2WP8,3M7N,2C38,5XEX,2NN6,5VZJ


Conserved Protein Domain Family
RNase_PH_C
?
pfam03725: RNase_PH_C 
Click on image for an interactive view with Cn3D
3' exoribonuclease family, domain 2
This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.
Links
?
Statistics
?
PSSM-Id: 427466
Aligned: 79 rows
Threshold Bit Score: 31.7778
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2WP8_A        191 HIPICVTFSFFNpqdteenikgetNSeiSIIDATLKEELLRDGVLTVTLNKNREVVQVSKAGGLP-MDALTLMKCCHEAY 269 baker's yeast
Q2NEX4        188 NRSILCTVVKIN------------NQ--LIVDPSKIEEILMDSSVSFGFREDGSLCALQKCGLNT-LTHKEVTKAMKIAS 252 Methanosphaera...
ABK78157      189 TIPVSVTMAKIN------------GH--ILVDPNQDEWAVMDARITITTNSDGNICALQKGGNSG-FTHAELVKCGEISV 253
Q8TYC2        189 DFPISVTIAKVG------------EY--LLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGD-FPEHLLEDAIDLAT 253 Methanopyrus k...
A0B8W2        181 DIPIATTAVEFG------------DV--VLFDPDVDEEAIADAKLTVITKADGTICGMQKSGPGM-LSEDQVYRIVDIAC 245 Methanothrix t...
Q8TGX5        184 EMPVGITIAKIG------------SK--LMVDPSLDEEAVCETKLTIVSSSDGSVAGMQKMGISP-LTEAELFEAIDLAL 248 Methanosarcina...
Q5JIR7        191 HVPIPVTFAKIG------------NS--IVVDPSLDEERVMDGRLTITTDETGHISAAQKGEAGA-FKMEEVMYALEVAL 255 Thermococcus k...
Q9HIP1        184 stPISVTMVKIG------------DT--LVCDPSLEEDQICGGRITVTTTEDGHI-RAMQKGEIGaFTVEDVKKAVKMSL 248 Thermoplasma a...
jgi:Tpen_0580 190 TLVVYVTVAKIG------------EY--LVVDPTLEEELTADAKITFGITERGEICAIQKSGEGS-FRPDEVLRARDMAL 254
2C38_G        195 YPVVTISVAKVD------------KY--LVVDPDLDEESIMDAKISFSYTPDLKIVGIQKSGKGS-MSLQDIDQAENTAR 259 Saccharolobus ...

2WP8_A        270 SI 271 baker's yeast
Q2NEX4        253 IR 254 Methanosphaera stadtmanae DSM 3091
ABK78157      254 RV 255
Q8TYC2        254 KK 255 Methanopyrus kandleri AV19
A0B8W2        246 DN 247 Methanothrix thermoacetophila PT
Q8TGX5        249 EK 250 Methanosarcina acetivorans C2A
Q5JIR7        256 KK 257 Thermococcus kodakarensis KOD1
Q9HIP1        249 Ev 250 Thermoplasma acidophilum DSM 1728
jgi:Tpen_0580 255 KA 256
2C38_G        260 ST 261 Saccharolobus solfataricus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap