Conserved Protein Domain Family
CYP73
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cd11074: CYP73 
cytochrome P450 family 73
Cytochrome P450 family 73 (CYP73 pr Cyp73), also called trans-cinnamate 4-monooxygenase (EC 1.14.14.91) or cinnamic acid 4-hydroxylase, catalyzes the regiospecific 4-hydroxylation of cinnamic acid to form precursors of lignin and many other phenolic compounds. It controls the general phenylpropanoid pathway, and controls carbon flux to pigments essential for pollination or UV protection. CYP73 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410697
Aligned: 17 rows
Threshold Bit Score: 837.512
Created: 17-Sep-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Salvia miltiorrhiza CYP76AH1 with bound heme (5YM3), defined at 4A contacts
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           #                        #   #       #    
P92994     63 KKFGDLFLLRMGqrNLVVVSSPDLTKEVLLTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRKMRRIMTVPFFTNKV 142 thale cress
AAD23378   66 KKYGEIFLLKMGqrNLVVVSSPDLAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRKMRRIMTVPFFTNKV 145 loblolly pine
ADF28536   93 KKYGEIFLLKMGqrNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRRMRRIMTVPFFTNKV 172 Selaginella moelle...
Q42797     63 KKFGDIFLLRMGqrNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRKMRRIMTVPFFTNKV 142 Glycine max
Q04468     63 KRFGEILLLRMGqrNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRKMRRIMTVPFFTNKV 142 Helianthus tuberosus
Q43067     63 KRFAEILLLRMEqrNLVVISSPELAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDIVFTVYGEHWRKMRRIMTVPFFTNKV 142 pea
Q43240     63 KKFGEIFLLRMGqrNLVVVSSPNLAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRKMRRIMTVPFFTNKV 142 Zinnia elegans
P37114     63 KRFGEIFLLRMGqrNLVVVSSPELAKEVLHTQCVEFGSRTRNVVFDIFTGkGQDMVFTVYGEHWRKMRRIMTVPFFTNKV 142 Medicago sativa
Q43033     64 KKFGDLFMLRMGqrNLVVVSSPELAKDVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYSEHWRKMRRIMTVPFFTNKV 143 parsley
Q9AR74     63 KKFGDVYLLRMGqrNLVVVSSPEMAKEVLHTQGVEFGSRTRNVVFDIFTGkGQDMVFTVYSEHWRKMRRIMTVPFFTNKV 142 common rue

Feature 1                                                #                                    
P92994    143 VqQNREGWEFEAASVVEDVKKNpdsatkGIVLRKRLQLMMYNNMFRIMFDrrFESEDDPLFLRLKALNGERSRLAQsfEY 222 thale cress
AAD23378  146 VqQYRFAWEDELGRAVDDIKKRpeasttGIVIRRRLQLVMYNIMYRMMFDrrFESEDDPLFLRLKALNGERSRLAQsfEY 225 loblolly pine
ADF28536  173 VqQSRPVWEQEIEFVLKDLLANkeaqegGTVIRRRLQLLMYNVMYKMMFDrrFESEDDPLFLKLRQLNGERSRLAQsfEY 252 Selaginella moelle...
Q42797    143 VqQYRHGWESEAAAVVEDVKKNpdaavsGTVIRRRLQLMMYNNMYRIMFDrrFESEEDPIFQRLRALNGERSRLAQsfEY 222 Glycine max
Q04468    143 VqQYRYGWEAEAAAVVDDVKKNpaaateGIVIRRRLQLMMYNNMFRIMFDrrFESEDDPLFLKLKALNGERSRLAQsfEY 222 Helianthus tuberosus
Q43067    143 VqQYRFGWESEAASVVDDVKKNskasvnGIVIRRRLQLMMYNIMYRIMFDrrFESEEDPLFVKLKALNGERSRLAQsfEY 222 pea
Q43240    143 VqQYRTGWEAEAAAVVDDVKKNpkaateGVVIRKRLQLMMYNNMFRIMFDrrFESEDDPLFVKLKMLNGERSRLAQsfEY 222 Zinnia elegans
P37114    143 VqQYRYGWESEAESVVNDVKNNaeasvgGIVIRKRLQLMMYNIMYRIMFDrrFESEEDPLFVKLKALNGERSRLAQsfEY 222 Medicago sativa
Q43033    144 VqQYRFGWEDEAARVVEDVKANpeaatnGIVLRNRLQLLMYNNMYRIMFDrrFESVDDPLFLKLKALNGERSRLAQsfEY 223 parsley
Q9AR74    143 VqQQRFNWEDEAARVVEDVKKDpqaattGIVLRRRLQLLMYNNMYRIMFDrrFESVDDPLFNKLKALNGERSRLAQsfEY 222 common rue

