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MIP6 Mip6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856408, updated on 25-Apr-2024

Summary

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Gene symbol
MIP6
Gene description
Mip6p
Primary source
SGD:S000001057
Locus tag
YHR015W
See related
AllianceGenome:SGD:S000001057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Involved in mRNA localization resulting in posttranscriptional regulation of gene expression; mRNA metabolic process; and regulation of translation. Located in prospore membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (134554..136533)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene tRNA-Gln Neighboring gene Ysc84p Neighboring gene Ysc83p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A multi-omics dataset of heat-shock response in the yeast RNA binding protein Mip6. Nuño-Cabanes C, et al. Sci Data, 2020 Feb 27. PMID 32109230, Free PMC Article
  2. Predicted RNA Binding Proteins Pes4 and Mip6 Regulate mRNA Levels, Translation, and Localization during Sporulation in Budding Yeast. Jin L, et al. Mol Cell Biol, 2017 May 1. PMID 28193845, Free PMC Article
  3. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. Segref A, et al. EMBO J, 1997 Jun 2. PMID 9214641, Free PMC Article
  4. A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression. Bolognesi B, et al. Cell Rep, 2016 Jun 28. PMID 27320918, Free PMC Article
  5. Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs. Martín-Expósito M, et al. EMBO Rep, 2019 Dec 5. PMID 31680439, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mip6 directly interacts with the ubiquitin-associated domain of Mex67 through a loop containing tryptophan 442. Mip6 shuttles between the nucleus and the cytoplasm in a Mex67-dependent manner and concentrates in cytoplasmic foci under stress.
    Title: Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs.
  2. This report describes the characterization of two related NDT80-induced genes, PES4 and MIP6, encoding predicted RNA binding proteins. These genes are necessary to regulate the steady-state expression, translational timing, and localization of a set of mRNAs that are transcribed by NDT80 but not translated until the end of meiosis II.
    Title: Predicted RNA Binding Proteins Pes4 and Mip6 Regulate mRNA Levels, Translation, and Localization during Sporulation in Budding Yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA localization resulting in post-transcriptional regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sporulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mip6p
NP_011879.1
  • mRNA-binding protein; interacts with the UBA domain of mRNA export factor Mex67p; participates in the export of Msn2/4 stress-dependent mRNAs; partially redundant function with paralog PES4 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; redundant role with PES4 in sporulation; shuttles between the nucleus and cytoplasm, localizes to stress granules and the prospore membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    134554..136533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179145.1 → NP_011879.1  TPA: Mip6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011879.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKW0, P38760
    UniProtKB/TrEMBL
    A0A6V8RZC8, A6ZSR9, B3LSD6, C7GXB0, C8ZA82, G2WF83, N1P2R4
    Conserved Domains (5) summary
    COG0724
    Location:8 → 187
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd21601
    Location:111 → 190
    RRM1_PES4_MIP6; RNA recognition motif 1 (RRM1) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
    cd21602
    Location:200 → 275
    RRM2_PES4_MIP6; RNA recognition motif 2 (RRM2) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
    cd21603
    Location:313 → 385
    RRM3_PES4_MIP6; RNA recognition motif 3 (RRM3) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
    cd21604
    Location:400 → 478
    RRM4_PES4_MIP6; RNA recognition motif 4 (RRM4) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38760.1

Gene LinkOut

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