Hspb3 heat shock protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspb3provided by MGI
Official Full Name: heat shock protein 3provided by MGI
Primary source: MGI:MGI:1928479
See related: Ensembl:ENSMUSG00000051456 AllianceGenome:MGI:1928479
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: spb3; Hsbp3; 2310035K17Rik
Summary: Predicted to be located in nucleus. Predicted to be active in cytoplasm and nuclear speck. Is expressed in several structures, including limb segment; lung; nervous system; skeletal musculature; and submandibular gland. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 2C. Orthologous to human HSPB3 (heat shock protein family B (small) member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 13; 13 D2.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (113799432..113800212, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (113662896..113663676, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that the endogenous HSPB3 protein distribution in the spinal cords of chicken and mouse embryos and in the postnatal nervous system (central and peripheral) of chicken, mouse and human.
Title: HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.
It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes' coexpression network.
Title: Map3k1, Il6st, Gzmk, and Hspb3 gene coexpression network in the mechanism of freezing reaction in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Homology

Homologs of the Hspb3 gene: The Hspb3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 396 organisms have orthologs with human gene Hspb3
Orthologs

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein beta-3

Names: heat shock 27kD protein 3; small heat shock protein B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019960.2 → NP_064344.1 heat shock protein beta-3

See identical proteins and their annotated locations for NP_064344.1

Status: VALIDATED

Source sequence(s)

AK009633

Consensus CDS

CCDS26785.1

UniProtKB/Swiss-Prot

Q569N3, Q9QZ57

UniProtKB/TrEMBL

A0A6P5R415

Related

ENSMUSP00000054193.5, ENSMUST00000054650.5

Conserved Domains (1) summary

cd06477
Location:67 → 149

ACD_HspB3_Like; Alpha crystallin domain (ACD) found in mammalian HspB3, also known as heat-shock protein 27-like protein (HSPL27, 17-kDa) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are ...