85 LAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSnVLTGWRYMFGLAII 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 187 PAVLLIILVIFLPNSPRWLAqkgrhieaeevlrmLRDtsekareelneireslklkqggfqlfknnrNVRRAVFLGMLLQ 266
Cdd:cd17436 165 PAAIQFASILLLPKKPEVLN--------------IKD------------------------------NMRRRTLVGLGLV 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 267 AMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclm 346
Cdd:cd17436 201 LFQQFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL--- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 347 qfdngtassglsWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAG 426
Cdd:cd17436 278 ------------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSW 345
|
410 420 430
....*....|....*....|....*....|.
gi 1231036662 427 TFWLYTALNLAFVGVTFWLVPETKNVTLEHI 457
Cdd:cd17436 346 TFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
64-457 |
5.10e-50 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 176.65 E-value: 5.10e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 64 VVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF---ATSVEVLLISRVLLGVAVGIASYTAPLYLSEM 140
Cdd:cd17432 55 TVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLskiAKSFEMIIVGRFLVGINAGISLNVVPMYLGES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 141 ASENVRGKMISMYQLMVTLGIVLA---FLSDTAFSYSGnWRAMLGVLALPAVLLIILVIFLPNSPRW-LAQKGRHIEAEE 216
Cdd:cd17432 135 APKNLRGAVGLVPAIFITLGILLGqvlGLRELLGNEEG-WPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 217 VLRMLRDtSEKAREELNEIRESLKLKQGG-----FQLFKnNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFT 291
Cdd:cd17432 214 ALQRLRG-KEDVDDEMEEMLEEQRAEKGVgtvsvLELFR-DRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 292 TTEEQMiATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNgtaSSGLSWVSVGMTMLCIAG 371
Cdd:cd17432 292 EDKIQY-VTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNT---VSWMPYLSIVCIFAYIAS 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 372 YAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAgTFWLYTALNLAFVGVTFWLVPETKN 451
Cdd:cd17432 368 FGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAY-CFLVFAVICLLTAIYIFFVLPETKG 446
|
....*.
gi 1231036662 452 VTLEHI 457
Cdd:cd17432 447 KTFLEI 452
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
63-455 |
2.24e-45 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 163.47 E-value: 2.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMAS 142
Cdd:cd17434 45 WFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 143 ENVRGKMISMYQLMVTLGIVLAFlsdtAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLR 222
Cdd:cd17434 125 PGVRGALGACPQIMAVFGSLALY----ALGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 223 DTSEKAREELNEIRESLKLKQGGFQLFK-NNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIAtl 301
Cdd:cd17434 201 GPNTDYMTEFEQIKDNIRKQSSRLSWAElKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEPKYDAA-- 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 302 VVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQfdngtassglswvsvgMTMLCIAGYAMSAAPVVW 381
Cdd:cd17434 279 LVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMGLIPLI----------------AAMLFIMGYAMGWGPITW 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 382 ILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPETKNVTLE 455
Cdd:cd17434 343 LLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-383 |
5.64e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 127.78 E-value: 5.64e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 17 DTRRMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGA 96
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 97 ILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN 176
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 177 WRAMLGVLALPAVLLIILVIFLpnsprwlaqkgrhieaeevlrMLRDTSEKAREELNEIRESLKlkqggfqlfknnrnvR 256
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRL---------------------LPESRPAARARLRGSLRELLR---------------R 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 257 RAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAI 336
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS-AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1231036662 337 GTLILGYclmqfdngtaSSGLSWVSVGMTMLCIAGYAMSAAPVVWIL 383
Cdd:COG2814 286 GLLLLAL----------AGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
20-221 |
3.22e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 119.15 E-value: 3.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 20 RMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILF 99
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 100 VAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRA 179
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1231036662 180 MLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRML 221
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAAL 211
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-445 |
1.85e-24 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 103.84 E-value: 1.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 27 VSAAVAGLLFGLDIGVIAGALPFITDHFT--LSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSL 104
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 105 GSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSG----NWRAM 180
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 181 LGVLALPAVLLIILviflpnsprwlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnrnvRRAVF 260
Cdd:cd17316 162 FLIGALPALLALLL-------------------------------------------------------------RRRTL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 261 LGMLLQAMQQFtGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLI 340
Cdd:cd17316 181 LLILLWFFISF-GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 341 LGYCLmqfdngtassGLSWVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGItcSTTTNWVSNMIIGATFL--TL 418
Cdd:cd17316 260 LFYLL----------SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV--GLSYNLGRLGGGGAPPLiaLL 327
|
410 420
....*....|....*....|....*..
gi 1231036662 419 LDAIGAAGTFWLYTALnLAFVGVTFWL 445
Cdd:cd17316 328 LASTGGTGVPALILAL-LAIVALIVAL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-380 |
4.93e-24 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 103.59 E-value: 4.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 13 RALRDTRRMNMFVSVSAAVAGLLF---GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRK 89
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSFLIMlmdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 90 YSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSD 168
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGgFLAG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 169 TAFSYSGnWRAMLGV-LALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGFQ 247
Cdd:TIGR00895 163 WLIPVFG-WRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 248 LFKNNRNVRRAVFLGMLlqamqqfTGMNIIMYYA-----PRIFKMAGFTTTeEQMIATLVVGLTFMFATFIAVFTVDKAG 322
Cdd:TIGR00895 242 ALFQGKTARITVLLWLL-------YFMLLVGVYFltnwlPKLMVELGFSLS-LAATGGALFNFGGVIGSIIFGWLADRLG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1231036662 323 RKpalkigfsVMAIGTLILGYCLMqfdngTASSGLSWVSVGMTMLCIAGYAMSAAPVV 380
Cdd:TIGR00895 314 PR--------VTALLLLLGAVFAV-----LVGSTLFSPTLLLLLGAIAGFFVNGGQSG 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-444 |
7.08e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.89 E-value: 7.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF--SYSGNWRAMLGVLAL 186
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 187 PAVLLIILVIFLPNSPRWLAQKgrhieaeevlrmlRDTSEKAREELNEIRESLKlkqggfqlfknnrnvRRAVFLGMLLQ 266
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARA-------------KNEEASSKSVLKLLKRVLK---------------NPGLWLLLLAI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 267 AMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclm 346
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 347 qfdngtASSGLSWVSVgmtMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAG 426
Cdd:cd06174 290 ------APSLLLLLLL---LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360
|
410
....*....|....*...
gi 1231036662 427 TFWLYTALNLAFVGVTFW 444
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-383 |
4.66e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 100.32 E-value: 4.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFA 109
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 110 TSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAV 189
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 190 LLIILVIFLpnsprwlaqkgrhieaeevlrmLRDTSEKAREELNEIRESLKLKQggfqlfknNRNVRRAVFLGMLLqamq 269
Cdd:cd17324 165 LAALLLWRL----------------------LPSLPPKKPGSLGLLSSLLLLLR--------NPRLRLAYLITFLL---- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 270 qFTGMNIIM-YYAPRIFKMAGFTTTEeQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGyclmqf 348
Cdd:cd17324 211 -FGGFFALYtYLAPFLTDVPGFSSSA-IIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL------ 282
|
330 340 350
....*....|....*....|....*....|....*
gi 1231036662 349 dngtASSGLSWVSVGMTMLCIAGYAMSAAPVVWIL 383
Cdd:cd17324 283 ----LGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-450 |
9.57e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 96.48 E-value: 9.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 16 RDTRRMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVG 95
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 96 AILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSG 175
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 176 NWRAMLGVLALPAVLLIILviflpnsprwlaqkgrhieaeevlrmlrdtsekareelneireslklkqggfqlfknnrnv 255
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 256 rraVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGR--KPALKIGFSV 333
Cdd:COG2271 181 ---RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 334 MAIGTLILGYclmqfdngtassgLSWVSVGMTMLCIAGYAMSAA-PVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIG 412
Cdd:COG2271 258 AALALLLLAL-------------LPSPALAIALLFLAGFGLGGAfGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324
|
410 420 430
....*....|....*....|....*....|....*...
