2NN6,2WP8,3M7N,2C38,2PNZ


Conserved Protein Domain Family
RNase_PH_C

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pfam03725: RNase_PH_C 
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3' exoribonuclease family, domain 2
This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.
Statistics
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PSSM-Id: 309009
View PSSM: pfam03725
Aligned: 88 rows
Threshold Bit Score: 28.6717
Threshold Setting Gi: 74685474
Created: 17-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NN6_B       159 DFVCACSAGFVDGTALADLSHVEeaAGGPQLALALLPASGQiALLEMDAR--LHEDHLERVLEAAAQA 224 human
3M7N_H       182 DLPVSVTSLIVGNKYLVDPSREEmsVGDTTLTITTDKDDNVvAMQKSGGYl-LDEKLFDELLDVSINC 248 Archaeoglobus fulgidus
A0B8W2       181 DIPIATTAVEFGDVVLFDPDVDEeaIADAKLTVITKADGTIcGMQKSGPGm-LSEDQVYRIVDIACDN 247 Methanosaeta thermophila PT
Q8TGX5       184 EMPVGITIAKIGSKLMVDPSLDEeaVCETKLTIVSSSDGSVaGMQKMGISp-LTEAELFEAIDLALEK 250 Methanosarcina acetivorans C2A
Q2NEX4       188 NRSILCTVVKINNQLIVDPSKIEeiLMDSSVSFGFREDGSLcALQKCGLNt-LTHKEVTKAMKIASIR 254 Methanosphaera stadtmanae D...
Q8TYC2       189 DFPISVTIAKVGEYLLVDPCLEEevIMDTRLTVTVTESGEVcAVQKGELGd-FPEHLLEDAIDLATKK 255 Methanopyrus kandleri AV19
Q5JIR7       191 HVPIPVTFAKIGNSIVVDPSLDEerVMDGRLTITTDETGHIsAAQKGEAGa-FKMEEVMYALEVALKK 257 Thermococcus kodakarensis KOD1
Q9HIP1       184 stPISVTMVKIGDTLVCDPSLEEdqICGGRITVTTTEDGHI-RAMQKGEIgaFTVEDVKKAVKMSLEv 250 Thermoplasma acidophilum DS...
WP_011953776 188 neVAMCTFVKIGDKLILDPTLNEekVASARLNVGVTKDGNIcAMQKGGISp-LTKEDIFYCVDKAVSK 254 Methanobrevibacter smithii
WP_012185237 194 NMPLTVTYYKIDKYLIVDPTLEEevMSDGRFTVASDGE-NIvALQK-GEGy-FTPEEVDSMMNNTLNI 258 Caldivirga maquilingensis
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