Conserved Protein Domain Family
TPP_ComE
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cd03372: TPP_ComE 
Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits, which catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway. ComDE requires TPP and divalent metal cation cofactors.
Links
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Statistics
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PSSM-Id: 239469
Aligned: 12 rows
Threshold Bit Score: 217.541
Created: 13-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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TPP-binding
Feature 1:TPP-binding site
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                    #                           ####   
P58416        5 RIDIIKKIVENVge-kEIIVSNIGIPSKELYYVKDRERNFYMLGSMGLASSIGLGLALNCe-----DKVIVIDGDGSILM 78  Methanocaldococc...
NP_769498     9 RRQVVSTLLADRk--dVVAIGGLGASTNDICAAGDHARNFYLWGGMGGAAMIGLGLALAQp----kLPVLVITGDGEMLM 82  Bradyrhizobium j...
YP_447330     5 RYDAIKKIITDLd--dELVISNIGFPSRELYGIKDRNNNFYMSGSMGMATPIALGLSLALeeksddRKVIVIDGDGSLLM 82  Methanosphaera s...
NP_769811    15 RFDVTSRLIAKLkh-eEAVIGGIGNTNFDLWAAGHRPQNFYMLGSMGLAFPIALGVALAQp----kRRVFALEGDGSLLM 89  Bradyrhizobium j...
NP_988809     5 RYEIIKILMEYVt--dEIVVCNIGIPSKELFKINDREKNFYMLGSMGLSSSIGHGLALSVn-----EKVIAIDGDGSVLM 77  Methanococcus ma...
ZP_00685111   8 RRAAVAHLLDDRk--eSIVVAGLGSPIYDVFAAGDHSLNFYDWGAMGSAAMVGLGLALAQp----rRPVIVFTGDGEMLM 81  Burkholderia amb...
ZP_00960279   3 RSDVLKTLIPMIs--dHFVVCNIGLPSQELHMLDDQPTNFYMLGTMGLSSSIGLGLALAQk-----QKVISIDGDGSVLT 75  Roseovarius nubi...
ZP_00862907   7 RRAAVQALLQDRg--dLLVISGLGSSSYDVFAAGDHPANFYLWGAMGGAAMMGLGLALAQp----sRPVAVITGDGEQLM 80  Bradyrhizobium s...
AAM06668    202 RNDAICTLASELd--dEITVTNLGVPCKELYACRDRELNFYMFGSMGLVSSIGLGLALRSe-----KTVITFDGDGSLLM 274 Methanosarcina a...
ZP_00867625 193 RADAIRVLASMMt--dELVVSNIGVPSKELYHARDNPANFYMLGSYTQASPLGFGIALGTd-----RRVVVLDGDGSLLG 265 Methanospirillum...
NP_613678     5 RIEALRVVADVAerydAVVTVHLGFPARELYRVNDRRLNFYMLGAMGQSCSVGLGLALCTd-----REVLAIEGDGGLMM 79  Methanopyrus kan...
O27275        5 RIEAIERITGVLe--dELVICNLGFPSRELYSIRDSPRHFYMLGSMGMASSIGLGLALSQe-----RRVVVLDGDGSILM 77  Methanothermobac...

