Conserved Protein Domain Family
PGM_like4

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cd05803: PGM_like4 
This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100096
View PSSM: cd05803
Aligned: 12 rows
Threshold Bit Score: 625.872
Threshold Setting Gi: 28261217
Created: 23-May-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #  #                                                                        
XP_640645      5 IRSISGVRGVVGadq--swTPTLVANHIIAFTQLlesshy-----nqnqkKIVVGRDSRVSGPWFEMITNGSLISRGYQV 77  Dictyostelium d...
NP_869094     38 IISVSGLRGILGet----lTPEVAVRFAAAFSASmp------------egKIVVGRDGRTTGPMLRSAIVSALTASGRDV 101 Rhodopirellula ...
ZP_01092838   16 IISVSGLRGVVGes----lTPSVAVRYIAAFAEQvs------------pgPILIARDGRPSGKPLAHLIAGTLNFCGRDV 79  Blastopirellula...
NP_713980     14 MVSVSGIRGIIPtg----lSPEVIFNSLRAFGTWie------------gsKIVIGRDSRPSGSYLENIALGLMQAMGKEV 77  Leptospira inte...
AAO31976       5 IATFSGLRWIHDe-----qSFGRIMCYVTAFAKAlpqmvdnc-sttrskkLVYVGRDGRNTGDEYPKYIIAALLLEGFNV 78  Giardia intesti...
XP_001315718   7 MLTISGIRGVVGgs----lTPEVVSKYVSGFAGLqltk--------gkgkQVILGYDTRPAVSWIKQVTIGALMACGIDV 74  Trichomonas vag...
XP_650107      6 MVTLSGIRGIAQks----lSEAVIIKYVKAFVTIqfeeh-------tknsLFILGRDSRVSGPWAEKIVIKALEECGCKV 74  Entamoeba histo...
YP_446467     87 IASISGIRGIVGqg----lDPSVLVRYAGAFGTWcreran----aadrpsRVVVGRDARPSGDACAQIVIGTLRGMGCDV 158 Salinibacter ru...
NP_661164      4 MISVSGIRGVVGks----lTPENLTAFTMAFATWirrrkqalnpgslakpIIVIGRDSRPTGAVITGLVSNALSLCGCDV 79  Chlorobium tepi...
NP_905306      4 IKSISGIRGTIGgmadeglNPISIAQFTAAYAHFikklt------ktkrpCIVVGRDARPSGLMVKNVVFGTLMGMGCDV 77  Porphyromonas g...
ZP_01854796    5 ILSISGLRGVVGng----lTPDYLTRFAAAVGTIan------------qgTVVLSRDGRGSGEMVRHAVIGGLLATGCRV 68  Planctomyces ma...
ZP_01922538    8 KFSESGVRGIVGeg----lTPRLVTELGAAFGFYqg------------ggRIVVGRDTRATGAMFEDALVAGLLSAGCQV 71  Victivallis vad...
Feature 1                                    ###       #                                         
XP_640645     78 IHIDIASTPTVQYMVEKTKSSGGIVITSSHNPIEWNGLKFIGPDGLFIAPKECEILFSMADKpeefkf------------ 145 Dictyostelium d...
NP_869094    102 IDADVAATPTIGVLVRELGAVGAIAISASHNPPEYNGIKLFGGDGRVLDAESGAKIRDAYFAgtnqwa------------ 169 Rhodopirellula ...
ZP_01092838   80 IQADIAATPTVGVLTRQYQCGGAVQISASHNPPQYNGIKLMGADGRVIPADQGESVLTAYHAnsaswv------------ 147 Blastopirellula...
NP_713980     78 LQLGIVPTPTVKAVVNLSKAGGGIMISASHNPIIWNAFKFIGPGGFFTNASDLEQILETVRNqsykpi------------ 145 Leptospira inte...
AAO31976      79 KYLDIVPTPTVQQLVRNSQCAGGVIATASHNPPKWNGLKFVGPSSIFLTPDECTRVYSCVTEdmlqkeyhsfmtkhphtv 158 Giardia intesti...
XP_001315718  75 VDIGIVPTPTVQLMVQQFKACGGIVITASHNPQQWCGLKFVEFTGIFLDQFNCDEMFSCKYSkfat-------------- 140 Trichomonas vag...
XP_650107     75 LNCGIVPTPTVQVMVQQHQASGGIIITSSHNPKPWNGLKFVDSDGLFIVPKKCAKVFTLADEgtfi-------------- 140 Entamoeba histo...