gi 1231036662 413 ATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPETK 450
Cdd:COG2271 325 LLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
66-455 |
2.78e-21 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 96.24 E-value: 2.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 146 RGKMISMYQLMVTLGIVlaFLSDTAFsYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDT- 224
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLV--LLPLVAY-FIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKIn 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 225 -----SEKAREELNEIRESLKLKQGGFQLFKnNRNVRRAVFLGMLLqamqqFTGMNIIMYYAPRIFKMAGFTTTEEQMIA 299
Cdd:TIGR00898 291 gkklpAEVLSLSLEKDLSSSKKQYSFLDLFR-TPNLRKTTLCLMML-----WFTTAFSYYGLVLDLGNLGGNIYLDLFIS 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 300 TLVVgltfMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYClmqfdngtaSSGLSWVSVGMTMLCIAGyAMSAAPV 379
Cdd:TIGR00898 365 GLVE----LPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFV---------PVDLYFLRTALAVLGKFG-ITSAFQM 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1231036662 380 VWILCSEIQPLKCRDFGITCSTTTNWVSNMIigATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWLvPETKNVTLE 455
Cdd:TIGR00898 431 VYLYTAELYPTVVRNLGVGVCSTMARVGSII--SPFLVYLGEKWLFLPLVLFGGLALLAGILTLFL-PETKGVPLP 503
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-378 |
3.49e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 3.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLFGLDIGVIAGALP-FITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPA 188
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 189 VLLIILVIFLPNSPrwlaqkgrhieaeevlrmlrdtsekareelnEIRESLKLKQGGFQLFKNNRNVRRAVFLGMLLQAM 268
Cdd:pfam07690 162 LLAAVLLLLPRPPP-------------------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 269 QQFTGMNIIMYYAPRIFKMAGFTTteeqMIATLVVGLTFMFATFIAVFT---VDKAGRKPALKIGFSVMAIGTLILGYCL 345
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSA----LLAGLLLGLGGLLGAIGRLLLgrlSDRLGRRRRLLLALLLLILAALGLLLLS 286
|
330 340 350
....*....|....*....|....*....|....*
gi 1231036662 346 MQFDNGTASSGLSWVSVGMTML--CIAGYAMSAAP 378
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVfpALNALVSDLAP 321
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
37-229 |
4.34e-19 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 90.42 E-value: 4.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 37 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLL 116
Cdd:TIGR01299 180 GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 117 ISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:TIGR01299 260 FCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAaamawaiiphygwsFQMGSAYQFH-SWRVFVI 338
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAR 229
Cdd:TIGR01299 339 VCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAK 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-446 |
1.35e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.25 E-value: 1.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFA 109
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 110 TSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAV 189
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 190 LLIILVIFLPnsprwlaqkgrhieaeevlrmlrdtsEKAREELNEIRESLKLKQGGFQLFKNNRNVrRAVFLGMLLQAMQ 269
Cdd:cd17325 162 LALVLALLLL--------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRL-LALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 270 QFTGMNIIMYYAPRIFKMAGFTTTeeqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclmqfd 349
Cdd:cd17325 215 FGALEPFLPLYAAELGGLSPAQIG----LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL------ 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 350 ngtaSSGLSWVSVGMTMLCIaGYAMSAAPVVWILCSEIQPlkcRDFGITCST-TTNWVSNMIIGATFLTLL-DAIGAAGT 427
Cdd:cd17325 285 ----ATSFWLLLLLLALLGL-GLGLVFPATLALLADIVPP---EGRGTAMGLfNTAFSLGMVLGPLLGGFLyDAFGFATP 356
|
410
....*....|....*....
gi 1231036662 428 FWLYTALNLAFVGVTFWLV 446
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
37-229 |
1.31e-17 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 84.85 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 37 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLL 116
Cdd:cd17363 12 GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 117 ISRVLLGVAVGIASYTAPLYLSEMASENVRGKMIS----------MYQLMVTLGIV----LAFLSDTAFSYSgNWRAMLG 182
Cdd:cd17363 92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSwlcmfwmiggLYASAMAWAIIphygWGFSMGTAYQFH-SWRVFVI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAR 229
Cdd:cd17363 171 VCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAK 217
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-445 |
2.14e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.78 E-value: 2.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 27 VSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 107 AFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLAL 186
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 187 PAVLLIILV-IFLPNSPrwlaqkgrhieaeevlrmlRDTSEKAREELNEIRESLKlkqggfqlfknnrnvRRAVFLGMLL 265
Cdd:COG2223 168 LLLVVAVLAwLFLRDPP-------------------AGAAAAAKASLRDQLEALR---------------DPRFWLLSLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 266 QAMqQFTGMNIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCL 345
Cdd:COG2223 214 YFG-TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 346 MQFdngtassglsWVSVGMTMLCIAGYAMSAApVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA- 424
Cdd:COG2223 293 GSL----------WLFLVLFLLLGLALGGGNG-AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSy 361
|
410 420
....*....|....*....|.
gi 1231036662 425 AGTFWLYTALNLAFVGVTFWL 445
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-195 |
9.07e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 81.45 E-value: 9.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFA 109
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 110 TSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAV 189
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
....*.
gi 1231036662 190 LLIILV 195
Cdd:cd17321 162 VALLLA 167
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-341 |
1.04e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 81.47 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRwl 205
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 206 aqkgrhieaeevlrmlrdTSEKAREELNEIRESLKLkqggfqLFKNNRNVRRAVFLGMLLQAMQQFTGMniimyyAPRIF 285
Cdd:cd17320 179 ------------------PEEKRKPLLSSLLRAYKR------VLKNRRFLGYALALGLSFAGLFAYLAA------APFIY 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1231036662 286 KMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIL 341
Cdd:cd17320 229 IEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL 284
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
30-221 |
3.03e-16 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 80.39 E-value: 3.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAgLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFA 109
Cdd:PRK11551 22 LVA-LLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 110 TSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLAL-PA 188
Cdd:PRK11551 101 WDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgPL 180
|
170 180 190
....*....|....*....|....*....|...
gi 1231036662 189 VLLIILVIFLPNSPRWLAQKGRHIEAEEVLRML 221
Cdd:PRK11551 181 LLVPLLMRWLPESRAFAQAAGAGKQRAPVLRAL 213
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-447 |
5.11e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 79.65 E-value: 5.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 27 VSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 107 AFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSDTAFSYSGN---WRAMLG 182
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtLLAALLFPLLPPeiaWRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLA--QKGRHIEAEEVLRMLRDtsekareelneireslklkqggfqlfknnRNVRRAVF 260
Cdd:cd17371 162 LGALPALLVLFIRRFVKEPPQWQAarAARRHFADRPSLRELFS-----------------------------PPLLRTTL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 261 LGMLLQAMQQFTgmniimYYAPRIFkMAGFTTTEEQMIATLVVGLTFMFA------TFIAVFTVDKAGRKPALKIGFSVM 334
Cdd:cd17371 213 LASLLATGALGG------YYGITTW-LPSYLTGERGLSFEGSAGYLVVTIlggflgYLAGGFLADRIGRRNNFALFALGS 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 335 AIGTLILGYclmqfdnGTASSGLSWVsvgmtMLCIAGYAMSAAPVVW-ILCSEIQPLKCRDfgiTCSTTTNWVSNMIiga 413
Cdd:cd17371 286 AISILLYFF-------LPLSPTLILI-----LGFPLGFFASGPFSGMgAYLTELFPTAVRA---TAQGFCYNVGRII--- 347
|
410 420 430
....*....|....*....|....*....|....
