Conserved Protein Domain Family
NAPRTase_PncB

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cd01567: NAPRTase_PncB 
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Statistics
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PSSM-Id: 238801
Aligned: 87 rows
Threshold Bit Score: 179.002
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
NP_444244  14 GRATDAYFDrtlealehadrnPHVVAEVTADQfpt----gefEVLAGLQDAAELLAdv--------------------pV 69  Halobacterium sp. ...
Q9UTK3      9 ILDTDLYKLtmlqavlehypdAQVSYKYTNRSpkma---lnqEAYNWLREQIRGLRnlhllpeeeqwlrkncpylkesfY 85  fission yeast
NP_810826   6 LLDTDLYKFttsyayiklfpyAMGTFSFNDRNete----yteEFLEALKSEFNKLSrlrlteeeleymtrncrflprvyW 81  Bacteroides thetai...
EAK96194   13 FLDTDLYKLfmhaavnkqfpdVPVKYRYTNRTpqlk---lnsQAISWLKKQIEYLGdlrfsaeeilylhrvlpqlpsdyL 89  Candida albicans S...
EAK85718   24 ILDTDLYKLtmqqavlrhyphTRVAYKFTNRSaatm--kftrQAMDRIRNHIDNLVhlslsaqerawlerscpylgkdyL 101 Ustilago maydis 521
NP_904408   7 ILDTDLYKFttgyayaklfprAYGEFRFIDRNrqg----fteEFAELVRGEIRAMAalsltrdekeflqrelpylppiyI 82  Porphyromonas ging...
EAA61949   14 LLDTDLYKLtmqcailkyfpdVQVTYGFTNRTphmk---ltrGAYKWMLAQMDKLAnirvtedeiaflkrrcpyfntayL 90  Aspergillus nidula...
XP_324829  16 FLDTDLYKLtmqcavlkyfkdVPVTYSFTNRTpekk---lsrEAFVWLEEQVMKLGnislspeelqflkthcpylteeyL 92  Neurospora crassa
Q9JTM8      8 LLDTDLYKFtmlqvvlhqfpqTHSLYEFRCRNastv--yplaDIKEDLEVELDALCqlrfthdeldy-lrslrfiksdfV 84  Neisseria meningit...
Q8TMW6      5 ILDNDLYKFtmqmavlelfpkAEAEYRFTNRGshhfseefveKLRRVIDEDISALMltedeyqwlg---encsflkpmyL 81  Methanosarcina ace...
Feature 1                                                                                     
NP_444244  70 DVHALpEGTLFdg------------------gpVMRITGPYqsfARYETALLGfLSHASGMATAALAARRAApd------ 125 Halobacterium sp. ...
Q9UTK3     86 EFMHEfEFDPEnsislny--------dsetkdlSIFIHGLWkntIFYEIPLLAlVSESYFKFVDKDWSPEGQfekayekg 157 fission yeast
NP_810826  82 EWLSSfRFDPDkidihl----------dttgrlHIEVSDFLykvTLYEVPLLAiVSEIKNKFFGNVPDMSEIlcklsekv 151 Bacteroides thetai...
EAK96194   90 EYLADfKLVPSsqikyld---------ndegdfELEIVGKWndtILYEIPLLAlVSEAYFKFVDTDWNYEGQyalaqkka 160 Candida albicans S...
EAK85718  102 DYLEAfRFQPKqqvqlrflp----tgedgwghlDLNVSGVWsdvIFYEVPLMAiVSEVYFSTIDTDWSLQDQyqqafdka 177 Ustilago maydis 521
NP_904408  83 DFLDGfRFDPEevtvsi----------daqghlDIRAQGLLyrvTLWETPILAvISELYYRFIGAEPDWKQVeevtrskg 152 Porphyromonas ging...
EAA61949   91 DFLTNfRLKPSeqidinftpvndtgsdsdfgdiDYIVKGAWvdtILYEIPLLAlTSQAYFMFSDKDWNYECQegkayrkg 170 Aspergillus nidula...
