Scpep1 serine carboxypeptidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scpep1provided by MGI
Official Full Name: serine carboxypeptidase 1provided by MGI
Primary source: MGI:MGI:1921867
See related: Ensembl:ENSMUSG00000000278 AllianceGenome:MGI:1921867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Risc; 2410018F01Rik; 4833411K15Rik
Summary: Enables serine-type carboxypeptidase activity. Involved in negative regulation of blood pressure. Acts upstream of or within blood vessel diameter maintenance. Predicted to be located in cytosol. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and musculature. Orthologous to human SCPEP1 (serine carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 73.9), bladder adult (RPKM 35.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 54.34 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (88814846..88846268, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (88924020..88955442, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in normal tissues the tandem of serine carboxypeptidases, Scpep1 and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Title: Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.
our results define the biological role of mammalian serine carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together participate in the control of ET-1 regulation of vascular tone and hemodynamics
Title: Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1.
A closer look to the mRNA transcriptome allowed authors to identify upregulation of five miRISC genes, including Dgcr8 and Fmr1, and Ago2, which were later confirmed by real time PCR.
Title: Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model.
SCPEP1 promotes smooth muscle cell proliferation and migration in a catalytic triad-dependent, cleavage-independent manner.
Title: Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells.
Scpep1-deficient mice were viable and fertile, and did not exhibit either lysosomal storage or reduced lysosomal SC activity under any tested condition.
Title: Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Gene trapped (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI957256 (e-PCR)
- UniSTS:180291

D11Mit370 (e-PCR), detects polymorphism
- UniSTS:141769

D10Rat131 (e-PCR), detects polymorphism
- UniSTS:226281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type carboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type carboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel diameter maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoid-inducible serine carboxypeptidase

Names: retinoid-inducible serine caroboxypeptidase; retinoid-inducible serine caroboxypetidase; serine caroboxypeptidase 1

NP_083299.3

EC 3.4.16.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.