gi 1231036662 414 tfltllDAIGAAGTFWLYTALNLAFVGVTFWLVP 447
Cdd:cd17371 348 ------GALFPFLVGFLATSGSLGTAIAVFAAVY 375
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
37-243 |
8.72e-16 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 79.57 E-value: 8.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 37 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLL 116
Cdd:cd17440 12 GVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 117 ISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:cd17440 92 FCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYAsamawaiiphygwsFSMGSAYQFH-SWRVFVI 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQ 243
Cdd:cd17440 171 VCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQPEKVFTVNRIKK 231
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
30-449 |
9.40e-16 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 78.86 E-value: 9.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLF---GLDIGVIAGALPFI-----TDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVA 101
Cdd:cd17364 2 IIAGMGFftdAYDLFSISLVTKILgrlyyGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 102 GSLGSAFATSVEV------LLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA----------- 164
Cdd:cd17364 82 GTILSALSPGSTPlgvmgwLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGaivtlilsaif 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 165 ---FLSDTAFSYSGNWRAMLGVLALPAVLLIIlviflpnsPRwlaqkgRHIEAEEVLRMLRDtsekareelneireslkl 241
Cdd:cd17364 162 ehpLPAGTYHHADLVWRIVLGLGAIPALSVLY--------FR------KHLLGTAGTWFLLD------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 242 kqggFQLFKNNrnvrraVFLGMLLQAMQQFTGMNIImyyaprifkMAGFTTTEEQMIATLVVGLTfmfATFIAVFTVDKA 321
Cdd:cd17364 210 ----IAFYGQN------LFQSTIISAIGFSKTMNAY---------QELFNIAVGQLIIALAGTVP---GYWFTVFLIDRI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 322 GRKPALKIGFSVMAIGTLILGYCLMQFDNGTAssglswVSVGMTMLCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCST 401
Cdd:cd17364 268 GRKKIQMMGFFGMTIFLLILAGPYDHWKISTI------GFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISA 341
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1231036662 402 TTNWVSNMIIGATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPET 449
Cdd:cd17364 342 ASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-211 |
2.00e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 78.05 E-value: 2.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 31 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFAT 110
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 111 SVEVLLISRVLlgVAVGIASYT--APLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAF-SYSGNWRAMLGVLALP 187
Cdd:cd17328 86 NFWQLLLFRAL--VGIGEASYSpiAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVL 163
|
170 180
....*....|....*....|....*
gi 1231036662 188 AVLL-IILVIFLPNSPRWLAQKGRH 211
Cdd:cd17328 164 GVLLaILLLLFVREPPRGAAEGGVM 188
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
60-445 |
2.30e-15 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 76.85 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 60 LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSE 139
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 140 MASENVRGKMISMYQLMVTLGIV-LAFLSdtafSYSGNWRAMLGVLALPAVLLIILVIFLPnsprwlaqkgrhieaeevl 218
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMlLALLA----YLIRDWRWLQLAISLPGLLFLLLLWWLP------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 219 rmlrdtsekareelneireslklkqggfqlfknnrnvRRAVFLGMLLqamqqftGMNIIMYYA--PRIFKMAGfttteEQ 296
Cdd:cd17317 163 -------------------------------------RRTIIVGLIW-------FVTSLVYYGlsLNSSNLGG-----NL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 297 MIATLVVGLTFMFATFIAVFTVDKAGRKPALkigFSVMAIGTLILGYCLMQFDNgtassglsWVSVGMTMLCIAGYAMSA 376
Cdd:cd17317 194 YLNFFLSGLVEIPAYFLALLLLDRLGRRWTL---SGSLLLAGLACLVTALLPDD--------ENTLALTLALVGKFAISA 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1231036662 377 A-PVVWILCSEIQPLKCRDFGI-TCSTttnwVSNM-IIGATFLTLLDAIGAAGTFWLYTALNLAFVGVTFWL 445
Cdd:cd17317 263 AfSVIYLYTAELYPTVVRNTGVgLCST----VARVgAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-195 |
3.13e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 76.86 E-value: 3.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 34 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVE 113
Cdd:cd17365 9 VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 114 VLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLII 193
Cdd:cd17365 89 QLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
..
gi 1231036662 194 LV 195
Cdd:cd17365 169 LL 170
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-203 |
4.45e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.84 E-value: 4.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 8 SVALPRALRDTRRMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLG 87
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 88 RKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVrGKMISMYQLMVTLGIVLAFLS 167
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGL 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 1231036662 168 DTAFSYSGNWRAMLGVLALPAVL-LIILVIFLPNSPR 203
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLaLLLWLPLLRRRPA 197
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
37-231 |
1.57e-14 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 75.73 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 37 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLL 116
Cdd:cd17438 12 GVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 117 ISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:cd17438 92 FCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYAsamawsiiphygwgFSMGTNYHFH-SWRVFVI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAREE 231
Cdd:cd17438 171 ICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGT 219
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-341 |
3.82e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.73 E-value: 3.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 18 TRRMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAI 97
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 98 LFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTAFSYSG-- 175
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 176 -NWRAMLGVLALPAVLLIILVIFLPnsprwlaqkgrhieaeevLRMLRDTSEKAREELNEIRESLKlkqggfqlfknnrn 254
Cdd:COG0738 161 lSWHLPYLILAVLLLLLALLFLRSK------------------LPEIEEEEEEAAGSAASLKSLLK-------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 255 vRRAVFLGMLLQAMQQFTGMnIIMYYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVM 334
Cdd:COG0738 209 -NPRLLLGGLAIFLYVGAEG-AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286
|
....*..
gi 1231036662 335 AIGTLIL 341
Cdd:COG0738 287 AVGLLLA 293
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-343 |
9.90e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 9.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 31 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFAT 110
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 111 SVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSDTAFSYSGNWRAMLGVLALpAV 189
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGpALGLFLYQHLGFAVLFIVAAVL-AL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 190 LLIILVIFLPnsprwlaqkgrhieaeevlrmlRDTSEKAREELNEIRESLKLkqggfqlfknnrnVRRAVFLGMLLQAMQ 269
Cdd:cd17489 162 LALLLVFLVK----------------------DPPPVAAEEAEAGTRAFRRL-------------VEKKVLPPALILFLA 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1231036662 270 QFTGMNII----MYYAPRIFKMAGFTTTeeqmiatlVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGY 343
Cdd:cd17489 207 SIAYGAIStflpLYAAERGISNAGLFFT--------VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-364 |
1.02e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 40 IGVIAGALPFITDHFTLSNRLQ-EWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLIS 118
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 119 RVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSySGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 199 PNSPRwlaqkgrhieaeevlrmlrdTSEKAREELNEIRESLKLKQGGFQLFknnrnvrrAVFLGMLLqamqqftgMNIIM 278
Cdd:cd17473 174 PEPAR--------------------KSKSAASPGAATAAALPWKRVLPIYF--------LAFLAMLL--------FYVIP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 279 YYAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclmqfdngtaSSGLS 358
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL----------ASGLW 287
|
....*.
gi 1231036662 359 WVSVGM 364
Cdd:cd17473 288 VVLLGA 293
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-378 |
7.19e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.91 E-value: 7.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFA 109
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 110 TSVEVLLISRVLLGVAVGIasytAPLYLSeMASENVRGKMISMYQLMVT----LGIVLAFLSDTAFSYSGNWRAMLGVLA 185
Cdd:cd17504 82 PNLPVLIAGRALQGIGGAV----FPLAFA-LVREEFPPERVPVAQGILSatfgIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 186 LPAVLLIILVIFLPnsprwlaqkgrhieaeevLRMLRdtsekareelneireslklkqggfqlfknnrnvRRAVFLGMLL 265
Cdd:cd17504 157 PVAVLLAALVPLID------------------LRLLR---------------------------------RRNVLLANIT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 266 QAMQQFtGMNIIMYYAPRIFKM---AGFTTTEEQMIATLV-VGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIL 341
Cdd:cd17504 186 ALLAGF-GMFMVFQLLPQLLQLptpTGFGLGITEAGLLLLpGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLL 264
|
330 340 350
....*....|....*....|....*....|....*..
