Conserved Protein Domain Family
ZZ_NBR1_like
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cd02340: ZZ_NBR1_like 
Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears to control the multiplication of sigma rhabdovirus. NBR1 (Next to BRCA1 gene 1 protein) interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB), and may function in cell signalling pathways. Sequestosome 1 is a phosphotyrosine independent ligand for the Lck SH2 domain and binds noncovalently to ubiquitin via its UBA domain.
Links
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Statistics
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PSSM-Id: 239080
Aligned: 36 rows
Threshold Bit Score: 53.0326
Created: 29-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Zinc-binding sites [ion binding site]
Evidence:
  • Comment:6 conserved cysteines and 2 conserved histidines coordinate 2 zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #  #           #  #     #  #      #   #     
CAF90222  134 VTCDGCEG-PVVGTRFKCSVCpNYDLCSACQAKg-TH-TEHPLLPI 176  Tetraodon nigroviridis
CAB04847  144 AKCDSCGT-QIAGRRYKCTMCaDFDICERCEAKs-VH-LQHAMLRI 186  nematode
CAE61858  163 IYCCHCHF-PIHGIRYHCLECpDYDICENCEKDl-VH-FEHALIRI 205  Caenorhabditis briggsae
AAC26954  450 FDCDECKAeCNWNNRYKCTICaDYDLCRQCEAKn-LH-ANHAMLRI 493  nematode
CAE69648  247 ARCDGCYR-EILGSRYKCTECsDFDLCGVCEMGp-IH-SFHKLIKI 289  Caenorhabditis briggsae
AAH09808  215 IACNNCQR-RIVGVRYQCSLCpSYNICEDCEAGpyGHdTNHVLLKL 259  human
XP_418128 199 ISCCNCQA-RIVGVRYQCSLCpAYNICEQCEAGmyAHdPNHILLKL 243  chicken
AAH57740  290 LLCINCKQ-QIIGIRYQCSTCvSFSICEHCEAEgcDHdPSHLYLKM 334  African clawed frog
AAF60536  164 TPCRNCFR-IIVGSRYHCLQCpDYDICGDCEKDl-VH-YEHALLRI 206  nematode
CAB87373  134 AICDHCEQ-PIHNVRYKCSVCdDYDICESCLTDn-SHsNTHAFVRI 177  fission yeast

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