1IVH


Conserved Protein Domain Family
IVD

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cd01156: IVD 
Click on image for an interactive view with Cn3D
Isovaleryl-CoA dehydrogenase
Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates.
Statistics
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PSSM-Id: 173845
View PSSM: cd01156
Aligned: 11 rows
Threshold Bit Score: 632.524
Threshold Setting Gi: 16081378
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1IVH_A       12 GLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFknLREFWKQLGNLGVLGITAPVQYGGSGlgYLEHVLVMEEISRASG 91  human
NP_250705     9 ALGETIDMLRDQVRGFVAAELQPRAAQIDQDNQF--PMDMWRKFGEMGLLGITVDEEYGGSAlgYLAHAVVMEEISRASA 86  Pseudomonas aeru...
ZP_00000489   2 HLKDEYIMIQQSAKEFAEKEIIPVAAKMDRENFF--PRELFRKMGKEGYLGVTIPEQYGGSGsdYVSQAIIEEEISYASG 79  Ferroplasma acid...
NP_393708     3 GYTDASEMIRSSIREFVRREIEPLRSKIDRDDYF--PVDKFRMMGKMGYLGVTVPPEYGGSGagYIAQAIIEDELGYSSP 80  Thermoplasma aci...
NP_500720    38 GLNDEEIALRQSIRQFADKELAPYADKIDKDNGWdqLRPFWKKLGDQGLLGITAPAEYGGSGmnYFSHVIAMEELSRAAG 117 Caenorhabditis e...
AAH45426     38 GLTEEQIQLRQTVQRFFQEKLAPYADEIDKKNEFpqMREFWKEMGDLGLLGVTAPVEFGGTGlgYLDHVIIMEEISRVSA 117 zebrafish
AAL32645     30 LFDDTQLQFKESVSKFAQDNIAPHAERIDKTNSFpkDVNLWKLMGEFNLHGITAPEEYGGLGlgYLYHCIAMEEISRASG 109 thale cress
NP_937102    22 GLGDTIDLLREQVNAFANEHIAPLAADIDRANHF--PDHLWTKLGEMGLHGVTISEEYGGADmgYLAHVVAMEEISRASA 99  Vibrio vulnificu...
NP_107987     9 GHDEDIEALRDMVRRFAQDRIAPIAGDIDRQNEF--PAHLWRELGALGLLGITADPDFGGSGmgYLAHVIAVEEISRASA 86  Mesorhizobium loti
NP_648239    38 GLDEDRQKLREVAFNFFQKELAPLAKEIDKLDNFkdMRPFWKKLGALGFLGITAEPDFGGTGgsYLDHCIIMEEFSRAAG 117 fruit fly
ZP_00024508  72 DLGEDIEMLRESVRNWAQAELAPRAAEIDRTDQF--PMDAWRKMGDLGVLGITVAEEYGGANmgYLAHMIAMEEISRASA 149 Ralstonia metall...
Feature 1                                                # ##    ##                       # #   
1IVH_A       92 AVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGp 171 human
NP_250705    87 SVALSYGAHSNLCVNQIKRNGNAEQKARYLPALVSGEHIGALAMSEPNAGSDVVSMKLRADRVGDRFVLNGSKMWITNGp 166 Pseudomonas aeru...
ZP_00000489  80 SLGLSYGAHSNLCLDNLYRNGSEYLREKYLEKLCSGEHVGSLGMTEPSSGSDALSMKTSATMDKGNFILNGSKTFITNAp 159 Ferroplasma acid...
NP_393708    81 SLALSYGAHSNLCLDNIYRNGSKYIRETFVPKLASGDYIGSLCLTEPGSGSDALAMSTHIDEVDGELYLSGSKMFITNAp 160 Thermoplasma aci...
NP_500720   118 GIALSYGAHSNLCINQIVRNGSEEQRKKYLPKLISGEHMGALAMSEAQAGSDVVSMKLRAEKKGDKYVLNGTKFWITNGp 197 Caenorhabditis e...
AAH45426    118 AIGLSYGAHSNLCVNQMVRHGNQKQKEKYMPKLLTGEHVGALAMSESNSGSDVVSMKLTAKKQGDHYVLNGNKFWITNGs 197 zebrafish
AAL32645    110 SVALSYGAHSNLCINQLVRNGTAAQKEKYLPKLISGEHVGALAMSEPNAGSDVVGMKCKAEKVDGGYILNGNKMWCTNGp 189 thale cress
NP_937102   100 SVALSYGAHSNLCINQIYRNGNAQQKAHYLPALISGEHIGALAMSEANSGSDVVSMQLKAKEKGDHFVLNGSKMWITNGp 179 Vibrio vulnificu...
NP_107987    87 SVGLSYGAHSNLCVNQINRWATPAQKEKFLPPLCSGERVGALAMSESGAGSDVVSLKLRAEKRNDRYVLNGTKMWITNGp 166 Mesorhizobium loti
NP_648239   118 GVALSYGAHSNLCINQLTKNGTPEQKEKYLPKLCSGEHVGGLAMSEPGAGSDVVSMKLRAERKGDYYVLNGSKFWITNGs 197 fruit fly
ZP_00024508 150 SVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRYVLNGTKMWITNGp 229 Ralstonia metall...
Feature 1                                                                                       
1IVH_A      172 DADVLIVYAKTdlaavpasRGITAFIVEKgmpGFSTSKKLDKLGMRGSNTCELIFEDCKIPAaNILGheNKGVYVLMSGL 251 human
NP_250705   167 DAHTYVIYAKTdad--kgaHGITAFIVERdwkGFSRGPKLDKLGMRGSNTCELIFQDVEVPEeNVLGavNGGVKVLMSGL 244 Pseudomonas aeru...
ZP_00000489 160 YADIFLVYARTg-------ENITPFVVESsdrGFSRGQEFDKTGMRGSPTGTIFFNDIILPEnRIVGklNGGRNVLLSGL 232 Ferroplasma acid...
NP_393708   161 YADLFLVHSRDg-------DGYSSVIVLAsdgGFNRGRSLEKMGMRGSPTGEIFFNRVRIEPgRIVGgrGSGKKIIMSGL 233 Thermoplasma aci...
NP_500720   198 DADVLVVYAKTdps--khqHGITCFLVEKntpGFSQSPKLDKLGMRGSNTCELVFDNCEIHEsQIMGgkGKGVYVLMTGL 275 Caenorhabditis e...
AAH45426    198 DADVLIVYAKTdpe--avaRGITAFIVEKgmpGFSSAQKLDKLGMRGSSTCELVFEDCKIPEeNVLGplNKGVYVLMSGL 275 zebrafish
AAL32645    190 SAETLVVYAKTdtk--agsKGITAFIIEKgmtGFSTAQKLDKLGMRGSDTCELVFENCFVPEeNILDkeGKGVYVLMSGL 267 thale cress
NP_937102   180 DAHTVVVYAKTnpk--aeaHGITAFIVERafpGFHSAQKLDKLGMRGSNTSELVFEDCLVPKeNVLGevNHGVRVLMSGL 257 Vibrio vulnificu...
NP_107987   167 DADTLVVYAKTdpe--rksRGITAFIVEKamtGFSVAQKLDKLGMRGSSTGELVFENVEVPFdNVLHeeGRGVEVLMSGL 244 Mesorhizobium loti
NP_648239   198 DADTLIVYAKTggsgvpdkHGITAFIVETaweGFSVAQKLDKLGMRGSSTCELVFQDLKVPAkNILGqeNRGVYVLMSGL 277 fruit fly
ZP_00024508 230 DCDVLVVYAKTepd--lgaRGMTAFIVEKgmkGFSVAQKLDKLGMRGSHTGELVFQDVEVPVeNILGaeNGGAKVLMSGL 307 Ralstonia metall...
Feature 1                                                                                       
1IVH_A      252 DLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEgh-----ctAK 326 human
NP_250705   245 DYERVVLSGGPVGIMQACMDVVVPYIHDRRQFGQSIGEFQLVQGKVADMYTALNASRAYLYAVAAACDRge-----ttRK 319 Pseudomonas aeru...