gi 1231036662 342 GYCLMQFDNGTASSGLSWVSVGMTMLCIAGYAMSAAP 378
Cdd:cd17504 265 ALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP 301
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-343 |
1.20e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFgLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:cd17474 5 FFATLLAV-LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL-----AFLSDTAfsysgnWRAMLGV 183
Cdd:cd17474 84 SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVgpllgGLLAAIS------WRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 184 LALPAVLLIILVIFLPnsprwlaqkgrhieaeevlrmlrdtsekaREELNEIRESLKLKQGGFQLFKNNRnvrraVFLGM 263
Cdd:cd17474 158 LAALIPVAFLAILFLL-----------------------------PEPKEKAKSSSATKLRDLKKALRGR-----GLLTF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 264 LLQAMQQFTGMNIIMYYAPRIFKM-AGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILG 342
Cdd:cd17474 204 LVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLG 283
|
.
gi 1231036662 343 Y 343
Cdd:cd17474 284 F 284
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
74-450 |
1.56e-12 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 68.86 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 74 IGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVE--------VLLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 146 RGKMISMYQLMVTLGIVLAFLSDTAFSY--------SGNWRAMLGVLALPAVLLIILVIFLPNSprwlaqkgrhieaeev 217
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWRIPFLLGGVLAVVVLWLRRGLEET---------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 218 lrmlrdtsekarEELNEIRESLKLKQGGFQLFKNNrnvRRAVFLGMLLQAmqqftGMNIIMY----YAPRIFKMAGFTTT 293
Cdd:cd17367 199 ------------ESFEAIAESNEASAGTLRELRRH---PRELLLVVGLTA-----GGTLAFYtwttYLQKFLVNTAGFSK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 294 EEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALkIGFSVMaiGTLILGYCLMQFDNGTASSGL-SWVSVGmtmLCIAGY 372
Cdd:cd17367 259 GDATWITTAALLVFMLLQPLGGRLSDRIGRRPLL-LFFGIG--GTLATVPLLSALDHTDSPYTAfALVLVG---LVFLSG 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 373 AMSAAPVVWilcSEIQPLKCRDFGITCSTTtnwVSNMIIGAT---FLTLLDAIGAAGTFWLYTALNLAFVGVTFWLVPET 449
Cdd:cd17367 333 YTSINAVVK---AELFPTHVRALGVGLPYA---LAVAIFGGTapyVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPET 406
|
.
gi 1231036662 450 K 450
Cdd:cd17367 407 R 407
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-198 |
1.87e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 68.36 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 31 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQeWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFAT 110
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 111 SVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAM------LGVL 184
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCfyinlpIGGL 161
|
170
....*....|....
gi 1231036662 185 ALPAVLLIILVIFL 198
Cdd:cd17502 162 ALALLRTILLSSIF 175
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
37-229 |
5.09e-12 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 67.75 E-value: 5.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 37 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLL 116
Cdd:cd17439 12 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 117 ISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTAFSYSgNWRAMLG 182
Cdd:cd17439 92 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYAsamawaiiphygwsFQMGSAYQFH-SWRVFVL 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRDTSEKAR 229
Cdd:cd17439 171 VCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAK 217
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
42-200 |
6.50e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.83 E-value: 6.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 42 VIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVL 121
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 122 LGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLA-LPAVLLIILVIFLPN 200
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAiISGFCLILIFLFLPI 176
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-343 |
8.75e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.45 E-value: 8.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-----FLSDTAfsysgNWRAMLGV 183
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGptlggWLTDNL-----SWRWIFYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 184 LALPAVLLIILVIFLPnsprwlaqkgrhieaeevlrmlrdtsekareelneireslklkqggFQLFKnNRNVRRAVFLGM 263
Cdd:cd17503 156 NLPIGILALLLAPLLD----------------------------------------------LRLFK-DRNFTLGLLLSF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 264 LLQaMQQFTGMNIIMYYAPRIFkmaGFTTTEEQMIaTLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGY 343
Cdd:cd17503 189 LLG-LGLFGAMFLLPLYLQNVL---GYSAFESGLV-LAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
63-200 |
3.09e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 61.13 E-value: 3.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMAS 142
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1231036662 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPN 200
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
71-459 |
6.78e-11 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 64.36 E-value: 6.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 71 GAAIGALFNGWLSFRLGRKYS------LMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASEN 144
Cdd:TIGR00887 68 GTLAGQLFFGWLADKLGRKRVygmeliIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKK 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 145 VRGKMISMY-------QL---MVTLGIVLAF-------------LSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNS 201
Cdd:TIGR00887 148 WRGAMMAAVfamqgfgILagaIVALIVLAGFkhsleaaadeascTGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPET 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 202 PRWLAQKGRHIE--AEEVLRMLRDTSEKAREELNEIRESLK-LKQGGFQLFKNNRNVRRAVFLgmLLQAMQQFTgMNIIM 278
Cdd:TIGR00887 228 PRYTADVAKDVEqaASDMSAVLQVKIEAEPDEVEKASTAVEvPKASWSDFFTHFFKWRHGKHL--LGTAGSWFL-LDIAF 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 279 Y----YAPRIFKMAGFTTTEEQMIATLVVGLTFMFATFIA-----------VFTVDKAGRKPALKIGFSVMAIGTLILGY 343
Cdd:TIGR00887 305 YgvnlNQKVILSAIGYSPPAATNNAYEELYKTAVGNLIIAlagtvpgywvtVFLVDIIGRKPIQLMGFFILTVLFFVLGF 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 344 CLmqfdNGTASSGLswvsvgMTMLCIAGYAMSAAP--VVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLD- 420
Cdd:TIGR00887 385 AY----NHLSTHGF------LAIYVLAQFFANFGPnaTTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQh 454
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1231036662 421 ---------AIGAAGTFWLYTALNLAFVGVTFwLVPETKNVTLEHIER 459
Cdd:TIGR00887 455 gdptkgyptGIWMGHVLEIFALFMFLGILFTL-LIPETKGKSLEELSG 501
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-198 |
1.65e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 1.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 38 LDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLI 117
Cdd:cd17319 17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 118 SRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIF 197
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
.
gi 1231036662 198 L 198
Cdd:cd17319 177 Y 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
31-203 |
2.03e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.19 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 31 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFAT 110
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 111 SVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVL 190
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLAL 162
|
170
....*....|...
gi 1231036662 191 LIILVIFLPNSPR 203
Cdd:cd17477 163 VPLLLTRRAAPEI 175
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
66-212 |
2.05e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 59.14 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:PRK11043 48 SLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQK 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1231036662 146 RGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHI 212
Cdd:PRK11043 128 ANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQDAL 194
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-198 |
2.12e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.17 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 20 RMNMFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILF 99
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 100 VAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRA 179
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 1231036662 180 MLGVLALPAVLLIILVIFL 198
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-164 |
2.32e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.83 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 11 LPRALRDTRRMNMFVSVSAAVAGLLFGLdIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKY 90
Cdd:COG2814 196 LRGSLRELLRRPRLLLLLLLAFLLGFGF-FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 91 SLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 164
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-197 |
3.11e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.93 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 23 MFVSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAG 102
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 103 SLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLG 182
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170
....*....|....*
gi 1231036662 183 VLALPAVLLIILVIF 197
Cdd:TIGR00711 161 INVPIGIIVVVVAFF 175
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
46-198 |
6.00e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 57.78 E-value: 6.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1231036662 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
63-194 |
1.19e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMAS 142
Cdd:cd17473 237 LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVP 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1231036662 143 ENVRGKMISMYQLMVTLG-----IVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIIL 194
Cdd:cd17473 317 PELRGRAMGIVTSAFFLGqflspLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
63-210 |
2.08e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 56.48 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLyLSEMAS 142
Cdd:cd06179 36 WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVP 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAF--SYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGR 210
Cdd:cd06179 115 NKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFFFYHPPPRPQLHGS 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-198 |
2.50e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 2.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 30 AVAGLLFGLDIGVIAGALP-FITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:COG2211 234 LLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 A--TSVEVLLISRVLLGVAVGIASYTAPLYLSEMA-------SENVRGKMISMYQLMVTLGIVLA------------FLS 167
Cdd:COG2211 314 LgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAgalaglllalfgYVA 393
|
170 180 190
....*....|....*....|....*....|.
gi 1231036662 168 DTAFSYSGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:COG2211 394 GAAQSPSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-203 |
2.87e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 55.46 E-value: 2.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTL-GIVLAFLSDTAFSYSGNWRAMLGVLALPAVLL-IILVIFLPNSPR 203
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVsLICFLLLRDSPQ 176
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-198 |
4.06e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 27 VSAAVAGLLFGLDIGVIAGALPFITD-HFTLSNRLQEWVVSSMMLGAAIGALFNG-WLSFRLGRKYSLMVGAILFVAGSL 104
Cdd:cd17474 201 LTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 105 GSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVL 184
Cdd:cd17474 281 LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360
|
170
....*....|....
gi 1231036662 185 ALPAVLLIILVIFL 198
Cdd:cd17474 361 AAIALAAAVLLALL 374
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
26-199 |
4.44e-08 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 54.85 E-value: 4.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 26 SVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLG 105
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 106 SAFATSVEVLLISRVLLGVAVGIASYTAPLYLsEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLA 185
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSS 159
|
170
....*....|....
gi 1231036662 186 LPAVLLIILVIFLP 199
Cdd:cd17372 160 VPSSLLLVFYRWTP 173
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
46-198 |
7.24e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 54.15 E-value: 7.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1231036662 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFF 165
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
34-198 |
7.74e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.25 E-value: 7.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 34 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVE 113
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 114 VLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLII 193
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAI 165
|
....*
gi 1231036662 194 LVIFL 198
Cdd:cd17333 166 LILLT 170
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-198 |
2.48e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.58 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 28 SAAVAGLLFGLdigviagalpfitdhftlsnrlqewvvssMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSA 107
Cdd:cd17325 233 SPAQIGLLFGA-----------------------------QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 108 FATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALP 187
Cdd:cd17325 284 LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363
|
170
....*....|.
gi 1231036662 188 AVLLIILVIFL 198
Cdd:cd17325 364 LLLAAVLFLLL 374
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
4-218 |
4.42e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 52.36 E-value: 4.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 4 LSNDSVALPRAL-RDTRRMNMFVSVSAAVAGLLFGLDIGviAGALPFITDHFTLSNRlQEWVVSSMMLGAAIGALFNGWL 82
Cdd:pfam06609 25 LATSAAELPDGYyRSPRIIASFAAFSLNVCATYFVLQAS--ASALPNILQDIGQSEN-QGLFSTLWTMGQAVSILMMGRL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 83 SFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASyTAPLYLSEMASENVR--GKMISMYQLMVTLG 160
Cdd:pfam06609 102 TDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAG-ASPLFIGELMSNKTKflGLLIVSAPTIAMNG 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1231036662 161 IVLAFlsDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVL 218
Cdd:pfam06609 181 AGPYF--GQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYHPPSFAQLHGKKARKRDEL 236
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
66-342 |
4.47e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.83 E-value: 4.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIG------ALFN---GWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLG----VAVGIAsyt 132
Cdd:cd17472 30 TPTLIGLALGiygltqAIFQipfGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGsgaiSSVVMA--- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 133 aplYLSEMASENVRGKMISMyqlmvtLGIVLAFLSDTAFSYSGNWRAMLGV-------LALPAVLLIILVIFLPNSPRwl 205
Cdd:cd17472 107 ---LLADLTREENRTKAMAL------IGASIGIAFAISMVLGPLLAAHLGVsglflitAILSLVSLLILLFFVPDPPK-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 206 aqkgrhieaeevlrmlrdtsekareeLNEIRESLKLKqggFQLFKNNRNVRRAVFLGMLLQAMqqftgMNIIMYYAPRIF 285
Cdd:cd17472 176 --------------------------IVQISEKEKKK---LKKLLKNKRLLRLDFSIFILHFV-----LMAFFYILPLLL 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1231036662 286 KMAGFTTTEEQMIATLVVGLTFmFATFIAVFTVDKAGR-KPALKIGFSVMAIGTLILG 342
Cdd:cd17472 222 TQLGGGKGQLWKVYLPAILIGF-ILMVPFVIYAEKKGKmKQVFVSSILLIAVGFLLLL 278
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
26-223 |
6.68e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.47 E-value: 6.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 26 SVSAAVAGLLFGLDIGVIAgalPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLG 105
Cdd:cd17475 1 ATLAQAAASLVAQGIPALA---PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 106 SAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLA 185
Cdd:cd17475 78 MALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1231036662 186 LPAVLL-IILVIFLPNSPRWLAQKGR-HIEAEEVLRMLRD 223
Cdd:cd17475 158 LVSILAaVLFWLFYREPPAASAATESaSTLLRSLKEVLRN 197
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
59-205 |
7.31e-07 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 51.35 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 59 RLQEW----VVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAP 134
Cdd:cd17441 30 RLPSWqvalLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVT 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1231036662 135 LYlSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWL 205
Cdd:cd17441 110 LY-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYW 179
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
74-449 |
8.65e-07 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 51.22 E-value: 8.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 74 IGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVE--------VLLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 146 RGKMISM----YQLMVTLGIVLAFLSDTAFSY----SGNWRA--MLGVLALPAVLLIILVifLPNSPRWLAQKgRHIEAE 215
Cdd:cd17368 135 RGFYTSWqsasQQVAIVAGALVGYLLSLTLTAealaEWGWRIpfFIGLLIIPLGLWLRRS--LEETEAFLERK-ARPTRR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 216 EVLRMLRdtsekareelneireslklkqggfqlfknnrNVRRAVFLGMLLQAMQQFTgMNIIMYYAPRIFKMAGFTTTEE 295
Cdd:cd17368 212 ELFALLA-------------------------------NNRRIILLGMLLVAGSTVT-FYFTTVYTPTYAKTVLGLSARD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 296 QMIATLVVGLTFMFATFIAVFTVDKAGRKPALkigfSVMAIGTLILGYCLMQFDNGTASSGlswVSVGMTMLCIAGYAMS 375
Cdd:cd17368 260 SFLVTLLAGVANFIWAPLGGALSDRIGRRPVL----LVITLAALVTLYPVFAWLTAAPSFG---RLLLVLLVLSFFFGMY 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 376 AAPVVwILCSEIQPLKCRDfgiTCSTTTNWVSNMIIG------ATFLTLLDAIGAAGTFWLYTALNLAFVGVtfWLVPET 449
Cdd:cd17368 333 GGAMV-VALVELFPVRVRS---TGFSLVYALAVAIFGgfaqfiVTWLIELTGSPLAPAWYLMGAALLGLLAT--LMLRET 406
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-203 |
1.00e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.65 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 36 FGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFAT-SVEV 114
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 115 LLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLG-IVLAFLSDTAFSYSGNWRAMLGVLALPAVLLII 193
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGgFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
170
....*....|
gi 1231036662 194 LVIFLPNSPR 203
Cdd:COG2223 378 LTLLLYRRPR 387
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
57-199 |
1.15e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 50.37 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 57 SNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAV-GIASYTAPL 135
Cdd:cd17374 33 SQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTLIL 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 136 yLSEMASENVRGKMISMYQLMVTLGIVLafLSDTAFSYSgNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17374 113 -GTEWTTPRHRALAITLTSCFFSIGQML--LAGLAYAIR-DWRLLQLVVSVPFFLFFLYSWWLP 172
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
28-209 |
1.34e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 50.47 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 28 SAAVAG-LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:PRK03893 23 SAAWLGyLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLAC 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 107 AFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGK----MISMYqlmvTLGIVLAFLSDTAFSYSGNWRAMLG 182
Cdd:PRK03893 103 GFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKasgfLISGF----SIGAVVAAQVYSLVVPVWGWRALFF 178
|
170 180
....*....|....*....|....*..
