Conserved Protein Domain Family
GH99_GH71_like_2
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cd11576: GH99_GH71_like_2 
Uncharacterized glycoside hydrolase family 99-like domain
This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism. The domain may co-occur with other domains involved in the binding/processing of glycans.
Links
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Statistics
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PSSM-Id: 211417
Aligned: 43 rows
Threshold Bit Score: 354.64
Created: 6-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Feature 1: putative catalytic site [active site], 2 residue positions
Conserved feature residue pattern:E EClick to see conserved feature residue pattern help
Evidence:
  • Comment:by similarity to other members of this family
  • Comment:The mechanism may involve one or both carboxylic acid side chains and imply a glycosyl-enzyme intermediate or a 1,2-anhydro sugar intermediate
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
NP_863991     143 STLTGKVMCGYQGWFNCEGDGA-GLGWRHWGRDskkplg----pgnvtVDLWPDMSEYspger----fateFQHSDGSVA 213  Rhodopirellul...
ZP_07387162   309 GDVVGKLIVGYQGWFNASGDSSpNNGWIHWTTNnsaptp----nsnikFELYPDMREYttqy-----atnlGNLGNGQPA 379  Paenibacillus...
EGR50094       35 STIQGKWLYGYQGWFRKPGPGV-NNHWSADGQTpgpn--------nieIDFIPDVSQYpancl----fdtaLTLPNGQPA 101  Trichoderma r...
YP_003955330  326 GDVVGKLFAGYQGWFNAAGDGSpNNGWIHWSKNssaptp----nsnvnFDLYPDLREYskly-----qtnlANLGNGQPA 396  Stigmatella a...
ZP_01465545    47 QGIRDKVIVGYQGWFTAYGDGSpTERWSHWSAGvyrsnegvpspghqtFDLYPDISEYapgsl---fqtgyAPLGNGTPA 123  Stigmatella a...
ZP_07273756    53 PTLKGHVYAGYQGWFNHPSDGSpLGAWRHWAGSqpsp-------gnqtFELWPDTRAYpdsvl---agtgyAPLGNGDPA 122  Streptomyces ...
YP_003124491   45 GDVVGKVTVGYQGWFTAPGDGSaVDRWTHQNLEm-------------wPEMKEYTTSYqt---------pfPALPDGRPA 102  Chitinophaga ...
YP_003126388   30 QSVTGKLMCGYQAWFNCYGDGSpIERWSHWSPGryrsdtpkpapgritFEAYPDVTEYpaanl---fqtalGNLNDGRNA 106  Chitinophaga ...
YP_003124150  188 SEFVGKSFAGYQLWHEAGPKPEdWSHWSYDKVPaagr-------gnhnTETFPNLADYennpnvpmyatnfANLGNGKPA 260  Chitinophaga ...
ZP_08846404    44 NDVVGKLTVGYQGWFACQGDGSpVNQWVHWSSSgqpap------gnqtFELWPDIRDYpngy-----qtgyGNLGNGDPA 112  Anaerophaga t...

Feature 1                                                                                         
NP_863991     214 EVFSSANEQTVRRHFQWMREYGIDGAFVQRFATSLRSpasl--anrTAILNHCRRGSEENGRAFAVMYDLSGLRege--- 288  Rhodopirellul...
ZP_07387162   380 KLFSSYDQSTVNKHFEWMQTYNISGAALQRFGASESDaydgwranrDNVAVKVKNAAEAYGRKFYVMYDITGMNasn--- 456  Paenibacillus...
EGR50094      102 KFYDSTCDGVIDLHFKWMQQYGIDGVIVQRFSGSINDqs------fITVLNQVKAAAEKYGRGFIVEWDVSGADssqg-- 173  Trichoderma r...
YP_003955330  397 KLFSSYDPETVNKHFEWMRTYNIDGAALQRFGASESTspdgwrtnrDSVAVKVKNAAEVYGRKFYVMYDITGMNpst--- 473  Stigmatella a...
ZP_01465545   124 KLFSSYPSDVVNKHFQWMQQYGIDGAAVQRFLTTDGVfma----hrDSVASKVRTAAEATGRLFYIMYDVSGLSdat--- 196  Stigmatella a...
ZP_07273756   123 RLFSSYPSAVVEQHFDWMRDNGLDGAALQRFGSDVSDpaspraavrNSVADKARKAAERTGRGFYVEYDVSGLTdan--- 199  Streptomyces ...
YP_003124491  103 KMFSSYDQSTVDVHFRWMQENGIDCAALQRFTGELSDppfk--smrDGMAQKVRNAAEASGRKFYIMYDISGDAdm---- 176  Chitinophaga ...
YP_003126388  107 RLFTSWKQTTIDLHFSWMQQNGIDGVAQQRFLGPTRDgvyk--asmDSLVSRIRRSAEKYQRIFYIMYDMNADDt----- 179  Chitinophaga ...
YP_003124150  261 RLYNSTDKGVIDVQMALLQRTGFDGVAIQRNAPVGRNiky---tstDDYYVNIKNACEANGRLFYVMYCMPDQNngevns 337  Chitinophaga ...
ZP_08846404   113 KLYSSYDSEVINTHVKWISDYGIDCIALQRFGVELSVpsfk--aqrDGVALKMKNAAEGYGKKFYIMYDISGWTnf---- 186  Anaerophaga t...

