3KRE,2GQS,4JA0,1A48


Conserved Protein Domain Family
SAICAR_synt

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pfam01259: SAICAR_synt 
SAICAR synthetase
Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
Statistics
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PSSM-Id: 460140
Aligned: 584 rows
Threshold Bit Score: 178.325
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KRE_A          27 KIYEGKAKIIFAT--LNP-LEVIQHFKDEITAFNNKKAAIIHEKGILNNYISSFLMKKLI-DkGIKTHFIsL--LNQREQ 100 Ehrlichia cha...
WP_013134221    34 LFYIGKNADLYTCpgDEA--KVLLVRSDRCSVFDIPLNLEIKEKGVWQTAISNSGAKFAE-KsGIKT-AVlSenVDPSLI 109 Arcobacter ni...
jgi:AciX8_3639  23 DKYPGKVRDTYD----LGdGRLLLVTTDRQSGFDRMLG-AIPFKGQVLNRTSLHWFAATKhI--VGNHVLrSph--aNAL 93 
XP_002505827    76 qkYEGKVRDTYV-----DdELMIAVTTDRQSAFDRHLA-SIPFKGAVLNRTSAWWFNQTKdI--VPNAWIsSpd--pNVT 145
EEY55596        41 kqiTGKVRDVYV-----FeDRVLLVSTDRQSAFDRALA-SVPFKSRVLTLTSVWWFNQTKhI--VANHLLgVph--pSAM 110
Q5NGF1          24 nkYIGKVRDMYF-----TdDKSILISTDRQSAFDRSLG-FIPFKGQILAQSSVWWFKETAhI--VKNHFIdSpd--pNVV 93  Francisella t...
EFJ31386        67 pkrRGKVRDVYE-----TkDHLVIVTTDRMSAFDRVLA-SIPFKGQVLNQTSVWWFNNTRhI--TPNAFVsApd--pNVT 136
P38025         108 SRIKGKVRDIYD-----AgDYLVLITTDRLSAFDRNLA-SIPFKGQVLNETSLWWFNNTQhI--TPNAIVsSpd--rNVV 177 thale cress
ERN02930        87 tkTRGKVRDVYD-----GgDYLVLVTTDRQSAFDRVLA-SIPFKGQVLNETSTWWFDRTQhI--VQNAVIsVpd--eNVT 156
EMS59140        19 LAAKGKVRDVYE-----SgEHLVLVTTDRQSAFDRVLA-SIPFKGQVLNETSLWWFNRTShI--TPNAVVsSpd--rNVT 88 
3KRE_A         101 LVKKITIIPI---------------EVVIRNLAAGNF------------SK----RF--QIADGTPFKSPIIEFYYKNDE 147 Ehrlichia cha...
WP_013134221   110 IAPRCQIMELckaleaqidgdvvqfEFIFRNYLTGSLfeat----kngnDPyg-lNLpsTLNEWHKFETPIFTPTTKGVK 184 Arcobacter ni...
jgi:AciX8_3639  94 LARKCRVLPI---------------EFVVRGYLTGSTdtsiwtqyakgvRQycghALpeGMRKNEKLQQNIVTPTTKETA 158
XP_002505827   146 VMKKCTVFPI---------------EFVVRGYLTGSTstslwthyskggRDycgnPLadGMVKNQKLPKNIVTPTTKEKE 210
EEY55596       111 LCKKCTVFPV---------------EFVVRGYITGSTstsmwtnykngsRDfcghKLqdGYKQHQKLPQNLVTPTTKDDE 175
Q5NGF1          94 IARKAKVLPI---------------EFVVRGYITGSTstslwthykngsRDycgnILpeGLKKNQKLPQNILTPTTKEQD 158 Francisella t...
