3II6


Conserved Protein Domain Family
BRCT_DNA_ligase_IV_rpt2
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cd17717: BRCT_DNA_ligase_IV_rpt2 
second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the second one.
Links
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Statistics
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PSSM-Id: 349349
Aligned: 10 rows
Threshold Bit Score: 80.9441
Created: 9-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:XRCC4 interaction site [polypeptide binding site]
Evidence:
  • Comment:the XRCC4/DNA ligase IV complex is required to reseal DNA strands during nonhomologous end-joining
  • Structure:3II6: Homo sapiens DNA ligase IV in complex with XRCC4, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                    ### ##  ## #   #                                          
3II6_X        165 FRRHTVYLDSYavindlstkneGTRLAIKALELR---FHGAKVVSCLae------gvSHVIIGEDHSrvadfk------- 228  human
Q90YB1        814 FRGNTIYVDYYaiinkpstkihGTRLSIRALELR---FYGAKVVPLLee------gvSHVVIGEDHSrvkemk------- 877  chicken
P49917        813 FRRHTVYLDSYavindlstkneGTRLAIKALELR---FHGAKVVSCLae------gvSHVIIGEDHSrvadfk------- 876  human
XP_005997060  813 FREYVVYVDLYyiisdtaakiqGTGLDIRVLELR---FHGAKVVTQLde------cvSHVIVSDDHSrvselk------- 876  coelacanth
AAL56554      813 FRHCTVYVDSFatindpttrinTSSLNIRALELR---FHGAKLVNQLde------giSHVLVSEDLSrleqik------- 876  African clawe...
NP_001096593  812 FRPYSAYFDRCadigdpksvicGTCLDTRALEFR---FHGGKVVEKLke------giSHVVVEDMKRaldlkt------- 875  zebrafish
Q54CR9        989 FKEFTFYLDLYqvvgekstlieNNNLELSNLNIQ---FYGGKISIEFnn------kiTHVVLDSLDLsr----------- 1048 Dictyostelium...
Q9LL84        802 LLSCCVYFYPYsqtls-teeeaLLGIMAKRLMLEv-lMAGGKVSNNLah-------aSHLVVLAMAEepldftlvsksfs 872  thale cress
XP_002973996  791 FEGCSFYFYYPreaav-adeamIAGVVLRRLEVEvelRKGAVKPSLAr--------aTHMIVFWDSErdhseagls---- 857  Selaginella m...
NP_501749     520 TGIHFHCFDSEkl--------fEDKLDRKNLEFMi-kYHGGDIEFEAskfherihqiTHVLVDSCRNtnvm--------- 581  nematode

Feature 1                                      #  ## 
3II6_X        229 --afrrtfKRKFKILKe---------SWVTDSIDK 252  human
Q90YB1        878 --alrrmfGKKFKIVSe---------LWVTESVKE 901  chicken
P49917        877 --afrrtfKRKFKILKe---------SWVTDSIDK 900  human
XP_005997060  877 --alrrtfKKKFKIVSd---------LWVIDSVKT 900  coelacanth
AAL56554      877 --tmrramAKKFKIVSv---------SWVLDSVKM 900  African clawed frog
NP_001096593  876 ---lrrlhAKKFKIVHe---------SWVTDSIKA 898  zebrafish
Q54CR9       1049 ------itFIKNKINSlslpiqivttNWIQLSINN 1077 Dictyostelium discoideum
Q9LL84        873 emekrlllKKRLHVVSs---------HWLEESLQR 898  thale cress
XP_002973996  858 fsenklvsSKKLRVLSh---------RWLEEALRR 883  Selaginella moellendorffii
NP_501749     582 -----tslEHRKRIVSi---------QWIIDVMER 602  nematode

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