4NMN,2VYE


Conserved Protein Domain Family
DnaB_C

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pfam03796: DnaB_C 
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DnaB-like helicase C terminal domain
The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Statistics
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PSSM-Id: 397735
Aligned: 458 rows
Threshold Bit Score: 129.843
Threshold Setting Gi: 378569553
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NMN_A               175 GLPSGFTELD-LKTTGFHPGDLIILAARPGMGKTA----FMLSII-YN-LA-K---DE-GkP--SAVFSLEMSKEQL--- 237 Aquifex...
Q3SH68               184 GVASGYGDLD-RLTCGLQPGDLVIVAGRPSMGKTT----LAVNIA-EN-VAaD--------GgvALVFSLEMGARQL--- 245 Thiobac...
WP_011804372         191 GLATGFRLLD-ELTCGLQAGDLIIVAGRPGMGKTT----LAVNIA-EN-VAlA--------GgaAFVVSLEMSAAQL--- 252 Acidovo...
jgi:Mpe_B0195         22 GLPTGFRELD-QLTTGMHRGDLIVIAGRPSIGKSA----LALNVA-TH-VA-IqqgT----P--VLIFSMEMDGRHV--- 84  Methyli...
jgi:Hore_23140       184 GLPTGFISLD-NLIGGFKKGHLNVIAASTSMGKTA----FAINIA--K-NVlkr-----nvP--VAIISLEMDAQEI--- 245 Halothe...
WP_015179649         191 GISTGFYDLDdLLGGGFYRGELIVIGGRPGSGKTA----LACALG-YN-IA-----SLpR-NgrVLMFSMEMPGRDL--- 255 Oscilla...
Q6FAC9               183 GVKFNLKHLD-ELLGTVQKGHFCVVGGRPGSGKSTlaqmLALDTAsSF-------------GkgVLFISAEMDQSTL--- 245 Acineto...
zhongguo:PM3016_2995 258 GVATGFQRLDdVLFGGLHSG-LYLLAGCASSGKTMlmkqMADHIAlG--------------GtpVVYVSWDMTAFELwar 322 Paeniba...
WP_013608007         156 GLTTGFKRLD-AAFGGLQKGRLYYIGARPSQGKST----LLMNIAiNSkVPcL-------------IFSAESSRREY--- 214 Sphaero...
WP_013534829         164 GITTGLQELD-EILGGWHDSDLTFIGGRPAMGKTA----FMLGLA-E-----A---AAdS-GrrVGIVSAEQPAVQL--- 225 Pseudox...
4NMN_A               238 -VMRLLS-----MMS-EVP---LFKI-----RSGSIS-NEDL------KKLEA-S-A---------IELAKYD-IYLDD- 282 Aquifex...
Q3SH68               246 -VERSVC-----RFG-GIS---TTAV-----RNGDMRqE-DF------ERLLV-A-H---------KRLQGKR-LVIDD- 290 Thiobac...
WP_011804372         253 -AERSVA-----RFG-AID---TQAL-----RSGRISqD-GF------TRLSA-A-L---------DRLRNQR-LVIAD- 297 Acidovo...
jgi:Mpe_B0195         85 -MDRLVS-----SIS-RVD---LQRV-----RMAQLS-DDDW------SHAIE-A-F---------NLLSDAP-LVIDD- 129 Methyli...
jgi:Hore_23140       246 -IDRMII-----QES-GVN---GWKY-----NQGQTSdE-ED------KRISK-A-L---------DNLHELP-LMISD- 290 Halothe...
WP_015179649         256 -AARLMA-----LES-GVS---VKDI-----RQ--VNlAGKY------EVLAS-A-L---------GKVSDAD-FWIDE- 299 Oscilla...
Q6FAC9               246 -ANRMIS---------ALGlipYHNIhnaelYN-------GLmkdyadAKAAYqR----------------LP-IWIQPk 291 Acineto...
zhongguo:PM3016_2995 323 sIARLIGtepqkVLGgTVSpdeVNEAnk--qY----------------IPISKmQwTlecspdttmERVLN--------- 375 Paeniba...
WP_013608007         215 -ADRMII-----KQE-KIN---SMNF-----YNGTLTeN-DT------AKVVQ-A-S---------NELYQRDyVTIHD- 260 Sphaero...
WP_013534829         226 -GIRRAA-----LAS-GVG---AQAI-----RAGNLQdE-DW------SKITA-G-I---------SRARDRH-LRVFD- 270 Pseudox...
4NMN_A               283 -TP--A-LTTTDL-----RIRARK----LRKE-------KEVEFVAVDYLQLLR-----PpvR------KS-PRQE--E- 327 Aquifex...
Q3SH68               291 -TP--S-TSPARM-----RAKARKvkhrYGR----------LDLVVIDYLQLMA--------G------DGnTRSE--Q- 334 Thiobac...
WP_011804372         298 -DP--AlASVARI-----RLAARKqsqrLGA----------LDLIVIDYLQLMR--------G------DGaNRND--E- 342 Acidovo...
jgi:Mpe_B0195        130 -TP--S-LSVNEL-----IARANKradaMGR----------LGLVVVDYMQLMA--------Ggl--tsNIeTRAG--Q- 177 Methyli...
jgi:Hore_23140       291 -ER--G-LNVAQI-----RARLRK----FKAQm------GDLGLVIIDYLQMIQlpeehAq-----------NTAR--A- 337 Halothe...
WP_015179649         300 -SL--E-PSPLEI-----RSRVRE----FVCEr------GPLGLVIVDYLQLMV--------Nsa--deNFvNK------ 344 Oscilla...
Q6FAC9               292 qKP-----SLSEV-----RSYARRakrrYKE----------LGCIIVDYLQLLR----------------DpSKKDrfQe 335 Acineto...
zhongguo:PM3016_2995 376 --------SIERIagiagKT----------------------PVVFIDHLNRIPlalggPvpRvtpaeyQT--------- 416 Paeniba...
WP_013608007         261 -EPniS-L--------------RR----LIQVahdafkyYKIKAIFIDYIQLIT--------Y------GDqTRAKneQ- 305 Sphaero...
WP_013534829         271 --Rs-A-VSLDEL-----VSVARK----WKHN-------DGLDVLFIDYAQRIT--------Vp-----GA-DRIT--E- 313 Pseudox...
4NMN_A               328 VAEVSRNLKALAKELRIPVMALAQLSREVE--KRSDKRPQLADL------RESGQIEQDADLILFLH--------RPEYY 391 Aquifex...
Q3SH68               335 LGGLTRALKLMARELGAPVVLLSQLNRGLE--QRTDKRPVLSDL------RESGAIEQDADVVLMVH--------RPDYY 398 Thiobac...
WP_011804372         343 LGGITRALKLLARELACPIILLSQLSRAVE--ARPDKRPILSDL------RESGAIEQDADVVMMAY--------RDGYY 406 Acidovo...
jgi:Mpe_B0195        178 VGEISRGLKRLARELGCPVVALSQLGRSPA--SRSDKRPTLADL------RDSGAIECDADVIVLLY--------RDDYT 241 Methyli...
jgi:Hore_23140       338 VGQIVLQLRNMASELEVPIILISQISRSFT--NRQDKRPVLSDL------RDSGNIEEIADGVIFLY--------RHAHT 401 Halothe...
WP_015179649         345 ISEITRQMKILAREVDTPVVLLSQLNRGVE--TRTNKRPSLSDL------RGSGGIEQDADVVLGVY--------RDDYY 408 Oscilla...
Q6FAC9               336 VSSISRELKSMAKEFECPVIALVQLNREAEkgKR----PKASDI------KESGQIEQDADQIILV-------------- 391 Acineto...
zhongguo:PM3016_2995 417 --SLAYALKQWSREWGGPVVAAI-----------------PSDIgeerlpEG---VEASADVMLLL-------------- 460 Paeniba...
WP_013608007         306 VSEISKRLKQLARELDVPVIAAAQLRRDAE--GK--Q-PQLSDF------SDSTQIERDADVAIMVYhiqnaisdRS--- 371 Sphaero...
WP_013534829         314 VSQIARGLKNLARDLNIPVVSLAQVVKGVD--SRPDKRPNAGDL------ANSDELTREADQVLMLY--------RDEVY 377 Pseudox...
4NMN_A               392 TkkPn-----PeeQg---------iA--EVI--IAKQRQGPTDIVKLAFIKEYTKFAN 431 Aquifex aeolicus VF5
Q3SH68               399 DadSph--tgL--------------A--EVL--IRKQRMGPLGTVTLCFEGEFSRFHD 436 Thiobacillus denitrificans AT...
WP_011804372         407 RpdGpl--qgF--------------A--EIL--VRKQRMGPTGDVPLIFQGWHSRFLD 444 Acidovorax sp. JS42
jgi:Mpe_B0195        242 RaaSmc--tgL--------------T--EII--VGKQRNGPTGTVRLMFVGPLTTFES 279 Methylibium petroleiphilum PM1
jgi:Hore_23140       402 SaaAreqaekEgtE-----------NdtEVI--VAKQRTGQTGAIKLYFEDEF--IRF 444 Halothermothrix orenii H 168
WP_015179649         409 NpdSpd--rgI--------------A--EII--GLKGRNSGTGTVKLLFDAECCRFRN 446 Oscillatoria nigro-viridis
Q6FAC9               392 NplTdpedstKp-M-----------GitELI--VVKNRHGKRGAVRVLDYLETCRFRS 435 Acinetobacter baylyi
zhongguo:PM3016_2995 461 -------------KsqcaseppakvEghPAAlhLMKHRNGPLATVPLRFLDGKARFDE 505 Paenibacillus mucilaginosus 3016
WP_013608007         372 -------------------------TdkETFllIQKNRDGRLDYVKMNYQPGYMLFEE 404 Sphaerochaeta globosa
WP_013534829         378 NreSp----dK--------------GvaEIL--IEKNRHGPTGFKRVRFVAETMAFES 415 Pseudoxanthomonas suwonensis
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