3VZD,4WER


Conserved Protein Domain Family
DAGK_cat

?
pfam00781: DAGK_cat 
Click on image for an interactive view with Cn3D
Diacylglycerol kinase catalytic domain
Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Statistics
?
PSSM-Id: 425868
Aligned: 105 rows
Threshold Bit Score: 54.8988
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3VZD_C  13 RVLVLLNPRGGKGKALQLFrSHVQPLLAEAEISFTLMLTE--RRNH---------------AREL----VRSEELGRW-- 69   human
Q7XQT2  45 PVVVFINSRSGGQLGSSLI-KTYRELLNKAQV-FDLSEEA---PEKvlhrlycnfeklksnGDPI----AFQIQSN---- 111  Japanese rice
Q9C5E5  40 PVLVFINSKSGGQLGGELI-LTYRSLLNHNQV-FDLDQET---PDKvlrriyl--nlerlkDDDF----ARQIREK---- 104  thale cress
Q8VZG1  91 PMVVFINPNSGGRHGPVLK-ERLQQLMSEEQV-FDLTEVK---PHEfvryglgclekvaaeGDEC----AKECRAR---- 157  thale cress
Q10024 418 PLLVFVNPKSGGNKGSKAL-HTLCWLLNPRQV-FDITSLK--GPKF---------------GLEM----FRKVVTQ---- 470  Caenorhabditis elegans
O08560 296 PLLVFVNPKSGGNQGAKII-QSFLWYLNPRQV-FDLSQGG--PRE----------------ALEM----YRKVHN----- 346  Norway rat
P34125 334 VLFVFVNSKSGGQFGSTLI-RKLSSLLNPLQI-IDLIKCG--GPDS---------------TLQMinryLAKHPE-QTnr 393  Dictyostelium discoi...
Q39017 361 PLLVFINKKSGAQRGDSLR-QRLHLHLNPVQV-FELSSVQ--GPEV---------------GLFL----FRKVPH----- 412  thale cress
Q9FFN7 342 PLLVFINAKSGGQLGPFLH-RRLNMLLNPVQV-FELGSCQ--GPDA---------------GLDL----CSKVKY----- 393  thale cress
Q7K579 205 PLIVIANTKSGSSTGANVL-SLLRGYLH----PLQVMELGsrGPQD---------------ALQW----AAKASP-RP-- 257  fruit fly
3VZD_C  70 DALVVMSGDGLMHEVVNGLMErpdwetaIQKPLCSLPAGSGNALAASLnhyagYEQv-TNEDlltnCTLLL--CRRLLSP 146  human
Q7XQT2 112 LRLIVAGGDGTASWLLGVVSDlk---lsHPPPIATVPLGTGNNLPFSFg----WGKk-NPTT----DQEAVksFLGQVKK 179  Japanese rice
Q9C5E5 105 LKIIVAGGDGTAGWLLGVVCDlk---lsHPPPIATVPLGTGNNLPFAFg----WGKk-NPGTdr-tAVESF---LEQVLK 172  thale cress
Q8VZG1 158 LRIMVAGGDGTVGWVLGCLGElnkdgksQIPPVGVIPLGTGNDLSRSFg----WGG--SFPF----AWRSA--VKRTLHR 225  thale cress
Q10024 471 LRILVCGGDGTVGWVLSTLDNln---wpAYPPMAIMPLGTGNDLARCMg----WGGv-FSDE----PISQL--MQAILHE 536  Caenorhabditis elegans
O08560 347 LRILACGGDGTVGWILSTLDQlr---lkPPPPVAILPLGTGNDLARTLn----WGGg-YTDE----PVSKI---LSHVEE 411  Norway rat
P34125 394 FRILVCGGDGTVGWLFKQMTKhl---vpSTIPIGIIPLGTGNDLARSLg----WGIgyDGEK----LIEIL----KSINE 458  Dictyostelium discoi...
Q39017 413 FRVLVCGGDGTAGWVLDAIEKqn---fiSPPAVAILPAGTGNDLSRVLn----WGG--GLGSverqGGLST--VLQNIEH 481  thale cress
Q9FFN7 394 FRVLVCGGDGTVAWVLDAIEKrn---feSPPPVAILPLGTGNDLSRVLq----WGRgiSVVD----GQGSL---RTFLQD 459  thale cress
Q7K579 258 CRILVAGGDGTIGWVLNTIYTln---ikPQPSVAIMPLGTGNDLSRVLg----WGA--EPPS----VLDPVk-ILRSIRR 323  fruit fly
3VZD_C 147 MNLLSL 152  human
Q7XQT2 180 AREMNI 185  Japanese rice
Q9C5E5 173 AKVMKI 178  thale cress
Q8VZG1 226 ASMGPV 231  thale cress
Q10024 537 TIVTHL 542  Caenorhabditis elegans
O08560 412 GNVVQL 417  Norway rat
P34125 459 AKTIQM 464  Dictyostelium discoideum
Q39017 482 AAVTVL 487  thale cress
Q9FFN7 460 IDHAAV 465  thale cress
Q7K579 324 ARSVNL 329  fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap