1PV9


Conserved Protein Domain Family
APP-like

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cd01092: APP-like 
Click on image for an interactive view with Cn3D
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.
Statistics
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PSSM-Id: 238525
Aligned: 61 rows
Threshold Bit Score: 269.379
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Inferred from parent family alignment

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                        #              
1PV9_A      130 IEIIEKACEIADKAVMAAIEEIteg--krEREVAAKVEYLMKmngaekpafDTIIASGhr-saLPHGVasdkRIERGDLV 206 Pyrococcus furiosus
ZP_00080158 135 IDLLAETARIASEALLASLDGLkpg--vvEREYALDLEFAMRragtddksfDFIVASGer-gaLPHGRastkVIGAGELV 211 Geobacter metall...
ZP_00017810   8 LALMERAVAIVEQALHTFIRQIrag--lsERTLSRMLSDAILaagadgesfANMVASGpn-aaNPHHEnsdrILQTGDLV 84  Chloroflexus aur...
ZP_00018792 139 IALLRRAAAITDAALAAVLPALtpt--mtEREAAWRLEVALHdlgaegpsfPIIVAAGrn-saRPHHTpgddVLGEGQPI 215 Chloroflexus aur...
Q10698      152 IDALRKAGAAIDRVHARVPEFLvpg--rtEADVAADIAEAIVaegh-sevaFVIVGSGphgadPHHGYsd-rELREGDIV 227 Mycobacterium bovis
NP_279722   146 LDALRRAGGAADAAMADVRGLGadaigmtEHELADFIADRLAahggtgvsfDVIAGSGpn-gaKPHHThdarEIQRGDPV 224 Halobacterium sp...
NP_662491   144 LDRMRRAVALSETVLEAVIGMIgpg--vtEIDIAAEITYRHRklgaekdsfDPIVAGGir-gaMPHAKptavAFEPGALI 220 Chlorobium tepid...
NP_868427   140 LATIRRAISIAERSFLSVTNKLtpr--mtELQIAHELEATMRslgasgvafDVIAGAEps-gaLPHYHprniALADCRTL 216 Pirellula sp. 1
NP_217051   140 LALLRLACEAADAALTDLVARGglrpgrtERQVSRELEALMLdhgadavsfETIVAAGan-saIPHHRptdaVLQVGDFV 218 Mycobacterium tu...
NP_627967   155 MARLTAAAAAADTAYEEVLGLRfgg--rsERELAADLAGLLRahgh-srvdFTVVGAGph-aaDPHHRpgdrVIGDGDMV 230 Streptomyces coe...
Feature 1         #           #                                                                 
1PV9_A      207 VIDLGALYn-HYNSDITRTIVVgsp----nekQREIYEIVLEAQKRAVEAAKPGmtAKELDSIAREIIKEygygdyfIHS 281 Pyrococcus furiosus
ZP_00080158 212 TIDFGAIFr-GYHSDETVTVCVgep----ddrQREIYGIVKEAHDRALAAVRPGvsFKELDAIARGFIEErgygaffGHG 286 Geobacter metall...
ZP_00017810  85 IIDCGAVYq-GYHSDITRTIAIgdp----gpmARHVYDIVLAANTAGRNACRPGvsGATIDAAARKVIEDagygaafVHR 159 Chloroflexus aur...
ZP_00018792 216 IIDMGARLd-GYHADLTRTIVLgqp----ddtFRAVYAATLKAQQAAMQALRPGlpWSEADAIARRVIGEagyaegiAHS 290 Chloroflexus aur...
Q10698      228 VVDIGGTYgpGYHSDSTRTYSIgep----dsdVAQSYSMLQRAQRAAFEAIRPGvtAEQVDAAARDVLAEaglaeyfVHR 303 Mycobacterium bovis
NP_279722   225 VCDFGTVVd-RYPSDQTRTVVFagdp---paaFRTVHEVVRDAHRAAVDAVEPGvsAGAVDAAARRVIADagygdafVHR 300 Halobacterium sp...
NP_662491   221 VIDMGCIVd-GYASDQTRTVAFgkv----seeQRTVYRIVQEAQQLGIDAAKAGmaARDLDAEVRNFIAAagygeafGHG 295 Chlorobium tepid...
NP_868427   217 LIDWGARVd-GYCSDLTRTLHKadvrsatadrFEAAYQAVLESQEAAISAIRDGveAIEVDRAARQVLQNaglgdafKHG 295 Pirellula sp. 1
NP_217051   219 KIDFGALVa-GYHSDMTRTFVLgka----adwQLEIYQLVAEAQQAGRQALLPGaeLRGVDAAARQLIADagygehfGHG 293 Mycobacterium tu...
NP_627967   231 VLDFGGLKd-GYGFDIARTVHVgap----tdeERRVHETVRAAQRAAFGAVRPGvsCQEVDRAARAVIEEaghaghgARR 305 Streptomyces coe...
Feature 1         #                                 #             #          
1PV9_A      282 LGHGVGLeihewpr-----isqydetVLKEGMVITIEPGIYIpklGGVRIEDTVLITENGA 337 Pyrococcus furiosus
ZP_00080158 287 LGHGVGLdvhekpv-----vsprgegVAEEGMVFTIEPGIYIpqwGGVRIEDAVAVTGNGY 342 Geobacter metallireducens
ZP_00017810 160 TGHGLGLethelpn-----ivagsdaPLLPGTTFTVEPGIYLpgqFGVRIEDDVVITPDGS 215 Chloroflexus aurantiacus
ZP_00018792 291 LGHGVGLviheapwlritapdappspPLQAGMVTSIEPGIYLpewGGVRIEDLVLITTNGY 351 Chloroflexus aurantiacus
Q10698      304 TGHGIGLcvheepy-----ivagndlVLVPGMAFSIEPGIYFpgrWGARIEDIVIVTEDGA 359 Mycobacterium bovis
NP_279722   301 TGHGVGLdvheapf-----ivadsdrKLDVGMVFSIEPGVYRpgeFGVRIEDLVVVTADSC 356 Halobacterium sp. NRC-1
NP_662491   296 LGHGVGVevheapr-----vgtastgTLREGTLFTIEPGIYLpgrFGVRIEDMVALGPNGA 351 Chlorobium tepidum TLS
NP_868427   296 LGHSFGLeihedpr-----mgpmstdVLREGMVLTVEPGVYFegeFGIRIEDDILVTADGF 351 Pirellula sp. 1
NP_217051   294 LGHGVGLqiheapg-----igvtsagTLLAGSVVTVEPGVYLpgrGGVRIEDTLVVAGGTP 349 Mycobacterium tuberculosis H37Rv
NP_627967   306 TGHGVGVttheppy-----lvegeeqPLEPGMCFSLEPGIHLpdrFGVRIEDVVTCTEDGG 361 Streptomyces coelicolor A3(2)

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