1O12,1UN7


Conserved Protein Domain Family
NagA

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cd00854: NagA 
Click on image for an interactive view with Cn3D
N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.
Statistics
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PSSM-Id: 238434
View PSSM: cd00854
Aligned: 49 rows
Threshold Bit Score: 351.881
Threshold Setting Gi: 33866816
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                       # #             
1O12_A       13 XIVEKvlivdpidgeftGDVEIEe--GKIVKVEkrec--------------iprGVLXPGFVDPHIHGVVGADTxn---- 72
1UN7_A        9 LLIKDiaivteneviknGYVGINd--GKISTVSterpkepys----keiqapadSVLLPGMIDIHIHGGYGADTmdas-- 80
gi 38102079  16 TKFTNcrlvrg-sslveEDLWVSsatGKIVRSQaifydhnvl---pdeiidlggRIVSPGLIDVQLNGAFGFNFsstfpd 91
gi 15838066  10 GFINGrvlidt-gfrhdLAVLLRg--GCIQALLphddprvte---gaqwmdlrgGLLLPGFIDIQVNGGGGVLFnnar-- 81
gi 16124789   3 IALVNgrvltpagfvsgKAVLVEn--GVVVALLdardvpad-----aqrhdlggDRLVPGFIDTQVNGGGGALFndap-- 73
gi 13473994   5 FALTGarifdgddwhddAALVVRd--GLVEAIVpsgaiard-----vravdtggGMLVPGFVDIQVNGGGGVMLndhp-- 75
gi 24375009   4 TLIAEqlfdge-sfhqdVPVTIEd--GLIASFDtalgak----------evrytGTLVPGFIDVQVNGGGGALFntsp-- 68
gi 15641786  10 RLFDGiqy------yenAAMVWEg--SHIHSIVpieslted-----iehqhfdgALIAPGFIDLQVNGGGDVMFnndm-- 74
gi 17988730   5 SAIAGarifdgerfhdqSALVFSd--GQIEAIVpeaslaeg-----heierlkgGVLAPGFIDAQVNGGGGRMLndep-- 75
gi 17228483  21 TDIINakvp----gyqdLQMLVVnqgGIIEQILpmgtgfnrvaspdlqiidvagDWISLGGVDLQINGALGLAFpdlaa- 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      #          #     
1O12_A       73 -----cdFSEXEEFLYSQGVTTFLATTVStsLEKXKEILRKARDYIlenp----stslLGVHLEGPYISKEKKGAHSEkh 143
1UN7_A       81 ----fstLDIMSSRLPEEGTTSFLATTITqeHGNISQALVNAREWKaaeessllgaelLGIHLEGPFVSPKRAGAQPKew 156
gi 38102079  92 mssygkkVKELNRKLVETGVTSYVPTVTSqtSELYHKVLPFLGPSGdhqiae-dgaesLGAHVEGPFISQTKNGIHNVdv 170
gi 15838066  82 ---dvdaLATIARAHRRYGTTGLLPTLISdtVEVMAEAIAATRAAIaqgv-----pgiLGIHLEGPYLNPLRKGTHDHtq 153
gi 16124789  74 ---tartIATIGEAHRAYGTTGFLPTLISddLEVVDAALRATEDAIaqgv-----pgvLGVHIEGPFLNPKRKGIHDEak 145
gi 13473994  76 ---dvasIETICRAHAPFGTTALLPTLITdtPAITAAAIAAGEAAAlqkv-----psfLGLHLEGPHLSIARKGAHDPal 147
gi 24375009  69 ---tvacIETIGKAHARFGTTGFLPTLITdnVQVMAKAADAVALAVaqks-----agvLGVHFEGPHLSVPKKGVHPQgf 140
gi 15641786  75 ---tlagIDSICRAHRTHGTAYLLPTLISatPEHINRALDAIQSAIenqv-----sgvLGIHLEGPWLNPEKKGAHNPdl 146
gi 17988730  76 ---tpetMFVIAGGHRKYGTTSLLPTLITdtMPVRDRAIEAAIEAVkad------rgvAGLHLEGPHLAPARKGAHLAel 146
gi 17228483  96 --enahfLGKICQFLWDVGVDGFLPTLVTtsVENIQRSLAVIADFIsttqp---gsqiLGVHLEGPFLNYQKRGAHPAey 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    #                  
1O12_A      144 i-rpPSERELSEIDSp---------------aKXLTFAPEIe-sSELLLRLVkrDIVLSAGHSiat-feEFXKFyk-egV 204
1UN7_A      157 i-rpSDVELFKKWQQeag-----------gliKIVTLAPEEdqhFELIRHLKdeSIIASMGHTdad-saLLSDAak-agA 222
gi 38102079 171 lreaLTMEDLEAMYGvdnikpastagsqrlpiRMITAAPELgrmMELIPELQdrNIIYSIGHTeat-yeEASLAva-agA 248
gi 15838066 154 f-rvPQLHEVMRCTAldn------------gvTLVTLAPEQv-pLEMIRVFVerGAIVFAGHTaat-yeQVRAGia-agV 217
gi 16124789 146 f-rvIDEDAIALLSSlkr------------gkLLLTLAPERt-tPDIIARLAaaGVIVAAGHTnah-yeTMRRAld-hgL 209
gi 13473994 148 irpmTDADQVMLIAArpk-----------lpvLLTTIAPESv-dPTRVAALAkaGIIVSLGHSdt--gyATAKGfaeagA 213
