1O12,1UN7


Conserved Protein Domain Family
NagA
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cd00854: NagA 
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N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.
Links
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Statistics
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PSSM-Id: 238434
Aligned: 49 rows
Threshold Bit Score: 351.881
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1UN7; B.subtilis NagA with bound metal and substrate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                     # #             
1O12_A     13 XIVEKvlivdpidgeftGDVEIEe--GKIVKVEkrec--------------iprGVLXPGFVDPHIHGVVGADTxn---- 72  Thermotoga maritima
1UN7_A      9 LLIKDiaivteneviknGYVGINd--GKISTVSterpkepys----keiqapadSVLLPGMIDIHIHGGYGADTmdas-- 80  Bacillus subtilis
EAA48962   16 TKFTNcrlvrg-sslveEDLWVSsatGKIVRSQaifydhnvl---pdeiidlggRIVSPGLIDVQLNGAFGFNFsstfpd 91  Magnaporthe grisea...
NP_298754  10 GFINGrvlidt-gfrhdLAVLLRg--GCIQALLphddprvte---gaqwmdlrgGLLLPGFIDIQVNGGGGVLFnnar-- 81  Xylella fastidiosa...
NP_419353   3 IALVNgrvltpagfvsgKAVLVEn--GVVVALLdardvpad-----aqrhdlggDRLVPGFIDTQVNGGGGALFndap-- 73  Caulobacter cresce...
NP_105562   5 FALTGarifdgddwhddAALVVRd--GLVEAIVpsgaiard-----vravdtggGMLVPGFVDIQVNGGGGVMLndhp-- 75  Mesorhizobium loti
NP_719052   4 TLIAEqlfdge-sfhqdVPVTIEd--GLIASFDtalgak----------evrytGTLVPGFIDVQVNGGGGALFntsp-- 68  Shewanella oneiden...
NP_231418  10 RLFDGiqy------yenAAMVWEg--SHIHSIVpieslted-----iehqhfdgALIAPGFIDLQVNGGGDVMFnndm-- 74  Vibrio cholerae O1...
NP_541363   5 SAIAGarifdgerfhdqSALVFSd--GQIEAIVpeaslaeg-----heierlkgGVLAPGFIDAQVNGGGGRMLndep-- 75  Brucella melitensi...
NP_485031  21 TDIINakvp----gyqdLQMLVVnqgGIIEQILpmgtgfnrvaspdlqiidvagDWISLGGVDLQINGALGLAFpdlaa- 95  Nostoc sp. PCC 7120

Feature 1                                                                    #          #     
1O12_A     73 -----cdFSEXEEFLYSQGVTTFLATTVStsLEKXKEILRKARDYIlenp----stslLGVHLEGPYISKEKKGAHSEkh 143 Thermotoga maritima
1UN7_A     81 ----fstLDIMSSRLPEEGTTSFLATTITqeHGNISQALVNAREWKaaeessllgaelLGIHLEGPFVSPKRAGAQPKew 156 Bacillus subtilis
EAA48962   92 mssygkkVKELNRKLVETGVTSYVPTVTSqtSELYHKVLPFLGPSGdhqiae-dgaesLGAHVEGPFISQTKNGIHNVdv 170 Magnaporthe grisea...
NP_298754  82 ---dvdaLATIARAHRRYGTTGLLPTLISdtVEVMAEAIAATRAAIaqgv-----pgiLGIHLEGPYLNPLRKGTHDHtq 153 Xylella fastidiosa...
NP_419353  74 ---tartIATIGEAHRAYGTTGFLPTLISddLEVVDAALRATEDAIaqgv-----pgvLGVHIEGPFLNPKRKGIHDEak 145 Caulobacter cresce...
NP_105562  76 ---dvasIETICRAHAPFGTTALLPTLITdtPAITAAAIAAGEAAAlqkv-----psfLGLHLEGPHLSIARKGAHDPal 147 Mesorhizobium loti
NP_719052  69 ---tvacIETIGKAHARFGTTGFLPTLITdnVQVMAKAADAVALAVaqks-----agvLGVHFEGPHLSVPKKGVHPQgf 140 Shewanella oneiden...
NP_231418  75 ---tlagIDSICRAHRTHGTAYLLPTLISatPEHINRALDAIQSAIenqv-----sgvLGIHLEGPWLNPEKKGAHNPdl 146 Vibrio cholerae O1...
NP_541363  76 ---tpetMFVIAGGHRKYGTTSLLPTLITdtMPVRDRAIEAAIEAVkad------rgvAGLHLEGPHLAPARKGAHLAel 146 Brucella melitensi...
NP_485031  96 --enahfLGKICQFLWDVGVDGFLPTLVTtsVENIQRSLAVIADFIsttqp---gsqiLGVHLEGPFLNYQKRGAHPAey 170 Nostoc sp. PCC 7120

