Conserved Protein Domain Family
STKc_Nek10

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cd08528: STKc_Nek10 (this model, PSSM-Id:173770 is obsolete and has been replaced by 270867)
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A-related kinase 10
Serine/Threonine Kinases (STKs), Never In Mitosis gene A (NIMA)-related kinase 10 (Nek10) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek10 subfamily is one of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24.
Statistics
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PSSM-Id: 173770
View PSSM: cd08528
Aligned: 5 rows
Threshold Bit Score: 501.263
Threshold Setting Gi: 7498109
Created: 18-Feb-2010
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #                      # #                                       
EAW64378      518 NYAILDhLGSGAFGCVYKVRKhs----------gQNLLAMKEVNlhnpafgkdkkdrdssvrNIVSELTIIKEQlyHPNI 587  human
XP_683719     504 GYAVLEhLGSGAFGSVFKVRKqn----------gQNILALKEVNfhnpafgkdkrsrdssveKIVSEMTIIKEQmsHPNI 573  zebrafish
XP_002169305   60 SYAVYEhLGTGAFGSVYKVQYtnisilqvkrkggQSYLAMKEISvrhpefgkg-rersenidSLINECSFVKKQlnHPNI 138  Hydra magnipa...
XP_002596929  471 TYAVYElLGSGAFGNVYKVKKkd---------ssGTFLALKEINvhnpalgktakekdksigDIVAEINIIREQlrHPNI 541  Florida lancelet
T15881        430 EYELLDqLGAGAFGCVYTVRKkaqsh----senpAKLLALKEIFmtnlndr----esdksfgDMISEVKIIKQQlrHPNI 501  nematode
Feature 1         #               ####   # #                                         # # ## #     
EAW64378      588 VRYYKTFLEndRLYIVMELIEGAPLGEHFSSLKEKhhHFTEERLWKIFIQLCLALRYLHKEKrIVHRDLTPNNIMLGdkD 667  human
XP_683719     574 VKYFKTFLEgdKLYIVMELIEGAPLAEHFSSLKEKkqTFTEERVWNIFIQICLALRYLHKEKrIIHRDLTPNNIMLGerD 653  zebrafish
XP_002169305  139 VKYHKAFLEgdKLYIIMDLIDGAPIGEHFNSLKEKgqRFSEERLWNIFVQMVLALRYIHKEKfIVHRDLTPNNIMLGedD 218  Hydra magnipa...
XP_002596929  542 VRYYKTFTEndRLYILMDLIEGAPLGEHFNSLKEKgeRFPEDRIWNIFLQIVLALRYLHKERkIVHRDLKPDNIMLGenD 621  Florida lancelet
T15881        502 VRYRRIFVEnhRLYIVMDLIQGCSLRDLIITMKEKkgNFEEKKIWAMVVQMMLALRYLHKEKqIVHRDLKPNNIMMTtdE 581  nematode
Feature 1              #  # #             ####                                                    
EAW64378      668 KVTVTDFGLAKQKQens-klTSVVGTILYSCPEVLKSEpYGEKADVWAVGCILYQMatLSPPFYStNMLSLATKIVEAvY 746  human
XP_683719     654 KVTITDFGLAKQKQens-klTSVVGTILYCCPEIVKNEpYGEKADVWAAGCILYQTvtLNPPFYSaNMLSLATKIVEAvY 732  zebrafish
XP_002169305  219 QVTITDFGLARQKNpeasklTSKVGTIVYSCPEIVKGLpYGEKADIWGIGCILYQMamLEPPFFSnNMLSMATKIVDGlY 298  Hydra magnipa...
XP_002596929  622 KVTITDFGLARQKSreeskmTSVVGTILYSCPEIVKSEpYTEKADVWASGCILYQMcaLQPPFYSsNMLSLATKIVNAeY 701  Florida lancelet
T15881        582 RVVITDFGLAKQKGpe--ylKSAAGTIIYSCPEIVQNLpYGEKADIWSFGCCIYEMcqLQPVFHStNMLTLAMQIVEAkY 659  nematode
Feature 1                                                
EAW64378      747 EPVpegiYSEKVTDTISRCLTPdAEARPDiVEVSSMISD 785  human
XP_683719     733 EPLedktFSERVTDMIKWCLTPnADVRPDiIEVSSRISD 771  zebrafish
XP_002169305  299 EPLkdgvYSTLVTLVIQRCLTVsAEERPDiIQVAAMIPD 337  Hydra magnipapillata
XP_002596929  702 EPLpedlYSQQITGVIGSCLTSePEDRPDiVQVAALISD 740  Florida lancelet
T15881        660 DPLne-mWSDDLRFLITSCLAPdPSARPDiLKVSGMCGV 697  nematode

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