gi 24375009 141 i-reITEAELAIFCRqdl------------giRVVTLAPENv-sPEVIRLLVesGVKVCLGHSnad-ydTVVAAlk-agA 204
gi 15641786 147 f-ysPTPEQLSQFHWptk------------gkVLVTVAAENl-sIDSLKWLKdhHVTLSCGHSnattaqLTTEKla--lI 210
gi 17988730 147 m-rpVNDADIALYIHtarq----------igtLLVTLAAEQv-tPEQVRRLSdgGVIVSIGHSdtt-aeEAFRRfd-agA 212
gi 17228483 171 l-lpLTIEEVQRVLGdya-----------hivKVITLAPELdptGEVIPYLRslGITVSLGHSqat-anQAQNAfa-lgA 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  ##                                 #                       #             
1O12_A      205 KRITHFPNGLKPLHHREIGITGAGLLLd---dVKLELICDGVHLSREXVKLVYKvkk-angIVLVTDSISAAGLk-dGTT 279
1UN7_A      223 SHMTHLYNAMSPFHHREPGVIGTALAHd---gFVTELIADGIHSHPLAAKLAFLakg-sskLILITDSMRAKGLk-dGVY 297
gi 38102079 249 TMITHLFNAMRPLHHRNPGVFGVLGIAerlprPYFGIIADGIHLHPTTIKIAYSahp--egFILVTDAMHLVGLp-dGTY 325
gi 15838066 218 TGFTHLYNAMSQLVGREPNVVGAALEDp---dTWCGIIVDGVHVHPASLRVALAakp-rgkVLLVTDAMPPVGSd-sVHY 292
gi 16124789 210 TGVTHLFNAMSPLTSREPGVVGAVLENq---nAWAGIIVDGRHVDPVTLKIALRtrp-ldrFMLVTDAMPTVGLt-nKRF 284
gi 13473994 214 AVVTHLFNAMSQIGNREPGLVGAAIDIg---tLSAGLIADGIHVHPAAIRIALDakqgpgkIVLVTDAMATIGTd-mTSF 289
gi 24375009 205 TGFTHLYNAMSPLGSREPGVVGAAIESe---tAWCGLIVDGHHVHPAAARIALRakp-rgkMMLVTDAMPPVGMddeTSF 280
gi 15641786 211 DGFTHLFNAMSPFESREPGVVGTALNTd---hAWCSVITDGIHVHPQSFLLAKRikp-kdkLLIVTDAMASLGSv-tSQF 285
gi 17988730 213 RSVTHLYNAMSQIGHRAPGLAGAALDHp---dIWCGIVADGHHVDPMALRLALRakrgdahLFLVTDAMALVGSd-aESF 288
gi 17228483 237 TMVTHAFNAMPPLHHREPGLLGAAMTNp---hVMCGFIADGQHVSPIMLQILLRat---qgIFLVSDALAPLGLp-dGVY 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #                                                      
1O12_A      280 TLGDLVVKVKd--gVPRLe---dGTLAGSTLFFSQAVKNFRKFtgcsiTELAKVSSYNSCVELGld-drGRIAEGTRADL 353
1UN7_A      298 EFGGQSVTVRg--rTALLs---dGTLAGSILKMNEGARHMREFtncswTDIANITSENAAKQLGifdrkGSVTVGKDADL 372
gi 38102079 326 DWTNGDQCSRivktGSVLtlegsGTIAGSSITLIECVNNFLNWsgctiPQALNAVTATPAALLGlqgvkGSLDPGADADL 405
gi 15838066 293 DLYGETITVMd--gVVRNa---aGALAGAALDMATAVRNTVHWlgvdlAEAVRMASTYPAQCIGlgdrlGRIAPGYQADL 367
gi 16124789 285 NLQGREIVVRd--gVCVDe---aGTLAGSDLDMAAAVRNAVSMlgltlEDAVMMASAAPSALLGlqqrrGAIAPGLAADF 359
gi 13473994 290 TLNGRTIYRKd--gSLRLa---dGTLAGADLDMISAVRFMHNIvgvdlSEALRMASLYPAQAIGqshrlGRLANGTVADI 364
gi 24375009 281 ELFGTQVLRV----GDRLna-vtGELAGCVLDMASAVHNTVNMlglplGEALRMAALYPAEFLGiadsvGRLAVGQRADL 355
gi 15641786 286 ELDGETIRVI----DNKLin-srGNLAGAHIGMDESVANVIRWgi-aeDEALKMASSYPAQAIQcd-dlGQLKPNYRAAA 358
gi 17988730 289 EINGRSVRRVpggiCSKLvl-pdGTIAGSDLDMASAVRFAVAEleltlAEALRMASLYPARYLRln-drGRFRPGMRMDA 366
gi 17228483 310 PWDSRQIEVQg--gTARLp---dGTLSGTTLPLLVGVENLVNWeicdvETALVLATDAPRKAIGlp--gMKPGQPANLLR 382
                       410       420
                ....*....|....*....|...
Feature 1                              
1O12_A      354 VLLDe-------DLNVVXTIKEG 369
1UN7_A      373 VIVSs-------DCEVILTICRG 388
gi 38102079 406 VIFSensqpdgpQLLVDQVWKRG 428
gi 15838066 368 VWIDd-------DVQVQGTWIAG 383
gi 16124789 360 CRLDd-------ALNVTSTWIDG 375
gi 13473994 365 VALSd-------GLDIRSVWIGG 380
gi 24375009 356 VLLDn-------QYQVLANYIAG 371
gi 15641786 359 TVLNs-------KYESLAVVSEG 374
gi 17988730 367 VHLDd-------GLFAKSTWLSG 382
gi 17228483 383 WHWD--------SHTKKLTWQRL 397

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