gi 1231036662 183 VLALPAVLLIILVIFLPNSPRWLAQKG 209
Cdd:PRK03893 179 IGILPIIFALWLRKNLPEAEDWKEKHA 205
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-164 |
1.81e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 27 VSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1231036662 107 AFATSVE---VLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 164
Cdd:pfam07690 283 LLLSLTLsslWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
80-223 |
2.25e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 49.82 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 80 GWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTL 159
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 160 GIVLAFLSDTAFSYSGNWRAMLGVLAlpAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLRD 223
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIA--VMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRN 213
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
71-199 |
3.98e-06 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 48.62 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 71 GAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMI 150
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAG 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1231036662 151 SMYQLMVTLGIvlAFLSDTAFsYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17377 131 SLGGLFFAVGI--AQYALLGY-FIRSWRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
70-199 |
4.26e-06 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 48.57 E-value: 4.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 70 LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAV-GIASYTAPLYLS--EMASENVR 146
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALtGFSIISMVLCVEwvDIEHRTVA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1231036662 147 GKMISmyqLMVTLGIVLafLSDTAFsYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17447 126 GVLIS---LFWTVGNML--LALVAY-LIRDWRWLILAVTLPCAPGIITWWWVP 172
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-203 |
6.16e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.32 E-value: 6.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 41 GVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGaILFVAGSLGS-AFATSVEVLLISR 119
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG-PLLTGLGLSLlGFAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 120 VLLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17478 92 ALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
....
gi 1231036662 200 NSPR 203
Cdd:cd17478 171 PLKK 174
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-341 |
8.62e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 8.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNrlqeWVVSSMMLGAAIGALFN----GWLS----FRLGRKYSLMVGAILFVAGSLGSAFAT------- 110
Cdd:COG2211 33 LLYFYTDVLGLSA----ALVGLILLVARLWDAITdpliGALSdrtrTRWGRRRPWILIGAIPLALSFVLLFTApdlsptg 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 111 SVEVLLISRVLLGVAVGIAS--YTAplYLSEMASE-NVRGKMISMYQLMVTLGIVLA------FLSDTAFSYSGNWRAML 181
Cdd:COG2211 109 KLIYALVTYLLLGLAYTLVNipYSA--LGAELTPDyEERTRLSSWRFAFAGLGGLLAsvlpppLVAAFGGDAALGYRLTA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 182 GVLALPAVLLIILVIFLpnsprwlaqkgrhieaeevlrmlrdtsekAREELNEIRESLKLKQGgFQLFKNNRNVRRaVFL 261
Cdd:COG2211 187 LIFAVLGLLAFLLTFFG-----------------------------TKERPVPEEEKVSLKES-LKALLKNRPFLL-LLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 262 GMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeeqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIL 341
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVG----LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-190 |
1.16e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 68 MMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRG 147
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1231036662 148 KMISMYQLMVTLGIVLA-----FLSD-----TAFSYSgnwrAMLGVLALPAVL 190
Cdd:cd17370 323 TAYGLFNTVVGIGWLLAsliagYLWDlispsAAFLFS----AVLALIALLLLL 371
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
66-198 |
1.72e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 46.94 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:PRK10473 45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1231036662 146 RGKMISMYQ----LMVTLGIVLAFLSDTAFSysgnWRAMLGVLALPAVLLIILVIFL 198
Cdd:PRK10473 125 RAKVLSLLNgitcIIPVLAPVLGHLIMLKFP----WQSLFYTMAAMGILVLLLSLFI 177
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
66-199 |
2.40e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 46.19 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 146 RGKMISMYQLMVTLGIVLafLSDTAFsYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLI--LPGIAY-FIPHWRWLQLAVTLPNFLFLLYYWFIP 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
47-223 |
2.72e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.07 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 47 LPFITDHFTLSNRLQEWVVSSMM----LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLL 122
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLalsaVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 123 GVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL-AFLSDTAFSYSGNWRAMLGVLALpAVLLIILVIFLPNS 201
Cdd:cd17329 99 GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIgPLLGGLLLLYSFRLLFLAAAVLF-LLAALVLLFLLPET 177
|
170 180
....*....|....*....|..
gi 1231036662 202 PRWLAQKGRHIEAEEVLRMLRD 223
Cdd:cd17329 178 RPKRRAAEKTEILRGYKIVLRD 199
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-196 |
3.04e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 25 VSVSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSL 104
Cdd:cd17324 200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 105 GSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVL-AFLSDTAFSYSGnWRAMLGV 183
Cdd:cd17324 280 LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALgAALGGLVLDHGG-WAGVGWV 357
|
170
....*....|...
gi 1231036662 184 LALPAVLLIILVI 196
Cdd:cd17324 358 GAALLLLALLLAL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
46-205 |
3.84e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.73 E-value: 3.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:cd17312 25 AKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 126 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWR-AMLGVLALPAVLLIILVIFLPNSPRW 204
Cdd:cd17312 105 QSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRaAFLVPGIVGLVVAIILFFFLRDSPPY 184
|
.
gi 1231036662 205 L 205
Cdd:cd17312 185 V 185
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-198 |
5.26e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 5.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 85 RLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 164
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341
|
90 100 110
....*....|....*....|....*....|....
gi 1231036662 165 FLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
74-379 |
6.65e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.21 E-value: 6.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 74 IGALFNGWLSFRLGRKYSLMV-----GAILFVAGSLGS-----AFATSVEVLLisRVLLGVAVGIASYTAPLYLSEMASE 143
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLtlllmGIATFLIGLLPTyaqigILAPILLVLL--RLLQGLALGGEWGGAVLMAVEHAPP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 144 NVRGKMISMYQLMVTLGIVLA---------FLSDTAFSYSGnWRamlgvlaLPAVLLIILVIFlpnsprwlaqkG----R 210
Cdd:cd17369 137 KRRGFYGSFPQLGAPVGLLLAtgvflllsaLLSDEAFLSWG-WR-------IPFLLSAVLVAV-----------GlyirL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 211 HIEAEEVLRMLRDTSEKAREELNEIReslklkqggfqlfknnRNVRRAVFLGMLLQAMQQ---FTGMNIIMYYAPRIFKM 287
Cdd:cd17369 198 RLEETPVFRRAKEAGQVVRAPLVEVL----------------RRHWRALLLAIGLRLAENvlfYLFTTFALSYATQTLGV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 288 AGFTTTEEQMIATLVVGLTFMFATFIAvftvDKAGRKPALKIGfsvmAIGTLILGYCLMQFDNGTASSGLSWVSVGMTML 367
Cdd:cd17369 262 DRSTVLLAVLIASVVAAITIPLFGWLS----DRVGRRPVYLAG----ALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGV 333
|
330
....*....|..
gi 1231036662 368 ciaGYAMSAAPV 379
Cdd:cd17369 334 ---LHGMMYGPQ 342
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
27-197 |
6.66e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.95 E-value: 6.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 27 VSAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 107 AFATSVEVLLISRVLLGVAVGIasyTAPLYLSEMASENVRGKM----ISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLG 182
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAF---LLPNAMALLGRTYPPGPRknivFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFW 157
|
170
....*....|....*
gi 1231036662 183 VLALPAVLLIILVIF 197
Cdd:cd17476 158 FLAILAAIVAVAAIF 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
70-198 |
7.98e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 7.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 70 LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKM 149
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1231036662 150 ISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
70-199 |
8.21e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.76 E-value: 8.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 70 LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGI---ASYTaplYLSEMASENVR 146
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGiqaLSRS---LLARLIPPGRE 361
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 147 GKMISMYQLMVTLGIVLA-FLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:COG2270 362 AEFFGLYALSGKAASFLGpLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVK 415
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
55-377 |
9.03e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 9.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 55 TLSNRLQEWVVSSMMLGAAIGA---------LFNGWLSFRLG-RKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGV 124
Cdd:cd17490 18 FLSPYAESLGASLSMIGIILGAygisqmllrIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 125 AVGI-ASYTApLYLSEMASENVrGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPR 203
Cdd:cd17490 98 AAATwVSFTV-LYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 204 wlaqkgrhieaeevlrmlrdTSEKAREELNEIRESLKlkqggfqlfknNRNVRRAVFLGMLlqamQQFTGMNIIMYYAPR 283
Cdd:cd17490 176 --------------------EKKPVLTELKELLSVLK-----------DKKLLFFSLLAIL----QQMITFSTTFGFTPL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 284 IFKMAGFTTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGY-------CLMQFDNGTASSG 356
Cdd:cd17490 221 IAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFapnltllYLLQALNGFGTGI 300
|
330 340
....*....|....*....|.
