1Z5Z,1Z3I,3DMQ,5GN1,5JXT,5O9G,5VVR


Conserved Protein Domain Family
SF2_C_SNF

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cd18793: SF2_C_SNF 
Click on image for an interactive view with Cn3D
C-terminal helicase domain of the SNF family helicases
The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Statistics
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PSSM-Id: 350180
Aligned: 249 rows
Threshold Bit Score: 65.1904
Created: 31-Jan-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingDNA binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:5O9G; Saccharomyces cerevisiae CHD1 binds ADP BeF3, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1Z5Z_A      25 LPDKIETNVycnltpeqaamykaevenlfnnidsvtgikr---------------------------------------- 64   Sulfolobus solfa...
5O9G_W     606 LPSKTERILrvelsdvqteyykniltknysaltagakgghfsllnimne------------------------------- 654  Saccharomyces ce...
NP_863922  468 LPPAKEDALfatlrmglslpdnkfftdrgfgsleyleqqavsqslepgflqqhnpivrhtvlrrrqtleeaglmervgvd 547  Rhodopirellula b...
ABE62176   483 LPAAAENDVifgfvrdaiqlrpdrfvtqvsfsdindafcrdqfvddvltpkddlgffqrnnpvvrhvvlrkrstlermgl 562  Nitrobacter hamb...
ACB10136   238 RTKKVVNDLekreifkkcdfnavivditeeekrffeeldevlfemvkdvhmnspvallavllrkraassyesalktinni 317  Thermotoga sp. RQ2
EES25917   264 LPPHVGHPRkfdllvvdeahnvapsagahyalesqrtrfvraigphfqhrlfltatphngytesftsllellddqrfarn 343  Burkholderia pse...
ADB76321   264 LASRTDALVlasatphngktasfaelvrmldpsavrpdggliedevkrlvirrhrhspdvasvvggdwaerkepqnllva 343  Geodermatophilus...
EFX13465   324 FPERNIVKLtrlasgaeeeayrrlvesqfrddddeqaqsnkgrlfkitlekalfs------------------------- 378  Escherichia coli...
ADX84674   365 IPQLIEFAKrvi-------------------------------------------------------------------- 376  Sulfolobus islan...
AEB27219   623 LADKYDEDEftdkldemvfegkakklskddfadg---------------------------------------------- 656  Francisella cf. ...
Feature 1                                                                                      
1Z5Z_A         --------------------------------------------------------------------------------      Sulfolobus solfa...
5O9G_W         --------------------------------------------------------------------------------      Saccharomyces ce...
NP_863922  548 vhpdpdapatsyagvgfnglglm--------------------------------------------------------- 570  Rhodopirellula b...
ABE62176   563 ipripvdihplpgshmppmfnglg-------------------------------------------------------l 587  Nitrobacter hamb...
ACB10136   318 ik------------------------------------------------------------------------------ 319  Thermotoga sp. RQ2
EES25917   344 ilpdenrlsqvmirrlksdlvdadgnplyarrtlqalevpytaeerevhrklddycasrekdaenagngfgtafvnrllk 423  Burkholderia pse...
ADB76321   344 pspaesaivreled------------------------------------------------------------------ 357  Geodermatophilus...
EFX13465       --------------------------------------------------------------------------------      Escherichia coli...
ADX84674       --------------------------------------------------------------------------------      Sulfolobus islan...
AEB27219       --------------------------------------------------------------------------------      Francisella cf. ...
Feature 1                                                                                      
1Z5Z_A      65 ----------------------------------------------------------------kgmilstllklkqivd 80   Sulfolobus solfa...
5O9G_W     655 -------------------------------------------------------lkkasnhpylfdnaeervlqkfgdg 679  Saccharomyces ce...
NP_863922  571 tnhpfdlayeaadaytvelkkrtkaagfmkslllqricssfasgestarkmlrqevadeeeqpmlieqtlqnttdkeaey 650  Rhodopirellula b...
ABE62176   588 gtshafdmayeaadkftkvlrkrkksagfmrslmlqrlcssyasglataekllagrslddeelelelgdegltlideerr 667  Nitrobacter hamb...
ACB10136   320 ---------------------nqysgasgedvledqikqifglgydemeleenseiddlissiinsvakrypldkgqina 378  Thermotoga sp. RQ2
