3M1I


Conserved Protein Domain Family
CRM1_C
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smart01102: CRM1_C 
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CRM1 C terminal
CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.
Links
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Statistics
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PSSM-Id: 198170
Aligned: 21 rows
Threshold Bit Score: 186.424
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3M1I_C        685 QLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKA----RNLD-------------- 746  baker's yeast
XP_002130430  710 QLGRIYLDMLNVYKCLSENISSAIQQNGEGVMKQPLIRSMRTVKKETLKLISGWVSRA----TDPE-------------- 771  Ciona intesti...
BAE98975       39 QISLIFLDMLNVYRMYSELVSSSIANGGPYASRTSLVKLLRSVKREILKLIETFLDKA----ENQP-------------- 100  thale cress
XP_001653391  691 QLGRIYLDMLNVYKIMSENITQAIALNGLAINNQPLIKAMHVVKKETLTLISEWVSKS----NDSQ-------------- 752  yellow fever ...
NP_741567     719 QLGNIYSDLLSLYKILSEKVSRAVTTAGEEALKNPLVKTMRAVKREILILLSTFISKN----GDAK-------------- 780  nematode
XP_635133     700 QISKIYLDLLNVYRTYSDHISR-----NPNIYRETLGQAMRSVKKETLKLLETFIEKS----SDKQ-------------- 756  Dictyostelium...
CBH18487      686 emGIIIYDLQGLYRTFFSAQTALVADHGTDAMERQEARYLRLAKREILRIFECFVDNT----EECD-------------- 747  Trypanosoma b...
XP_001467796  690 emMMITQDLYGFYRMFSEAQVRAIADGGETALHRPEMRYVRLAKREILRIFERFVSHA----TQLK-------------- 751  Leishmania in...
NP_586330     739 QIFPKFFTIFDICNSIT-----LENKEGTAFNNAKAV------KAEIIELFATVIDS--------K-------------- 785  Encephalitozo...
XP_764741     770 QFNKIFSTLMVLYHLYSKYIQISVSTGGTQTIKHLAVNTLFLARRAIIHLSETYISNVpnklNQTNtqytglssnvnrsr 849  Theileria par...

3M1I_C        747 ----------------------------------------------------------------------------DVVK 750  baker's yeast
XP_002130430  772 ----------------------------------------------------------------------------MVAE 775  Ciona intesti...
BAE98975      101 ----------------------------------------------------------------------------HIGK 104  thale cress
XP_001653391  753 ----------------------------------------------------------------------------MVME 756  yellow fever ...
NP_741567     781 ----------------------------------------------------------------------------LILD 784  nematode
XP_635133     757 ----------------------------------------------------------------------------VIYS 760  Dictyostelium...
CBH18487      748 ----------------------------------------------------------------------------FVAT 751  Trypanosoma b...
XP_001467796  752 ----------------------------------------------------------------------------FIAE 755  Leishmania in...
NP_586330     786 ----------------------------------------------------------------------------FVQN 789  Encephalitozo...
XP_764741     850 yrtqdqnrtsavtynaedsycyfiedksekkdagkkfnffkfgpngtqeltmdgcnqtdstessaefagqgnwfdnEMIV 929  Theileria par...

3M1I_C        751 VLVEPLLNAVLEDYMNN-VPDARDAEVLNCMTTVVEKVGH----MIPQGVILILQSVFECTLDMINKDFT---------- 815  baker's yeast
XP_002130430  776 NFVPPLLEAVLIDYRTN-VPAAREPEVLSTIATIVNKLEG----AITKEIGQIFDAVFECTLEMINKDFE---------- 840  Ciona intesti...
BAE98975      105 QFVPPMMDQVLGDYARN-VPDARESEVLSLFATIINKYKV----VMRDEVPLIFEAVFQCTLEMITKNFE---------- 169  thale cress
XP_001653391  757 NFIPPLLETVLFDYQRTkVPNAREPLVLSTMASIVNKLQA----VITPEVPKIFDAVFDCTLDMINKNFE---------- 822  yellow fever ...
NP_741567     785 SIVPPLFDAVLFDYQKN-VPQAREPKVLSLLSILVTQLGS----LLCPQVPSILSAVFQCSIDMINKDME---------- 849  nematode
XP_635133     761 NFLQPLLEAVLGDYRTN-IPETRDPEVLSLMTAIITSLKQ----LVHPEVPKILEAVFETTLSMITKNFE---------- 825  Dictyostelium...
CBH18487      752 NCMPSILTTVLEDYRDS-LPIVKEAGALALVTACVNKLGT----RLAGDCAAILDHTFDTTISMICANAE---------- 816  Trypanosoma b...
XP_001467796  756 SCLPDMFSVVLLDYENA-IAAAKEPGALALATACVRTLGR----CIENNCEAILDHTFNTTVAIIAQDME---------- 820  Leishmania in...
NP_586330     790 DFVNMVCEKVIFDY-KN-NPVYKEPAILSLGSSIVRNVENdgsvIYLQREAFMISALIEPSIPFVMQADEnleisknyll 867  Encephalitozo...
XP_764741     930 TLLDNLVVVMMGDYRDS-VFETRDYEILSLSTKIIERLAS----NYSSVLVQIFNYVFDTSLDMVKMDFH---------- 994  Theileria par...