Feature 1                                                                                     
P92994    223 NYGDFIPILRPFLRGYLKICQDVKDRRIALFKKYFVDERKQIASSKptgseg-lkcaiDHILEAEQKGEINEDNVLYIVE 301 thale cress
AAD23378  226 NYGDFIPVLRPFLRGYLKICKEVKESRLLLFKDYFIDERKKLASTTgskvtg-dkcaiDHIFEAEEKGEINEDNVLYIVE 304 loblolly pine
ADF28536  253 NYGDFIPILRPFLKRYLQMCKDVKENRLGLFKKYFLDERKQLLNAGktgpd---kvaiDHILEAQKQGEITEANVLYIVE 329 Selaginella moelle...
Q42797    223 NYGDFIPILRPFLKGYLKICKEVKETRLKLFKDYFVDERKKLGSTKstnnnnelkcaiDHILDAQRKGEINEDNVLYIVE 302 Glycine max
Q04468    223 NYGDFIPILRPFLRNYLKLCKEVKDKRIQLFKDYFVDERKKIGSTKkmdnnq-lkcaiDHILEAKEKGEINEDNVLYIVE 301 Helianthus tuberosus
Q43067    223 NYGDFIPILRPFLKGYLKVCKEVKDRRLQLFKDYFVDERKKLGSTKstyneg-lkcaiDHILDAQKKGEINDDNVLYIVE 301 pea
Q43240    223 NYGDFIPILRPFLKGYLKLCKEVKEKRFQLFKDYFVDERKKLGSTKsmdnnq-lkcaiDHILDAKDKGEINEDNVLYIVE 301 Zinnia elegans
P37114    223 NYGDFIPILRPFLKGYLKVCKEVKDRRLQLFKDYFVDERKKLESTKsttsndglkcaiDHILDAQKKGEINDDNVLYIVE 302 Medicago sativa
Q43033    224 HFGDFIPILRPFLRGYLKLCQEIKDKRLKLFKDYFVDERKKLESIKsvdnns-lkcaiDHIIEAQQKGEINEDNVLYIVE 302 parsley
Q9AR74    223 NYGDFIPILRPFLRGYLKLVKEVKERRLKLFKDYFVEERKKLTSTKsmteen-fkcaiDHVLDAQQKGEINEDNVLYIVE 301 common rue

Feature 1      #  ##  ##                                                          #   ## #    
P92994    302 NINVAAIETTLWSIEWGIAELVNHpeIQSKLRNELDTVLGpgvqvtepDLHKLPYLQAVVKETLRLRMAipLLVPHMNLH 381 thale cress
AAD23378  305 NINVAAIETTLWSMEWGLAEIVNHpeIQQKIRAELDAVIGrgvpltepDTTKLPYLQAVVKETLRLHMAipLLVPHMNLH 384 loblolly pine
ADF28536  330 NINVAAIETTLWSMEWVIAELVNNrdIQDKVREELDRVLGpgvaitepDIPKFTYLTAVIKETFRYHMAipLLVPHMNLR 409 Selaginella moelle...
Q42797    303 NINVAAIETTLWSIEWGIAELVNHpeIQQKLRDEIDRVLGaghqvtepDIQKLPYLQAVVKETLRLRMAipLLVPHMNLH 382 Glycine max
Q04468    302 NINVAAIETTLWSIEWGIAELVNHpeIQAKLRHELDTKLGpgvqitepDVQNLPYLQAVVKETLRLRMAipLLVPHMNLH 381 Helianthus tuberosus
Q43067    302 NINVAAIETTLWSIEWGIAELVNHqeIQNKLREEMDKVLGpghqvtepDLEKLPYLQAVIKETLRLRMAipLLVPHMNLH 381 pea
Q43240    302 NINVAAIETTLWSIEWAIAELVNHpeIQAKLRHELVSQLGpgvqvtepDLHKLPYLQAVIKETLRLRMAipLLVPHMNLH 381 Zinnia elegans
P37114    303 NINVAAIETTLWSIEWGIAELVNHqdIQNKVREEMDRVLGpghqvtepDLHKLPYLQAVIKETLRLRMAipLLVPHMNLH 382 Medicago sativa
Q43033    303 NINVAAIETTLWSIEWGIAELVNNpeIQKKLRHELDTVLGagvqicepDVQKLPYLQAVIKETLRYRMAipLLVPHMNLH 382 parsley
Q9AR74    302 NINVAAIETTLWSIEWGIAELVNHpdIQKKLRAEIDRVLGpdhqitepDTHKLPYLQAVIKETLRLRMAipLLVPHMNLN 381 common rue