XP_324829  93 DYLSEfRLRPReqvavsfrp----dgdsdlgdiHYDIKGNWaetILYEIPLLAlTSEAYFKFMDTDWDYDGQeekayekg 168 Neurospora crassa
Q9JTM8     85 DYLELfQLQRRfvevgt----------ddkgrlNIRIEGPMiqaMFFEIFILAiVNELYFRRLETPAVIEEGerrlqaka 154 Neisseria meningit...
Q8TMW6     82 EYLKNfRFKPGevevcl----------teekelDIRIKGPWhstILWEIVLMAaVSELYFTTIEKEWNGKEWdgnisats 151 Methanosarcina ace...
Feature 1                                  ###                                ##              
NP_444244 126 ----------------------shLLSFGARHVhp----siAAVVERaa--------liGGFDGFSHvaagDVLDREPGG 171 Halobacterium sp. ...
Q9UTK3    158 k---------------rliragcaFTDFGTRRRrdphtqeiVLQGLMkaqed---fkgpGSFLGTSNvyfaAKYNLNVSG 219 fission yeast
NP_810826 152 e---------------lsnqhqlrFSEFGTRRRfsidvqetVIKRLNdt---------aKYCTGTSNcyfaMKYGMKMMG 207 Bacteroides thetai...
EAK96194  161 k---------------qlisnecnFSEFGTRRRrsyesqeiVIKAIKdvqi----dtqsKYIAGTSNvyfaMKYDLPPIG 221 Candida albicans S...
EAK85718  178 c---------------rltsngirYSEFGTRRRrsyqthriVLQGLMagdlsassgcssGKLLGTSNvhfaQQFDLVPIG 242 Ustilago maydis 521
NP_904408 153 e---------------lmrehratFSIFGMRRRfslevedrVTDILKqy--------agESLFGTSNvhlaHKHGLRVSG 209 Porphyromonas ging...
EAA61949  171 y---------------vllengctFSEFGTRRRrsyhtqdlVMQGLCraaregkakglpGVFTGSSNvhfaMKYDVDPVG 235 Aspergillus nidula...
XP_324829 169 m---------------rlleagcvFSEFGTRRRrdyhtqalVFRGLTkaakeaekrgltGKLSGTSNvhlaMRFNIPPVG 233 Neurospora crassa
Q9JTM8    155 arlke------iaaaqnpdeppflISDFGTRRRyklawqehVIRTLLea--------apSIVRGTSNvflaKKLGITPIG 220 Neisseria meningit...
Q8TMW6    152 esiltaygekileigkileengclFAEFGTRRRrsfelhdqVMKTLLq----------iETLTGTSNvffaKKYGLKPIG 221 Methanosarcina ace...
Feature 1                                                                                     
NP_444244 172 TMPHALVicfgrg---nqeaawRAFTDgvgdd------------vpriaLCDTYSDe-----KDEVLRAVDelg------ 225 Halobacterium sp. ...
Q9UTK3    220 TVAHEWYmgiaaitqnykqanrIASLKwvqtfg----------tslliaLTDTFSTd----vFLKSFTANSaddl----- 280 fission yeast
NP_810826 208 THPHEWFmfhgaqf-gykhanyMALENwvnvyd----------gdlgiaLSDTYTSg----iFLSNLSRKQak------- 265 Bacteroides thetai...
EAK96194  222 TVAHEWYmgiasitqdyvhankLAMDYwidtfga---------kyaglaLTDTFGTd----nYLTMFVAPYvn------- 281 Candida albicans S...
EAK85718  243 TVAHEWTmaiaalq-gyahsnlKALQLwdavysapdfvansathdltiaLTDTFSTn----vFWNDLLDNPsgiei---- 313 Ustilago maydis 521
NP_904408 210 THPHEWIqfhgaiy-gykmanyVAMEDwinvyd----------gdlgtvLTDTYTTd----vFMRNFSKKHam------- 267 Porphyromonas ging...
EAA61949  236 TVAHEWYmtiaaitddyenaneMALKYwlgcfge---------gvlgiaLTDTFGTpafldaFRKPIPDYTsagtgavst 306 Aspergillus nidula...
