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    EEF1D eukaryotic translation elongation factor 1 delta [ Bos taurus (cattle) ]

    Gene ID: 516473, updated on 5-Apr-2024

    Summary

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    Official Symbol
    EEF1Dprovided by VGNC
    Official Full Name
    eukaryotic translation elongation factor 1 deltaprovided by VGNC
    Primary source
    VGNC:VGNC:53861
    See related
    Ensembl:ENSBTAG00000014643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See EEF1D in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (1113581..1126356)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene tigger transposable element derived 5 Neighboring gene uncharacterized LOC132342144 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene maestro heat like repeat family member 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle. Xie Y, et al. Gene, 2014 Jan 25. PMID 24239553
    2. Regulation of DNA methylation on EEF1D and RPL8 expression in cattle. Liu X, et al. Genetica, 2017 Oct. PMID 28667419, Free PMC Article
    3. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. result suggests that the DNA methylation of EEF1D plays an important role in the spatial and temporal regulation of its expression and possibly have an effect on the milk production traits
      Title: Regulation of DNA methylation on EEF1D and RPL8 expression in cattle.
    2. Findings present the first report on the alternative splicing of the bovine EEF1D gene.
      Title: Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elongation factor 1-delta
    Names
    EF-1-delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206620.2 → NP_001193549.1  elongation factor 1-delta isoform 2

      See identical proteins and their annotated locations for NP_001193549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (EEF1Da, PMID:24239553) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BC105375, EV683636, EV704156, NKLS02000014
      UniProtKB/Swiss-Prot
      A5D989
      UniProtKB/TrEMBL
      A0A3Q1M9K4, L7R5X3
      Related
      ENSBTAP00000067245.2, ENSBTAT00000078970.2
      Conserved Domains (2) summary
      pfam00736
      Location:197 → 280
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:159 → 185
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    2. NM_001289966.1 → NP_001276895.1  elongation factor 1-delta isoform 1

      See identical proteins and their annotated locations for NP_001276895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC105375, EV704156, EW685785, NKLS02000014
      UniProtKB/TrEMBL
      A0A452DIM3
      Related
      ENSBTAP00000019499.6, ENSBTAT00000019499.6
      Conserved Domains (2) summary
      pfam00736
      Location:554 → 637
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:516 → 542
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      1113581..1126356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059893228.1 → XP_059749211.1  elongation factor 1-delta isoform X1

    2. XM_005215199.3 → XP_005215256.3  elongation factor 1-delta isoform X2

    3. XM_059893229.1 → XP_059749212.1  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      A0A452DIM3
      Related
      ENSBTAP00000091872.1, ENSBTAT00000089901.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5D989.2 GenPept UniProtKB/Swiss-Prot:A5D989

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.