1EF5: SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL

Citation:
Abstract
The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.
PDB ID: 1EF5Download
MMDB ID: 12697
PDB Deposition Date: 2000/2/7
Updated in MMDB: 2007/10
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 1EF5
Label Count Molecule
Protein (1 molecule)
1
RGL(Gene symbol: Rgl1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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