Conserved Protein Domain Family
MFS_GLUT6_8_Class3_like

?
cd17358: MFS_GLUT6_8_Class3_like 
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily
This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
?
PSSM-Id: 340916
Aligned: 40 rows
Threshold Bit Score: 366.515
Created: 16-Mar-2016
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
chemical
Feature 1:chemical substrate binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1                     #   #                                                              
Q9UGQ3        39 FLATFAAVLGNFSFGYALVYTSPVIPAL.[ 9].LTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAA 121 human
NP_995620     11 YLAAISVNIISISYGAFCGWPSSSFLEL.[11].LTPTDQGWVASNICLGGLVGTFLFTWLADRIGRKLCLMWMALPNLL 95  fruit fly
NP_608766     26 FLVTLLLNIATFSHGLGVGWMSPVMRDL.[10].VLVSQVSWIGSLVGIGSVMGNLIAGLLMDRIGRKMVLFFIAIPYTT 109 fruit fly
NP_608761     19 LLVSLSATLITFCHGIALGWLSPMLPKL.[11].IDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKVSIYALAVPHTC 103 fruit fly
NP_608767     21 LLTTLLINVISISHGIGIGWLSPTLRKL.[10].KSEFEISWVGSMLGMGSVTGNILIGCLLGRLGSKRCLLLIAIPHSC 104 fruit fly
NP_726368     59 ILATCAVLLLSAGCGMPIGFSAILLPQL.[ 9].IDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLL 141 fruit fly
NP_001097067  18 LLATVIVNIITFGHGVGVGWLSPTLTKI.[10].VNLAQISWLGSMLGLDSLCGNLTIAMLIERAGRKFCLYLMAGPYAC 101 fruit fly
NP_608764     14 SVATALGNILCFNFGLMFGITPAHMTLY.[11].TDPAGTAWLTGYLFLSAALGALVSGFLALKIGPKSVLLCSGLLQIS 98  fruit fly
NP_001334690  20 FIATMTVHIMTLTHGIAVGWLSPSLRLL.[10].LTITQASWVGSLIGLGSLTGNIIFGLLLDRLGRKVCMYFLAIPNMI 103 fruit fly
NP_611060     46 VIAVILANVGVFSTGMTLAMPTATLHQL.[ 8].LNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIIL 127 fruit fly

Feature 1                                                             #  ##  #                   
Q9UGQ3       122 GYALMAGA.[ 4].MLLLGRTLTGFAGGLTAACIPVYVSE.[6].RGALGATPQLMAVFGSLSLYALGLLL.[1].WRWL 196 human
NP_995620     96 GWVIIPFA.[ 4].HLIIARFIGGAAGGGCFTVIPIYIAE.[6].RGILGVFLVLTCNFGLVLAFVLGYYF.[1].YAQV 170 fruit fly
NP_608766    110 FWCLIYFV.[ 4].FLYIGRLMAGITGGACYVVLPTFISE.[6].RGRLGSIILLSVNTGVLAGYIVSTRV.[1].YFTS 184 fruit fly
NP_608761    104 IWFLFYFA.[ 4].WLYVARVFAGLTGGGMFVVLPIFIGE.[6].RGRLCSFFTLTMNTGIMVGFVVSSHI.[1].YHVI 178 fruit fly
NP_608767    105 FWILVYFA.[ 4].YLYVGRLLAGICGGGMYIVHPILLSE.[6].RGTFSAMVMLSVNVGILVGYIIGTHL.[2].YSIP 180 fruit fly
NP_726368    142 GWSTLAIA.[ 4].VVIFARFLCGFATGILGGPGQVYIAE.[6].RSLLIGAPYVAYSSGILMVYSLGSMM.[1].WRSV 216 fruit fly
NP_001097067 102 IWILIYCA.[ 4].YLYAARFLCGFTGGAGYLVVPIFISE.[6].RGALTSMVMLSVDLGILAGYILSTYL.[1].YHVV 176 fruit fly
NP_608764     99 GWACIHFG.[ 4].HIYASRLFAGVASGAAFVVLPIFINE.[7].AARLTFTIELWRTLGILIGFVLGFYV.[1].YAFV 174 fruit fly
NP_001334690 104 YWILIYSA.[ 4].YLYAGRFLAGMSGGGCYVVLPIFIAE.[6].RGALSSMAMMYVSIGMMVGFTLASYL.[1].YYLM 178 fruit fly
NP_611060    128 AWILLATP.[10].QLIVSRFMLGVGMGLASAPPGVYAAE.[6].RGSLILGTSISVAGGITILYGIGYCI.[3].FRLI 210 fruit fly

Feature 1                                                                               ##   ##  
Q9UGQ3       197 AVAGEAPVLIMILLLSFMPNSPRFL.[3].GRDEEALRALAWLRGTDVDVHWE.[26].RPITVALLMRLLQQLTGITPI 294 human
NP_995620    171 SWIVSSLSFVFVGCFWFMPETPQHL.[3].NKIEEAEHSLRYYRNIKSNPAKE.[43].KAFLIGLGLISFNQLCGCFAM 285 fruit fly
NP_608766    185 PPFIIGLPVCYFICNFLIPETPHHL.[3].GKFEAAKRSFMFYKNIRKNDIKA.[33].KAYASAAVLLISNQFSASFCV 289 fruit fly
NP_608761    179 PCAVVGLPVLYVLLATRYPEPPQQL.[3].KREEEAEKSLRYYRRCDGPNVSK.[40].KALATGLVLMVANIFTGTFAF 290 fruit fly
NP_608767    181 LMVLILPLWYLISVLLFIKESPMHL.[3].GKYSAAERSFRYYKNIKDSDNIH.[37].KAYGPALVLLIANQFSGLFTM 289 fruit fly
NP_726368    217 AWCANVLPLLSMVSISFIPETPAWL.[3].GHEKRALQALSFLRGSEISAQKE.[31].KPLVIVIVFSLLQMFSGTFIV 319 fruit fly
NP_001097067 177 PFLAIILPVAYFIANIMLPETAPYL.[3].SQLAAAENSFRYYRNQRSAICEQ.[35].KGFAASIVLSLGYQFSGVFSF 283 fruit fly
NP_608764    175 NIVGCAVSFVFTMTFPFVQESPHYY.[3].NNMASLEKSLRWYRGIRDIDDRE.[33].RLTFVSFLLTVCAKLSGVFVE 279 fruit fly
NP_001334690 179 PCIIVALPVVFMLSVIGLSETPQYL.[3].GRDDQAEKSFYFYKNLTPPTSSD.[40].KIFGLIFVLIICNQLSGSFAI 290 fruit fly
NP_611060    211 ALICCGYQLVALLCVLPLPESHCWL.[3].KRVTEAKRSLNYFRGFNKSDEIT.[36].KPLVILMSLFAFQQLTGIFVV 318 fruit fly

Feature 1        ##                      #                                                       
Q9UGQ3       295 LVYLQSIF.[8].PKDDAAIVGAVRLLSVLIAALTMDL.[1].GRKVLLFVSAAIMFAANLTLG.[38].LVPLLATMLF 405 human
NP_995620    286 LNYTAVIF.[8].PTVAAIIVGVIQLMGTYASTVLVER.[1].GRKILLLVSAVGIGLGQSAMG.[16].WVPIAGFSFM 374 fruit fly
NP_608766    290 TTYLADVF.[8].LGMCTIIIGVLQIVGNYVTTLLCDK.[1].GRRILMLTSTLGASVCLTAFG.[15].WLPLVILSCF 377 fruit fly
NP_608761    291 NNYMSNIF.[8].PNTNTIIIGAVQILGTLASIYLVDR.[1].GRKILLIVSCAGSGIGTSAFG.[18].WLPVTLMAFI 381 fruit fly
NP_608767    290 VNYMSDIF.[8].PDTCTIIIGAVQILGTYVTTLLCDI.[1].GRKLLMLVSTGGVAISLTAFG.[15].WIPLLLMSMD 377 fruit fly
NP_726368    320 IFYAVDMI.[8].SKQAAIATAVVRVICCMVFCVVLIF.[1].RRRRIMIVSGIGSGLFCLVLS.[15].VFVGAGCLLG 407 fruit fly
NP_001097067 284 INYMSDIF.[8].VNTATIIIGLVQIVGVYTSTILVDI.[1].GRRVLMLISTMGVGIGCIAFG.[15].WLPLVLMIII 371 fruit fly
NP_608764    280 LNYAADFL.[6].TETNYVVLASAQCAGALLARLVGPR.[1].PRKLLLCLSSLFAAAAVIALA.[17].YLPIILLAIQ 367 fruit fly
NP_001334690 291 FNYTSHIF.[8].PNTSTIVVGAAQLVGIFSAVVLVDR.[1].GRRVLLLTSMGGMGLGELAIA.[15].WLPLVIMCLV 378 fruit fly
NP_611060    319 IVFAVQIS.[8].PFMCAVLIGLARLITTCPMGYILEW.[1].GRRRAGIISTLGMSVCMFLLA.[12].YLPVVAIVGF 403 fruit fly

Feature 1           ##  ##   #                          ##  #                                    
Q9UGQ3       406 IMGYAVGWGPITWLLMSEVLP.[1].RARGVASGLCVLASWLTAFVLTKSF.[6].FGLQVPFFFFAAICLVSLVFTGCC 482 human
NP_995620    375 LFLAAVGLLSLPFLVVSEIMP.[1].KIRSTAIMILMSTLWLISTCAVKLM.[6].LGMHGTVFMFASLSFLAAIFIAIF 451 fruit fly
NP_608766    378 VFLCNIGLVGCLFVVLVELFP.[1].KIRSVSVSTFVVILSSTVFLTLKIF.[6].WGTSVTMWSCSGITFFSFLYFCFF 454 fruit fly
NP_608761    382 IFIANVGVISVTMVVLVEILP.[1].KIRAVATSFCLGCLSFFAFASLKTF.[6].LGLAATMWFCAAVSVICLFYVVVC 458 fruit fly
NP_608767    378 IFLGNIGLVGCFFVSLVEMFP.[1].KIRAKAASMAIVVCSIFVFLMLNIF.[6].WGISATMWSCAGVTALSSLYFTYF 454 fruit fly
NP_726368    408 YIIFNTALMVMPGIMIGELFP.[1].RIRGRTAGGVFASMNVALFIFAKKF.[6].LKMRGVFLVFGVSSFLLTAFMCLF 484 fruit fly
NP_001097067 372 CYVANIGLIGIFFLVLVELFP.[1].KIRSLATSLSVIFLSLLVFGTLKLF.[6].WGISFTMWFSAASALLTFFYFWLF 448 fruit fly
NP_608764    368 LALVSFGLYPLAAVVSSEVLP.[1].KLHDLLYSLASAVSWLLLFGMIEAF.[8].PGLLLYLWVFAGASIFVGLISLPL 446 fruit fly
NP_001334690 379 ACIASLGVIALIFIIIIELLP.[1].KIRSIGTSLSMATFSGFIFVALKIY.[6].QGLAATMFMSAGMCLFGFIVLGLF 455 fruit fly
NP_611060    404 IVLSTLGLYTLPFFMISELFP.[1].KVRGPASGLTVAVGMFISFVVLKTY.[6].LGMSNCFIIFGVMALFALIFVYLA 480 fruit fly

Feature 1                   
Q9UGQ3       483 VPETKGRSLEQ 493 human
NP_995620    452 VPETKGKSVDA 462 fruit fly
NP_608766    455 LEETNGKSLLA 465 fruit fly
NP_608761    459 LEETKGRSMYD 469 fruit fly
NP_608767    455 MKETKGKSMLD 465 fruit fly
NP_726368    485 QPETKGRSLEH 495 fruit fly
NP_001097067 449 LQETKGKSMIE 459 fruit fly
NP_608764    447 LPETRNRRPSA 457 fruit fly
NP_001334690 456 LPETKGKLMTH 466 fruit fly
NP_611060    481 LPETRRRTLLE 491 fruit fly

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap