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Nudt12 nudix hydrolase 12 [ Mus musculus (house mouse) ]

Gene ID: 67993, updated on 25-Apr-2024

Summary

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Official Symbol
Nudt12provided by MGI
Official Full Name
nudix hydrolase 12provided by MGI
Primary source
MGI:MGI:1915243
See related
Ensembl:ENSMUSG00000024228 AllianceGenome:MGI:1915243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610016O18Rik
Summary
Enables RNA NAD-cap (NMN-forming) hydrolase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in NAD-cap decapping; circadian regulation of gene expression; and mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Is expressed in eye. Orthologous to human NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 3.4), kidney adult (RPKM 2.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 30.64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (59307104..59320317, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (59000107..59013367, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene general transcription factor III A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42933 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene predicted gene, 33751 Neighboring gene STARR-seq mESC enhancer starr_42935 Neighboring gene nudix hydrolase 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42936 Neighboring gene STARR-seq mESC enhancer starr_42937 Neighboring gene nuclear encoded tRNA valine 3 (anticodon CAC) Neighboring gene predicted gene, 23769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. Sharma S, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32432673, Free PMC Article
  2. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim SR, et al. Biochem J, 2003 Sep 1. PMID 12790796, Free PMC Article
  3. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Grudzien-Nogalska E, et al. Nat Chem Biol, 2019 Jun. PMID 31101919, Free PMC Article
  4. Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs. Wu H, et al. Cell Rep, 2019 Dec 24. PMID 31875550
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
    Title: Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH pyrophosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA NAD-cap (NMN-forming) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphodiesterase decapping endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NAD catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in NAD catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD-cap decapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD-cap decapping ISO
Inferred from Sequence Orthology
more info
  
involved_in NADH metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NADP catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in NADP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA methylguanosine-cap decapping ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
NAD-capped RNA hydrolase NUDT12
Names
NADH pyrophosphatase NUDT12
deNADding enzyme NUDT12
nucleoside diphosphate-linked moiety X motif 12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
nudix (nucleoside diphosphnudix (nucleoside diphosphate linked moiety X)-type motif 12ate linked moiety X)-type motif 12
nudix motif 12
peroxisomal NADH pyrophosphatase NUDT12
NP_001355322.1
NP_080773.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368393.1 → NP_001355322.1  NAD-capped RNA hydrolase NUDT12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009564

  2. NM_026497.3 → NP_080773.1  NAD-capped RNA hydrolase NUDT12 isoform 1

    See identical proteins and their annotated locations for NP_080773.1

    Status: VALIDATED

    Source sequence(s)
    AK002641, CT009564
    Consensus CDS
    CCDS28933.1
    UniProtKB/Swiss-Prot
    Q6PFA5, Q9DCN1
    UniProtKB/TrEMBL
    Q3UGL8
    Related
    ENSMUSP00000025065.6, ENSMUST00000025065.12
    Conserved Domains (7) summary
    COG2816
    Location:126 → 457
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:16 → 98
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323 → 457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:147 → 277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279 → 302
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:31 → 86
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:14 → 43
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    59307104..59320317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCN1.1 GenPept UniProtKB/Swiss-Prot:Q9DCN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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