YP_446467    159 VDLGMASTPTVEMAVLQEQAAGGIVMSASHNPEEWNALKLLNETGEFLTPAQGEAVIERAEAgeaap------------- 225 Salinibacter ru...
NP_661164     80 IDVGMTTTPTVEIATAGEGADGGLIVTASHNPVEWNALKMLDEKGEFLTASDVGELLEIAEKkafdfa------------ 147 Chlorobium tepi...
NP_905306     78 VDIDLATTPTTEMAVTGCGADGGIIITASHNPVQWNALKLLGPSGEFLNDAEGKEILRIAEAgeaefa------------ 145 Porphyromonas g...
ZP_01854796   69 IDAGIATTPTCGVLVTHLKAAGGIQITASHNPIPWNGLKPFSSEGSVYNQEQGEKLLSVLNNetfnyv------------ 136 Planctomyces ma...
ZP_01922538   72 VKLGVVPTPTIQFTVTRTGASGAVAITASHNPAQWNALKFIGSRGTFLDRGEASELFDLYSQgslpcr------------ 139 Victivallis vad...
Feature 1                                                                                        
XP_640645    146 ---------------sgydqlGKIEKCVDANQQHVGAILSLAFLdiski-rerrFKVCLDSVNGAGGPIMSYLLTQLNce 209 Dictyostelium d...
NP_869094    170 ----------------tydkiGQVDSIEDPHAAHLEKVLATVDVdaik---akqFRVLIDSNHGAGGLLGVRLLEALGct 230 Rhodopirellula ...
ZP_01092838  148 ----------------aheqlGSLTNCEDTLSQHLTKVLAIVDVarik---qrkFRVLLDSNEGAGSLLGRRLLETLGce 208 Blastopirellula...
NP_713980    146 ----------------qykpsSKIVFGTEWSEKHIESVLKRVDVnsir---kkkYKVLIDSVNGAGSYLVPELLKKLGck 206 Leptospira inte...
AAO31976     159 lvqeiadsiqnkktythnkakMEYVGSDDAIAEHIKHVLAQTPLvnaasiresnFSIGFSGCNASGAMYIVSLCEHLGvs 238 Giardia intesti...
XP_001315718 141 -----------------wdklGTLTNYPNAIQDHINNIFGQKFIdveki-kkqhFKVAVDTINGAGSLAIPVILRQLGce 202 Trichomonas vag...
XP_650107    141 -----------------hqegGITQSLSTAIDEHLNKILSLPYIdveai-kkqhFKVAVDSVCGAGGPIMTELLTRLGce 202 Entamoeba histo...
YP_446467    226 ----------------athaaLGGYRSRNALPEHIDEILALDLIdpegi-aaqnLSVVVDGVNSVGGVALPRLLHRLGva 288 Salinibacter ru...
NP_661164    148 ----------------rwdgiGTVTANGSWDAAHIDKILKLSCLdldlv-ksmnFRVLIDAVEGAGSYIVPELCRKLGit 210 Chlorobium tepi...
NP_905306    146 ----------------pvekmGRLADTLDYTPAHIKAVLALPSVdvaai-raakFKVAIDCVNSVGGIAIPALLTALGve 208 Porphyromonas g...
ZP_01854796  137 ----------------swdqlGSVETLEDAAAPHMDRVFKLIDReqik---qrqFKVVLDCNHGSGAVSTPRFLESLGce 197 Planctomyces ma...
ZP_01922538  140 ----------------gekdfREVRFMEGAFKEHMARIFSVVDAelir---errFRVAVDCANGVGALCSAGFLEKLGc- 199 Victivallis vad...
Feature 1                                                     # # ##                             
XP_640645    210 ---vIGINLETTGLFAHTPEPVPSNLGQLCEMVvky-kaDFGIAVDPDVDRCVFIDehGKPLGEEYTLAMAVElvlgd-c 284 Dictyostelium d...
NP_869094    231 ---vEAMGHEPTGKFAHTPEPTAENLQGISADVtgr-kcVVGFCQDPDADRLALIDetGRYIGEECTLALCVRqamet-g 305 Rhodopirellula ...
ZP_01092838  209 ---fEILGNNASGNFLHTPEPTAANLQEVCAKIvas-gaDIGFCQDPDADRLAIIDaaGRYIGEEYTVALCLDhvla--- 281 Blastopirellula...
NP_713980    207 ---pILLHCVPDGTFPRPPEPTPEALKQTSRKMkss-gaDIGFALDPDADRLVVLTpkKGAISEEYTLPLSFLsltleki 282 Leptospira inte...
AAO31976     239 ---lKVPYMMEPGPLPLQPEPIPENLVQFGQAIkdqgdvHVGFAVDPDADRLVILTe-TGVVGEDYTLALCVDyalslqp 314 Giardia intesti...
XP_001315718 203 ---vTELNTEPTGLFAHTPEPIPENLTQLCDAVkg---hDIGIAVDPDSDRCVLIGedGIPLVEEYTLALAVNyalky-g 275 Trichomonas vag...
XP_650107    203 ---iIPLNIKPTGDFPHIPEPLPENLTDLCHIVkes-kaDLGIAVDPDVDRCVLIGgdGNPIGEEYTLVCAVYfvlky-c 277 Entamoeba histo...
YP_446467    289 eenvHCLHCEPTGAFAHPAEPRPDHLTELTAAVpeh-gaDLGLAVDPDADRLALVDdrGRFMLEELTQVLAADflwr--- 364 Salinibacter ru...
NP_661164    211 --eiKTLACEGTGIFPRNPEPIEQNLRQTMAILase-scEFGIIVDPDVDRLALVCedGTLFGEEYTLIACADfylk--- 284 Chlorobium tepi...
NP_905306    209 --hvFPLYCTPDGQFPHNPEPLPQNLTEICKVVkek-kaNVGFVVDPDVDRLAIVDenGEFFGEEYTLVAIADyllg--l 283 Porphyromonas g...
ZP_01854796  198 ---vIVLGGTADGHFAHTPEPLKENLTGLSEAVvka-gaDAGFAQDPDADRLAIVDdtGRYIGEELTLALAADyvla--- 270 Planctomyces ma...
ZP_01922538  200 ---eVFAVNTGIDGFRRPPEPLPENLGELAELVkre-hcDVGFGQDPDGDRLTVVTdrGEALNPHYTVALAVEqvle--g 273 Victivallis vad...
Feature 1                  #                         ###                  # # #                  
XP_640645    285 grrGNVCKNLSSSRAIDDIck-----kYESQVICAPVGEIQVAKKMqq--vnAVIGGEGNGGVMLPdi-hIGRDAPVAAT 356 Dictyostelium d...
NP_869094    306 rrsGPIVINGATSSMSTLIak-----qHGVETFRSAVGEANVCDLMia--kkAAYGGEGNGGPIDPav-gYVRDSFVGMA 377 Rhodopirellula ...
ZP_01092838  282 srqGPVVINCATSLMNEAIak-----kHGSPIFRSSVGEANVTDMMia--kqAIFGGEGNGGPIDPrv-gYIRDSFVGMA 353 Blastopirellula...
NP_713980    283 pkkANIVVNLSTSFINEFVar-----qNGVPVFRSKVGEANVVSEMlr--qkSIFGGEGNGGVIDPtiasFGRDSLSGIA 355 Leptospira inte...
AAO31976     315 pgeYHIVTNISTSLVVADAcrkheergVKGVLHYTAVGEVNVALKMlelgdrCLVGGEGNGGVMLPsa-hIGRDSIVAIV 393 Giardia intesti...
XP_001315718 276 gvkTPVCRNISTSRAVDDIcr-----qHGVTCYGTPIGEVNVAMRMve--vgSEIGGEGNGGVMLTsc-hIGRDALVATA 347 Trichomonas vag...
XP_650107    278 gkkGNVCKNLSSSRATSKVce-----kFGSKCYNTPVGEIQVGIGMkq--lnAVIGGEGNGGVMLPdv-hIGRDAMVAST 349 Entamoeba histo...
YP_446467    365 hreGPFVTNLSSSRAIDDVaa-----rHGQPVYRSAVGEINVVQRMke--vdAVLGGEGNGGVILPdl-hYGRDALAGTA 436 Salinibacter ru...
NP_661164    285 hhkGPVVNNLSSSHALFDIar-----kHEVECFSAKVGEANVIEVMke--keAVIGGEGNGGIILPel-hYGRDALAGIA 356 Chlorobium tepi...
NP_905306    284 nggGNTVSNLSSTRALRDVta-----rHGGKYEAAAVGEVNVVTKMke--igALIGGEGNGGVILPel-hYGRDALVGIA 355 Porphyromonas g...
ZP_01854796  271 rtpGPVVVNGSTSRVTADIaa-----kYNCPFFRSYVGEAHVCAKMkq--esAILGGEGNGGVIDPkv-gYVRDSYVSMA 342 Planctomyces ma...
ZP_01922538  274 gdpGPVVVNMQTSRLLEYIcg-----sFDCKLLSSKVGEINVVEKMie--ndSEIGGEGNCGGVIYrrvhPGRDSFTGMA 346 Victivallis vad...
