1G29,1OXV,1Z47


Conserved Protein Domain Family
ABC_Carb_Solutes_like

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cd03259: ABC_Carb_Solutes_like 
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ATP-binding cassette domain of the carbohydrate and solute transporters-like
This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Statistics
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PSSM-Id: 213226
Aligned: 52 rows
Threshold Bit Score: 238.573
Created: 19-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:1OXV; Mg-ADP bound, 3.5A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          ## ###                                     
1G29_1      4 VRLVDVWKVfge--vtaVREMSLEVKDgEFMILLGPSGCGKTTTLRMIAGleepSRGQIYIGdklvadpekgifvppkdR 81  Thermococcus litor...
1OXV_D      4 IIVKNVSKVfkkgkvvaLDNVNINIENgERFGILGPSGAGKTTFMRIIAGldvpSTGELYFDdrlvasng-klivppedR 82  Sulfolobus solfata...
NP_736801   3 LRIDGVTRTfgq--vraLDEVSLNVPTgSITVVVGPSGSGKTTLLRLLAGldapDAGEVSIDgqp-----------vtlG 69  Corynebacterium ef...
NP_744409   3 LVLEQVSRSvdn--qpwIVDASLRFEPgSFNVLLGRTLAGKTSLMRLMAGldrpDRGRVLMDgqdvtg------vpvrqR 74  Pseudomonas putida...
NP_889594   3 LVLDGIQLRags--qvhLYPLSLQPAPgAMTVLLGATLAGKTSVMRIMAGldrpTEGKVLVDgadvtg------vpvrqR 74  Bordetella bronchi...
NP_949745   3 VSLENVTRVldg--vpaIRNVSLTLERgTLSVLLGPTLSGKTSIMRLLAGldkpTTGRVLVDgkdvtg------advrtR 74  Rhodopseudomonas p...
NP_822572   3 LHATDLCLTvdg--vdhLKNVTATFRPgRLHTVIGRTMAGKTTLLRALAGlqkvDSGSLTRAgadflk------tpvwrR 74  Streptomyces averm...
NP_441282   2 IRVEQVSKTygs--vavLRQLCLTIPPgGKTAILGRSGSGKTTLLRLIAGldrlDGGEIYLGdrqvscpq--hylpphqR 77  Synechocystis sp. ...
P31548      2 LKLTDITWLyh----hlPMRFSLTVERgEQVAILGPSGAGKSTLLNLIAGfltpASGSLTIDgvdhtt------mppsrR 71  Escherichia coli
NP_868089  28 LEINGLAIDrgs--triVDDFDLALAPgEYCVVLGPSGCGKSTLLHCIAGlldaACGSISIDgrdvth------vmarkR 99  Rhodopirellula bal...
Feature 1           #                                                                         
1G29_1     82 DIAMVFQSYaLYPHMTVYDNIAFPlklrk--vprqEIDQRVREVAELLGLtel--lnRKPRELSGGQRQRVALGRAIVRk 157 Thermococcus litor...
1OXV_D     83 KIGMVFQTWaLYPNLTAFENIAFPltnmk--mskeEIRKRVEEVAKILDIhhv--lnHFPRELSGGQQQRVALARALVKd 158 Sulfolobus solfata...
NP_736801  70 ATALCFQDApLYPHLTVAENVAFPlrlrasrtprpQVETRVGRVLEMLHIdhl--asRRVAGLSGGQRQRVGIARALVRe 147 Corynebacterium ef...
NP_744409  75 NVSMVYQQFiNYPTLSVYENIASPlrqar--maedQIRRRVQETAEMLRIety--lqRLPLELSGGQQQRTAMARALVKd 150 Pseudomonas putida...
NP_889594  75 NVAMVYQQFiNYPSMRVADNIASPlrlr----gaaDIPARVRAMAERLHIehl--leRYPSELSGGQQQRVALARALVKd 148 Bordetella bronchi...
NP_949745  75 SVAMVYQQFiNYPSLTVYENIASPlrvqr--ksraEIEQRVQEAAKLLKLepy--lqRTPLQLSGGQQQRTAIARALVKg 150 Rhodopseudomonas p...
NP_822572  75 DTAMVYQQFiNYPHLNVFDNVAFPlkrag--lsrdVIRRRARQSLASVGLadf--ekRKPSQLSGGQQQRVAMARALARd 150 Streptomyces averm...
NP_441282  78 GIGFVFQSPaLWPHLTVQQNIAFGlahl---skteQQERIEPLLARLAIApl---idRYPHQLSGGEAKRVAFARTLAPr 151 Synechocystis sp. ...
P31548     72 PVSMLFQENnLFSHLTVAQNIGLGlnpgl--klnaVQQGKMHAIARQMGIdnl--maRLPGELSGGQRQRVALARCLVRe 147 Escherichia coli
NP_868089 100 DVGLLFQHDtMYPHLTVEQTLQIAcranlngrpsaTETNQKIQSMLRTLNldpawlpRRPETLSGGQRRRVALAKTLIRe 179 Rhodopirellula bal...
Feature 1           ##                                 #                         
1G29_1    158 PQVFLMDEPLSNLDAKLRVRMRAELKKLQrql-gvTTIYVTHDQVEAm-tMGDRIAVMNrGVLQQVG 222 Thermococcus litoralis
1OXV_D    159 PSLLLLDEPFSNLDARMRDSARALVKEVQsrl-gvTLLVVSHDPADIf-aIADRVGVLVkGKLVQVG 223 Sulfolobus solfataricus
NP_736801 148 VQVYLFDEPMAHLDEQLARGIVADLRRIQrel-glTFVYITHSREEAf-aLADQMVILHeGRVVQAD 212 Corynebacterium efficiens YS-314
NP_744409 151 ASLILFDEPLVNLDYKLREGLRQELRELFaar-hcIAVYATTEPNEAl-aLGGTTTLVHeGRIVQSG 215 Pseudomonas putida KT2440
NP_889594 149 APLVLLDEPLVNLDYKLREALREELAGLFaqg-rsTVVYATTEPAEAl-lLGGHTAVLDaGRLLQYG 213 Bordetella bronchiseptica RB50
NP_949745 151 ADLVLLDEPLANLDYKLREELRTELPKIFeas-gaIFVYATTEPSEAl-lLGGRTICMWeGQALQVG 215 Rhodopseudomonas palustris CGA009
NP_822572 151 TGILLLDEPLANLDYKLREQLRDEFKALFsdqgdtIVIYTTTEPAEAm-mLGDVVLVMHeGRILQTG 216 Streptomyces avermitilis MA-4680
NP_441282 152 PPFLLLDEPLSNLDQGLKEELLTYLQDYLdft-qaCTLYVTHDLAEAq-fLTSDIQLLRdGQLVPHS 216 Synechocystis sp. PCC 6803
P31548    148 QPILLLDEPFSALDPALRQEMLTLVSTSCqqq-kmTLLMVSHSVEDAa-rIATRSVVVAdGRIAWQG 212 Escherichia coli
NP_868089 180 PSVCLLDEPMAAIDRLAAENLMQHLADVSrqt-dsTTFVHVTHDGDEamrMADKIVVMSnGCILQTG 245 Rhodopirellula baltica SH 1

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