gi 1231036662 357 LSWVSVGMTMLCIAGYAMSAA 377
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRSTA 321
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-204 |
1.11e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.18 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPF---ITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLG 105
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFiipIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 106 SAFATSVEVLLISRVLLGVA-VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLG-IVLAFLSDTAFSYSGnWRAMLGV 183
Cdd:cd17355 85 LALATSLWQLYLLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALIEAFG-WRTALLV 163
|
170 180
....*....|....*....|.
gi 1231036662 184 LALPAVLLIILVIFLPNSPRW 204
Cdd:cd17355 164 LALLALLVLVPVLLLLRRRPA 184
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
28-208 |
1.23e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 44.15 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 28 SAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSA 107
Cdd:PRK12307 22 SAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 108 FATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALP 187
Cdd:PRK12307 102 LASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLP 181
|
170 180
....*....|....*....|.
gi 1231036662 188 AVLLIILVIFLPNSPRWLAQK 208
Cdd:PRK12307 182 VLLVIYIRARAPESKEWEEAK 202
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
66-199 |
1.26e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 43.89 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIGALFNGWLS-FRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASEN 144
Cdd:cd17378 40 SSFFVGCLIGSGVLGHLAdSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1231036662 145 VRGKMISMYQLMVTLGIvlAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17378 120 WRGQVGMSTFFFFVLGF--MSLPGIAYLNGSSWRVLYFWTSIPALIYCILVYLFA 172
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-198 |
1.84e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVG-AILFVAGSLGSAFATSvEVLLISRVLLGVAVGIASYTAPLYLSEMA 141
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLlGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1231036662 142 -SENVRGKMISMyqlMVTLGIVLAFLSDTAFSY----SGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:COG2807 333 rTPAEAAALSGM---AQSVGYLLAALGPLLVGAlhdaTGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
63-205 |
1.99e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASyTAPLYLSEMAS 142
Cdd:cd17330 38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS-VAQAYIADITD 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1231036662 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWL 205
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRL 179
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
63-175 |
2.89e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 42.97 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLG-RKYSLMVGAILFVAGSLGSAFATSVE-----VLLISRVLLGVAVGIASYTAPlY 136
Cdd:cd17326 40 WVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPsnrkyVMLVARFLIGVGAGNVAVLRA-Y 118
|
90 100 110
....*....|....*....|....*....|....*....
gi 1231036662 137 LSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSG 175
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIG 157
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
74-338 |
3.09e-04 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 43.01 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 74 IGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVL--------LISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:PRK15075 71 LGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIglaapllvLLGRLLQGFSAGVELGGVSVYLAEIATPGR 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 146 RGKMISM----YQLMV----TLGIVL-AFLSDTAFSYSGnWRamlgvlaLPAVL--LIILVIFLpnsprwlaqkgrhiea 214
Cdd:PRK15075 151 KGFYTSWqsasQQVAVvfaaLLGYLLnQWLSPAQMAEWG-WR-------IPFLIgcLIVPFIFL---------------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 215 eeVLRMLRDTSE----KAREELNEIRESLKlkqggfqlfknnRNVRRaVFLGMLLQAMQQfTGMNIIMYYAPRIFKMAGF 290
Cdd:PRK15075 207 --IRRSLEETEEflarKHRPSMREIFRSLA------------ANWRI-VLAGMLMVAMTT-VSFYLITVYTPTFGKTVLH 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1231036662 291 TTTEEQMIATLVVGLTFMFATFIAVFTVDKAGRKPALkIGFSVMAIGT 338
Cdd:PRK15075 271 LSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVL-IAFTVLAILT 317
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
34-222 |
3.75e-04 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 42.72 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 34 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVE 113
Cdd:PRK03633 16 LLLTLAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVGFW 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 114 VLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSysgnwRAMLGVlaLPAVLLII 193
Cdd:PRK03633 96 SWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVS-----TELMSV--LPWVTGLV 168
|
170 180 190
....*....|....*....|....*....|
gi 1231036662 194 LVIFLPNS-PRWLAQKGRHIEAEEVLRMLR 222
Cdd:PRK03633 169 LAAILPLLfTRILNQQAENHDSTSIWPMLK 198
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
69-341 |
3.86e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 69 MLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISR-VLLGVAVGIAsYTAPLYLSEMASENVRG 147
Cdd:cd17353 48 IVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGIG-YITPVSTAVKWFPDKRG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 148 kMISMyqlMVTLG-----IVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLPNSPRWLAQKGRHIEAEEVLRMLR 222
Cdd:cd17353 127 -LATG---IVIAGfglgsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 223 DtsekareelneireslklkqggfqlFKNNRNVRRAVFLGMLLQ-AMQQFTGMNIIMYYAPRIFKMAGFTTteeqMIATL 301
Cdd:cd17353 203 D-------------------------YTPREMLRTPTFWLLWLMfFLNATAGLMLIGQAKPIGQEFAGLDA----GIAAL 253
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1231036662 302 VVGLTFMFATF---IAVFTVDKAGRKPALKIGFSVMAIGTLIL 341
Cdd:cd17353 254 AVSILSIFNGGgrpFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
29-191 |
4.71e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLG---RKYSLMVGAILFVAGSLG 105
Cdd:cd17475 204 AIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 106 SAFATSVEVLLISRVLLGVAVGIASYTAPLYL---SEMASENVRGKMISMYQLMVTLGIVLA-----FLSDTAFSYSGNW 177
Cdd:cd17475 284 LSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLtlvAESAGPEQAGTALGLANTINFIGIAIGpplfgLLVDATHSYAPAW 363
|
170
....*....|....
gi 1231036662 178 RAMLGVLALPAVLL 191
Cdd:cd17475 364 LALALLLVLAALLL 377
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
63-202 |
6.78e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 41.80 E-value: 6.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIgalfngwLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVllGVAVGIA---SYTAPLYLsE 139
Cdd:PRK03545 55 WVVALMSLPLML-------LTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRI--GIAFAHAifwSITASLAI-R 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 140 MASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPA-VLLIILVIFLPNSP 202
Cdd:PRK03545 125 VAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGAlITLLLLIKLLPLLP 188
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
63-199 |
6.82e-04 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 41.63 E-value: 6.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMAS 142
Cdd:cd17410 38 LLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGGLGIAIIQALVPGLIKRRFP 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1231036662 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17410 118 ARVPLAMGLYSASLMAGGGLAASLSPRLAQHSAGWQLGLGIWAVPALVALVLWWRQP 174
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
29-127 |
7.02e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.86 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLF--GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGS 106
Cdd:cd17393 2 LAVAAFFFinGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100
....*....|....*....|.