Feature 1                                                                  #                  
1O12_A    144 i-rpPSERELSEIDSp---------------aKXLTFAPEIe-sSELLLRLVkrDIVLSAGHSiat-feEFXKFyk-egV 204 Thermotoga maritima
1UN7_A    157 i-rpSDVELFKKWQQeag-----------gliKIVTLAPEEdqhFELIRHLKdeSIIASMGHTdad-saLLSDAak-agA 222 Bacillus subtilis
EAA48962  171 lreaLTMEDLEAMYGvdnikpastagsqrlpiRMITAAPELgrmMELIPELQdrNIIYSIGHTeat-yeEASLAva-agA 248 Magnaporthe grisea...
NP_298754 154 f-rvPQLHEVMRCTAldn------------gvTLVTLAPEQv-pLEMIRVFVerGAIVFAGHTaat-yeQVRAGia-agV 217 Xylella fastidiosa...
NP_419353 146 f-rvIDEDAIALLSSlkr------------gkLLLTLAPERt-tPDIIARLAaaGVIVAAGHTnah-yeTMRRAld-hgL 209 Caulobacter cresce...
NP_105562 148 irpmTDADQVMLIAArpk-----------lpvLLTTIAPESv-dPTRVAALAkaGIIVSLGHSdt--gyATAKGfaeagA 213 Mesorhizobium loti
NP_719052 141 i-reITEAELAIFCRqdl------------giRVVTLAPENv-sPEVIRLLVesGVKVCLGHSnad-ydTVVAAlk-agA 204 Shewanella oneiden...
NP_231418 147 f-ysPTPEQLSQFHWptk------------gkVLVTVAAENl-sIDSLKWLKdhHVTLSCGHSnattaqLTTEKla--lI 210 Vibrio cholerae O1...
NP_541363 147 m-rpVNDADIALYIHtarq----------igtLLVTLAAEQv-tPEQVRRLSdgGVIVSIGHSdtt-aeEAFRRfd-agA 212 Brucella melitensi...
NP_485031 171 l-lpLTIEEVQRVLGdya-----------hivKVITLAPELdptGEVIPYLRslGITVSLGHSqat-anQAQNAfa-lgA 236 Nostoc sp. PCC 7120

Feature 1         #  ##                                 #                       #             
1O12_A    205 KRITHFPNGLKPLHHREIGITGAGLLLd---dVKLELICDGVHLSREXVKLVYKvkk-angIVLVTDSISAAGLk-dGTT 279 Thermotoga maritima
1UN7_A    223 SHMTHLYNAMSPFHHREPGVIGTALAHd---gFVTELIADGIHSHPLAAKLAFLakg-sskLILITDSMRAKGLk-dGVY 297 Bacillus subtilis
EAA48962  249 TMITHLFNAMRPLHHRNPGVFGVLGIAerlprPYFGIIADGIHLHPTTIKIAYSahp--egFILVTDAMHLVGLp-dGTY 325 Magnaporthe grisea...
NP_298754 218 TGFTHLYNAMSQLVGREPNVVGAALEDp---dTWCGIIVDGVHVHPASLRVALAakp-rgkVLLVTDAMPPVGSd-sVHY 292 Xylella fastidiosa...
NP_419353 210 TGVTHLFNAMSPLTSREPGVVGAVLENq---nAWAGIIVDGRHVDPVTLKIALRtrp-ldrFMLVTDAMPTVGLt-nKRF 284 Caulobacter cresce...
NP_105562 214 AVVTHLFNAMSQIGNREPGLVGAAIDIg---tLSAGLIADGIHVHPAAIRIALDakqgpgkIVLVTDAMATIGTd-mTSF 289 Mesorhizobium loti
NP_719052 205 TGFTHLYNAMSPLGSREPGVVGAAIESe---tAWCGLIVDGHHVHPAAARIALRakp-rgkMMLVTDAMPPVGMddeTSF 280 Shewanella oneiden...
NP_231418 211 DGFTHLFNAMSPFESREPGVVGTALNTd---hAWCSVITDGIHVHPQSFLLAKRikp-kdkLLIVTDAMASLGSv-tSQF 285 Vibrio cholerae O1...
NP_541363 213 RSVTHLYNAMSQIGHRAPGLAGAALDHp---dIWCGIVADGHHVDPMALRLALRakrgdahLFLVTDAMALVGSd-aESF 288 Brucella melitensi...
NP_485031 237 TMVTHAFNAMPPLHHREPGLLGAAMTNp---hVMCGFIADGQHVSPIMLQILLRat---qgIFLVSDALAPLGLp-dGVY 309 Nostoc sp. PCC 7120

Feature 1                              #                                                      
1O12_A    280 TLGDLVVKVKd--gVPRLe---dGTLAGSTLFFSQAVKNFRKFtgcsiTELAKVSSYNSCVELGld-drGRIAEGTRADL 353 Thermotoga maritima
1UN7_A    298 EFGGQSVTVRg--rTALLs---dGTLAGSILKMNEGARHMREFtncswTDIANITSENAAKQLGifdrkGSVTVGKDADL 372 Bacillus subtilis
EAA48962  326 DWTNGDQCSRivktGSVLtlegsGTIAGSSITLIECVNNFLNWsgctiPQALNAVTATPAALLGlqgvkGSLDPGADADL 405 Magnaporthe grisea...
NP_298754 293 DLYGETITVMd--gVVRNa---aGALAGAALDMATAVRNTVHWlgvdlAEAVRMASTYPAQCIGlgdrlGRIAPGYQADL 367 Xylella fastidiosa...
NP_419353 285 NLQGREIVVRd--gVCVDe---aGTLAGSDLDMAAAVRNAVSMlgltlEDAVMMASAAPSALLGlqqrrGAIAPGLAADF 359 Caulobacter cresce...
NP_105562 290 TLNGRTIYRKd--gSLRLa---dGTLAGADLDMISAVRFMHNIvgvdlSEALRMASLYPAQAIGqshrlGRLANGTVADI 364 Mesorhizobium loti
NP_719052 281 ELFGTQVLRV----GDRLna-vtGELAGCVLDMASAVHNTVNMlglplGEALRMAALYPAEFLGiadsvGRLAVGQRADL 355 Shewanella oneiden...
NP_231418 286 ELDGETIRVI----DNKLin-srGNLAGAHIGMDESVANVIRWgi-aeDEALKMASSYPAQAIQcd-dlGQLKPNYRAAA 358 Vibrio cholerae O1...
NP_541363 289 EINGRSVRRVpggiCSKLvl-pdGTIAGSDLDMASAVRFAVAEleltlAEALRMASLYPARYLRln-drGRFRPGMRMDA 366 Brucella melitensi...
NP_485031 310 PWDSRQIEVQg--gTARLp---dGTLSGTTLPLLVGVENLVNWeicdvETALVLATDAPRKAIGlp--gMKPGQPANLLR 382 Nostoc sp. PCC 7120

Feature 1                            
1O12_A    354 VLLDe-------DLNVVXTIKEG 369 Thermotoga maritima
1UN7_A    373 VIVSs-------DCEVILTICRG 388 Bacillus subtilis
EAA48962  406 VIFSensqpdgpQLLVDQVWKRG 428 Magnaporthe grisea 70-15
NP_298754 368 VWIDd-------DVQVQGTWIAG 383 Xylella fastidiosa 9a5c
NP_419353 360 CRLDd-------ALNVTSTWIDG 375 Caulobacter crescentus CB15
NP_105562 365 VALSd-------GLDIRSVWIGG 380 Mesorhizobium loti
NP_719052 356 VLLDn-------QYQVLANYIAG 371 Shewanella oneidensis MR-1
NP_231418 359 TVLNs-------KYESLAVVSEG 374 Vibrio cholerae O1 biovar eltor str. N16961
NP_541363 367 VHLDd-------GLFAKSTWLSG 382 Brucella melitensis 16M
NP_485031 383 WHWD--------SHTKKLTWQRL 397 Nostoc sp. PCC 7120

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