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Mfsd4a major facilitator superfamily domain containing 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 498228, updated on 29-Apr-2024

Summary

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Official Symbol
Mfsd4aprovided by RGD
Official Full Name
major facilitator superfamily domain containing 4Aprovided by RGD
Primary source
RGD:1566090
See related
Ensembl:ENSRNOG00000024657 AllianceGenome:RGD:1566090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mfsd4; RGD1566090
Summary
Predicted to enable glucose transmembrane transporter activity. Predicted to be involved in glucose transmembrane transport. Predicted to be integral component of membrane. Orthologous to human MFSD4A (major facilitator superfamily domain containing 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 103.8), Thymus (RPKM 77.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46015321..46062633, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43469488..43510467, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48807720..48848997, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 45, member 3 Neighboring gene uncharacterized LOC134481494 Neighboring gene ETS transcription factor ELK4 Neighboring gene uncharacterized LOC134481495 Neighboring gene cyclin-dependent kinase 18 Neighboring gene BLACAT1 overlapping LEMD1 locus Neighboring gene microRNA 135b Neighboring gene LEM domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, et al. PeerJ, 2019. PMID 31687280, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 4A
Names
major facilitator superfamily domain containing 4
major facilitator superfamily domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109069.2 → NP_001102539.1  major facilitator superfamily domain-containing protein 4A isoform 1

    See identical proteins and their annotated locations for NP_001102539.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IC39, D4A6P2
    Related
    ENSRNOP00000061845.1, ENSRNOT00000068003.3
    Conserved Domains (2) summary
    cd06174
    Location:18 → 480
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:22 → 442
    MFS_1; Major Facilitator Superfamily

  2. NM_001429795.1 → NP_001416724.1  major facilitator superfamily domain-containing protein 4A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001429796.1 → NP_001416725.1  major facilitator superfamily domain-containing protein 4A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  4. NM_001429797.1 → NP_001416726.1  major facilitator superfamily domain-containing protein 4A isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  5. NM_001429798.1 → NP_001416727.1  major facilitator superfamily domain-containing protein 4A isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    46015321..46062633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272534.1 → XP_063128604.1  major facilitator superfamily domain-containing protein 4A isoform X4

    UniProtKB/TrEMBL
    A6IC39, D4A6P2

  2. XM_006249791.3 → XP_006249853.1  major facilitator superfamily domain-containing protein 4A isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6P5
    Related
    ENSRNOP00000073892.1, ENSRNOT00000077857.2
    Conserved Domains (2) summary
    cd06174
    Location:18 → 480
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:22 → 442
    MFS_1; Major Facilitator Superfamily

  3. XM_063272533.1 → XP_063128603.1  major facilitator superfamily domain-containing protein 4A isoform X3

  4. XM_039090963.2 → XP_038946891.1  major facilitator superfamily domain-containing protein 4A isoform X2

    UniProtKB/TrEMBL
    A0A8I6GFK9
    Related
    ENSRNOP00000087008.1
    Conserved Domains (1) summary
    cl28910
    Location:18 → 428
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version

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