2QP9,1XWI,3EIE,2RKO,3EIH,2ZAM,5UIE,5XMI,6BMF,6AP1


Conserved Protein Domain Family
RecA-like_VPS4

?
cd19521: RecA-like_VPS4 
ATPase domain of vacuolar protein sorting-associated protein 4
Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Statistics
?
PSSM-Id: 410929
Aligned: 16 rows
Threshold Bit Score: 328.745
Created: 27-Nov-2017
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
ATP bindinghexamer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3EIH; Saccharomyces cerevisiae Vps4 with bound ATP, contacts at 4A
    View structure with Cn3D
  • Comment:contains Walker A and Walker B motifs

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1            ### #                                    #######                         
2QP9_X     45 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVAtea-nsTFFSVSSSDLVSK 123 baker's yeast
1XWI_A      6 RPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVAteannsTFFSISSSDLVSK 85  human
Q54PT2    129 KPNVKWDDVAGLYQAKEYLKEAVIFPIKFPQMFTGNRKPWKGILLYGPPGTGKSYLAKAVAtei-ssTFFSISPSDIVTK 207 Dictyostelium disc...
3EIH_A     30 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVAtea-nsTFFSVSSSDLVSK 108 baker's yeast
2ZAM_A    128 RPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVAteannsTFFSISSSDLVSK 207 house mouse
5UIE_A    127 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVAtea-nsTFFSVSSSDLVSK 205 baker's yeast
NP_490816 112 KPNVKWTDIAGLEGAKEALKEAVILPIKFPQLFTGNRKPWQGILLFGPPGTGKSYIAKAVAteagesTFFSISSSDLMSK 191 Caenorhabditis ele...
NP_573258 126 KPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVAteanrsTFFSVSSSDLMSK 205 fruit fly
NP_180328 126 KPNIKWSDVAGLESAKQALQEAVILPVKFPQFFTGKRRPWRAFLLYGPPGTGKSYLAKAVAtea-dsTFFSVSSSDLVSK 204 thale cress
6BMF_A     27 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVAtea-nsTFFSVSSSDLVSK 105 baker's yeast
Feature 1                               #                                             #       
2QP9_X    124 WMgesEKLVKQLFAMAREnkPSIIFIDQVDALTGTRGEg-ESEASRRIKTELLVQMngvgndsqGVLVLGATNIPwQLDS 202 baker's yeast
1XWI_A     86 WLgesEKLVKNLFQLAREnkPSIIFIDEIDSLCGSRSEn-ESEAARRIKTEFLVQMqgvgvdndGILVLGATNIPwVLDS 164 human
Q54PT2    208 WLgdsEKLVKQLFEMAREknNSVIFIDEVDSLCSSRNDq-ESESARRIKTEFLIQMngvgndsdGILVLAATNIPwGLDL 286 Dictyostelium disc...
3EIH_A    109 WMgesEKLVKQLFAMAREnkPSIIFIDQVDALTGTRGEg-ESEASRRIKTELLVQMngvgndsqGVLVLGATNIPwQLDS 187 baker's yeast
2ZAM_A    208 WLgesEKLVKNLFQLAREnkPSIIFIDEIDSLCGSRSEn-ESEAARRIKTEFLVQMqgvgvdndGILVLGATNIPwVLDS 286 house mouse
5UIE_A    206 WMgesEKLVKQLFAMAREnkPSIIFIDEVDALTGTRGEg-ESEASRRIKTELLVQMngvgndsqGVLVLGATNIPwQLDS 284 baker's yeast
NP_490816 192 WLgesEKLVKNLFALAREhkPSIIFIDEIDSLCSARSDn-ESESARRIKTEFMVQMqgvglnndGILVLGATNIPwILDS 270 Caenorhabditis ele...
NP_573258 206 WLgesEKLVKNLFELARQhkPSIIFIDEIDSMCSARSDn-ENDSVRRIKTEFLVQMqgvgndtdGILVLGATNIPwVLDS 284 fruit fly
NP_180328 205 WMgesEKLVSNLFEMAREsaPSIIFVDEIDSLCGTRGEgnESEASRRIKTELLVQMqgvghndeKVLVLAATNTPyALDQ 284 thale cress
6BMF_A    106 WMgesEKLVKQLFAMAREnkPSIIFIDEVDALTGTRGEg-ESEASRRIKTELLVQMngvgndsqGVLVLGATNIPwQLDS 184 baker's yeast
Feature 1                 
2QP9_X    203 AIRRRFERRIYI 214 baker's yeast
1XWI_A    165 AIRRRFEKRIYI 176 human
Q54PT2    287 AIRRRFEKRIYI 298 Dictyostelium discoideum AX4
3EIH_A    188 AIRRRFERRIYI 199 baker's yeast
2ZAM_A    287 AIRRRFEKRIYI 298 house mouse
5UIE_A    285 AIRRRFERRIYI 296 baker's yeast
NP_490816 271 AIRRRFEKRIYI 282 Caenorhabditis elegans
NP_573258 285 AIRRRFEKRIYI 296 fruit fly
NP_180328 285 AIRRRFDKRIYI 296 thale cress
6BMF_A    185 AIRRRFERRIYI 196 baker's yeast

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap