Conserved Protein Domain Family
RRM3_PTBPH1_PTBPH2

?
cd12690: RRM3_PTBPH1_PTBPH2 
RNA recognition motif 3 (RRM3) found in plant polypyrimidine tract-binding protein homolog 1 and 2 (PTBPH1 and PTBPH2)
This subfamily corresponds to the RRM3 of PTBPH1 and PTBPH2. Although their biological roles remain unclear, PTBPH1 and PTBPH2 show significant sequence similarity to polypyrimidine tract binding protein (PTB) that is an important negative regulator of alternative splicing in mammalian cells and also functions at several other aspects of mRNA metabolism, including mRNA localization, stabilization, polyadenylation, and translation. Both, PTBPH1 and PTBPH2, contain three RNA recognition motifs (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Statistics
?
PSSM-Id: 410091
Aligned: 7 rows
Threshold Bit Score: 186.225
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1            # #                          # # #    # #                             #  ## 
Q9MAC5       242 SNVLLGLIENMQYAVTVDVLHTVFSAYGtVQKIAIFEKNGSTQALIQYSDIPTAAMAKEALEGHCIYDGGYCKLRLSYSR 321 thale cress
ADE77057     243 SNVLLASIENMQYAVTLDVLRSVFTAFGtVQKIAIFEKNAGFQALIQYPDVATAVTAKEALEGHCIYDGGFCKLHLSYSR 322 Sitka spruce
XP_002976368 244 SNVLLASIENMQYSVTIDVLHTVFAAFGpIQKIAIFEKNAGFQALIQYADVTTAVAAKEALEGHCIYEGGYCKLHLSYSR 323 Selaginella moe...
Q9FGL9       243 SNVLLASIENMQYAVTLDVLHMVFAAFGeVQKIAMFDKNGGVQALIQYSDVQTAVVAKEALEGHCIYDGGFCKLHITYSR 322 thale cress
EIE19256     241 GNVLLCQIENQAYPVNVDALNTVFSPYGfVQKIAIFDKNGQSQALIQYPDPLSATNAKSALEGHAIYDGGYNRLKISYSV 320 Coccomyxa sp. C...
XP_019577498 243 SNVLLASIENMQYAVTLDVLHMVFAAFGaVQKIAMFDKNGGVQALVQYPDVQTAVVAKGALEGHCIYDGGYCKLHITYSR 322 Chinese rufous ...
PNR27394     243 SNVLLVSIENMQYAVTIDVIHTVFSAFGfVQKIAIFEKSAGFQALVQYPDIPTAVGAKEALEGHCIYDGGFCKLHLSYSR 322 Physcomitrella ...
Feature 1           #####         
Q9MAC5       322 HTDLNVKAfsDKSRDYT 338 thale cress
ADE77057     323 HTDLNVKVnnDRSRDYT 339 Sitka spruce
XP_002976368 324 HTDLNVKVnnDRSRDYT 340 Selaginella moellendorffii
Q9FGL9       323 HTDLSIKVnnDRSRDYT 339 thale cress
EIE19256     321 HRNLNVKAnnDRSCDYT 337 Coccomyxa sp. C-169
XP_019577498 323 HTDLSIKVnnDRSRDYT 339 Chinese rufous horseshoe bat
PNR27394     323 HTDLNVNN--DRSRDYT 337 Physcomitrella patens

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap