Conserved Protein Domain Family
PI3Ka_III
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cd00870: PI3Ka_III 
Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III phosphorylate phosphoinositol (PtdIns) only. The prototypical PI3K class III, yeast Vps34, is involved in trafficking proteins from Golgi to the vacuole.
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Statistics
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PSSM-Id: 238442
Aligned: 12 rows
Threshold Bit Score: 189.079
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P42339     274 DRDLKPSNIERKSIQRVLKYPp-TRTLSGDERQLLWKFRFSLMSe-----------KRALTKFLRCVEWs--dVQEAKQA 339  thale cress
P22543     294 DKQVKPDIKKRDYLNKIINYPp-GTKLTAHEKGSIWKYRYYLMNn-----------KKALTKLLQSTNLr--eESERVEV 359  baker's yeast
P50520     257 DKDLKPNSKIRKELESILSYPp-SEELSLEEKDLIWKFRFYLTRn-----------KKAMTKFLKSVVWt--dSSEVNQA 322  fission yeast
EAA22859   710 ISVTTPPIDEIKTLNYVLSIP--LTKINDDGKKCLWKFRLFLVNr-----------KETLGKFIKSVNWn--dKNEEKEA 774  Plasmodium yoeli...
AAD43472   328 DKDIKPTLKLRAELTKILHKQf-FEKLSQKEKNMIWKYRFFLLNnlilnk-nntefNNFVINFIKCIDWe--dDFEVNEF 403  Pichia angusta
T25442     275 HRQVKPNKQAKDRLETIVNLPs-SQVLTREQRDLVWKFRHYLRQf-----------PKALNKYLRSVNWv--hPQEVKTA 340  Caenorhabditis e...
P54676     276 HKDLKPNSTELKGNSDILKQPp-NTKVTSKEALLIWRFRYYLTNn-----------KKALTKFLRCVEWs--eSHQKNEA 341  Dictyostelium di...
T08420      46 DRDLKPNSEERRRLQAILKLPp-NKPLHAEERALLWRFRASLTQd-----------TRALTKFLQCVDWs--dATEAKQA 111  Chlamydomonas re...
Q92213     331 DKELKPTPQLRDELLRIMIKPs-NAESTDNEKNLIWKFRYYFSKnnsgndpsnksvKSFLPKFLRSINWen-dYELDHTF 408  Candida albicans
NP_477133  284 DRDAKPTASIRDQLHTIVYRYppTYVLSSEEQDLVWKFRFYLSSh-----------KKALTKFLKCINWk--lEDEVTQA 350  fruit fly
NP_002638  283 DHDLKPNAATRDQLNIIVSYPp-TKQLTYEEQDLVWKFRYYLTNq-----------EKALTKFLKCVNWd--lPQEAKQA 348  human
BAC92570   290 DREMKPSSVDQKLIQNILKYPp-TRTLNVDEKQLLWKFRFYLTSe-----------KKALVKFLLSVEWsdiqLQEAKQA 357  Japanese rice

P42339     340 IQLMYKWe----------mIDVCDALELLSPLFES----------------------------------EEVRAYAVSVL 375  thale cress
P22543     360 LELMDSWa----------eIDIDDALELLGSTFKN----------------------------------LSVRSYAVNRL 395  baker's yeast
P50520     323 LSLLDSWt----------eIDIDDALELLSPSFVH----------------------------------PKVRAYAVSRL 358  fission yeast
EAA22859   775 ISLLRKWs----------kPSLENCLELFHLYMHY----------------------------------NVIKKYIIDII 810  Plasmodium yoeli...
AAD43472   404 LVIINNLntdpysnvfiqkMEIVDCLELLSANYKN----------------------------------YIVRNMALERL 449  Pichia angusta
T25442     341 LALMNDWe----------lIEAEDALELLSSAFTH----------------------------------PAVRAYSVSRL 376  Caenorhabditis e...
P54676     342 LSIMPKWd----------pIDIADSLELLSSAFTHkn-------------------------------tIMVRRYAVEIL 380  Dictyostelium di...
T08420     112 AELMRQWa----------pISAADALELLSPDFRS----------------------------------EVVRQHAVQAL 147  Chlamydomonas re...
Q92213     409 KEIIPFYwnv-------dkLQIGDALELLGDYFNPytlgkptyqddsmtsksskmksdekrfikiynnvCFLRKLAVERL 481  Candida albicans
NP_477133  351 LWMLANWa----------pMDVEDALELLSPTFTH----------------------------------PQVRKYAVSRL 386  fruit fly
NP_002638  349 LELLGKWk----------pMDVEDSLELLSSHYTN----------------------------------PTVRRYAVARL 384  human
BAC92570   358 VALIPRWe----------sIDVADALGLLSPVFQNe---------------------------------EVVRAYAVGVF 394  Japanese rice

