1KUT,2GQS


Conserved Protein Domain Family
SAICAR_synt_PurC

?
cd01415: SAICAR_synt_PurC 
Click on image for an interactive view with Cn3D
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Statistics
?
PSSM-Id: 133470
View PSSM: cd01415
Aligned: 80 rows
Threshold Bit Score: 283.574
Threshold Setting Gi: 22001858
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2GQS: Escherichia coli SAICAR synthetase complexed with CAIR-Mg2+ and ATP, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1       # #### #         #           #                                 #          ####
1KUT_A      1 XNYEGKTKIVKVTGD---YALLEFKDDITAGDGLKHDvLTGKGSICAETTAILXKYLSEkGIKTHLVEYIPpRTLKVIPL 77  Thermotoga maritima
2GQS_A      6 ELYRGKAKTVYSTENp-dLLVLEFRNDTSAGDGARIEqFDRKGMVNNKFNYFIMSKLAEaGIPTQMERLLSdTECLVKKL 84  Escherichia coli A...
O05946      4 KLYEGSSKILYSAEEd-fLLIMAFSDKAVLETGETVD-ISGKGVLNNNISSFLMDKLEMiGIENHLIEKINmREQLIQYV 81  Rickettsia prowazekii
Q4FLJ7      6 KLYEGKAKIIYATSDk-nLVIQYFKDDATAFNNLKKStIEGKGVLNNRISEHILSNLTQiGIKNHLVKRLNmREQIIKLV 84  Candidatus Pelagib...
Q2GCS7      6 KIYEGKAKILFSFPDnpnLVTQHFKDDVTAYNNRKHSvIPGKGVINNYISAFFMQNLQNvGIKTHFVKVLNmREQLVKKA 85  Neorickettsia senn...
A0L4X9      6 KLYEGKAKVLFATDDp-nMLIQYFKDDATAFNGIKKGtIADKGVVNSLISTRIYHILEKvGIPTHLEELLSpREQLVHKV 84  Magnetococcus sp. ...
Q5GT56      6 IIYEGKAKFIIETKDp-lTVIQYFKDEVTAFNKEKYKiIEGKGTINNRISTFIMETLEKaGINTHFIKTLSeREQLVKKL 84  Wolbachia endosymb...
Q2GHH2      6 KIYEGKAKIIFATLNp-lEVIQHFKDEITAFNNKKAAiIHEKGILNNYISSFLMKKLIDkGIKTHFISLLNqREQLVKKI 84  Ehrlichia chaffeen...
YP_153534   7 ALYEGKAKIIFPGPDs-sSVVQHFKDDITAFNSQKRDiIPGKGAVNNRVSYLIMRHLEShGIKTHILGFLDdREQLVRRV 85  Anaplasma marginal...
AAR05348    6 TLYEGKAKKIIKGPRk-nTVIQIFKDDATAYNKKKHKiFKGKGVLNNHISAHIMQYLKSkRIPTHFEEKLNdREQLIKKC 84  uncultured marine ...
Feature 1      #   # # #   ###                    # #     #                                   
1KUT_A     78 KXFPLEVVVRLKKAGSFVRRYGGAEGEDLpVPLVEFFIKDDERHDPXVCvDHLEILGiatKKQAEKXKEAAVKITLALKE 157 Thermotoga maritima
2GQS_A     85 DMVPVECVVRNRAAGSLVKRLGIEEGIELnPPLFDLFLKNDAMHDPMVNeSYCETFGwvsKENLARMKELTYKANDVLKK 164 Escherichia coli A...
O05946     82 EVFPIQVIISSVACGRFVKEFGMDEGYVFdKPIIDFKVRSREFNYPIVNeYQISNFGwltMDEIRIVKAQTLRIYDFLSG 161 Rickettsia prowazekii
Q4FLJ7     85 EIIPIEFIVRNVATGSITKRLGIEDGTVLkQPLLEYCLKDDKLGDPLIAeEHILAFDwatKSELEKVKKMILRINDFMIG 164 Candidatus Pelagib...
