1SGJ,1DXE,2VWS


Conserved Protein Domain Family
HpcH_HpaI

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pfam03328: HpcH_HpaI 
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HpcH/HpaI aldolase/citrate lyase family
This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.
Statistics
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PSSM-Id: 427247
Aligned: 16 rows
Threshold Bit Score: 212.214
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SGJ_A         9 RSVLFAPGNRADLIAKLPRSAPDAVVIDLEDAVpgtaeakaaarPVAHDAARDLIA-AAPh-lAVFVRVNALHSPYFEDd 86  Deinococcus rad...
Q9KTU0        11 RSMLFVPGANAAMLSNTFIYQPDSIMFDLEDSValrek--dtarMLVFHALQHPMY-QEM---ETVVRVNPLDSEFGIKd 84  Vibrio cholerae
P0A9I1        15 RSMLFVPGANAAMVSNSFIYPADALMFDLEDSValrek--dtarRMVYHALQHPLY-RDI---ETIVRVNALDSEWGVNd 88  Escherichia col...
Q8RDW5         9 RTMMFLPGNNPSMITDAYIYGPDSVMIDLEDATsvnqk--daarFLVSEALKTIDY-KTT---ETVVRVNGLDTPFGADd 82  Fusobacterium n...
O82487        90 LYGLFLLSFSPTLAEIAAHAGYDYVVVDMEHGP-----------GGIPEALDCIRAlNAAg-tSAILRLPENSPTWAKK- 156 thale cress
1DXE_A        20 QIGCWSALSNPISTEVLGLAGFDWLVLDGEHAP-----------NDISTFIPQLMAlKGSa-sAPVVRVPTNEPVIIKR- 86  Escherichia coli
WP_010891051  18 QLGFWLALAHPDIAEICAGQGYDWLLIDGEHGP-----------QTLPGIVAQLRAvEATppcSAIVRVPGHDSVTIKQ- 85  Novosphingobium
Q9RYM1        24 QIGLWLGLADPYCAEICAGAGFDWLLIDGEHAP-----------NDVRSTLAQLQAlAAYp-vAPVVRPPVGDTHLIKQ- 90  Deinococcus rad...
2VWS_C        19 QIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAP-----------NTIQDLYHQLQAvAPYa-sQPVIRPVEGSKPLIKQ- 85  Escherichia col...
A6THU5        15 QIGLWLGLCSSYSAELLAGAGFDWLLIDGEHAP-----------NNVPTVLTQLQAiAPYp-sQPVVRPSWNDPVQIKQ- 81  Klebsiella pneu...
1SGJ_A        87 l-sVLTPELSGVVVPKLEMGAEARQVAQMLQERS---------------------------LPLPILAGLETGAGVWNAR 138 Deinococcus rad...
Q9KTU0        85 lnaVVRXGAKVVRLPKTDNANDVIEMEKVIEQIEracg--------------------revGSTRMLAAIESAQGINNAV 144 Vibrio cholerae
P0A9I1        89 leaVVRGGADVVRLPKTDTAQDVLDIEKEILRIEkacg--------------------repGSTGLLAAIESPLGITRAV 148 Escherichia col...
Q8RDW5        83 iraVVKAGVNVVRLPKTDTPNEIIAVDKLIPEVEkei---------------------greGETLLMAAIESATGIMNVK 141 Fusobacterium n...
O82487       157 ---ALDLGPQGIMFPMIESRKDATKAVSYCRFPPdgirgsahtvvrasnygidegylsnyaEEILIMCQVESGEGVKKAD 233 thale cress
1DXE_A        87 ---LLDIGFYNFLIPFVETKEEAELAVASTRYPPegirgvsvshran-mfgtvadyfaqsnKNITILVQIESQQGVDNVD 162 Escherichia coli
WP_010891051  86 ---VLDLGAQTLMVPMVETAEQAKAIVTASRYPPagerglggarasr--wggypayvaeanAQVCIIAQIETATAVDNIE 160 Novosphingobium
Q9RYM1        91 ---YLDLGVQTLLVPMVDTPEQARQLVQATRYPPqgirgvgsalarasrwnavpdyltranDEICLLVQVESRLGLENLD 167 Deinococcus rad...
