Conserved Protein Domain Family
YacG

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pfam03884: YacG 
DNA gyrase inhibitor YacG
YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.
Statistics
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PSSM-Id: 397803
Aligned: 48 rows
Threshold Bit Score: 65.3127
Threshold Setting Gi: 283439252
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_005221139     5 VPCPTCATPVEWSEQSPWRPFCSERCRLIDLGEWFNENHRIsepidPETPPQQ 57  Marichromatium purpuratum
Q3A419          24 VKCPHCGASKPWEG-NAYRPFCSSRCRQMDLGAWVDEEYRV-----PDASCPS 70  Pelobacter carbinolicus DSM 2380
Q74DU7           5 LTCPRCRAETVWEG-NPHRPFCSARCKTVDLAAWADEEYRI-----AGPEAPS 51  Geobacter sulfurreducens PCA
Q39UV8          32 VPCPRCRKETPWQG-NPFRPFCSERCKTMDLAAWADEEYRI-----ASEDTPG 78  Geobacter metallireducens GS-15
EHR73181         5 VRCPGCGQPAEYTPENRWRPFCGERCRNHDLGAWATESYRV-----PAAPPQD 52  Burkholderiales bacterium JOSHI_001
jgi:Daci_5493   29 VRCPTCSGPSLFAPANRFRPFCSERCYQIDLGAWANEEFRV-----PAPMPPE 76  Delftia acidovorans SPH-1
Q21UD5          15 VVCPSCGGESVYAASNPFRPFCSERCKNVDFGAWASESFRV-----PASGLPE 62  Rhodoferax ferrireducens T118
WP_011800185    11 VVCPGCGGPSVYASSNPFRPFCSERCKNIDLGAWASEDFRL-----PADTPPD 58  Polaromonas naphthalenivorans
CAS:CtCNB1_0757  2 VTCPTCGGPSVFLPSNKFRPFCSERCRNIDLGAWGNEEFRV-----PAQTPPE 49  Comamonas thiooxydans
WP_011804249    18 VPCPTCGGPSLYSPANRFRPFCSERCKQIDLGAWAAEDFRM-----PAEAPPE 65  Comamonadaceae
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