Q2GCS7     86 ELIPIEVVIRNIVAGGLAKRLGLEEGMILdAPLIETYYKSDSLGDPMVTdDHILSFNwlkLSEIEEMKVMAWRINDFLSG 165 Neorickettsia senn...
A0L4X9     85 EILPIEVVIRNRVAGSLARRLGIEEGTELaRPLVEFYYKNDELDDPMVTiDHAEVFGwakHREIEEMIEMSLRINDILIG 164 Magnetococcus sp. ...
Q5GT56     85 KIIPLEIVVRNIAAGSFCKRFNIKEGEKLaFPIIEFFYKNDGLADPMVNeNHVLYFGwlsYEEMEEIKTITIKINTVLID 164 Wolbachia endosymb...
Q2GHH2     85 TIIPIEVVIRNLAAGNFSKRFQIADGTPFkSPIIEFYYKNDELSDPMVSeGHILSFQwltNQELEKIKILSLKINNILSE 164 Ehrlichia chaffeen...
YP_153534  86 DMIPIEVVVRNLACGSFCKRFGVAPGTPIlPPVVEFYYKNDALSDPMMTeDHLVSLGyatSGEVGHIKAESLRVNTILRK 165 Anaplasma marginal...
AAR05348   85 EIIPIEFVVRNITAGSIAKKLGIKEGLKLkKPLLEYYYKEDSLDDPMISrDHLITFGwatNSELKKIDKMSLQINKHLRN 164 uncultured marine ...
Feature 1               ### #               #    ####                                   
1KUT_A    158 FFERANFELWDIKYEFGLDkd---gNVVLGDEISPDTFRLRKk--GEIFDKDVYRRDLGdPLKKYREVLELCRS 226 Thermotoga maritima
2GQS_A    165 LFDDAGLILVDFKLEFGLYk----gEVVLGDEFSPDGSRLWDketLEKMDKDRFRQSLGgLIEAYEAVARRLGV 234 Escherichia coli ATCC 8739
O05946    162 LFIGIGIRLVECKLEFGRVfngeesIIMLTDEISPDNCRLWHinsNEKLGFELIQNEPNkAFESYQLIANRLKE 235 Rickettsia prowazekii
Q4FLJ7    165 MFRGVGIKLIDFKLEFGRLkengknEVILADEISPDTCRLWDsitDKKLDKDRFRKDLGdLIPAYTEVAKRLGI 238 Candidatus Pelagibacter ...
Q2GCS7    166 ALSSAGIILVDLKLEFGFYd----dQIILIDEISPDTCRFWDtetKEKMDKDRFRRDLGgVSKYYREVARRLGI 235 Neorickettsia sennetsu s...
A0L4X9    165 FFANIGIDLIDYKLEYGRLavs-psTLVLADEISPDGCRLWDmetGEKLDKDRFRRDLGgVEEAYQEVARRMGL 237 Magnetococcus sp. MC-1
Q5GT56    165 LFLNAGIDLVDLKLEFGRPind-ntKITLADEISPDNCRLWDkntHKKLDKDVFRLNLGnLKEAYLEVAKRLSV 237 Wolbachia endosymbiont s...
Q2GHH2    165 LFFNVGIKLVDFKLEFGKLhndeqsDLFLADEISPDTCRLWDistNKRLDKDRYRLNLGnVIEGYREVAHKLNA 238 Ehrlichia chaffeensis st...
YP_153534 166 VMREVGIVLVDFKLEFGRLqqa-dgEIVLADEISPDTCRLHNasdDAVLDKDLYRLNLGdTLSGYAEVLRRIES 238 Anaplasma marginale str....
AAR05348  165 LFLKKNIILVDFKIEFGRLssn-pkKIVLADEISPDSCRLWDkktNKKLDKDVFRRNLGsLLSAYEEVASRLGI 237 uncultured marine alpha ...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap