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ncoa1 nuclear receptor coactivator 1 [ Oreochromis niloticus (Nile tilapia) ]

Gene ID: 100700776, updated on 8-Mar-2024

Summary

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Gene symbol
ncoa1
Gene description
nuclear receptor coactivator 1
See related
Ensembl:ENSONIG00000015724
Gene type
protein coding
RefSeq status
MODEL
Organism
Oreochromis niloticus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Oreochromini; Oreochromis
Expression
Broad expression in testis (RPKM 4.6), brain (RPKM 3.6) and 9 other tissues See more
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: LG15
Exon count:
24
Annotation release Status Assembly LG Location
104 current O_niloticus_UMD_NMBU (GCF_001858045.2) LG15 NC_031980.2 (19457832..19538040)
103 previous assembly ASM185804v2 (GCF_001858045.1) LG15 NC_031980.1 (17784778..17867619)

Linkage Group LG15 - NC_031980.2Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 184 member Ab Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene uncharacterized LOC112842521 Neighboring gene unc-93 homolog A Neighboring gene afadin, adherens junction formation factor a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oreochromis niloticus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference O_niloticus_UMD_NMBU Primary Assembly

Genomic

  1. NC_031980.2 Reference O_niloticus_UMD_NMBU Primary Assembly

    Range
    19457832..19538040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025899255.1 → XP_025755040.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A669BMX2, I3KF92
    Related
    ENSONIP00000019787.1, ENSONIT00000019804.2
    Conserved Domains (9) summary
    smart00353
    Location:31 → 86
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1053
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:573 → 644
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262 → 371
    PAS_11; PAS domain
    pfam16665
    Location:450 → 508
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26464
    Location:794 → 1083
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:638 → 927
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28087
    Location:818 → 1391
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. XM_019346076.2 → XP_019201621.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A669BMX2, I3KF92
    Conserved Domains (9) summary
    smart00353
    Location:31 → 86
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1053
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:573 → 644
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262 → 371
    PAS_11; PAS domain
    pfam16665
    Location:450 → 508
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26464
    Location:794 → 1083
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:638 → 927
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28087
    Location:818 → 1391
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  3. XM_013265044.3 → XP_013120498.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A669BMX2, I3KF92
    Conserved Domains (9) summary
    smart00353
    Location:31 → 86
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1053
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:573 → 644
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262 → 371
    PAS_11; PAS domain
    pfam16665
    Location:450 → 508
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26464
    Location:794 → 1083
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:638 → 927
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28087
    Location:818 → 1391
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  4. XM_025899256.1 → XP_025755041.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A669BMX2, I3KF92
    Related
    ENSONIP00000035755.1, ENSONIT00000069126.1
    Conserved Domains (9) summary
    smart00353
    Location:31 → 86
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1053
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:573 → 644
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262 → 371
    PAS_11; PAS domain
    pfam16665
    Location:450 → 508
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26464
    Location:794 → 1083
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:638 → 927
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28087
    Location:818 → 1391
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  5. XM_019346075.2 → XP_019201620.1  nuclear receptor coactivator 1 isoform X2

    UniProtKB/TrEMBL
    A0A669BMX2

  6. XM_019346074.2 → XP_019201619.1  nuclear receptor coactivator 1 isoform X1

    UniProtKB/TrEMBL
    A0A669BMX2

  7. XM_013265045.3 → XP_013120499.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A669BMX2, I3KF92
    Conserved Domains (9) summary
    smart00353
    Location:31 → 86
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam08815
    Location:1007 → 1053
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:573 → 644
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262 → 371
    PAS_11; PAS domain
    pfam16665
    Location:450 → 508
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26464
    Location:794 → 1083
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:638 → 927
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28087
    Location:818 → 1391
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version

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