hspb3 heat shock protein, alpha-crystallin-related, b3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspb3provided by ZNC
Official Full Name: heat shock protein, alpha-crystallin-related, b3provided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-338
See related: Ensembl:ENSDARG00000067714 AllianceGenome:ZFIN:ZDB-GENE-070705-338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-193c22.3
Summary: Predicted to be active in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 2C. Orthologous to human HSPB3 (heat shock protein family B (small) member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (40292790..40297086, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (39696234..39696916, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hspb3 is expressed during development.
Title: Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein beta-3

Names: small heat shock protein HSPB3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099452.1 → NP_001092922.1 heat shock protein beta-3

See identical proteins and their annotated locations for NP_001092922.1

Status: PROVISIONAL

Source sequence(s)

EF583629

UniProtKB/TrEMBL

A5JV81

Related

ENSDARP00000088297.2, ENSDART00000097526.4

Conserved Domains (1) summary

cd06477
Location:60 → 143

ACD_HspB3_Like; Alpha crystallin domain (ACD) found in mammalian HspB3, also known as heat-shock protein 27-like protein (HSPL27, 17-kDa) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are ...