2WP8,2C38,3M7N,5XEX,2NN6,5VZJ


Conserved Protein Domain Family
RNase_PH_C

?
pfam03725: RNase_PH_C 
Click on image for an interactive view with Cn3D
3' exoribonuclease family, domain 2
This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.
Statistics
?
PSSM-Id: 397681
Aligned: 80 rows
Threshold Bit Score: 30.9903
Threshold Setting Gi: 74685474
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2WP8_A       191 HIPICVTFSFFNpqdteenikgetNSeiSIIDATLKEELLRDGVLTVTLNKNREVVQVSKAGGLP-MDALTLMKCCHEAY 269 baker's yeast
Q9YC05       196 TRVVTVTTAKID------------RY--IVVDPNIEEEAVSDVRLVTAVDENGRIVGLQKTGMGS-LTEADIETMIGYSL 260 Aeropyrum perni...
WP_012185237 194 NMPLTVTYYKID------------KY--LIVDPTLEEEVMSDGRFTVASDGE-NIVALQK-GEGY-FTPEEVDSMMNNTL 256 Caldivirga maqu...
Q5JIR7       191 HVPIPVTFAKIG------------NS--IVVDPSLDEERVMDGRLTITTDETGHISAAQKGEAGA-FKMEEVMYALEVAL 255 Thermococcus ko...
Q9HIP1       184 stPISVTMVKIG------------DT--LVCDPSLEEDQICGGRITVTTTEDGHI-RAMQKGEIGaFTVEDVKKAVKMSL 248 Thermoplasma ac...
ABK78157     189 TIPVSVTMAKIN------------GH--ILVDPNQDEWAVMDARITITTNSDGNICALQKGGNSG-FTHAELVKCGEISV 253 Cenarchaeum sym...
3M7N_H       182 DLPVSVTSLIVG------------NK--YLVDPSREEMSVGDTTLTITTDKDDNVVAMQKSGGYL-LDEKLFDELLDVSI 246 Archaeoglobus f...
A0B8W2       181 DIPIATTAVEFG------------DV--VLFDPDVDEEAIADAKLTVITKADGTICGMQKSGPGM-LSEDQVYRIVDIAC 245 Methanothrix th...
Q8TGX5       184 EMPVGITIAKIG------------SK--LMVDPSLDEEAVCETKLTIVSSSDGSVAGMQKMGISP-LTEAELFEAIDLAL 248 Methanosarcina ...
Q8TYC2       189 DFPISVTIAKVG------------EY--LLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGD-FPEHLLEDAIDLAT 253 Methanopyrus ka...
2WP8_A       270 SI 271 baker's yeast
Q9YC05       261 EA 262 Aeropyrum pernix K1
WP_012185237 257 NI 258 Caldivirga maquilingensis
Q5JIR7       256 KK 257 Thermococcus kodakarensis KOD1
Q9HIP1       249 Ev 250 Thermoplasma acidophilum DSM 1728
ABK78157     254 RV 255 Cenarchaeum symbiosum A
3M7N_H       247 NC 248 Archaeoglobus fulgidus
A0B8W2       246 DN 247 Methanothrix thermoacetophila PT
Q8TGX5       249 EK 250 Methanosarcina acetivorans C2A
Q8TYC2       254 KK 255 Methanopyrus kandleri AV19
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap