1QPO,2B7P,4KWV,3C2R


Conserved Protein Domain Family
QRPTase_C
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pfam01729: QRPTase_C (485197 is an unknown moldel)
Quinolinate phosphoribosyl transferase, C-terminal domain
Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyzes the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.
Links
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Statistics
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PSSM-Id: 485197
Aligned: 15 rows
Threshold Bit Score: 182.511
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1QPO_E 116 IATATAAWVDAVRGT--KAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGS---VVDALRAVRN 190 Mycobacterium tubercu...
Q2RUG2 119 IATRTRRFGDAIAHT--RARLTCTRKTTPGLRGLEKYAVRCGGGSNHRFGLDDAVLIKDNHIAVAGG---VSAALSRARA 193 Rhodospirillum rubrum...
P39666 108 IATMTREAVRCLDDE--QIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGS---ILEACKKARQ 182 Bacillus subtilis sub...
2B7P_B 103 IATLTSRFVEALNSH--KVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKD---LKSFLTHARK 177 Helicobacter pylori
Q57278 106 VAQYTAEMIANAKSVnpTAVVACTRKSIPNTRKLATNAVLAAGGHIHRQGVSETLLVFTNHRNLLSDpndWTKIVDRLRQ 185 Haemophilus influenza...
4KWV_D 118 IASAAAAAVEAARGAgwTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGG---VEKAVRAARQ 194 human
3C2R_B 119 IATASHKIISLARSTgyKGTIAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGS---ITNAVKNARA 195 brewer's yeast
O67029 107 IATTARKFVEKLKGTn--VKILDTRKTTPGFRYFEKYAVRIGGGTNHRFGLYDMVLIKDNHKRVAGS---IKEAVKRVRE 181 Aquifex aeolicus
P30011 131 VASKVRHYVELLEGT--NTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLSDAFLIKENHIIASGS---VRQAVEKASW 205 Escherichia coli K-12
Q9ZU32 151 IATLTKLMADAASPA----CILETRKTAPGLRLVDKWAVLIGGGRNHRMGLFDMVMIKDNHISAAGG---IVNAVKSVDE 223 thale cress

1QPO_E 191 AA-PDLP---CEVEVDSLEQLDAVLP---------EK-PELILLDNF---------AVWQTQTAVQRRDSRAPT---VML 244 Mycobacterium tubercu...
Q2RUG2 194 GV-GHMVr--IEIEVDTLEQLAEVLA---------VGgAEVVLLDNM---------DAPTLTRAVD---MVAGR---LVT 246 Rhodospirillum rubrum...
P39666 183 AA-GHMVn--IEVEIETEEQLREAIA---------AG-ADVIMFDNC---------PPDTVRHFAKLT-PAN-----IKT 234 Bacillus subtilis sub...
2B7P_B 178 NL-PFTAk--IEIECESFEEAKNAMN---------AG-ADIVMCDNL---------SVLETKEIAAYRDAHYPF---VLL 232 Helicobacter pylori
Q57278 186 EA-PENK---ITLEADNYAQFEQMYM---------AE-PDIIQLDKW---------LLEDVKKALDLLQSKQKD---ILL 239 Haemophilus influenza...
4KWV_D 195 AA-DFTLk--VEVECSSLQEAVQAAE---------AG-ADLVLLDNF---------KPEELHPTATVLKAQFPS---VAV 249 human
3C2R_B 196 VC-GFAVk--IEVECLSEDEATEAIE---------AG-ADVIMLDNF---------KGDGLKMCAQSLKNKWNGkkhFLL 253 brewer's yeast
O67029 182 RI-SPVy--kIEVEVENLEEVEEALS---------AG-VDVIMLDNF---------TPEEVKRAVEIIKGRAL------V 233 Aquifex aeolicus
P30011 206 LH-PDAP---VEVEVENLEELDEALK---------AG-ADIIMLDNF---------ETEQMREAVK---RTNGK---ALL 256 Escherichia coli K-12
Q9ZU32 224 YLkQKNLemdVEVETRTLEEVKEVLEyasgsetrlTR----IMLDNMvvplengdvDVTMLKDAVE---LINGR---FET 293 thale cress

1QPO_E 245 ESSGGLSLQTAATYAETGvDYLAVGALTHSVRVLDIGLD 283 Mycobacterium tuberculosis H37Rv
Q2RUG2 247 EASGGVSLDTIAALAESGvDYISVGALTHSVTTLDIGLD 285 Rhodospirillum rubrum ATCC 11170
P39666 235 EASGGITLESLPAFKGTGvNYISLGFLTHSVKSLDISMD 273 Bacillus subtilis subsp. subtilis str. 168
2B7P_B 233 EASGNISLESINAYAKSGvDAISVGALIHQATFIDMHMK 271 Helicobacter pylori
Q57278 240 SVAGGVNKNNVSDYAKLG-IRLFITSAPYYVPPEDIKVV 277 Haemophilus influenzae Rd KW20
4KWV_D 250 EASGGITLDNLPQFCGPHiDVISMGMLTQAAPALDFSLK 288 human
3C2R_B 254 ECSGGLNLDNLEEYLCDDiDIYSTSSIHQGTPVIDFSLK 292 brewer's yeast
O67029 234 EVSGNITLDNVLDYAVEGvDFISSGAIVHSSRWLDISLK 272 Aquifex aeolicus
P30011 257 EVSGNVTDKTLREFAETGvDFISVGALTKHVQALDLSMR 295 Escherichia coli K-12
Q9ZU32 294 EASGNVTLETVHKIGQSGvTFISSGALTHSVKALDISLK 332 thale cress
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