3LY5


Conserved Protein Domain Family
DEADc_DDX18
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cd17942: DEADc_DDX18 
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DEAD-box helicase domain of DEAD box protein 18
This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350700
Aligned: 14 rows
Threshold Bit Score: 327.395
Created: 30-Jan-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on structures of other members of the DEAD-box helicase family with bound ADP/AMP
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ## ###  #                 ########                                     
3LY5_A     65 TLKAIKe-mGFTNMTeIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVELIVKLrfmPRNGTGVLILSPTRELAMQTF 143 human
NP_732694 198 TLRAIKe-mGFTEMTeIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLrfmPRNGTGVIIISPTRELSMQTF 276 fruit fly
Q9SB89    165 TYKSIKe-mGFARMTqIQAKAIPPLMMGEDVLGAARTGSGKTLAFLIPAVELLYRVkftPRNGTGVLVICPTRELAIQSY 243 thale cress
CAK91823   85 SKKALEk-mNFTKMThIQARAIPHLLKGRDVLGAAKTGSGKTLAFLVPALELLYKNqfqQKNGTGIIVLTPTRELAQQIF 163 Paramecium tetraur...
1351666   100 IQKAIKe-mGFETMTeIQKRSIPPLLAGRDVLGAAKTGSGKTLAFLIPTIEMLYALkfkPRNGTGVIIISPTRELALQIF 178 Schizosaccharomyce...
Q7S2N9    118 TMKAIAe-mGFTKMTeIQRRGIPPLLAGKDVLGAAKTGSGKTLAFLIPAIEMLSSLrfkPRNGTGAIVVTPTRELALQIF 196 Neurospora crassa ...
EFV52921  303 TLKAIRd-mGFETMTeIQAQTIPSLLEGRDVMGAAKTGSGKTLAFLVPAVELLYKLrflPRNGTGCIVISPTRELSMQTY 381 Trichinella spiralis
2500537    53 TLKAIEk-mGFTTMTsVQARTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIELLHSLkfkPRNGTGIIVITPTRELALQIF 131 Saccharomyces cere...
CBH15675  120 IVTALEndfKFQELTgIQGRCIPAALAGRDLLAEAKTGSGKTLAFLIPIVEIITRVgfrQRSGTAAIIIGPTRELCLQIE 199 Trypanosoma brucei...
Q54S03    130 TKKSIEe-mGFKKMTpIQAKSILPLLEGKDLLGAARTGSGKTLAFLIPAIEVLVKSnfkPRNGTGVIIISPTRELALQIY 208 Dictyostelium disc...

Feature 1                                                                                     
3LY5_A    144 GVLKELMth--hvHTYGLIMGGsNRSAEAQKLGnGINIIVATPGRLLDHMQNtp----gfMYKNLQCLVIDEADRILdVG 217 human
NP_732694 277 GVLKELMah--hhHTYGLVMGGsNRQVESEKLGkGINILVATPGRLLDHLQNsp----dfLYKNLQCLIIDEVDRILeIG 350 fruit fly
Q9SB89    244 GVAKELLky--hsQTVGKVIGGeKRKTEAEILAkGVNLLVATPGRLLDHLENtn----gfIFKNLKFLVMDEADRILeQN 317 thale cress
CAK91823  164 DVAKDLLfy--hqKTLGLLIGGaNRKEEAIRLQkGVNILIATPGRLLDHLQNtk----gfIYHNLQCLIIDEADQLLkIG 237 Paramecium tetraur...
1351666   179 GVAKELLky--hhQTFGIVIGGaNRRAEADKLVkGVNLLVATPGRLLDHLQNtk----gfVFRNLRSLVIDEADRILeIG 252 Schizosaccharomyce...
Q7S2N9    197 GVARELMkn--hsQTYGVVIGGaNRRAEAEKLGkGVNLLIATPGRLLDHLQNtp-----fVFKNMRSLIIDEADRILeIG 269 Neurospora crassa ...
EFV52921  382 GVLIELLky--hsITHGLVIGGaNRKIEAAKLStGICILVATPGRLLDHLRVsglnttefTYKNLQCLIIDEADRILeIG 459 Trichinella spiralis
2500537   132 GVARELMef--hsQTFGIVIGGaNRRQEAEKLMkGVNMLIATPGRLLDHLQNtk----gfVFKNLKALIIDEADRILeIG 205 Saccharomyces cere...
CBH15675  200 GVLLKLLkhfngsVTFLCCIGGiSRKQEAFKLVsGMMVVMATPGRLLDHLKLtt----dwLTKNLLVLAVDEADRVLdNG 275 Trypanosoma brucei...
Q54S03    209 GVARELMky--htQTHGIVIGGaSKKPEEERLEkGVNLLVATPGRLLDHLQNtk----gfITKNLKCLIIDEADRILeVG 282 Dictyostelium disc...

Feature 1                                                   
3LY5_A    218 FEEELKQIIKLLPt-RRQTMLFSATQTRKVEDLARISLK-KEPLYV 261 human
NP_732694 351 FEEELKQIINLLPk-RRQTMLFSATQTARIEALSKLALKsEPIYVG 395 fruit fly
Q9SB89    318 FEEDLKKILNLLPk-TRQTSLFSATQSAKVEDLARVSLT-SPVYID 361 thale cress
CAK91823  238 YEEEMNEILNLLPs-ERQTVLFSATQTKKVDDLARLSLN-QPIYIG 281 Paramecium tetraurelia
1351666   253 FEDEMRQIMKILPseNRQTLLFSATQTTKVEDLARISLKpGPLYVN 298 Schizosaccharomyces pombe 972h-
Q7S2N9    270 FEDEMRQIIKILPkeDRQTMLFSATQTTKVEDLARISLRpGPLYVN 315 Neurospora crassa OR74A
EFV52921  460 FELEMQQIIRLLPk-QRQTMLFSATQTAKIEDLAKLALKkEPLFVG 504 Trichinella spiralis
2500537   206 FEDEMRQIIKILPneDRQSMLFSATQTTKVEDLARISLRpGPLFIN 251 Saccharomyces cerevisiae S288c
CBH15675  276 FEDDMREIVSLLPr-QRQTFLFSATQTTRVEQLARVSFYrPPLFIS 320 Trypanosoma brucei gambiense DAL972
Q54S03    283 FEEEMHQIIKKVPk-TRQTMLFSATQTRKVDDIAKVSLNnSPVYVG 327 Dictyostelium discoideum

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