Feature 1                             # #                                                       
P58416       79 nLGSLSTIGYMNPKNYILVIIDNSAYGSTGNQKTHTgknTNLEEIAKGCGLDTITTE-----SLEEFEKEFKNAlneeKC 153 Methanocaldococc...
NP_769498    83 gMGSLATIGLQKPSNLSIVVLDNEAYGETGGQTSHTsaaADLVGVARACGIGDARAIst-maEVEAFAKAVHDVs--aGP 159 Bradyrhizobium j...
YP_447330    83 nFGELITVYAQNPSNLIIALIDNEAYGSTGSQETYTs-kVNLSNIAKSIGYNEVYYVda-rnSVDNIDIKQYLDk--kEP 158 Methanosphaera s...
NP_769811    90 qLGALSTIAALKPKNLIMIVMDNGIYQITGAQPTPAadvADIVAIAAGSGLANSAWAa----DEEDFERLVEEAmsapEP 165 Bradyrhizobium j...
NP_988809    78 nMGSLATIGKTTPKDFLLLIVDNCAYGSTGNQETHSt-cTDLYQVSKACGIDSIGVF-----NEEQLRDAVKLAlsesGT 151 Methanococcus ma...
ZP_00685111  82 gLGAFATIAQHCPPNLAIVVLDNEQYAETGMQRTATgigTDLAAVARGCGLKNAVTLts--dSELTLLKEKIQAc--dGT 157 Burkholderia amb...
ZP_00960279  76 nFGTLPTIANNVADNFILLIIDNGSYGSTGDQPTYAgkkTSLTAVAQACGCENVIEC-----AAEDCADVMEQAltgdKM 150 Roseovarius nubi...
ZP_00862907  81 gLGGLATAAAKKPSNLSIIVLDNAHFGETGMQMSHSglgARLELIASGAGFPSVSTIad-qvALDAFRPKLRDRa---GP 156 Bradyrhizobium s...
AAM06668    275 nPNALLEIAKEAPKNLIIIALDNGAYGSTGSQETCAlryIDLEIFANACGIQNTAKVnskegVIEAFRKFKAMR----EL 350 Methanosarcina a...
ZP_00867625 266 -TAVLPVIASESPKNLIIIGLDNGVYGSTGNQCSPAhstVDLELLAQASGFHRTWKVh----TPDELKQAYAQAq--gGL 338 Methanospirillum...
NP_613678    80 nMGVLPTIAQERPRNYTLVLIDNSTYATTGDQPTPSd-rIDWEKVAEAHGLTYFEAS-----EPESAEVALEDAlateGP 153 Methanopyrus kan...
O27275       78 nLGGLVTAAAQSPGNLIIVLLDNRCYATTGSQCTYAd-vIDLGAVAESMGFNVIRFA-----DDLNFEQALAMD----GP 147 Methanothermobac...

Feature 1                                       
P58416      154 KVIIAKTIPYNekcSNIEIPPVVLKYRFMEAI 185 Methanocaldococcus jannaschii
NP_769498   160 RFANVKIDSASlerILPSRDGTYIVNRIRGDL 191 Bradyrhizobium japonicum USDA 110
YP_447330   159 VFLHIKVKPGNtkaPIIDKTPSQIKNRFMESI 190 Methanosphaera stadtmanae DSM 3091
NP_769811   166 SLIAVRIDDKPg-vGTTRRDPVQIRERFMQGL 196 Bradyrhizobium japonicum USDA 110
NP_988809   152 KVIVAKARPHNenvPNINLVPTEIKHRFMNAI 183 Methanococcus maripaludis S2
ZP_00685111 158 KVAVLKIVPGDqprTIPMRDGAAIANRFILAL 189 Burkholderia ambifaria AMMD
ZP_00960279 151 TIIVCKCESGNipvPVITKDPVTIRDRFMTAL 182 Roseovarius nubinhibens ISM
ZP_00862907 157 HFARVVISTDHvdrALPPRDGVFLKNRFRGHL 188 Bradyrhizobium sp. BTAi1
AAM06668    351 SFIHVILKPGNtnaPNIPMSPEEATKRFKETL 382 Methanosarcina acetivorans C2A
ZP_00867625 339 SFIHVIIRPGNskaSNIPLSPADIKNRFCSEA 370 Methanospirillum hungatei JF-1
NP_613678   154 RMVRLEVEPGNadvPLIDLDPEEIKVRFVRAL 185 Methanopyrus kandleri AV19
O27275      148 VFAHVPVKPGNadvPVIDLDAEEIIERFIKEV 179 Methanothermobacter thermautotrophicus str. Delta H

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