P42339     376 ER-ADDEELQCYLLQLVQALRFErs------------------------------------------------------- 399  thale cress
P22543     396 KK-ASDKELELYLLQLVEAVCFEnlstfsdksnseftivdavssqklsgdsml--------------------------- 447  baker's yeast
P50520     359 ET-ASNEELLLYLLQLVQALRYDnpissd--------------------------------------------------- 386  fission yeast
EAA22859   811 KN-AKKEQLKLYLFQIVQRLRTFnyq------------------------------------------------------ 835  Plasmodium yoeli...
AAD43472   450 RL-ASDDDLEMYMVQLVQCIKNEanylsprtdidddgegdnnseensefldfedstyttns------------------- 509  Pichia angusta
T25442     377 LEaASPEQVLLYLPQLVQALKYEqgqqlpeegnpvpvvseeegkipsva------------------------------- 425  Caenorhabditis e...
P54676     381 KP-ADDEELLYYLLQLVQATKYEqfdg----------------------------------------------------- 406  Dictyostelium di...
T08420     148 QA-VEVEELGAYLLQLVQALRYEaad------------------------------------------------------ 172  Chlamydomonas re...
Q92213     482 KL-ANSEELLLYLLQLVQALKYEaliyeksppfcer-------------------------------------------- 516  Candida albicans
NP_477133  387 AQ-APDEDLLLYLLQLVQALKYEdprhivhlhgcifperdvvrsilddngslldqsslsdlsatssglhgsvipanqraa 465  fruit fly
NP_002638  385 RQ-ADDEDLLMYLLQLVQALKYEnfddikngleptkkdsqssvsenvsnsginsae------------------------ 439  human
BAC92570   395 ER-ASDEELQCYLLQLVQGLRFErs------------------------------------------------------- 418  Japanese rice

P42339     400 ---------------------------------------------------------------drSCLSQFLVQRALQNI 416  thale cress
P22543     448 -----------------------------------lstshanqkllksissesetsgteslpiviSPLAEFLIRRALVNP 492  baker's yeast
P50520     387 ------------------------------------------------------------erfqpSPLALFLVNRAISSP 406  fission yeast
EAA22859   836 --------------------------------------------------------------ridDLFIDILIHKCVKSK 853  Plasmodium yoeli...
AAD43472   510 ---------------------------sefqvinteeedpvvkllnnpnitnpegkiieklpklqSPLAKFLIERSIDSE 562  Pichia angusta
T25442     426 ----------------------------------------ttpteelegrdmtvvtkkearkaasGDLATFLIDYALASP 465  Caenorhabditis e...
P54676     407 -------------------------------------------------------------npsdSPLISFLFERSNKNF 425  Dictyostelium di...
T08420     173 ---------------------------------------------------------------tgSRLGAFLVQRAAEDP 189  Chlamydomonas re...
Q92213     517 ----------------------------------------------------sdqiednasstlkSPLADFLIERAVENE 544  Candida albicans
NP_477133  466 svlaaiksdksvspgsaggsgsggqgsvalpnpsapatpgssslpcdsnsnalmlaegisfgsvpANLCTFLIQRACTNA 545  fruit fly
NP_002638  440 --------------------------------idssqiitsplpsvsspppasktkevpdgenleQDLCTFLISRACKNS 487  human
BAC92570   419 ---------------------------------------------------------------drSRLAHFLVNRALSNY 435  Japanese rice

P42339     417 ELASFLRWYVAVELHD 432  thale cress
P22543     493 RLGSFFYWYLKSESED 508  baker's yeast
P50520     407 SIGNDLYWYLVVEIED 422  fission yeast
EAA22859   854 KLSIYLYWFLLSETQD 869  Plasmodium yoelii yoelii
AAD43472   563 RLSNFFYWNLKVEVDD 578  Pichia angusta
T25442     466 KVSNYLYWHLKTEIES 481  Caenorhabditis elegans
P54676     426 ILGSHFYWYLTVDSVL 441  Dictyostelium discoideum
T08420     190 ALAVQLHWYLFCELDD 205  Chlamydomonas reinhardtii
Q92213     545 KLGNFFYWYVKVENED 560  Candida albicans
NP_477133  546 TLANYFYWYLSIEVEE 561  fruit fly
NP_002638  488 TLANYLYWYVIVECED 503  human
BAC92570   436 ELASFLRWYLVVELHD 451  Japanese rice
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