Conserved Protein Domain Family
RHO_alpha_C_1

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cd08885: RHO_alpha_C_1 
C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases
C-terminal catalytic domain of the oxygenase alpha subunit of a functionally uncharacterized subgroup of the Rieske-type non-heme iron aromatic ring-hydroxylating oxygenase (RHO) family. RHOs, also known as aromatic ring hydroxylating dioxygenases, utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. This group contains two putative Parvibaculum lavamentivorans (T) DS-1 oxygenases; this organism catabolizes commercial linear alkylbenzenesulfonate surfactant (LAS) and other surfactants, by a pathway involving an undefined 'omega-oxygenation' and beta-oxidation of the LAS side chain. The nature of the LAS-oxygenase is unknown but is likely a multicomponent system. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.
Statistics
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PSSM-Id: 176894
View PSSM: cd08885
Aligned: 15 rows
Threshold Bit Score: 199.139
Threshold Setting Gi: 15610297
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ## ## ##   #                                                   
YP_001413224 186 VGRVVFDQRYNWKVLADNFMEAYHHFAIHPETFEPNYPAAMsqadeargpFAALRMPHkgn-----------elsEPLFP 254 Parvibaculum la...
YP_001264628 184 VHRSEIEGDYNWKVMLENANENYHTIAVHRDSFHAISPAEHsy-----ssDGRGRNWHdlytp--------ytgpEPMVA 250 Sphingomonas wi...
YP_001412264 189 VPDEPQSYPWNWKVMMENNNDGYHATRLHKGPLHDFIPSELatfp-empeGSAGYLRFngtlhpd---aafnplqKAVLP 264 Parvibaculum la...
YP_168873    180 VHVAEEDWQTNWKCLVENFMEGYHLSVVHPQTLHGYTPSGLsrk----lvSGDGFTSYaany---------pdniTPRGE 246 Silicibacter po...
YP_003060925 187 RPGDAPHLQWNWKVMFENNNDGYHASRLHQGPLHDFVPSEQasfp-kapkGAAGYLRFngtthad---asfnptqKAVLP 262 Hirschia baltic...
ABL97546     200 VIRESMSWDANWKNLIENFTESYHVPMAHQKTFANHKKAIEdyv---cgeDNDHYCYHyapqe-------aesgpGAAHP 269 uncultured mari...
ZP_03626423  234 VIAREWACPFNWKVLAENFMESYHHLGIHHKTLQPLMPARDtwteqerrrYVRAHLPYkdtvredfrafekkadfSEALP 313 bacterium Ellin514
ZP_04683556  213 HTQTWEGVPANWKVAVENGCENYHHMGTHAATLEPVLSARDtev---decDGRWFTMF-----------------TPLSR 272 Streptomyces gh...
NP_217677    192 VESWSHEWRANWKVAAENGHENYHVLGLHRQTLEPFVPGGGd-------lDVRQYSRWa----------------LRLRV 248 Mycobacterium t...
ZP_01753656  184 LFRAEEIWDTNWKILVQNFTEGYHLFVAHAKTIEPAMPTKLana----mhGSEGHSLYkqgripg----ksyeraSDMQV 255 Roseobacter sp....
Feature 1                                    ## #       # #      # #                             
YP_001413224 255 PLPd--------IPDEARr---------GFSVFNIYPSMLLAVfvdtVTWYRMEIESAGSFRLTIYLFAHprsld--vpd 315 Parvibaculum la...
YP_001264628 251 GPRi-------aGVPEWAg--------qRLSFFALHPQFLMSVsedsVSTYVTEIVAHRKTRFVWTMYMMngakd--qpg 313 Sphingomonas wi...
YP_001412264 265 VFPk--------LTAEERh---------RAMFANIPPTLSLVVtsdmVIYLILHAESAGRHSMTIGWLVApgams-eplf 326 Parvibaculum la...
YP_168873    247 GALg--------LSEPERk---------RSSLFAKFPTQVASQaaslLVSLCIFPVNASLIRVKWTMSVYrdn------l 303 Silicibacter po...
YP_003060925 263 VFAg--------LNEEQRn---------RMTFANIPPTLSLVLtadmVIYMILRPTGAGSLEMDTGVLVApgam---eda 322 Hirschia baltic...
ABL97546     270 NNIk--------LEGPWRr---------TMVDFCIFPNHLITLmpdyLWWVSVLPEGVNRFKATWGVAVPpeilk--eip 330 uncultured mari...
ZP_03626423  314 PLPl--------LNPEQKs---------EWGLFLVHPTFLLATapdrVIWYRLLPLGPNRLDLMTTTLVApdt------t 370 bacterium Ellin514
ZP_04683556  273 PERg--------GTGLGRqartgrgpqpGMLIAGIFPQFVLAVlpdsAVGIRWLPTGPATHDTRITVMVPpevad--tpg 342 Streptomyces gh...
NP_217677    249 PFTvpveakslqLNEVQKs---------NLVVLWTFPNSALAIagerVVWFGFIPQSIDRVQVLGGVLTTpela----ad 315 Mycobacterium t...
ZP_01753656  256 DNPl--------LTEEDRn---------TAVLSAVFPCHVMSVvaerTFWLSLQPHGTNQVKVLWGADYFpgavpddpee 318 Roseobacter sp....
Feature 1              #  #        ##  #                                           
YP_001413224 316 aEALKEFLREa----aTAVHIEDIAACEGVQKGLESRMa-vPGRLSPLE--AAIHQHQQWLMGELV 374 Parvibaculum lavamentivorans ...
YP_001264628 314 aAEHIADMGAw----iDRINSEDLVICRGVQAGLESDGw-ePTRFSHLE--KPIWQFQNWYLDRMI 372 Sphingomonas wittichii RW1
YP_001412264 327 qERLDMNMRSa-----MEITEQDLHVDRLVQIGLKSRFs-vRGRYSWQE--RAQSDLNHWLVSRYR 384 Parvibaculum lavamentivorans ...
YP_168873    304 dHDTIQQRISl----wEEVNREDREKLERMQVALRSAHa-vEGPLAEDDfeGTIRDFQTWLASQDA 364 Silicibacter pomeroyi DSS-3
YP_003060925 323 aFEPKMEMIMns---tHHIIAQDWHVDELVQIGLRSRFa-kRGRYSWQE--SAQQQFNEWLVDRYK 382 Hirschia baltica ATCC 49814
ABL97546     331 eAEYDEWLQQmtn-ymEAANNEDKLLVQGLNRGTGSRIl-pEGTLHPIE--KNLWQFTKYLARISS 392 uncultured marine bacterium E...
ZP_03626423  371 rLKNFEKLRSlateqlTAFHVEDMEVCTAVQRGLYASGw-qPGRLSHLE--MPVWLFHRYLAARIS 433 bacterium Ellin514
ZP_04683556  343 sVERSDGLRAr----iARIQEEDLVAVRGVQRGLASHPapsNGRFSHLE--RPLWQFQRYLAERLL 402 Streptomyces ghanaensis ATCC ...
NP_217677    316 aAATAQTSQFv----mAMINDEDRLGLEAVQVGAGSRFa-eRGHLSSKEw-PGMLAFYRNLAMALV 375 Mycobacterium tuberculosis H37Rv
ZP_01753656  319 rAAYAAELKAg----fDVINDEDKPIIGGIVKNAGALAa-aPGRLSPKE--RTVWYFQQYLARILT 377 Roseobacter sp. SK209-2-6

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