gi 1231036662 107 AFATSVEVLLISRVLLGVAVG 127
Cdd:cd17393 82 GLAPSVPALALALFLFGAANG 102
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
50-197 |
7.26e-04 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 41.84 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 50 ITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIA 129
Cdd:PRK03699 33 IAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVSGIT 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1231036662 130 SYTAPLYLSEMASENVRGKMismyqLMVT------LGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIF 197
Cdd:PRK03699 113 MSIGTFLITHVYEGKQRGSR-----LLFTdsffsmAGMIFPIIAAYLLARSIEWYWVYACIGLVYVAIFILTLF 181
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
46-197 |
1.42e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 40.66 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1231036662 126 VGIA---SYTAPLYLSEMASENVRGKMISMYQLMVTL-GIVLAFLSDTAFsysgNWRAMLGVLALPAVLLIILVIF 197
Cdd:PRK11652 110 TGVGgvmARTLPRDLYEGTQLRHANSLLNMGILVSPLlAPLIGGLLTTLF----GWRACYLFLLLLGAGVTFSMAR 181
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
74-434 |
1.72e-03 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 40.56 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 74 IGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEV--------LLISRVLLGVAVGIASYTAPLYLSEMASENV 145
Cdd:PRK10406 78 IGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETigtwapalLLLARLFQGLSVGGEYGTSATYMSEVAVEGR 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 146 RGKMISMY-------QLMVTLGIVL--AFLSDTAFSYSGnWRAmlgVLALPAVLLIILViflpnsprWLAqkgrhieaee 216
Cdd:PRK10406 158 KGFYASFQyvtliggQLLALLVVVVlqQTLEDAELREWG-WRI---PFALGAVLAVVAL--------WLR---------- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 217 vlRMLRDTSEKareELNEIRESLKLKqggfQLFKNnrnvRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEEQ 296
Cdd:PRK10406 216 --RQLDETSQQ---ETRALKEAGSLK----GLWRN----RRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVAS 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 297 MIATLVVGLTFMFATFIAVFTvDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNGTASSGLSwvsvgMTMLCIAGYAMSa 376
Cdd:PRK10406 283 GIMTAALFVFMLIQPLIGALS-DKIGRRTSMLCFGSLAALFTVPILSALQNVSSPYAAFGLV-----MCALLIVSFYTS- 355
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1231036662 377 apVVWILCSEIQPLKCRDFGITCSTTtnwVSNMIIG--ATFLTL-LDAIGAAGTFWLYTAL 434
Cdd:PRK10406 356 --ISGILKAEMFPAQVRALGVGLSYA---VANALFGgsAEYVALsLKSIGMETAFFWYVTL 411
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
73-198 |
1.90e-03 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 40.34 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 73 AIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFAT------SVEVLLISRVLLGVAVGIASY--TAPLYLSEMASEN 144
Cdd:cd17386 44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVyfttvpSVWWFYLSAIPLALFGGFTAFlsASFAYISDISSEK 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1231036662 145 VRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAML---GVLALPAVLLIILVIFL 198
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFsisAALLLIALLYILFFLTL 180
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
64-197 |
1.93e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 64 VVSSMMLGAAIGALFN---GWLSFRLGRKYSLMVGAILFVAGSLG--SAFATSVEVLLISRVLLGVAVGIASYTAPL--Y 136
Cdd:cd17369 266 VLLAVLIASVVAAITIplfGWLSDRVGRRPVYLAGALLAALFAFPffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQaaF 345
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1231036662 137 LSEMASENVRGKMISM-YQLMVTL-GIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVIF 197
Cdd:cd17369 346 LAELFPTRVRYTGASLgYQLGAILgGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
63-415 |
2.09e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 40.31 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 63 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMAS 142
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 143 ENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGN------WRAML---GVLALPAVLLIILviFLPNSP---RWLAQKGR 210
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGvgglagWRWLFiieGLITIIIGLVIFF--WLPDNPskaWFLTEEEK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 211 HIEAEEVLRMLRDTSEKaREELNEIRESLKlkqggfqlfknnrnvrRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGF 290
Cdd:cd17327 203 ELAVERLRANQTGKGDQ-KFKWKQIKEAFK----------------DPRTWLLFLFFFCSQITNNGISNFLPLILKSLGF 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 291 TTTEEQMIATLVVGLTFMFATFIAVFTvDKAGRKPALKIGFSVMAigtlILGYCLMqfdngtASSGLSWVSVGMTMLCIA 370
Cdd:cd17327 266 YSLQTNLLSVPIGALGAVSLLIAALLS-DRFKKRGLFAIFACVLA----LVGSIIL------LAAPNPPGAYFAAYILGG 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1231036662 371 GYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATF 415
Cdd:cd17327 335 GSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIF 379
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
2-198 |
2.99e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.98 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 2 AFLSNDSVALPRALRDTRRMNMFVSVsaAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGW 81
Cdd:pfam13347 204 DTGQKEAGSLLDMLKEVFRNRAFLIL--LASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 82 LSFRLGRKYSLMVGAILFVAGSLGSAF--ATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASEN-------VRGKMISM 152
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIAGFALALLlgPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGelrtgkrREGTFFAM 361
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1231036662 153 YQLM----VTLGIVLAFLSDTAFSY---------SGNWRAMLGVLALPAVLLIILVIFL 198
Cdd:pfam13347 362 WSFIsklaTGVGLGVSGLLLSAFGYnagdsvqspQAVTAIRLLYAVLPAVLFLVALLLL 420
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
29-198 |
3.17e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 29 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAF 108
Cdd:cd17477 193 ALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 109 ATSVEVLLIsrVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWramLGVLALPA 188
Cdd:cd17477 273 VPGLPLALL--VLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDA---FGPHGLFL 347
|
170
....*....|
gi 1231036662 189 VLLIILVIFL 198
Cdd:cd17477 348 FLAAVALLFL 357
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
69-192 |
3.88e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 39.37 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 69 MLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRgK 148
Cdd:cd17445 46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQR-L 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1231036662 149 MISMYQLMVTLGIVLAFLSdTAFSySGNWRAMLGVLALPAVLLI 192
Cdd:cd17445 125 LVAMAGGLTMVGGHFLLLG-LALG-CGSWRVLQGTITAPLSLFL 166
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
57-125 |
5.83e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.94 E-value: 5.83e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1231036662 57 SNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVA 125
Cdd:cd17446 31 HRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMA 99
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
34-152 |
6.04e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 6.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 34 LLFGLDIGVIAGALP-FITDHFTLSNRLQEWVVS-SMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATS 111
Cdd:cd17331 217 LLSGLPIGMFQSMFSlVAMDFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTT 296
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1231036662 112 VEVLLISRVLLGVAVGIASYTAPLYLSEMASENVRGKMISM 152
Cdd:cd17331 297 VWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGL 337
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
80-163 |
6.62e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 6.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 80 GWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVaVGIASYTAPLYLSEMASENVRGKMISMYQLMVTL 159
Cdd:cd17390 52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSL 130
|
....
gi 1231036662 160 GIVL 163
Cdd:cd17390 131 GFIL 134
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
66-199 |
6.82e-03 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 38.60 E-value: 6.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 66 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAvGIASYTAPLYL-SEMASEN 144
Cdd:cd17376 42 SLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMG-QISNYVVAFVLgTEILGKS 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1231036662 145 VRgkmISMYQLMVTLGIVLAFLSDTAFSYS-GNWRAMLGVLALPAVLLIILVIFLP 199
Cdd:cd17376 121 VR---ILFSTLGVCIFYAIGYMLLPLFAYFiRDWRMLLLALTLPGVLCVPLWWFIP 173
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
34-195 |
6.89e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.48 E-value: 6.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 34 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVE 113
Cdd:cd17396 10 FVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 114 VLLISRVLLGVA---VGIASYTA--PLYLSEMASENVRGK-MISMYQLMvtLGIVLAFLSDTAFSYSGNWRAMLGVLALP 187
Cdd:cd17396 90 IAYVFALLAGAAnsfLDTGTYPAlmEAFPKASGSANILVKaFVSFGQFL--LPFIIAFLAANNLWYGWSFIVPAAVLVLN 167
|
....*...
gi 1231036662 188 AVLLIILV 195
Cdd:cd17396 168 ALLLLKLS 175
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
67-199 |
7.14e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 38.79 E-value: 7.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 67 SMMLGAAIGALFN----------GWLSFRLGRKYSLMVGAILFVAGSLGSAFATSVEVLLISRVLLGVAVGIASYTAPLy 136
Cdd:cd17389 62 SVLFGGLIGSLFSllqflsspitGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAI- 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 137 LSEMASENVRGKMISMYQLMVTLGIVL-----AFLSDTAFSYSGNWRAMLGVLAL--PAVLLIILVIFLP 199
Cdd:cd17389 141 VADVTSPKKRSKGMALIGVAFSLGFIIgpmigAYFASFTRSLGEVFFSMPALFALvlALADLLFIFFFLP 210
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
46-129 |
9.54e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 9.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231036662 46 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFvagSLGSAF-----ATSVEVLLISRV 120
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALW---SLATLLtpllaYSSLPLLILSRI 97
|
....*....
gi 1231036662 121 LLGVAVGIA 129
Cdd:cd17380 98 LLGLGEGVH 106
|
|
| |
