1EF5,1WGR,1RLF,1RAX


Conserved Protein Domain Family
RA
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smart00314: RA 
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Ras association (RalGDS/AF-6) domain
RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Kalhammer et al. have shown that not all RA domains bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. Predicted RA domains in PLC210 and nore1 found to bind RasGTP. Included outliers (Grb7, Grb14, adenylyl cyclases etc.)
Links
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Statistics
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PSSM-Id: 214612
Aligned: 41 rows
Threshold Bit Score: 46.5224
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EF5_A         17 DTCIIRISVE-DN-N--GNMYKSIMLTSQDKTPAVIQRAMSKHNLESd-Pa--EEYELVQVI---------SEDKELVIP 80   house mouse
Q22744        396 KTTSLRTITS-FFlP--RNTAKVINIDSKTTARKMIVTLLKKFRVADn-P---RKFALYECEqitdeatctLNRKLTRIS 468  Caenorhabditi...
O13488        638 TSYCIRVFKS-D------GTFATLQMSIDSSVQDLIGQLSKKSYVSG--G---LEYHIALRK----------HGLIRVLG 695  Magnaporthe g...
EAW47486       39 FHGVMRFYFQ-DK-AagNFATKCIRVSSTATTQDVIETLAEKFRPDMr-MlssPKYSLYEVH---------VSGEERRLD 106  human
EAX10446      174 HFYNHKTSVF-TP-A--YGSVTNVRINSTMTTPQVLKLLLNKFKIENs-A---EEFALYVVH---------TSGEKQKLK 236  human
XP_003268283  787 FQNYLRVAFQeVN-S--GCTGKTLLVRPYITTEDVCQICAEKFKV-Gd-P---EEYSLFLFV----------DETWQQLA 848  White-cheeked...
XP_003273941  624 FQHLLRVAYQ-DP-Ss-GCTSKTLAVPPQASIATLNQLCATKFRVTq--P---NTFGLFLYK---------EQG-YHRLP 685  White-cheeked...
AAA34549      676 RHYAIRIFNT-D------DTFTTLSCTPATTVEEIIPALKIKFNITA--Q---GNFQISLKV-----------GKLSKIL 732  baker's yeast
Q01513        637 HNYCIRVFRA-D------GTFATLQMPLLTSVSELINQIVKKSYLQD--P---DKFKLVLKK----------HDLYKVLQ 694  Podospora ans...
BAA00755      749 SNYYIRVFRS-D------STWTTLTLPLTATAEDVIMGVAKKTYLPPgaQ---DSYSLLIKK----------HDLFRVLN 808  Neurospora cr...

1EF5_A         81 DSANVFYAMN----S--QVNFDFILRKKN 103  house mouse
Q22744        469 DDACPLKVVLnwqsP--HCGRALVLQEND 495  Caenorhabditis elegans
O13488        696 SAEKPLFIQKrl-------lrQVGFEERD 717  Magnaporthe grisea
EAW47486      107 IDEKPLVVQLnwnkD--DREGRFVLKNEN 133  human
EAX10446      237 ATDYPLIARIlqgpC--EQISKVFLMEKD 263  human
XP_003268283  849 EDTYPQKIKAelhsRpqPHIFHFVYKRik 877  White-cheeked Gibbon
XP_003273941  686 PGALAHRL----------PTTGYLVYRRa 704  White-cheeked Gibbon
AAA34549      733 RPTSKPILIErk------llLLNGYRKSD 755  baker's yeast
Q01513        695 STDRPLLLQKrl-------leQVGFEERD 716  Podospora anserina DSM 980
BAA00755      809 SAEQPLRIQKrl-------fqQIGYQEKD 830  Neurospora crassa
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