Feature 1                                                              ####  #####  ##        
P92994    382 DAKLagYDIPAESKILVNAWWLANNPnsWKKPEEFRPERFFEeeshveangnDFRYVPFGVGRRSCPGIILALPILGITI 461 thale cress
AAD23378  385 QAKLggYDIPAESKILVNAWFLANNPewWEKPEEFIPERFLGeekie-asgnDFRFLPFGVGRRSCPGIILALPILALAL 463 loblolly pine
ADF28536  410 PAKLagYDIPAESKILVNAWWLGNNPelWDKPDVFDPSRFLDgkie--asgnDFRFLPFGVGRRSCPGIIIAMPLLHLVI 487 Selaginella moelle...
Q42797    383 DAKLggYDIPAESKILVNAWWLANNPahWKKPEEFRPERFFEeeslveangnDFRYLPFGVGRRSCPGIILALPILGITL 462 Glycine max
Q04468    382 DAKLggFDIPAESKILVNAWWLANNPdqWKKPEEFRPERFLEeeakveangnDFRYLPFGVGRRSCPGIILALPILGITI 461 Helianthus tuberosus
Q43067    382 DAKLggFDIPAESKILVNAWWLANNPalWKKPEEFRPERFLEeeahveangnDFRYLPFGVGRRSCPGIILALPILGITI 461 pea
Q43240    382 DAKLggYDIPAESKILVNAWWLANNPdqWKKPEEFRPERFLEeeskveangnDFRYLPFGVGRRSCPGIILALPILGITI 461 Zinnia elegans
P37114    383 DPKLngFDIPAESKILVNAWWLPNNPahWKKPEEFRPERFLEeeshveangnDFRYLPFGVGRRSCPGIILALPILGITI 462 Medicago sativa
Q43033    383 DAKLagYDIPAESKILVNAWWLANNPahWNKPDEFRPERFLEeeskveangnDFKYIPFGVGRRSCPGIILALPILGIVI 462 parsley
Q9AR74    382 DAKLagYDIPAESKILVNAWWLANNPahWKDPQVFRPERFLEeesgveangnDFRYIPFGVGRRSCPGIILALPILGITI 461 common rue

Feature 1                                        
P92994    462 GRMVQNFELlPPPGQSKVDTSEKGGqFSLHILNHS 496 thale cress
AAD23378  464 GRLVQNFELlPPPGQSKVDVTEKGGqFSLHILNHS 498 loblolly pine
ADF28536  488 GSLVAKFELlPPPGCDKIDVSEKGGqFSLHIAKHS 522 Selaginella moellendorffii
Q42797    463 GRLVQNFELlPPPGQSQIDTSEKGGqFSLHILKHS 497 Glycine max
Q04468    462 GRLVQNFELlPPPGQSKIDTDEKGGqFSLHILKHS 496 Helianthus tuberosus
Q43067    462 GRLVQNFELlPPPGQSKIDTSEKGGqFSLHILKHS 496 pea
Q43240    462 GRLVQNFELlPPPGQDKVDTTEKGGqFSLHILKHS 496 Zinnia elegans
P37114    463 GRLVQNVELlPPPGQSKIDTSEKGGqFSLHILKHS 497 Medicago sativa
Q43033    463 GRLVQNFELlPPPGQSKIDTAEKGGqFSLQILKHS 497 parsley
Q9AR74    462 GRMVQNFELlPPPGQSKIDTSEKGGqFSLFILNHS 496 common rue

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