Feature 1                                                                                        
XP_640645    357 LALQLMAnrys--qapSISKLKETLPTYEIVK-LKAGI----EGLDPDSILAEYTSqfinkpg-vvinqeDGLKIDSq-- 426 Dictyostelium d...
NP_869094    378 QTLALLArt-----gkPLSELADELPQLSIHK-SKAGV----SAVQLPAVFDKLEAkftda----eatrgDGMRLQWs-- 441 Rhodopirellula ...
ZP_01092838  354 LVLDAMAas-----ssTVAELADSIPRFEILK-TTMPL----DREQLAGSLDRLTAyfsda----rasrlDGLRFAWd-- 417 Blastopirellula...
NP_713980    356 HILNVMAat-----gkKIDSIVEELPAIYMQK-TSFKI----AGKNLQDIYSKFRGefstf----seetiDGLRLTSe-- 419 Leptospira inte...
AAO31976     394 LVLSWLAkmrklhgerPISELVAERFQKYYIKkNKYTI----APEKRAKLDKKLQAlaqease-ydvdtvDGVKFTSvss 468 Giardia intesti...
XP_001315718 348 MVLQLFAaereqnpniTISQIKGALPQWRISK-KKIPMk--nTTNVPELIEQWKEKmmkqyartialdekDGLRVDNr-- 422 Trichomonas vag...
XP_650107    350 LTLMLMTke-----qkPLKEIVSQLPQFRIYK-TKVDTnkvnVDKAFELVKKTYQQeei--------derDGLYVSTk-- 413 Entamoeba histo...
YP_446467    437 FVLQHLAds-----grSLGALHDDLPHYAMAK-DNLPL----PDVAPDRLLAALAEkysdt----nqstlDGLKINFd-- 500 Salinibacter ru...
NP_661164    357 LFIQAFAgwks-atggTLSEFRKTFPDYFMSK-KKVELtt-lSKESLDRIFDTVAAnhpda----ecnrlDGLKLDFe-- 427 Chlorobium tepi...
NP_905306    356 LFLTHMAkr-----keAVSRIRAEYPAYFMSK-QRVDTp---AGTDTQRLLQTMFErykne----qistvDGVKIDFp-- 420 Porphyromonas g...
ZP_01854796  343 YVLAGLAas-----gqKLSSWSDSLPQYSIVK-NKITC----PREKVEDACKALEShfdsa----tasrgDGLRLDWd-- 406 Planctomyces ma...
ZP_01922538  347 LILERLAms-----dgPLSEIIDGYPPMCNLS-ARFTVp---PIPAREVLASLSRKyekyh-----pltfDGLRFDLe-- 410 Victivallis vad...
Feature 1              # ###    #                   
XP_640645    427 dWWVHLRKSNTEHIIRVIAEAKSVKEATDIATKFI 461 Dictyostelium discoideum AX4
NP_869094    442 dRWLLVRGSNTEPIVRMIAEAPTADEAASLCDQAS 476 Rhodopirellula baltica SH 1
ZP_01092838  418 dAWLLIRGSNTEPIVRIIAESPASDRSAALCEAAA 452 Blastopirellula marina DSM 3645
NP_713980    420 dSWIHIRPSNTEPIIRIIGEARTKKDLNSLLDRAG 454 Leptospira interrogans serovar Lai str. 56601
AAO31976     469 rKWVHMRFSNTEPIIRIISEAPSEDEAVELIKNYE 503 Giardia intestinalis
XP_001315718 423 dWWVHVRKSNTEPIVRVIGEAHTQDEADDLCNKVY 457 Trichomonas vaginalis G3
XP_650107    414 dFWVHLRRSNTEPIVRVIAEAESLEKAKETAEKVM 448 Entamoeba histolytica HM-1:IMSS
YP_446467    501 eSWVHMRPSNTEPILRVYTEAPTQDDAQALADRFC 535 Salinibacter ruber DSM 13855
NP_661164    428 nGWVHLRPSNTEPIVRIYTEASTQAEADALAARFI 462 Chlorobium tepidum TLS
NP_905306    421 dSWVHMRRSNTEPIVRIYTEARTEKEAQDLADRFR 455 Porphyromonas gingivalis W83
ZP_01854796  407 dRWVQVRASNTEPIIRVIAEAPESEAAEALCESAM 441 Planctomyces maris DSM 8797
ZP_01922538  411 eGRILVRSSNTEPIMRLNVEADDRPTAEALLNRFT 445 Victivallis vadensis ATCC BAA-548

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