XP_324829 234 TVAHEWFmgnaailgdyksateEALSRwvgcygp---------gvlgiaLTDTFGTp----eFLRAFSKPMsasgepvpq 300 Neurospora crassa
Q9JTM8    221 TMAHEFLqafqaldvrlrnfqkAALESwvheyr----------gdlgvaLTDVVGMd----aFLRDFDLYFak------- 279 Neisseria meningit...
Q8TMW6    222 TVGHEWImgtsali-glryanrFAFENwvevyk----------gdlgiaLTDTFGSe----aFFKDMDLKLsk------- 279 Methanosarcina ace...
Feature 1                                                     #                               
NP_444244 226 ----------------------------------------ddlDAVRLDTtssrrGDFRHIAREVQWALDaggn--sdvS 263 Halobacterium sp. ...
Q9UTK3    281 ---------------------------------------anvfHGVRQDS-----GCAEEYIEKVVKHYKsigvdpstkV 316 fission yeast
NP_810826 266 -----------------------------------------lfDGVRCDS-----GNEFDFIDKLVARYKelgidattkT 299 Bacteroides thetai...
EAK96194  282 -----------------------------------------eySGVRQDS-----GDPELYAEKIARHYEkmgiakntkI 315 Candida albicans S...
EAK85718  314 ---------------------------------------arrwRGLRQDS-----GDSKAFAQKALDAYRsigvdpkskV 349 Ustilago maydis 521
NP_904408 268 -----------------------------------------lfTSLRHDS-----GDPEIFIEKAVRRYEelrvdpkikY 301 Porphyromonas ging...
EAA61949  307 tasgpsttaesniqseaetkapitaplspdhpppavktyaqvyAGVRQDS-----GDPSYFVKMARDFYDregi-tgtkT 380 Aspergillus nidula...
XP_324829 301 prdrkistadaf----------isaakdfikdlhpdktyaqvfTGVRQDS-----GDPKEFVKLMRKFYDeqgi-kdkkV 364 Neurospora crassa
Q9JTM8    280 -----------------------------------------lfDGLRHDS-----GDPYIWGDKAYAHYQklkidsrtkM 313 Neisseria meningit...
Q8TMW6    280 -----------------------------------------iyDGFRHDS-----GDPFTFVDRVIDHYRkmgidpmkkV 313 Methanosarcina ace...
Feature 1        ##                       # ##  #                     
NP_444244 264 VFVSGGlt-pTDLRGLRDV-----VDGFGVGGFVSna-----------tpVDFGLD 302 Halobacterium sp. NRC-1
Q9UTK3    317 IVHSDAlnvdRCIELYKYCekcgiKSAFGIGTNLTsdfqkvsnpsevskpMNIVIK 372 fission yeast
NP_810826 300 IVFSNAldftKALEIQEYCkd-kiRCSFGIGTNLTndtg--------fapSNIVMK 346 Bacteroides thetaiotaomicron VPI-5482
EAK96194  316 ICFSDSlnveKCLKYKNTAdklglISTFGIGTFFTndfnkls-ngeksqpMNIVIK 370 Candida albicans SC5314
EAK85718  350 VIYSDGldvdRCLELAAYSnhigiGAAFGIGTSFTndfiqls-taqkskpLNIVIK 404 Ustilago maydis 521
NP_904408 302 IIFSDSltpqRAIEIQKLCag-riKASFGIGTNLTndvgg------gvepLNIVMK 350 Porphyromonas gingivalis W83
EAA61949  381 VVFSDSldieHCLEYKVLAeeagfKPVFGVGTFFTndfintt-tneksqpLNIVIK 435 Aspergillus nidulans FGSC A4
XP_324829 365 IVFSDSldidRCLEYKEVAeaagfQPTFGVGTYFTndfvhka-tgkkstpLNIVIK 419 Neurospora crassa
Q9JTM8    314 LTFSDGldieRSWALHQYFkd-rfKTGFGIGTNLTndmg--------htpLNIVLK 360 Neisseria meningitidis serogroup A
Q8TMW6    314 IVFSDAlnaeAAIRLKKYCqd-kiNCSFGIGTSLTnnseff----resppLNMVIK 364 Methanosarcina acetivorans

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