1IVN,1U8U


Conserved Protein Domain Family
Lysophospholipase_L1_like

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cd01822: Lysophospholipase_L1_like 
Click on image for an interactive view with Cn3D
Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.
Statistics
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PSSM-Id: 238860
Aligned: 80 rows
Threshold Bit Score: 178.861
Created: 30-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:includes catalytic triad and oxyanion hole
  • Structure:1U8U_A, E. coli thioesterase binds octanoic acid, contacts at 3.5A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                    #                            #     
1IVN_A        2 DTLLILGDSLSAGYrmsasAAWPALLNdk---wqSKTSVVNASISGDTSQQGLARLPALLKqhQPRWVLVELGGNDGLRG 78  Escherichia coli
1U8U_A        2 DTLLILGDSLSAGYrmsasAAWPALLNdk---wqSKTSVVNASISGDTSQQGLARLPALLKqhQPRWVLVELGGNDGLRG 78  Escherichia coli
AAR35788     33 GTIVAVGDSLTAGYgldehDAYPAQLErllreagRPWRVVNAGISGETSSGALSRVNWVLTl-KPDIVILVTGANDGLRG 111 Geobacter sulfur...
BAD40006     61 PVIVAFGDSLTAGLgvdpdRNYPSQLQalldergYRYRVVNAGVSGELTAGGLSRVDQVLEh-RPAVVILELGANDGMQA 139 Symbiobacterium ...
ZP_00678381  31 GVVLAYGDSLTFGTgagpdQSYPAVLSr-----lIGRRVVNAGIPGEVSAEGLRRLPATLEtvKPSLVILCHGANDLMQG 105 Pelobacter propi...
YP_741332    33 GVILAFGDSLTYGTgapggESYPEQLQa-----lTGRTVIRAGVPGERSAEGRQRLPGALNehQPDLLILMHGGNDILRR 107 Alkalilimnicola ...
ZP_01312934  34 GVIVAFGDSLTVGVganrsDSYPSVLQq-----lTGRQVINAGISGETTAEGAKRLPEVLAdtEPELLILLEGGNDILRN 108 Desulfuromonas a...
ZP_01387462  29 GVILAFGDSITYGTgaasgESYPAMLEq-----lTGRKVVNGGVPGEVTAEGVQRLPGLLEqvKPAMVIICEGGNDMLRH 103 Geobacter sp. FR...
ZP_00837139  33 ARILAFGDSLTQGVgaspgMDYPAQLQa-----mSGREVINAGISGETTSQGRERFARVLDetAPDLIILLEGGNDFLRN 107 Shewanella sp. PV-4
ZP_01142575  71 AVVLAFGDSITYGSgarpeESYPAVLEq-----lIGKRVVNAGVSGEGTDEGKARLPALLDehRPALVIICLGGNDFLRH 145 Geobacter uraniu...
Feature 1                                                                                  #  # 
1IVN_A       79 FQPQQTEQTLRQILQDVKAaNAEPLLMQIRLPanygrryneAFSAIYPKLAKEfdvPLLPFFMEEVYLkpqwmqdDGIHP 158 Escherichia coli
1U8U_A       79 FQPQQTEQTLRQILQDVKAaNAEPLLMQIRLPanygrryneAFSAIYPKLAKEfdvPLLPFFMEEVYLkpqwmqdDGIHP 158 Escherichia coli
AAR35788    112 IDPKVTEKNLDEMVRTLKErNVTVVLGGMKMVanlgrdytrAFAAVYPAVAKRhdlILIPFFLEGVAGrpdlnqaDGIHP 191 Geobacter sulfur...
BAD40006    140 RPVAEVRENLAGIIARLQEeGVAVLLAGMRAPpnhgpeyeaAFAQVYPDLAAEfgvPLIPFFLEGVAGspylnqrDGIHP 219 Symbiobacterium ...
ZP_00678381 106 LDQKRTADNLRAMLAMIRErGASAVLVSVPAIgl-----slEPPPFYDQVAEEagiPIERKVLPRIIAkps-lksDIVHP 179 Pelobacter propi...
YP_741332   108 ESMDRLRANMAAMIEEAQRrEVPVLLVGVPEPal-----ppRPPALYRDLAETyglAYEGRVIGRILRdsg-lraDGVHP 181 Alkalilimnicola ...
ZP_01312934 109 HNLTQTRNHLATMIEYAQNqGVQVVLIAVPEKnl-----fsEQAPLYRELAEEyqvVLIDDMISDLLRtps-yksDTIHL 182 Desulfuromonas a...
ZP_01387462 104 ASHGEIAANLRAMVRIVKGkGASAVLVSVPALdl-----sfAPPPFYAEIAEEvgiPCDEKTLTRILTkrs-lksDPIHP 177 Geobacter sp. FR...
ZP_00837139 108 GNAAQVEANLSAMLAQAQGrDIPVVLIGVPQKsi-----wlETAPLYGQLAAQyqpLFIEDFLTELLKlse-vksDAIHL 181 Shewanella sp. PV-4
ZP_01142575 146 LDEATTEANLREMVRTAQErGCGVLLVGIPRLgf-----glEVPSLYERIARDagiPLDEKSLKRILAdnp-lksDPIHP 219 Geobacter uraniu...
Feature 1                        
1IVN_A      159 NRDAQPFIADWMAKQLQ 175 Escherichia coli
1U8U_A      159 NRDAQPFIADWMAKQLQ 175 Escherichia coli
AAR35788    192 TAEGYRIVSDTVLPYVI 208 Geobacter sulfurreducens PCA
BAD40006    220 TAQGYAIVVRTVLSALE 236 Symbiobacterium thermophilum IAM 14863
ZP_00678381 180 NAAGYRAMAEAFSDLLR 196 Pelobacter propionicus DSM 2379
YP_741332   182 NAEGYRKMARAFEEALR 198 Alkalilimnicola ehrlichei MLHE-1
ZP_01312934 183 NARGYRVMAEEIYSVLE 199 Desulfuromonas acetoxidans DSM 684
ZP_01387462 178 NAAGYRKLAEGLAKLLH 194 Geobacter sp. FRC-32
ZP_00837139 182 NDEGYRRLAEHLYQSLQ 198 Shewanella sp. PV-4
ZP_01142575 220 NAAGYRQLAERIAAALR 236 Geobacter uraniumreducens Rf4

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