ZP_00000489 233 NLERAVLAFNSIGIARRALDLAIGYASERKQFGRPISDFELVQEKLAYMYTKFESSRLFAMEALKRVQEdr-----mdSL 307 Ferroplasma acid...
NP_393708   234 NSERVILAFIFIGLARRAIDEAVNYASQRKQFGQHIADFELIQEKLSYMYVRYEASRMLAFRALEKLQFdm-----mdPI 308 Thermoplasma aci...
NP_500720   276 DYERLVLSGGPLGLMQAACDIAFDYAHQRTAFGQKIGSFQLLQGKLADMYTTLNASRSYLYMVAKAADKgn-----vsNK 350 Caenorhabditis e...
AAH45426    276 DLERLVLASGPVGIMQAVLDHAIPYLHVREAFGQKIGHFQLMQGKMADMYTRLSSCRQYLYNVARACDKgh-----fsAK 350 zebrafish
AAL32645    268 DLERLVLAAGPLGIVQACLDNVLPYIRQREQFGRPVGEFQFIQGKVADMYTALQSSRSYVYSVARDCDNgk-----vdPK 342 thale cress
NP_937102   258 DYERVVLAGGPLGIMRSCLDAVIPYIHDRKQFGQPIGEFQLVQGKLADMYTQMNAARSYVYTVAAACDRge-----vtRK 332 Vibrio vulnificu...
NP_107987   245 DYERTVLAGGPIGLMAACLDVAIPYVHERKQFGQPIGEFQLVQGKLADMYTVMNAARAYVYAVAAGCDRgq-----ttRK 319 Mesorhizobium loti
NP_648239   278 DFERLVLAAGPVGLMQAACDVAFDYAHQRKQMNKLIGEFQLLQGKMADMYTTLSACRSYLYTVARSCDAgn-----rsPK 352 fruit fly
ZP_00024508 308 DYERAVLSGGPVGIMQACMDVITPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSlgtdhvrqvRK 387 Ralstonia metall...
Feature 1                                                         # #            
1IVH_A      327 DCAGVILYSAECATQVALDGIQCFGGNGYINDfPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNA 391 human
NP_250705   320 DAAGVILYSAERATQMALDAIQILGGNGYINEfPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFN 384 Pseudomonas aeruginosa PAO1
ZP_00000489 308 DAASAILYASESSEYIAREALQIFGGYGYIKDfEIERVFRDSILLTIGAGTNEIRKKVISEALIK 372 Ferroplasma acidarmanus
NP_393708   309 DAASAIMYASESAEYIAREAIQIFGGYGYIKDtGIEMLLRDAILGQIGAGTTEIRKRVIARSLVK 373 Thermoplasma acidophilum
NP_500720   351 DCAGVILYVAEKCTQVCLDAIQILGGNGYINDyPAGRLLRDAKLYEIGAGTSEVRRLIIGRALNK 415 Caenorhabditis elegans
AAH45426    351 DCAGVILYCAENATQVALDGIQCLGGNGYINDyPMGRFLRDAKLYEIGAGTSEIRRIIIGRSSNA 415 zebrafish
AAL32645    343 DCAGTILCAAERATQVALQAIQCLGGNGYINEyATGRLLRDAKLYEIGAGTSEIRRIVIGRELFK 407 thale cress
NP_937102   333 DAAGVILYSAELATRMALDAIQLLGGNGYVNEfPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFN 397 Vibrio vulnificus YJ016
NP_107987   320 DAAGCVLFAAEKATQMALDAIQLLGGNGYINDyPTGRLLRDAKLYEIGAGTSEIRRWLIGREIMA 384 Mesorhizobium loti
NP_648239   353 DCAGVILYTAEKATKVALDAIQILGGNGYINEnPTGRILRDAKLYEIGAGTSEIRRWLIGRQLNQ 417 fruit fly
ZP_00024508 388 DCAAVILYTAEKATWMAGESVQILGGNGYINEyPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFS 452 Ralstonia metallidurans

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