Conserved Protein Domain Family
ClC_6_like

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cd03685: ClC_6_like 
ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family belongs to the ClC superfamily of chloride ion channels, which share the unique double-barreled architecture and voltage-dependent gating mechanism. The gating is conferred by the permeating anion itself, acting as the gating charge. ClC chloride ion channel superfamily perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, and transepithelial transport in animals.
Statistics
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PSSM-Id: 239657
Aligned: 16 rows
Threshold Bit Score: 554.185
Created: 3-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative Cl- selectivity filter
Evidence:
  • Comment:Based on sequence similarity to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
CAA96065      45 NSLDYEVIENyayreeqahrg-klyvgyyvavKWFFSLLIGIGTGLAAVFINLSVENFAGWKFAltfaii---------- 113 thale cress
AAH12737      95 ESLDYDNSENqlfleeerrin-htafrtveikRWVICALIGILTGLVACFIDIVVENLAGLKYRvikgnidk-------f 166 human
NP_506022     70 ESLNYEISENrlyrdaekkpshqltlwrisrnRWFVCFLIGVFTGLVAAFIDIMVHYSKDIKFNwilkyllskcgeeqrg 149 Caenorhabditis ...
NP_610798    115 ESLDYEVCENtlfqdeqrkrlterfslrkdiiRWIIFIQIGIITALIACTIDIIIEELSIRKYTflynsvkenvp--lsd 192 fruit fly
BAB97269      81 ESLDYEVVENdlfkqdwrsrk-kkqifqyivlKWTLVLLIGLLTGLVGFFNNLAVENIAGFKLLltgnlml--------- 150 Japanese rice
AAP04392      63 ESLDYEVVENdlfkqdwrsrk-kkqifqyivlKWSLVLLIGLLTGFVGFFNNLAVENIAGFKLLltsdlm---------- 131 Zea mays
AAH73264      88 ESLDYDNSENllfmeeerrin-haafrtvevtRWVICGLIGIFTGLIACFIDILVEKLAGVKYQvikdnidk-------f 159 African clawed ...
XP_642961     68 ESLDFNAIDNiihrkytfekk-kyqkilktlgKWVICTLIGVVVGLVCYCLKESVDQLQSLKLTqvkkfys--------- 137 Dictyostelium d...
NP_001025815  91 ESLDYDNSENqlfleeerrin-haafrtveikRWVICAMIGILTGLVACFIDIVVENLAGLKYRvvkdnidk-------f 162 chicken
P51797        49 ESLDYDRCINdpylevletmd-nkkgrryeavKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGvvqtsvee-------c 120 human
Feature 1                                            #####                                     ##
CAA96065     114 --qksyfAGFIVYLLINLVLVFSSAYIItqFAPAAAGSGIPEIKGYLNGIdiPGTLLFRTLIGKIFGSIGSVGGGLaLGK 191 thale cress
AAH12737     167 tekgglsFSLLLWATLNAAFVLVGSVIVafIEPVAAGSGIPQIKCFLNGVkiPHVVRLKTLVIKVSGVILSVVGGLaVGK 246 human
NP_506022    150 ttagcmwTVMIAWIGYNCVLVTIAAILViyVAPIAGGSGIPQIKCYLNGIaiPEVVRLKTLVSKAVGVACSVGGGLcAGK 229 Caenorhabditis ...
NP_610798    193 asdrdllIPYLYWLLFSIVPVAFGAAMVtyIEPITAGSGIPQVKSYLNGVkiPRIVRIKTLAVKAIGVITSVVGGLaGGK 272 fruit fly
BAB97269     151 kgkcrylTAFFAYGGCNLVLAAAAAAICayIAPAAAGSGIPEVKAYLNGVdaYSILAPSTLFVKIFGSILGVSAGFvLGK 230 Japanese rice
AAP04392     132 -lkgryiRAFFVYGGCNLVLAAAAAAICayIAPAAAGSGIPEVKAYLNGVdaYSILAPSTLFVKIFGSILGVSAGFvLGK 210 Zea mays
AAH73264     160 tekgglsFSLLLWAALNCTFVMVGSLMVayIEPVAAGSGIPQIKCFLNGVkiPHVVRLKTLMVKVVGVILSVAGGLaVGK 239 African clawed ...
