1QDE,3EIQ,1WRB,3DKP,2KBE,2PL3,2OXC,3BER,3FE2,3IUY,5H1Y,3LY5,4LJY,1S2M,4NHO,2DB3,3SQW,1XTI,1HV8,2Z0M,3MWJ,4KBF,2GXQ,5GJU,1Q0U,5IVL,5E7I


Conserved Protein Domain Family
DEADc
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cd00268: DEADc 
Click on image for an interactive view with Cn3D
DEAD-box helicase domain of DEAD box helicases
DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350669
Aligned: 250 rows
Threshold Bit Score: 129.484
Created: 1-Nov-2000
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2PL3; Homo sapiens DDX10 with bound ADP, contacts at 4A
  • Structure:3BER: Homo sapiens DDX47 binds AMP; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                ## ###  #                 ########                                      
1QDE_A        25 LLRGVFgyGFEEPSaIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIdtsv------------------------ 80  baker's yeast
2PL3_A        36 TLKGLQeaQYRLVTeIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrlqwt---------------------s 94  human
YP_001295581   7 SNNILLnlGIESLNeMQEVAQDAILNDNNVLLLSPTGSGKTLAFLLPIFEMLqeni------------------------ 62  Flavobacterium ...
AAK39673      13 LTSNLTrlGYKFLTkVQELCFPLIINGKNLILSSPTGSGKTLALLIPIIEKChrmqwn---------------------l 71  Guillardia theta
EAP86388       8 QKEILDklNIKTLNpMQEEALLAITSTANTVLLSPTGTGKTVAFLLPLINDLnrdi------------------------ 63  Croceibacter at...
EGJ71340       6 IKQAMQelGIDELTpLQQKTINLAIDKRDLIVLSPTGSGKTLAYLLPLLLNLkenk------------------------ 61  Bacteroides cop...
XP_003239982  22 TIQSLSklGYKKMTsIQKISIPPALMGFDVLGSAKTGSGKTLCFVIPVIEISliqnyiqn-----------------dml 84  Cryptomonas par...
NP_810067      8 IQSALQnlKIESLNsMQEAALEQGTGRKDVILLSPTGSGKTLAYLLPLLLTLkpnd------------------------ 63  Bacteroides the...
Q54CH6        25 LINNIKryGITKLTpFQMEVIKEIKENSNVIVDSIEGTGRTISLIIGTLDKIdetkqqqeqeqq--------erqqtdqq 96  Dictyostelium d...
CAK90308      12 IVEAFEkmNFKKPSlIQQKSIPSILQKEDVICQGEAGTGKTLCFLVQVLQYGleiqqdayerkariqqtlvvdntiqnfe 91  Paramecium tetr...

Feature 1                                                                                        
1QDE_A        81 -kapQALMLAPTRELALQIQKVVMALafh------mdIKVHACIGGtsfved--aeglrDAQIVVGTPGRVFDNIQRrr- 150 baker's yeast
2PL3_A        95 tdglGVLIISPTRELAYQTFEVLRKVgkn------hdFSAGLIIGGkdlkhe--aerinNINILVCTPGRLLQHMDEtvs 166 human
YP_001295581  63 -tsvQCLILVPSRELALQIEQVWKKMgt--------sYKVNVCYGGhsidte-iknlsnPPAVLIGTPGRIADHIDRgt- 131 Flavobacterium ...
AAK39673      72 ndemIGCIITPSRELSFQIFDISINLtkf------srIKISLVISKinwk------lknNFTFIIGTPGCIFLVFKQeqk 139 Guillardia theta
EAP86388      64 -eqvQALILVPSRELAIQIEQVIREMgs--------gFKANAVYGGrpfskd-kielshAPAILIGTPGRVADHLRRgt- 132 Croceibacter at...
EGJ71340      62 pkkiSTLILVPSRELAQQVNRVFSSLks--------gFNSVCAYGGhsiqeeknslltgSPHVLVGTPGRILDHMNRgn- 132 Bacteroides cop...
XP_003239982  85 vnlvKSCILFPTRELGIQIFDFVKNIea--------kIKIKLCLGKime--------keKCSMVLSTPGSLFNHLNNks- 147 Cryptomonas par...
NP_810067     64 -dsvQVLILVPSRELALQIDTVFRSMgt--------sWKTCCCYGGhpiaeekksiagnHPAIILGTPGRITDHLSKgn- 133 Bacteroides the...
Q54CH6        97 fsfpQILMILPTKELSQTTKVIYSSLgggen--nnndFKVLSCIGGvkismdieilkkgNTQILLGTPGRISDLFSRkr- 173 Dictyostelium d...
CAK90308      92 nplpFALIIVPTRELAIQITDILTKLvnklegvekdyFQSHLFIGGlpveqdrdvlktrRCTIIIGTVGRIMQMIQEkl- 170 Paramecium tetr...

