2NN6,2WP8,3M7N,2C38,2PNZ


Conserved Protein Domain Family
RNase_PH_C

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pfam03725: RNase_PH_C 
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3' exoribonuclease family, domain 2
This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.
Statistics
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PSSM-Id: 309009
View PSSM: pfam03725
Aligned: 88 rows
Threshold Bit Score: 28.6717
Threshold Setting Gi: 74685474
Created: 17-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2NN6_B       159 DFVCACSAGFVDGTALADLSHVEeaAGGPQLALALLPASGQiALLEMDAR--LHEDHLERVLEAAAQA 224
3M7N_H       182 DLPVSVTSLIVGNKYLVDPSREEmsVGDTTLTITTDKDDNVvAMQKSGGYl-LDEKLFDELLDVSINC 248
gi 121694778 181 DIPIATTAVEFGDVVLFDPDVDEeaIADAKLTVITKADGTIcGMQKSGPGm-LSEDQVYRIVDIACDN 247
gi 29336812  184 EMPVGITIAKIGSKLMVDPSLDEeaVCETKLTIVSSSDGSVaGMQKMGISp-LTEAELFEAIDLALEK 250
gi 121707544 188 NRSILCTVVKINNQLIVDPSKIEeiLMDSSVSFGFREDGSLcALQKCGLNt-LTHKEVTKAMKIASIR 254
gi 29336820  189 DFPISVTIAKVGEYLLVDPCLEEevIMDTRLTVTVTESGEVcAVQKGELGd-FPEHLLEDAIDLATKK 255
gi 73919277  191 HVPIPVTFAKIGNSIVVDPSLDEerVMDGRLTITTDETGHIsAAQKGEAGa-FKMEEVMYALEVALKK 257
gi 29336948  184 stPISVTMVKIGDTLVCDPSLEEdqICGGRITVTTTEDGHI-RAMQKGEIgaFTVEDVKKAVKMSLEv 250
gi 500587962 188 neVAMCTFVKIGDKLILDPTLNEekVASARLNVGVTKDGNIcAMQKGGISp-LTKEDIFYCVDKAVSK 254
gi 501136676 194 NMPLTVTYYKIDKYLIVDPTLEEevMSDGRFTVASDGE-NIvALQK-GEGy-FTPEEVDSMMNNTLNI 258
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