XP_642961    138 -testifIPFLVYLGFNLCYGLISGLLVciFGPMSSSSGLPEVKGYLNGIriSKAFNLKTVLGKLVSLIFSFSSGLvLGP 216 Dictyostelium d...
NP_001025815 163 tekgglsFSLLLWATLNASVVMVGSVIVafIEPVAAGSGIPQIKCYLNGVkiPHVVRLKTLVIKVCGVILSVVGGLaVGK 242 chicken
P51797       121 sqkgclaLSLLELLGFNLTFVFLASLLVl-IEPVAAGSGIPEVKCYLNGVkvPGIVRLRTLLCKVLGVLFSVAGGLfVGK 199 human
Feature 1        ###                                                                             
CAA96065     192 EGPLVHTGACIASLLGQGGSTkyhlnsrwpqlFKSDRDRRDLVTCGCAAGVAAAFRAPVGGVLFALEEVTSWWRSQLMWR 271 thale cress
AAH12737     247 EGPMIHSGSVIAAGISQGRSTslkrdfkifeyFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326 human
NP_506022    230 EGPMIHSGAAVGAGISQGKSYslgidfglfreFRNDREKRDFVSAGAAAGVAAAFGAPIGGVLFSLEEGASFWNQALTWR 309 Caenorhabditis ...
NP_610798    273 EGPMIHAGAVVAAGISQGKSTtflkdfrifkaFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWR 352 fruit fly
BAB97269     231 EGPMVHTGACIANLLGQGGSRkyrltcnwlryFKNDRDRRDLITCGSAAGVAAAFRAPVGGVLFALEEAASWWRSALLWR 310 Japanese rice
AAP04392     211 EGPMVHTGACIANLLGQGGSRkyhltcnwlryFKNDRDRRDLITCGSAAGVAAAFRAPVGGVLFALEEAASWWRSALLWR 290 Zea mays
AAH73264     240 EGPMIHSGAVVAAGISQGRSTslkkdfkifeyFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQLLTWR 319 African clawed ...
XP_642961    217 EGPMFHIGAGIGSSMSQFKSKtlkfhlksfwiFQNDSDKRDFISCGAAAGIAAAFGAPIGGVLFCLEEGSSFWSRQLTWR 296 Dictyostelium d...
NP_001025815 243 EGPMIHSGAVIAAGISQGRSTslkrdfkifeyFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 322 chicken
P51797       200 EGPMIHSGSVVGAGLPQFQSIslrkiqfnfpyFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWK 279 human
Feature 1                                                                                        
CAA96065     272 VFFTSAIVAVVVRTamgwcksgicghfgg------ggfiiwdvsdgqddYYFKELLPMAVIGVIGGLLGALFNQLTLYMT 345 thale cress
AAH12737     327 IFFASMISTFTLNFvlsiyhgnmwdlssp------glinfgrfdsekmaYTIHEIPVFIAMGVVGGVLGAVFNALNYWLT 400 human
NP_506022    310 MFFSAMISSFTVNWilswfngrsgwlsw--------tglanfgvfenkdYNIWEIPLFLLIGIIGGCLGALFNYLNTKLT 381 Caenorhabditis ...
NP_610798    353 TLVASIISVFTLNIvlsayhglndftft--------glfnlgkfdtplkFDYFELPIFMILGVTGGLLGAAWNSLNTKIN 424 fruit fly
BAB97269     311 AFFTTAVVAVVLRSliefcrsgkcglfgq------gglimfdlsstvatYSTPDLIAIIILGIIGGIFGGLFNFLLDKVL 384 Japanese rice
AAP04392     291 TFFTTAVVAVVLRGliefcrsgkcglfgq------gglimfdlsstvavYSTPDLIAIIVLGIIGGIFGGLFNYLLDKIL 364 Zea mays
AAH73264     320 IFFASMISTFTLNFflsiynqkpgdlsnp------glinfgrfdtdensYQYFELPIFMFMGVVGGMLGALFNALNHCLT 393 African clawed ...