Feature 1                                                                                        
1QDE_A       151 fRTDKIKMFILDEADEMLs-SGFKEQIYQIFTLLPp------tTQVVLLSATMP-------NDVLEVTTKFMr------- 209 baker's yeast
2PL3_A       167 fHATDLQMLVLDEADRILd-MGFADTMNAVIENLPk------kRQTLLFSATQT-------KSVKDLARLSLk------- 225 human
YP_001295581 132 fSVDAIQTLILDEFDKSLq-LGFHEQMSFIINRLPk------lNKRVLVSATSDie---ipKYTRVINPTVLd------- 194 Flavobacterium ...
AAK39673     140 iNYGSLYFLMCDEYDKILd-LGFFKILFAIFKMTSn------kKQILFSSASLKidfkifhSFAINFPINFLdlnkkkss 212 Guillardia theta
EAP86388     133 fETAELKTLVLDEFDKSLe-VGFETEMKEIIEALPt------iEKRILTSATRLdeipvfvGVTKELTIDYLdt------ 199 Croceibacter at...
EGJ71340     133 vDVSDIELLIIDEFDKSLe-LGFHEDMAEIIHLLPa------lKRRFLLSATDAkei-pqfTGVGRVARLDFldekde-- 202 Bacteroides cop...
XP_003239982 148 lNLNQLKILAMDEADEILn-TNFIKITDLLMFILPk------kRQVLFFSATLN-------SKLKNITRINLk------- 206 Cryptomonas par...
NP_810067    134 fDPETIETLIIDEFDKSLe-FGFHDEMAEIITQLPg------lKKRMLLSATDA-------EEIPQFTGLNRtvk----- 194 Bacteroides the...
Q54CH6       174 fDTDNIKILVFDELDEILs-RGFECQLEDIIKPLNnn----nnLQIIVSTSGIN-------ELTSNFINTFIk------- 234 Dictyostelium d...
CAK90308     171 mNLCNIKLLVLDEADKLHenYTFQPHFKKILANIVgrnqdqnkPQILCFSATYP-------TKIIGLIQLCLs------- 236 Paramecium tetr...

Feature 1                     
1QDE_A       210 -------NPVRIL 215 baker's yeast
2PL3_A       226 -------NPEYVW 231 human
YP_001295581 195 ------fIPSEEE 201 Flavobacterium psychrophilum JIP02/86
AAK39673     213 tkiknlcVPICIS 225 Guillardia theta
EAP86388     200 -----krSKLEIK 207 Croceibacter atlanticus HTCC2559
EGJ71340     203 --lasriQLMQVH 213 Bacteroides coprosuis DSM 18011
XP_003239982 207 -------NPIFCS 212 Cryptomonas paramecium
NP_810067    195 ----ldfLPEATE 203 Bacteroides thetaiotaomicron VPI-5482
Q54CH6       235 -------IPKIIK 240 Dictyostelium discoideum AX4
CAK90308     237 -------NPKLIK 242 Paramecium tetraurelia

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