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AGER advanced glycosylation end-product specific receptor [ Bos taurus (cattle) ]

Gene ID: 280986, updated on 5-Mar-2024

Summary

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Official Symbol
AGERprovided by VGNC
Official Full Name
advanced glycosylation end-product specific receptorprovided by VGNC
Primary source
VGNC:VGNC:25724
See related
BGD:BT12093; Ensembl:ENSBTAG00000014420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
RAGE
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27205663..27209270)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene notch receptor 4 Neighboring gene PBX homeobox 2 Neighboring gene ring finger protein 5 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene EGF like domain multiple 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Up-regulation in receptor for advanced glycation end-products in inflammatory circumstances in bovine coccygeal intervertebral disc specimens in vitro. Yoshida T, et al. Spine (Phila Pa 1976), 2009 Jul 1. PMID 19564763
  2. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. Schmidt AM, et al. J Biol Chem, 1992 Jul 25. PMID 1321822
  3. RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages. Yan L, et al. Int J Mol Sci, 2023 Apr 10. PMID 37108174, Free PMC Article
  4. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. Neeper M, et al. J Biol Chem, 1992 Jul 25. PMID 1378843
  5. Complex tissue-specific patterns and distribution of multiple RAGE splice variants in different mammals. López-Díez R, et al. Genome Biol Evol, 2013. PMID 24273313, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
    Title: RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
  2. Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan content in nucleus pulposus.
    Title: Up-regulation in receptor for advanced glycation end-products in inflammatory circumstances in bovine coccygeal intervertebral disc specimens in vitro.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC140817

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
advanced glycosylation end product-specific receptor
Names
receptor for advanced glycosylation end products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173982.3 → NP_776407.1  advanced glycosylation end product-specific receptor precursor

    See identical proteins and their annotated locations for NP_776407.1

    Status: PROVISIONAL

    Source sequence(s)
    M91212
    UniProtKB/Swiss-Prot
    Q28173
    UniProtKB/TrEMBL
    F1N306
    Related
    ENSBTAP00000019179.3, ENSBTAT00000019179.4
    Conserved Domains (4) summary
    smart00408
    Location:261 → 316
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254 → 328
    IG_like; Immunoglobulin like
    pfam00047
    Location:24 → 110
    ig; Immunoglobulin domain
    pfam08205
    Location:123 → 218
    C2-set_2; CD80-like C2-set immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27205663..27209270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010818312.1 → XP_010816614.1  advanced glycosylation end product-specific receptor isoform X1

    UniProtKB/TrEMBL
    F1N306
    Conserved Domains (4) summary
    cd00096
    Location:34 → 110
    Ig; Immunoglobulin domain
    smart00408
    Location:267 → 322
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260 → 334
    IG_like; Immunoglobulin like
    pfam08205
    Location:123 → 218
    C2-set_2; CD80-like C2-set immunoglobulin domain

  2. XM_010818313.1 → XP_010816615.1  advanced glycosylation end product-specific receptor isoform X2

    UniProtKB/TrEMBL
    F1N306
    Conserved Domains (4) summary
    cd00096
    Location:34 → 110
    Ig; Immunoglobulin domain
    smart00408
    Location:254 → 309
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:247 → 321
    IG_like; Immunoglobulin like
    pfam08205
    Location:123 → 218
    C2-set_2; CD80-like C2-set immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28173.1 GenPept UniProtKB/Swiss-Prot:Q28173

Gene LinkOut

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