XP_642961    297 TFFSCLIATMTANLflqgftqqihdy-----------gvltfgvsksylYTYTELIPFMIMGIIGGLLGAIFVHVNVRVN 365 Dictyostelium d...
NP_001025815 323 IFFASMISTFTLNSvlsvyhgnawdlssp------glinfgrfdsekmgYTIQEIPIFIFMGVVGGILGALFNALNYWLT 396 chicken
P51797       280 VLFCSMSATFTLNFfrsgiqfgswgsfqlpgllnfgefkcsdsdkkchlWTAMDLGFFVVMGVIGGLLGATFNCLNKRLA 359 human
Feature 1                                                                                        
CAA96065     346 SWRRnslhkkgnrvKIIEACIISCITSAISFglpllrkcspcpesvpdsgiecprppgmygnyvnffcktdneyndlati 425 thale cress
AAH12737     401 MFRIryih--rpclQVIEAVLVAAVTATVAFvliyssrdcqplqggsmsyplqlfcadge--------------ynsmaa 464 human
NP_506022    382 EFRKkyvs--sklgRLFECLLVAAVSGFLAFltifaiddcqpiganptatstqinqmwckk-----------geysavas 448 Caenorhabditis ...
NP_610798    425 KFRKrfip--wkigKVLEAVVVAMMGVTLAClmiyfindcrplgndptnnpvqlfcedne--------------ynavaa 488 fruit fly
BAB97269     385 RVYSiiner-gapfKILLTITISIITSMCSYglpwlaactpcpvdaveqcptigrsgnfknfqc-----ppghyndlasl 458 Japanese rice
AAP04392     365 RVYSiiner-gapfKILLTITISIITSMCSYglpwlaactpcpvdaveqcptvgrsgnyknfqc-----ppghynglasl 438 Zea mays
AAH73264     394 TFRIrymh--rrflQVIEAMLVAAVTATVAFvtiyystdcqplrqddtdyplqlfcsdge--------------ynamas 457 African clawed ...
XP_642961    366 HWRKklfanksklyKMIEVCVIVILSSVVCFfpalladcrpisgisgltpgtcdpgddstlilnqf--ncaegyynpmat 443 Dictyostelium d...
NP_001025815 397 MFRIryih--rpclQVIEAMLVAAVTAAVGFvmiycsrdcqpiqgssvayplqlfcadge--------------ynsmat 460 chicken
P51797       360 KYRMrnvhpkpklvRVLESLLVSLVTTVVVFvasmvlgecrqmssssqigndsfqlqvtedvnssiktffcpndtyndma 439 human
Feature 1                                                       #####                            
CAA96065     426 ffntqddairnlfsaktmrefsAQSLLTFLAMFYTLAVVTFGtAVPAGQFVPGIMIGSTYGRLVGMFvvrfy-kklniEE 504 thale cress
AAH12737     465 affntpeksvvslfhdppgsynPLTLGLFTLVYFFLACWTYGlTVSAGVFIPSLLIGAAWGRLFGISlsyltgaaiwaDP 544 human
NP_506022    449 lffqnpeesvksmfhspinsfgVTTLVIFGIEYFLLTLWTFGiSVPSGVFIPAILTGAAWGRLFGIFverlfpsvtgiDP 528 Caenorhabditis ...
NP_610798    489 lwfqtpeatvrslfhdppgshkILTLALFTVVYYVLSCATFGlNVSLGVFIPTALVGAAWGRLLAMLtyyvfpqaeflHP 568 fruit fly
BAB97269     459 ffntnddairnlfsngtesefhMSTLFIFFTAVYCLGILTYGvAVPSGLFIPVILAGATYGRIVGTLlgsi----sdlDP 534 Japanese rice
AAP04392     439 ffntnddairnlfsngtstefqMSSLFIFFTAIYCLGLVTYGiAVPSGLFIPVILAGATYGRIVGTLlgsi----sdlDP 514 Zea mays
AAH73264     458 affttpeksvrrlfhdppgsfnPQTLGVFTILYFFLACWTYGlTVSAGVFIPSLLLGAAWGRLFGILltivpngvtwaDP 537 African clawed ...