2VWS_C        86 ---VLDIGAQTLLIPMVDTAEQARQVVSATRYPPygergvgasvaraarwgrienymaqvnDSLCLLVQVESKTALDNLD 162 Escherichia col...
A6THU5        82 ---LLDVGAQTLLVPMVQNAEEARLAVRATRYPPagirgvgsalarasrwnrvpdyihqanDAMCVLVQIETREALKNLP 158 Klebsiella pneu...
1SGJ_A       139 EIM-EVPEVAWAYFGAEDYTTDLGGKRTPGGLEVL----YARSQVALAARLTGVAALDIVVTALNDPETFRADAEQGRAL 213 Deinococcus rad...
Q9KTU0       145 EIAfSSRRLIGIALGAEDYVRDLRTQRSAEGIELL----FARCSILQAARAAGIMAFDTVYSDANNEEGFLREAEHIKQL 220 Vibrio cholerae
P0A9I1       149 EIAhASERLIGIALGAEDYVRNLRTERSPEGTELL----FARCSILQAARSAGIQAFDTVYSDANNEAGFLQEAAHIKQL 224 Escherichia col...
Q8RDW5       142 EIAlASKRLMGIALGAEDYVTNLKTSRSKHGWELY----YAREAIVLAARNAGIYCFDTVYSDVNNLDGFRQEVQFIKDL 217 Fusobacterium n...
O82487       234 EIA-AVDGVDCVQMGPLDLSASLGYLWDPGHKKVRemmkKAEKSVLTTDPAKGGAYLSGFAMPHDGAGEIRGRGYHMVAG 312 thale cress
1DXE_A       163 AIA-ATEGVDGIFVGPSDLAAALGHLGNASHPDVQkaiqHIFNRASAHGKPSGI-----LAPVEADARRYLEWGATFVAV 236 Escherichia coli
WP_010891051 161 AIA-AVDGIDALFLGPADLAATEGLLGASSFDALFkltgEALARIVATGKPAGI-----LSRDERLVQQFLDGGARFIAN 234 Novosphingobium
Q9RYM1       168 EIA-AVEGVDGVFIGPADLSASLGHLGHPGHPDVAqaieDALRRIVGAGKAAGI-----LSADERLARHYLALGATFVAV 241 Deinococcus rad...
2VWS_C       163 EIL-DVEGIDGVFIGPADLSASLGYPDNAGHPEVQriieTSIRRIRAAGKAAGF-----LAVAPDMAQQCLAWGANFVAV 236 Escherichia col...
A6THU5       159 QIL-DVDGVDGVFIGPADLSADMGHGGNPQHPEVQaaieDAIQQIRQAGKAPGI-----LMANEQLAKRYLELGALFVAV 232 Klebsiella pneu...
1SGJ_A       214 GYSGKLCIHP 223 Deinococcus radiodurans
Q9KTU0       221 GFDGKSLINP 230 Vibrio cholerae
P0A9I1       225 GFDGKSLINP 234 Escherichia coli K-12
Q8RDW5       218 GFDGKSCIHP 227 Fusobacterium nucleatum subsp. nucleatum
O82487       313 AVDVGLFRNA 322 thale cress
1DXE_A       237 GSDLGVFRSA 246 Escherichia coli
WP_010891051 235 GIDSFTFAkg 244 Novosphingobium
Q9RYM1       242 GVDTTLLARA 251 Deinococcus radiodurans
2VWS_C       237 GVDTMLYSDA 246 Escherichia coli K-12
A6THU5       233 GVDTTLLArg 242 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
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