3M1I_C        816 ------------------EYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLV 877  baker's yeast
XP_002130430  841 ------------------EFPEYRTNFFLLLQAVNNHCFPALLSIPQPQFKLVLDSIIWAFKHTMRNVAHTGLSILYQLL 902  Ciona intesti...
BAE98975      170 ------------------DYPEHRLKFFSLLRAIATFCFRALIQLSSEQLKLVMDSVIWAFRHTERNIAETGLNLLLEML 231  thale cress
XP_001653391  823 ------------------DYPQHRTNFYELLQAVNTHCFKAFLSIPPNQFKLVFDSIVWAFKHTMRNVADTGLNILMQML 884  yellow fever ...
NP_741567     850 ------------------AFPEHRTNFFELVLSLVQECFPVFMEMPPEDLGTVIDAVVWAFQHTMRNVAEIGLDILKELL 911  nematode
XP_635133     826 ------------------DYPYHRINFFNLIRAINSNAFTVFHNLHPQQFKLLIDCVVWAFKHTERNISETGLHILKELI 887  Dictyostelium...
CBH18487      817 ------------------DFPEFRVNLFKLLHALNTRCFSNFLSYASTK-GDVINGMLWVIKHTDFAIMETGLKTLDAFL 877  Trypanosoma b...
XP_001467796  821 ------------------SHPDFRVNLFKLLQALNAHCFEAFICYTSTH-EDVVLGMLWAIKHTDYPTMSTGLETLDLFL 881  Leishmania in...
NP_586330     868 lmenmllfsfssffsslfGQPSFRQVYNTLLYSLI----------------------------CIRDVSDLSLNCLTII- 918  Encephalitozo...
XP_764741     995 ------------------AYPDHREYFYEMLHKATKCSFDSVLLLPNERLRDFVMSLVWAFKHEHPSIADRGLLITLEFM 1056 Theileria par...

3M1I_C        878 KNIERMgNVPFANEFHKNYFFIFVSETFFVLTDSD--HKSGFSKQALLLMKLISLVYDNKISVPlyqe-aevpQGTS--N 952  baker's yeast
XP_002130430  903 QNIT-L-VDDAAQSFYQMYFTDILQHVFSVGTDTS--HTAGLTMHASILAYMFSLVEQNKITVPlha----nqP--N--N 970  Ciona intesti...
BAE98975      232 KNFQK---SDFCNKFYQTYFLQIEQEVFAVLTDTF--HKPGFKLHVLVLQHLFSLVESGSLAEPlwdaatvphPYSN--N 304  thale cress
XP_001653391  885 QNLEQH--PQAAQSFYQTYFTDILMQIFSVVTDTS--HTASLQNHATILAYMFSLVEAGRITVSlgp----spD-----N 951  yellow fever ...
NP_741567     912 ARVSEQ-DDKIAQPFYKRYYIDLLKHVLAVACDSSqvHVAGLTYYAEVLCALFR-APEFSIKVPlnd----anPSQP--N 983  nematode
XP_635133     888 ENVSK--NSDVANVFFKTYLVSLLNDILYILTDSF--HKSGFALECDILRMMFQVVENGVVKIPlfd----pqQANFpsN 959  Dictyostelium...
CBH18487      878 ENVSR---SELLQPFYDAFMQQIFVEVLVSAMDSL--HAAGFELHCSILIKLFTVSSMFPVDLP-----------KL--G 939  Trypanosoma b...
XP_001467796  882 ENVSK---SEYAEVFFKAYMQRILVDVMVASMDSL--HASGFQHHVRILQKLFNVSSMVPPDTP-----------TI--G 943  Leishmania in...
NP_586330     919 --FKKC-HEQKIYQFYAQNYMSTLENILGIIFDKD--MKYNFDQQCLLFAFMIRISKDVPSl----------dGINP--N 981  Encephalitozo...
XP_764741    1057 KNI---------------------------------------------------------IS------------------ 1061 Theileria par...

3M1I_C        953 QVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQYK-DLVVFKGTLRDFLVQIKEVGG 1009 baker's yeast
XP_002130430  971 LVFVQEYVANLLKTAFPHLQDAQIKLFVRGLFSLNH-DIALFKDHLRDFLVQIKEFAG 1027 Ciona intestinalis
BAE98975      305 VAFVLEYTTKLLSSSFPNMTTTEVTQFVNGLYESRN-DVGRFKDNIRDFLIQSKEFSA 361  thale cress
XP_001653391  952 VLNIQDYVATLLKSAFSHLTDNQIKIFVTGLFNLDQ-DVHAFKEHLRDFLIQIKEVTG 1008 yellow fever mosquito
NP_741567     984 IDYIYEHIGGNFQAHFDNMNQDQIRIIIKGFFSFNT-EISSMRNHLRDFLIQIKEHNG 1040 nematode
XP_635133     960 SEYVKEIVVTFLSAS-PNVSRPQIQAFVTRLFNLANiNNNDFKSATRDFLITLKEWks 1016 Dictyostelium discoideum AX4
CBH18487      940 RNDIESFLCENLST-IATLTPALIKQFIAGAYEKYG-DPVEFRRSFADFLIEMQVWGA 995  Trypanosoma brucei gambiense DAL972
XP_001467796  944 KNVIRAYLLDSL-TVIPTLTTTSILSFVDMCYESFT-DDERFRTQFADFLIEVKVWGA 999  Leishmania infantum JPCM5
NP_586330     982 ITILSEYIVGLFVKSFPNITQESVKIFSVGLFELCG-DDEIFKEHVEDFRVKVYEFGT 1038 Encephalitozoon cuniculi GB-M1
XP_764741    1062 -----------------------------------------------------KGYNR 1066 Theileria parva strain Muguga
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