EES25917   424 krllsspaafastlekhvtslsearpakldtmaerilhkailkadedyaddgdvenaqaeaveeatrrsipltpeqratl 503  Burkholderia pse...
ADB76321   358 ---------twlyppdgsspysgangglfpwtlakaflsspaalresvrerirrldpprkgdqaarpaptseqrreieal 428  Geodermatophilus...
EFX13465   379 -------------------------------------------------spmacasvvanrlkrfesrkdhnsqsqinel 409  Escherichia coli...
ADX84674       --------------------------------------------------------------------------------      Sulfolobus islan...
AEB27219   657 ----------------------------------------------------------------------yldelkadly 666  Francisella cf. ...
Feature 1                                                                                      
1Z5Z_A      81 hpallkggeqsvrrSGKMIRTMEIIEeald-----egdKIAIFTQFVdmgKIIRNIIEkel-----------nteVPFLY 144  Sulfolobus solfa...
5O9G_W     680 kmtrenvlrglimsSGKMVLLDQLLTrlkk-----dghRVLIFSQMVrmlDILGDYLSikg------------inFQRLD 742  Saccharomyces ce...
NP_863922  651 lntiieelsreearDPKLTAIRYFLTqhrtegktwlehGCIVFSQYYdtaFSVARELAlvlrdepvgvyagagksGLFRN 730  Rhodopirellula b...
ABE62176   668 hlqtiidvlsphptDPKFDAVLYFLEerrw-----lelGCIVFSQYFdttKWVAEGLTgrlprepvavyagagksGIYIN 742  Nitrobacter hamb...
ACB10136   379 lekilkigkaigknDSKLKTLAEVLAyhlk-----kneKVIVFTEFKdtlEYLRNNLPtlleqegi--hlseekdISVLH 451  Thermotoga sp. RQ2
EES25917   504 ddlrawaqrarnqaDSKAQAILRWLSaylkpdgqwndrRVILFTEYRtthQWMHQILAshgf---------ggerLGLLH 574  Burkholderia pse...
ADB76321   429 enldalaaeagtetSGKCAALLTYLRkigvg--pkkpmRAVVFAERVatlRWLQESLCadlgl--------sqdqVAVLH 498  Geodermatophilus...
EFX13465   410 eslllalnnidasqFSKYQLLLDTIRkdlawkanntedRLVIFTESIktlEFLEQQLRadlkl--------kddqIATLR 481  Escherichia coli...
ADX84674   377 ------------nnDSRIKALTNLVKahln-----rgdKVIVFTEYKdtaNYILDKLKrelnl--------sdkeIKKVT 431  Sulfolobus islan...
AEB27219   667 fidklckdwgnvnkDPKLDRLKQIIQsnk-------kdKIVVFTESKktaNYLGQQLAdt-------------eqVLTIT 726  Francisella cf. ...
Feature 1                                            ## #                       #  #           
1Z5Z_A     145 GelskkERDDIISKFqnnp----svkFIVLSVKAggFGINLTs-ANRVIHFDrwWNPAVEDQATDRVYRIGQtrNVIVHK 219  Sulfolobus solfa...
5O9G_W     743 GtvpsaQRRISIDHFnspd---sndfVFLLSTRAggLGINLMt-ADTVVIFDsdWNPQADLQAMARAHRIGQknHVMVYR 818  Saccharomyces ce...
NP_863922  731 GdfanvEREELKHAVkkr------elRLLVATDAacEGLNLQt-LGTLINVDlpWNPSRLEQRLGRIKRFNQarRTVDML 803  Rhodopirellula b...
ABE62176   743 GewksvEREQIKRAVker------tiRLIVATDAacEGLNLQt-LGTLINVDlpWNPSRLEQRIGRIKRFGQrrDRVDML 815  Nitrobacter hamb...
ACB10136   452 GgmkseEIEKQVEKFan-------dgKLLISTDVasEGLNLQv-ANILINYEipWSPIKLEQRVGRIWRLNQtkETIAYT 523  Thermotoga sp. RQ2
EES25917   575 GglsqeEREPIKAAFqaspq--dspvRILLATDAasEGIDLQnhCNRLIHLEipYNPNVMEQRNGRIDRHGQreKEVLIW 652  Burkholderia pse...
ADB76321   499 GglsdvDQQEVVESFkqas----spiRVLVTGDVasEGVNLHaqCHELIHFDipWSLIRIEQRNGRIDRYGQkhQPQITT 574  Geodermatophilus...
EFX13465   482 GdqgdtVLMETVEAFgktq----splRLLVCSDVasEGINLHhlSHKMIHFDipWSLMVFQQRNGRIDRYGQkhQPQIRY 557  Escherichia coli...
ADX84674   432 SetvnqEGIDQIKKWles-----kesKVLVATDVasEGLNLQs-ANVIIHYEipLSIVRFEQRNGRVWRLKQtkPVYIYY 505  Sulfolobus islan...
AEB27219   727 SenrdrLKDTIRENFdanyhkqkndySVIISTDTlsEGVNMHr-SNIIYNYDipWNSTRLMQRIGRINRIGTkhDEIFVY 805  Francisella cf. ...
Feature 1        
1Z5Z_A     220 LI 221  Sulfolobus solfataricus P2
5O9G_W     819 LV 820  Saccharomyces cerevisiae S288c
NP_863922  804 NL 805  Rhodopirellula baltica SH 1
ABE62176   816 NL 817  Nitrobacter hamburgensis X14
ACB10136   524 LL 525  Thermotoga sp. RQ2
EES25917   653 HP 654  Burkholderia pseudomallei 1106b
ADB76321   575 LL 576  Geodermatophilus obscurus DSM 43160
EFX13465   558 LL 559  Escherichia coli O157:H- str. 493-89
ADX84674   506 IS 507  Sulfolobus islandicus REY15A
AEB27219   806 NF 807  Francisella cf. novicida Fx1

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