XP_642961    444 ltlttlenslqivfsrstniftAQTLLTFSIFYYVLTIITSGlYVASGIFIPMMLIGSSWGRLIGIFlsky---ftsiDP 520 Dictyostelium d...
NP_001025815 461 affntpeksvvnlfhdppgsynPMTLGMFTLMYFFLACWTYGlTVSAGVFIPSLLIGAAWGRLFGISlsylskgsiwaDP 540 chicken
P51797       440 tlffnpqesailqlfhqdgtfsPVTLALFFVLYFLLACWTYGiSVPSGLFVPSLLCGAAFGRLVANVlksyi-glghiYS 518 human
Feature 1                                                                  #                     
CAA96065     505 GTYALLGAASFLGGSmRMTVSLCVIMVEITNn-LKLLPLIMLVLLISKAVGDAFNEGLYEvqarlkGIPLLesrpkyhmr 583 thale cress
AAH12737     545 GKYALMGAAAQLGGIvRMTLSLTVIMMEATSn-VTYGFPIMLVLMTAKIVGDVFIEGLYDmhiqlqSVPFLhweapvtsh 623 human
NP_506022    529 GKYALAGAAAQLGGVvRMTISLTAIIMEATKd-ITFGLPIMLVLMVTKWVGDMFNEGLYDahidlaEVPILgwnppkmsr 607 Caenorhabditis ...
NP_610798    569 GKYALIGAAANLGGVlRMTISLSVILMETTGveTSFFFPLIIALISAKWVGDYFNEGIYDtqiqvnHVPMLtweplpqyk 648 fruit fly
BAB97269     535 GLFALLGAASFLGGTmRMTVSVCVILLELTNd-LAMLPLVMLVLLISKTIADNFNKGVYDqivvmkGLPYMeahaepymr 613 Japanese rice
AAP04392     515 GLFALLGAASFLGGTmRMTVSVCVILLELTNd-LPMLPLVMLVLLISKTIADSFNKGVYDqivvmkGLPYMeahaepymr 593 Zea mays
AAH73264     538 GKYALMGAAAQLGGIvRMTLSLTVIMVEATGn-VTYGFPIMLVLITAKLVGDYFVEGLYDlhiklqSVPFLhweapvtsh 616 African clawed ...
XP_642961    521 SIYALIGAASMMAGSlRMTISLVVIIVELTEt-TQYLLPVILSVMVGKWCGDIFNESIYEhlielkHIPYLnsqppnhlr 599 Dictyostelium d...
NP_001025815 541 GKYALMGAAAQLGGIvRMTLSLTVIMMEATGn-VTYGFPIMLVLMTAKIVGDYFVEGLYDmhiqlqSVPFLhweapvtsh 619 chicken
P51797       519 GTFALIGAAAFLGGVvRMTISLTVILIESTNe-ITYGLPIMVTLMVAKWTGDFFNKGIYDihvglrGVPLLewetevemd 597 human
Feature 1                                                 
CAA96065     584 qmiakeacqsqk-vislprvirvadvasilgsnkHNGFPVI 623 thale cress
AAH12737     624 sltarevmstpvtclrrrekvgvivdvlsdtasnHNGFPVV 664 human
NP_506022    608 niladrvmrkdv--valerrervsriveilrstlHHGFPVV 646 Caenorhabditis elegans
NP_610798    649 glkareilskpv--icikirdsanyiyemlkkcdHNGFPVV 687 fruit fly
BAB97269     614 hlvagdvvsgpl--itfsgvekvgnivhalrftgHNGFPVV 652 Japanese rice
AAP04392     594 hlvagdvvsgpl--itfsgvekvgnivhalrltgHNGFPVI 632 Zea mays
AAH73264     617 slaarevmstpvvwlrrrekvgvivdilsdtssnHNGFPVV 657 African clawed frog
XP_642961    600 kktvaeamstdv--ktlpeivkvktaltiletcpHNGFPVV 638 Dictyostelium discoideum AX4
NP_001025815 620 sltarevmstpvtclrriervgtvvdilsdtssnHNGFPVV 660 chicken
P51797       598 klrasdimepnl--tyvyphtriqslvsilrttvHHAFPVV 636 human

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