EFJ31386       137 IARKCAVFPV---------------EFVVRGYITGSTstslwtvynqgiRYycgnDLpeGLIKNQRLDYLMLTPTTKSDD 201
P38025         178 IAKKCSVFPI---------------EFVVRGYVTGSTdtslwtvynkgvRNycgnELsdGLVKNQKLPANILTPTTKAAD 242 thale cress
ERN02930       157 IAKKCSVFPV---------------EFVVRGFVTGSTdtslwmvyskgiRHycgnVLldGLVKNQKLATNILTPTTKGID 221
EMS59140        89 IAKRCSVFPV---------------EFVVRGFVTGSTdtslwtvynkgvRNycgnAIpdGMVKNQKLPANILTPTTKAAD 153
3KRE_A         148 lsDPMVSEGHILsfQwlTNqELEKIKILSLKINNILSELFFNVGIKLVDFKLEFGKLHndeQSDLFLADEI-SPDTCRLW 226 Ehrlichia cha...
WP_013134221   185 --DIPLNSQNV-------ReKFPEIISSLEKLFKEFTQYAQDNGIVVVDTKLEVFVNA---KGEWILGDEIlTPESSRFI 252 Arcobacter ni...
jgi:AciX8_3639 159 h-DRPITAQEIVaeGwmTAeQWEFCSAKALALFAFGQKIAAEHGLILVDTKYEFGVGd---DGEILLIDEIhTPDSSRYW 234
XP_002505827   211 h-DRPISLADIVseGwmEKdDLDYCVAKTLEVFEFAQRVAAERGLILVDTKYEFGRDa---DGVIRLIDEInTPDSSRYW 286
EEY55596       176 h-DELISGVEIVssGrmTQeQWDYCEKKTLELFAFGQEQAAKRGLILVDTKYEFGYDEa--TGEILLIDEIhTPDSSRYW 252
Q5NGF1         159 h-DRPISAEDIVkeGwlTQqQWDFASQKALELFEFGQKKALEHGLILADTKYEFGIDEq--TGEIILIDEIhTPDSSRFW 235 Francisella t...
EFJ31386       202 h-DRPISGEEIVeqGlmSEaDYKSVSSKALALFAYGQEVALKHGLLLVDTKYEFGKMa---DGSICLIDEVhTPDSSRYW 277
P38025         243 h-DVPISPNEIVegGfmTQaEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSs---DGSILLIDEIhTPDSSRYW 318 thale cress
ERN02930       222 h-DIPVTPDQIIgqGlmTKdEFDEASHKALQLFEYGQHVALEHGLILVDTKYEFGKDs---DGSLCLIDEVhTPDSSRYW 297
EMS59140       154 h-DVPITPDEIVksGlmSKdDFDEARSKALSLFEYGQKVALENGVILVDTKYEFGKTa---DGTVVLIDEVhTPDSSRYW 229
3KRE_A         227 DIST----------NKRLDKDRYRLNLGNVIEGYRE 252 Ehrlichia chaffeensis str. Arkansas
WP_013134221   253 SKENfda-----knFISMDKQILRNFAKE--NNWKE 281 Arcobacter nitrofigilis
jgi:AciX8_3639 235 LADSyaerlavgqePDMIDKEFFRLWFRERCDPYKD 270
XP_002505827   287 LADSyaerhaaglePDMIDKEFLRLWFAERCDPYND 322
EEY55596       253 LADSyeqrmaegksPENIDKEFLRLWFKERCDPYND 288
Q5NGF1         236 LKDSyatrfengeePENIDKEFFRLWFAKNCDPYND 271 Francisella tularensis subsp. tularensis
EFJ31386       278 IAGSyeermkqglePENIDKEFLRLWFKDNCNPYED 313
P38025         319 LAGSyeerfqkglePENVDKEFLRLWFKENCNPYED 354 thale cress
ERN02930       298 IAHSyeeriknglePENVDKEFLRLWFKDHCNPYED 333
EMS59140       230 IANSyeerfksglePENVDKEFLRLWFKNNCNPYED 265
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