Feature 1                                                                                         
NP_863991     289 ---ldVVQQDWTRLVNEEAITSs-dAYLHHNGMPLVAIWGVGFAERhqpgayTLDDCKALIAQLKRaGCSIMLGIPTGWR 364  Rhodopirellul...
ZP_07387162   457 --wvnAVKHDWTVNVKANMNLTsssAYAIQDGKPVVCIWGIGFTDRp----gTAAESSELISWFKNqGIYVIGGVPTYWR 530  Paenibacillus...
EGR50094      174 -svasLLLSDYNAKIKQFTSSP---AYIHQDGKPVVMVFGIGFQGMk----tSAADSVNIANQLKNaGLYVGFGVPEQWA 245  Trichoderma r...
YP_003955330  474 --wvnAVKHDWTANIVNAMRLTsssAYARQNGKLVVCIWGIGFTDRp----gTAAEATDIINWFKGqGIYVIGGVPTYWR 547  Stigmatella a...
ZP_01465545   197 --flqMVKDDWTNRIVGQLQLPsssRYATQDGKPVVSIWGLGFTDRp----gSAAQASELIDWFRNqGAYVIGGVPTHWR 270  Stigmatella a...
ZP_07273756   200 --feqVLQDDWTNVVTGSLHLTdspAYVHQDGKPVVELWGLGFSNRp----gSAEQSERIVNWFRSkGLYVVGGVPTGWR 273  Streptomyces ...
YP_003124491  177 ---qsRIKTDWTNTITGTLNLLsspAYAKQNGKPVVCIFGMGYLGAkvpgagDSAQCLDVISWFKSqGCYVIGSVPMDWR 253  Chitinophaga ...
YP_003126388  180 ----aFFKADWLHVENDLRPQEs-pYYAHQNGKPVICIWGFGLNERs----nQPANSLAIINWLKGkGYYVIGGVPAGWR 250  Chitinophaga ...
YP_003124150  338 vdlveGIKRDWVYQMEQIYELTksgAYATVNGKPVVELWGLGYSTIl----vDRIQALELAQFFKDrGCYVIAGVPRDWR 413  Chitinophaga ...
ZP_08846404   187 ---qtEIKTDWTNAIIGDLNLInsnAYAKQDGKPVVAIWGIGVSGRp----gDVNSWLDIINWFKNqSCYVIVGTHNNWR 259  Anaerophaga t...

Feature 1                                                                                         
NP_863991     365 El-NRDCVTDPavrsifemaDVISPWTPGRYRNpeqaqrhgEQTWQPDQQECGANGQGYLPVVFPGFSWFNlrngda--p 441  Rhodopirellul...
ZP_07387162   531 Tg-NNDSKAGFenvy--rslDMLSPWFVGRFGTladadsykVNQWQPDYDWTKQNGITYQPVIFPGFAWANmtggp---- 603  Paenibacillus...
EGR50094      246 G--DVNGNTGYvqaf--kaaDFISPWTVGGYSAagyq-gfhNSVQVPDSQLLQSLGKKYAPVIFPGTSAYHlnggtnpsa 320  Trichoderma r...
YP_003955330  548 Tg-TNDSRTGFenvy--rslDMISPWFVGRFGGaegadhylANQWQPDYAYTQQYGIAYQAVIWPGFSWANlqggp---- 620  Stigmatella a...
ZP_01465545   271 Ts-SGDSKPGFtdvy--kkfHMISPWTVGRYSTdadvdhfkNNNLLPDLAYCNTQGQAYQPVMFPGFAWYNwngga---- 343  Stigmatella a...
ZP_07273756   274 T--DSHAKPGFgpvy--ealDMLSPWMVGNAGDn-------APQIAADLAALTPRGQDYLPVIYPGFSWSNwkdgp---- 338  Streptomyces ...
YP_003124491  254 TpqGVFTRDNFmtvy--esfDMLSPWAVAAQVGpt-----yQPWIKGDYDYCEAHGMDYQPIAYPGFSFHNtnags---p 323  Chitinophaga ...
YP_003126388  251 Tg-TRDSYAGYenvy--kafNMLSPWAVGRFGSiagadnfkNENLAPDLAYCNANGLDYQPVIFPGFAWSNwnggt---- 323  Chitinophaga ...
YP_003124150  414 Lr-NGGSRTDFedvy--kayNMISPWTVGVYNDttgadnfrTESLIPDKQYCDQNGMGFYPVIFPGSAWSQhvhgy---- 486  Chitinophaga ...
ZP_08846404   260 SdsSILPAINAa--------NMVSPWTVGVYSDnggv-dnyATVMEADKNYCNQYNMDYQPVVFPGFAWSNwnggs---- 326  Anaerophaga t...

Feature 1                                            #  #                                         
NP_863991     442 lddiPRLKGQFLWSQIIAAKK--AGAEMLYVAMFDEVDEATAIFKCTNNpprgr-----dakfvTYEGLPSDHYLKIVGR 514  Rhodopirellul...
ZP_07387162   604 rnqiPRQHGDFMWRQAYNLKS--IGVDTSYVAMFDEYDEGTAIAKAAENssmipnnqyflsldaDGVAVSSDFYLRLTGD 681  Paenibacillus...
EGR50094      321 fdyfPRYNGSFLSAQADALTSmaIKPFFIFNAMFDEVNEGTQSMPALKTnqlptn---qkfvglDNDFPDTSFYLSLGGQ 397  Trichoderma r...
YP_003955330  621 rnqiPRLHGDFMWRQAYNLKS--VGISTGYVAMFDEYDEGTAIAKGAENssmvptnqyfltldaDGVAVSSDFYLRLAGD 698  Stigmatella a...
ZP_01465545   344 knliPRRAGALLWKQATNIRA--AGIPAAYIAMFDEYDEGTAIAKAAEDssmaptnqyfltlssDGTYLSSDFYLRLAGK 421  Stigmatella a...
ZP_07273756   339 rneiPRRSGDFLWQQAVNVRK--AGVGQAFLAMFDEYDEATAIAPAAEDssmiptdqyfqttsaDGTYLSADFYLRLAGA 416  Streptomyces ...
YP_003124491  324 lneiPRNHGDFMWAQVAVMKQ--VGAKSLYVAMFDEVNEGTAIFKVAENasqapantsfvhldqDGVAVSSDFYLRLVND 401  Chitinophaga ...
YP_003126388  324 rnqiSRSKGEFFWRQLYNIKS--LGMNTAYIAMFDEYDEGTVIAKMADSyfavpdnqyflttsaDGTYIGADFYLRLAGQ 401  Chitinophaga ...
YP_003124150  487 pndtRRLGGKFLWKQARNIKS--VGVKSMYFAMLDEFEESTNIISSAVDyfdiptdqyfgtlsmDGIWTSSDFYLRLAGQ 564  Chitinophaga ...
ZP_08846404   327 rnqiPRMHGDFMWRQFAQVRN--KGIPSAYVAMFDEYDEATAIAKAAEDvlmtpsdqyfltldaDGITVSSDFYLRLTGD 404  Anaerophaga t...

Feature 1                 
NP_863991     515 AAQLLRGE 522  Rhodopirellula baltica SH 1
ZP_07387162   682 IARMFSGQ 689  Paenibacillus curdlanolyticus YK9
EGR50094      398 KAAAFHSA 405  Trichoderma reesei QM6a
YP_003955330  699 INRLFKGQ 706  Stigmatella aurantiaca DW4/3-1
ZP_01465545   422 VTRLIQGL 429  Stigmatella aurantiaca DW4/3-1
ZP_07273756   417 ATGMISGR 424  Streptomyces sp. SPB78
YP_003124491  402 AGKMIKGQ 409  Chitinophaga pinensis DSM 2588
YP_003126388  402 ATKVLKGT 409  Chitinophaga pinensis DSM 2588
YP_003124150  565 AARLLTST 572  Chitinophaga pinensis DSM 2588
ZP_08846404   405 GGRMIRNE 412  Anaerophaga thermohalophila DSM 12881

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